Pedro F Ferreira, Sonia Nielles-Vallespin, Andrew D Scott, Ranil Silva, Philip J Kilner, Daniel B Ennis, Daniel A Auger, Jonathan D Suever, Xiaodong Zhong, Bruce S Spottiswoode, Dudley J Pennell, Andrew E Arai and David N Firmin.
Evaluation of the impact of strain correction on the orientation of cardiac diffusion tensors with in vivo and ex vivo porcine hearts..
Magnetic resonance in medicine 79(4):2205–2215, April 2018.
URL, DOI BibTeX
@article{Ferreira2018,
abstract = "PURPOSE To evaluate the importance of strain-correcting stimulated echo acquisition mode echo-planar imaging cardiac diffusion tensor imaging. METHODS Healthy pigs (n = 11) were successfully scanned with a 3D cine displacement-encoded imaging with stimulated echoes and a monopolar-stimulated echo-planar imaging diffusion tensor imaging sequence at 3 T during diastasis, peak systole, and strain sweet spots in a midventricular short-axis slice. The same diffusion tensor imaging sequence was repeated ex vivo after arresting the hearts in either a relaxed (KCl-induced) or contracted (BaCl2-induced) state. The displacement-encoded imaging with stimulated echoes data were used to strain-correct the in vivo cardiac diffusion tensor imaging in diastole and systole. The orientation of the primary (helix angles) and secondary (E2A) diffusion eigenvectors was compared with and without strain correction and to the strain-free ex vivo data. RESULTS Strain correction reduces systolic E2A significantly when compared without strain correction and ex vivo (median absolute E2A = 34.3° versus E2A = 57.1° (P = 0.01), E2A = 60.5° (P = 0.006), respectively). The systolic distribution of E2A without strain correction is closer to the contracted ex vivo distribution than with strain correction, root mean square deviation of 0.027 versus 0.038. CONCLUSIONS The current strain-correction model amplifies the contribution of microscopic strain to diffusion resulting in an overcorrection of E2A. Results show that a new model that considers cellular rearrangement is required. Magn Reson Med 79:2205-2215, 2018. {\textcopyright} 2017 International Society for Magnetic Resonance in Medicine.",
author = "Ferreira, Pedro F and Nielles-Vallespin, Sonia and Scott, Andrew D and de Silva, Ranil and Kilner, Philip J and Ennis, Daniel B and Auger, Daniel A and Suever, Jonathan D and Zhong, Xiaodong and Spottiswoode, Bruce S and Pennell, Dudley J and Arai, Andrew E and Firmin, David N",
doi = "10.1002/mrm.26850",
issn = "1522-2594",
journal = "Magnetic resonance in medicine",
keywords = "cardiac,cardiomyocyte,diffusion tensor imaging,microstructure,sheetlets,strain",
month = "apr",
number = 4,
pages = "2205--2215",
pmid = 28734017,
title = "{Evaluation of the impact of strain correction on the orientation of cardiac diffusion tensors with in vivo and ex vivo porcine hearts.}",
url = "http://doi.wiley.com/10.1002/mrm.26850 http://www.ncbi.nlm.nih.gov/pubmed/28734017 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5776058",
volume = 79,
year = 2018
}
Vassilios S Vassiliou, Katharina Wassilew, Donnie Cameron, Ee Ling Heng, Evangelia Nyktari, George Asimakopoulos, Anthony Souza, Shivraman Giri, Iain Pierce, Andrew Jabbour, David Firmin, Michael Frenneaux, Peter Gatehouse, Dudley J Pennell and Sanjay K Prasad.
Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T 1 mapping: averaging to improve precision and correlation with collagen volume fraction.
Magnetic Resonance Materials in Physics, Biology and Medicine 31(1):101–113, February 2018.
URL, DOI BibTeX
@article{Vassiliou2018,
abstract = "OBJECTIVES Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T1mapping versus assessment at a single ventricular level. MATERIALS AND METHODS For assessment of T1mapping precision, a cohort of 15 healthy volunteers underwent two CMR scans on separate days using an 11 heartbeat MOLLI with a 5(3)3 beat scheme to measure native T1and a 4(1)3(1)2 beat post-contrast scheme to measure post-contrast T1, allowing calculation of partition coefficient and ECV. To assess correlation of T1mapping with collagen volume fraction, a separate cohort of ten aortic stenosis patients scheduled to undergo surgery underwent one CMR scan with this 11 heartbeat MOLLI scheme, followed by intraoperative tru-cut myocardial biopsy. Six models of myocardial diffuse fibrosis assessment were established with incremental inclusion of imaging by averaging of the basal and mid-myocardial left ventricular levels, and each model was assessed for precision and correlation with collagen volume fraction. RESULTS A model using 11 heart beat MOLLI imaging of two basal and two mid ventricular level averaged T1maps provided improved precision (Intraclass correlation 0.93 vs 0.84) and correlation with histology (R2 = 0.83 vs 0.36) for diffuse fibrosis compared to a single mid-ventricular level alone. ECV was more precise and correlated better than native T1mapping. CONCLUSION T1mapping sequences with repeated averaging could be considered for applications of 11 heartbeat MOLLI, especially when small changes in native T1/ECV might affect clinical management.",
author = "Vassiliou, Vassilios S. and Wassilew, Katharina and Cameron, Donnie and Heng, Ee Ling and Nyktari, Evangelia and Asimakopoulos, George and de Souza, Anthony and Giri, Shivraman and Pierce, Iain and Jabbour, Andrew and Firmin, David and Frenneaux, Michael and Gatehouse, Peter and Pennell, Dudley J. and Prasad, Sanjay K.",
doi = "10.1007/s10334-017-0630-3",
issn = "0968-5243",
journal = "Magnetic Resonance Materials in Physics, Biology and Medicine",
keywords = ",Correlation with collagen volume fraction,Extracellular volume,Gadolinium,MOLLI,Precision,T 1 mapping",
month = "feb",
number = 1,
pages = "101--113",
pmid = 28608326,
title = "{Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T 1 mapping: averaging to improve precision and correlation with collagen volume fraction}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28608326 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5813064 http://link.springer.com/10.1007/s10334-017-0630-3",
volume = 31,
year = 2018
}
Michael McGarvey, Omar Ali, Bilal M Iqbal, Charles Ilsley, Joyce Wong, Carlo Di Mario, Simon Redwood, Tiffany Patterson, Dudley J Pennell, Paula Rogers, Miles Dalby and ORCA-3 For Optimal Restoration Cardiac Activity (ORCA) Group.
A feasibility and safety study of intracoronary hemodilution during primary coronary angioplasty in order to reduce reperfusion injury in myocardial infarction.
Catheterization and Cardiovascular Interventions 91(2):234–241, February 2018.
URL, DOI BibTeX
@article{McGarvey2018,
abstract = "OBJECTIVES We designed a pilot study to evaluate safety and feasibility of an inexpensive and simple approach to intracoronary hemodilution during primary angioplasty (PPCI) to reduce reperfusion injury. INTRODUCTION Early revascularization in acute myocardial infarction decreases infarct size and improves outcomes. However, abrupt restoration of coronary flow results in myocardial reperfusion injury and increased final infarct size. Dilution of coronary blood during revascularization may help reduce this damage. If proved effective, such an approach would need to be simple and suitable for widespread adoption. METHODS Ten patients presenting with STEMI underwent intracoronary dilution with room temperature Hartmann's solution delivered through the guiding catheter during primary angioplasty (PPCI). Infusion of perfusate began prior to crossing the occluded artery with the guidewire, continuing until 10 min after completion of the balloon and stenting procedure. Infusion was briefly interrupted for contrast injection and pressure monitoring. The outcome measures were safety, including intracoronary temperature reduction and volume of intracoronary perfusate infused, and technical feasibility. RESULTS There were no significant symptomatic, hemodynamic, ECG ST/T segment or rhythm changes observed during perfusate administration. The median (interquartile range) volume of perfusate administered was 550 mL (350-725 mL) and the median intracoronary temperature reduction observed was 3.4°Celsius. Myocardial salvage was 0.54 (0.43-0.65). CONCLUSIONS Transcatheter intracoronary hemodilution with room temperature perfusate during PPCI is feasible and appears safe. Such a strategy is simple and inexpensive, with potential to be widely applied. Further mechanistic and subsequent outcome powered studies are required to evaluate whether this strategy can reduce reperfusion injury in STEMI.",
author = "McGarvey, Michael and Ali, Omar and Iqbal, M. Bilal and Ilsley, Charles and Wong, Joyce and {Di Mario}, Carlo and Redwood, Simon and Patterson, Tiffany and Pennell, Dudley J. and Rogers, Paula and Dalby, Miles and {ORCA-3 For the Optimal Restoration of Cardiac Activity (ORCA) Group}",
doi = "10.1002/ccd.27136",
issn = 15221946,
journal = "Catheterization and Cardiovascular Interventions",
keywords = "STEMI,cooling,primary angioplasty,reperfusion injury,transcoronary",
month = "feb",
number = 2,
pages = "234--241",
pmid = 28636165,
title = "{A feasibility and safety study of intracoronary hemodilution during primary coronary angioplasty in order to reduce reperfusion injury in myocardial infarction}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28636165 http://doi.wiley.com/10.1002/ccd.27136",
volume = 91,
year = 2018
}
Riikka Rydman, Yumi Shiina, Gerhard-Paul Diller, Koichiro Niwa, Wei Li, Hideki Uemura, Anselm Uebing, Umberto Barbero, Beatriz Bouzas, Sabine Ernst, Tom Wong, Dudley J Pennell, Michael A Gatzoulis and Sonya V Babu-Narayan.
Major adverse events and atrial tachycardia in Ebstein's anomaly predicted by cardiovascular magnetic resonance.
Heart 104(1):37–44, January 2018.
URL, DOI BibTeX
@article{Rydman2018,
abstract = "{OBJECTIVES Patients with Ebstein's anomaly of the tricuspid valve (EA) are at risk of tachyarrhythmia, congestive heart failure and sudden cardiac death. We sought to determine the value of cardiovascular magnetic resonance (CMR) for predicting these outcomes. METHODS Seventy-nine consecutive adult patients (aged 37±15 years) with unrepaired EA underwent CMR and were followed prospectively for a median 3.4 (range 0.4-10.9) years for clinical outcomes, namely major adverse cardiovascular events (MACEs: sustained ventricular tachycardia/heart failure hospital admission/cardiac transplantation/death) and first-onset atrial tachyarrhythmia (AT). RESULTS CMR-derived variables associated with MACE (n=6) were right ventricular (RV) or left ventricular (LV) ejection fraction (EF) (HR 2.06, 95{\%} CI 1.168 to 3.623",
p = "",
author = "Rydman, Riikka and Shiina, Yumi and Diller, Gerhard-Paul and Niwa, Koichiro and Li, Wei and Uemura, Hideki and Uebing, Anselm and Barbero, Umberto and Bouzas, Beatriz and Ernst, Sabine and Wong, Tom and Pennell, Dudley J and Gatzoulis, Michael A and Babu-Narayan, Sonya V",
doi = "10.1136/heartjnl-2017-311274",
issn = "1355-6037",
journal = "Heart",
keywords = "Ebstein's anomaly,arrhythmia,cardiovascular magnetic resonance,sudden cardiac death",
month = "jan",
number = 1,
pages = "37--44",
pmid = 28684436,
title = "{Major adverse events and atrial tachycardia in Ebstein's anomaly predicted by cardiovascular magnetic resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28684436 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5749347 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2017-311274",
volume = 104,
year = 2018
}
Beatrice Bonello, Darryl F Shore, Anselm Uebing, Gerhard-Paul Diller, Jennifer Keegan, Elisabeth D Burman, Yumi Shiina, Lorna Swan, Dudley J Pennell, Philip J Kilner, Sylvain Beurtheret, Michael A Gatzoulis and Sonya V Babu-Narayan.
Aortic Dilatation in Repaired Tetralogy of Fallot..
JACC. Cardiovascular imaging 11(1):150–152, January 2018.
URL, DOI BibTeX
@article{Bonello2018,
author = "Bonello, Beatrice and Shore, Darryl F and Uebing, Anselm and Diller, Gerhard-Paul and Keegan, Jennifer and Burman, Elisabeth D and Shiina, Yumi and Swan, Lorna and Pennell, Dudley J and Kilner, Philip J and Beurtheret, Sylvain and Gatzoulis, Michael A and Babu-Narayan, Sonya V",
doi = "10.1016/j.jcmg.2017.01.021",
issn = "1876-7591",
journal = "JACC. Cardiovascular imaging",
month = "jan",
number = 1,
pages = "150--152",
pmid = 28412425,
title = "{Aortic Dilatation in Repaired Tetralogy of Fallot.}",
url = "http://linkinghub.elsevier.com/retrieve/pii/S1936878X17301948 http://www.ncbi.nlm.nih.gov/pubmed/28412425",
volume = 11,
year = 2018
}
Paul Kirk, Mary Sheppard, John-Paul Carpenter, Lisa Anderson, Taigang He, Tim St Pierre, Renzo Galanello, Gualtiero Catani, John Wood, Suthat Fucharoen, John B Porter, Malcolm J Walker, Gian Luca Forni and Dudley J Pennell.
Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia.
Journal of Cardiovascular Magnetic Resonance 19(1):36, December 2017.
URL, DOI BibTeX
@article{Kirk2017,
abstract = "BACKGROUND Heart failure related to cardiac siderosis remains a major cause of death in transfusion dependent anaemias. Replacement fibrosis has been reported as causative of heart failure in siderotic cardiomyopathy in historical reports, but these findings do not accord with the reversible nature of siderotic heart failure achievable with intensive iron chelation. METHODS Ten whole human hearts (9 beta-thalassemia major, 1 sideroblastic anaemia) were examined for iron loading and fibrosis (replacement and interstitial). Five had died from heart failure, 4 had cardiac transplantation for heart failure, and 1 had no heart failure (death from a stroke). Heart samples iron content was measured using atomic emission spectroscopy. Interstitial fibrosis was quantified by computer using picrosirius red (PSR) staining and expressed as collagen volume fraction (CVF) with normal value for left ventricle {\textless}3{\%}. RESULTS The 9 hearts affected by heart failure had severe iron loading with very low T2* of 5.0 ± 2.0 ms (iron concentration 8.5 ± 7.0 mg/g dw) and diffuse granular myocardial iron deposition. In none of the 10 hearts was significant macroscopic replacement fibrosis present. In only 2 hearts was interstitial fibrosis present, but with low CVF: in one patient with no cardiac siderosis (death by stroke, CVF 5.9{\%}) and in a heart failure patient (CVF 2{\%}). In the remaining 8 patients, no interstitial fibrosis was seen despite all having severe cardiac siderosis and heart failure (CVF 1.86{\%} ±0.87{\%}). CONCLUSION Replacement cardiac fibrosis was not seen in the 9 post-mortem hearts from patients with severe cardiac siderosis and heart failure leading to death or transplantation, which contrasts markedly to historical reports. Minor interstitial fibrosis was also unusual and very limited in extent. These findings accord with the potential for reversibility of heart failure seen in iron overload cardiomyopathy. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT00520559.",
author = "Kirk, Paul and Sheppard, Mary and Carpenter, John-Paul and Anderson, Lisa and He, Taigang and {St Pierre}, Tim and Galanello, Renzo and Catani, Gualtiero and Wood, John and Fucharoen, Suthat and Porter, John B and Walker, J Malcolm and Forni, Gian Luca and Pennell, Dudley J",
doi = "10.1186/s12968-017-0349-3",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
keywords = "Cardiac MR,Cardiac siderosis,Fibrosis,Heart,Histopathology,Iron,Thalassaemia",
month = "dec",
number = 1,
pages = 36,
pmid = 28343449,
title = "{Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28343449 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5367003 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-017-0349-3",
volume = 19,
year = 2017
}
Upasana Tayal, Simon Newsome, Rachel Buchan, Nicola Whiffin, Brian Halliday, Amrit Lota, Angharad Roberts, John A Baksi, Inga Voges, Will Midwinter, Alijca Wilk, Risha Govind, Roddy Walsh, Piers Daubeney, Julian W E Jarman, Resham Baruah, Michael Frenneaux, Paul J Barton, Dudley Pennell, James S Ware, Sanjay K Prasad and Stuart A Cook.
Phenotype and Clinical Outcomes of Titin Cardiomyopathy.
Journal of the American College of Cardiology 70(18):2264–2274, October 2017.
URL, DOI BibTeX
@article{Tayal2017,
abstract = "BACKGROUND Improved understanding of dilated cardiomyopathy (DCM) due to titin truncation (TTNtv) may help guide patient stratification. OBJECTIVES The purpose of this study was to establish relationships among TTNtv genotype, cardiac phenotype, and outcomes in DCM. METHODS In this prospective, observational cohort study, DCM patients underwent clinical evaluation, late gadolinium enhancement cardiovascular magnetic resonance, TTN sequencing, and adjudicated follow-up blinded to genotype for the primary composite endpoint of cardiovascular death, and major arrhythmic and major heart failure events. RESULTS Of 716 subjects recruited (mean age 53.5 ± 14.3 years; 469 men [65.5{\%}]; 577 [80.6{\%}] New York Heart Association function class I/II), 83 (11.6{\%}) had TTNtv. Patients with TTNtv were younger at enrollment (49.0 years vs. 54.1 years; p = 0.002) and had lower indexed left ventricular mass (5.1 g/m2reduction; padjusted = 0.03) compared with patients without TTNtv. There was no difference in biventricular ejection fraction between TTNtv+/-groups. Overall, 78 of 604 patients (12.9{\%}) met the primary endpoint (median follow-up 3.9 years; interquartile range: 2.0 to 5.8 years), including 9 of 71 patients with TTNtv (12.7{\%}) and 69 of 533 (12.9{\%}) without. There was no difference in the composite primary outcome of cardiovascular death, heart failure, or arrhythmic events, for patients with or without TTNtv (hazard ratio adjusted for primary endpoint: 0.92 [95{\%} confidence interval: 0.45 to 1.87]; p = 0.82). CONCLUSIONS In this large, prospective, genotype-phenotype study of ambulatory DCM patients, we show that prognostic factors for all-cause DCM also predict outcome in TTNtv DCM, and that TTNtv DCM does not appear to be associated with worse medium-term prognosis.",
author = "Tayal, Upasana and Newsome, Simon and Buchan, Rachel and Whiffin, Nicola and Halliday, Brian and Lota, Amrit and Roberts, Angharad and Baksi, A. John and Voges, Inga and Midwinter, Will and Wilk, Alijca and Govind, Risha and Walsh, Roddy and Daubeney, Piers and Jarman, Julian W.E. and Baruah, Resham and Frenneaux, Michael and Barton, Paul J. and Pennell, Dudley and Ware, James S. and Prasad, Sanjay K. and Cook, Stuart A.",
doi = "10.1016/j.jacc.2017.08.063",
issn = 07351097,
journal = "Journal of the American College of Cardiology",
keywords = "CMR,DCM,genetics,titin",
month = "oct",
number = 18,
pages = "2264--2274",
pmid = 29073955,
title = "{Phenotype and Clinical Outcomes of Titin Cardiomyopathy}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/29073955 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5666113 http://linkinghub.elsevier.com/retrieve/pii/S0735109717394731",
volume = 70,
year = 2017
}
Ee Ling Heng, Michael A Gatzoulis, Anselm Uebing, Babulal Sethia, Hideki Uemura, Gillian C Smith, Gerhard-Paul Diller, Karen P McCarthy, Siew Yen Ho, Wei Li, Piers Wright, Veronica Spadotto, Philip J Kilner, Paul Oldershaw, Dudley J Pennell, Darryl F Shore and Sonya V Babu-Narayan.
Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study..
Circulation 136(18):1703–1713, October 2017.
URL, DOI BibTeX
@article{Heng2017,
abstract = "BACKGROUND Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate of ventricular structural and functional adaptation are scarce. We aimed to assess immediate and midterm post-PVR changes and predictors of reverse remoeling. METHODS Fifty-seven patients with repaired tetralogy of Fallot (age ≥16 y; mean age, 35.8±10.1 y; 38 male) undergoing PVR were prospectively recruited for cardiovascular magnetic resonance performed before PVR (pPVR), immediately after PVR (median, 6 d), and midterm after PVR (mPVR; median, 3 y). RESULTS There were immediate and midterm reductions in indexed RV end-diastolic volumes and RV end-systolic volumes (RVESVi) (indexed RV end-diastolic volume pPVR versus immediately after PVR versus mPVR, 156.1±41.9 versus 104.9±28.4 versus 104.2±34.4 mL/m2; RVESVi pPVR versus immediately after PVR versus mPVR, 74.9±26.2 versus 57.4±22.7 versus 50.5±21.7 mL/m2;P{\textless}0.01). Normal postoperative diastolic and systolic RV volumes (the primary end point) achieved in 70{\%} of patients were predicted by a preoperative indexed RV end-diastolic volume ≤158 mL/m2and RVESVi ≤82 mL/m2. RVESVi showed a progressive decrease from baseline to immediate to midterm follow-up, indicating ongoing intrinsic RV functional improvement after PVR. Left ventricular ejection fraction improved (pPVR versus mPVR, 59.4±7.6{\%} versus 61.9±6.8{\%};P{\textless}0.01), and right atrial reverse remodeling occurred (pPVR versus mPVR, 15.2±3.4 versus 13.8±3.6 cm2/m2;P{\textless}0.01). Larger preoperative RV outflow tract scar was associated with a smaller improvement in post-PVR RV/left ventricular ejection fraction. RV ejection fraction and peak oxygen uptake predicted mortality (P=0.03) over a median of 9.5 years of follow-up. CONCLUSIONS Significant right heart structural reverse remodeling takes place immediately after PVR, followed by a continuing process of further biological remodeling manifested by further reduction in RVESVi. PVR before RVESVi reaches 82 mL/m2confers optimal chances of normalization of RV function.",
author = "Heng, Ee Ling and Gatzoulis, Michael A and Uebing, Anselm and Sethia, Babulal and Uemura, Hideki and Smith, Gillian C and Diller, Gerhard-Paul and McCarthy, Karen P and Ho, Siew Yen and Li, Wei and Wright, Piers and Spadotto, Veronica and Kilner, Philip J and Oldershaw, Paul and Pennell, Dudley J and Shore, Darryl F and Babu-Narayan, Sonya V",
doi = "10.1161/CIRCULATIONAHA.117.027402",
issn = "1524-4539",
journal = "Circulation",
keywords = "magnetic resonance imaging,pulmonary valve,tetralogy of Fallot,ventricular remodeling",
month = "oct",
number = 18,
pages = "1703--1713",
pmid = 29084778,
title = "{Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study.}",
url = "http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.117.027402 http://www.ncbi.nlm.nih.gov/pubmed/29084778 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5662153",
volume = 136,
year = 2017
}
Vassilios S Vassiliou, Paul D Flynn, Claire E Raphael, Simon Newsome, Tina Khan, Aamir Ali, Brian Halliday, Annina Studer Bruengger, Tamir Malley, Pranev Sharma, Subothini Selvendran, Nikhil Aggarwal, Anita Sri, Helen Berry, Jackie Donovan, Willis Lam, Dominique Auger, Stuart A Cook, Dudley J Pennell and Sanjay K Prasad.
Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance.
PLOS ONE 12(7):e0181077, July 2017.
URL, DOI BibTeX
@article{Vassiliou2017,
abstract = "BACKGROUND Aortic stenosis is the most common age-related valvular pathology. Patients with aortic stenosis and myocardial fibrosis have worse outcome but the underlying mechanism is unclear. Lipoprotein(a) is associated with adverse cardiovascular risk and is elevated in patients with aortic stenosis. Although mechanistic pathways could link Lipoprotein(a) with myocardial fibrosis, whether the two are related has not been previously explored. In this study, we investigated whether elevated Lipoprotein(a) was associated with the presence of myocardial replacement fibrosis. METHODS A total of 110 patients with mild, moderate and severe aortic stenosis were assessed by late gadolinium enhancement (LGE) cardiovascular magnetic resonance to identify fibrosis. Mann Whitney U tests were used to assess for evidence of an association between Lp(a) and the presence or absence of myocardial fibrosis and aortic stenosis severity and compared to controls. Univariable and multivariable linear regression analysis were undertaken to identify possible predictors of Lp(a). RESULTS Thirty-six patients (32.7{\%}) had no LGE enhancement, 38 (34.6{\%}) had midwall enhancement suggestive of midwall fibrosis and 36 (32.7{\%}) patients had subendocardial myocardial fibrosis, typical of infarction. The aortic stenosis patients had higher Lp(a) values than controls, however, there was no significant difference between the Lp(a) level in mild, moderate or severe aortic stenosis. No association was observed between midwall or infarction pattern fibrosis and Lipoprotein(a), in the mild/moderate stenosis (p = 0.91) or severe stenosis patients (p = 0.42). CONCLUSION There is no evidence to suggest that higher Lipoprotein(a) leads to increased myocardial midwall or infarction pattern fibrosis in patients with aortic stenosis.",
author = "Vassiliou, Vassilios S. and Flynn, Paul D. and Raphael, Claire E. and Newsome, Simon and Khan, Tina and Ali, Aamir and Halliday, Brian and {Studer Bruengger}, Annina and Malley, Tamir and Sharma, Pranev and Selvendran, Subothini and Aggarwal, Nikhil and Sri, Anita and Berry, Helen and Donovan, Jackie and Lam, Willis and Auger, Dominique and Cook, Stuart A. and Pennell, Dudley J. and Prasad, Sanjay K.",
doi = "10.1371/journal.pone.0181077",
editor = "Cheng, Xianwu",
issn = "1932-6203",
journal = "PLOS ONE",
month = "jul",
number = 7,
pages = "e0181077",
pmid = 28704465,
title = "{Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28704465 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5509300 http://dx.plos.org/10.1371/journal.pone.0181077",
volume = 12,
year = 2017
}
Matthew Cauldwell, Michael A Quail, Gillian S Smith, Ee Ling Heng, Sarah Ghonim, Anselm Uebing, Lorna Swan, Wei Li, Roshni R Patel, Dudley J Pennell, Philip J Steer, Mark R Johnson, Michael A Gatzoulis and Sonya V Babu-Narayan.
Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot..
Journal of the American Heart Association 6(7):e005420, July 2017.
URL, DOI BibTeX
@article{Cauldwell2017,
abstract = "BACKGROUND The aim was to assess whether cardiovascular adaptation to pregnancy in women with repaired tetralogy of Fallot (TOF) adversely affects hemodynamic stability, in particular with respect to right ventricular (RV) dilatation, pulmonary regurgitation, or aortic root dilatation. METHODS AND RESULTS This was a retrospective cohort study of women with repaired TOF with paired cardiovascular magnetic resonance scans before and after their first pregnancy (baseline RV end systolic volume index 49 mL/m2and RV end diastolic volume index 118 mL/m2) matched with a comparison group of nulliparous women with TOF. Cases were matched for age at baseline cardiovascular magnetic resonance scan, time between follow-up of cardiovascular magnetic resonance scans, QRS duration, RV ejection fraction, and indexed RV end systolic and diastolic volume at baseline. Effect of pregnancy and time on parameters was assessed using mixed-effects modelling. Nineteen women with repaired TOF who had completed their first pregnancy were identified and matched with 38 nulliparous women. We observed no deleterious effects of pregnancy on RV volumes, aortic dimensions, or exercise data. There was an effect of pregnancy observed in both left ventricular end diastolic volume and left ventricular stroke volume, consistent with a sustained small increase in left ventricular stroke volume attributed to pregnancy (53-55 mL/m2). CONCLUSIONS Women with repaired TOF and with mild-to-moderate RV dilatation considering pregnancy can be reassured that pregnancy is unlikely to cause deterioration in their cardiovascular status. We recommend that women are routinely assessed and followed up before and after pregnancy and that prepregnancy counseling is tailored to their individual clinical status.",
author = "Cauldwell, Matthew and Quail, Michael A and Smith, Gillian S and Heng, Ee Ling and Ghonim, Sarah and Uebing, Anselm and Swan, Lorna and Li, Wei and Patel, Roshni R and Pennell, Dudley J and Steer, Philip J and Johnson, Mark R and Gatzoulis, Michael A and Babu-Narayan, Sonya V",
doi = "10.1161/JAHA.116.005420",
issn = "2047-9980",
journal = "Journal of the American Heart Association",
keywords = "cardiovascular magnetic resonance imaging,pregnancy,tetralogy of Fallot",
month = "jul",
number = 7,
pages = "e005420",
pmid = 28736387,
title = "{Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot.}",
url = "http://jaha.ahajournals.org/lookup/doi/10.1161/JAHA.116.005420 http://www.ncbi.nlm.nih.gov/pubmed/28736387 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5586280",
volume = 6,
year = 2017
}
Maria Boutsikou, Dudley J Pennell and Eva Nyktari.
Anomalous drainage of isolated superior caval vein to the left atrium: the oldest reported unrepaired case..
Cardiology in the young 27(5):1008–1010, July 2017.
URL, DOI BibTeX
@article{Boutsikou2017,
abstract = "Isolated right superior caval vein drainage into the left atrium is a rare congenital cardiac anomaly usually presenting with hypoxaemia and cyanosis. Surgical repair is the definitive treatment for this condition. In this report, we present the case of a 72-year-old patient with uncorrected anomalous drainage of a right superior caval vein into the left atrium, first diagnosed in the 1960s. To the best of our knowledge, this is the oldest reported unrepaired case.",
author = "Boutsikou, Maria and Pennell, Dudley J and Nyktari, Eva",
doi = "10.1017/S1047951116002808",
issn = "1467-1107",
journal = "Cardiology in the young",
keywords = "Superior caval vein,brain abscess,hypoxia,left atrium,paradoxical emboli",
month = "jul",
number = 5,
pages = "1008--1010",
pmid = 28196557,
title = "{Anomalous drainage of isolated superior caval vein to the left atrium: the oldest reported unrepaired case.}",
url = "https://www.cambridge.org/core/product/identifier/S1047951116002808/type/journal{\_}article http://www.ncbi.nlm.nih.gov/pubmed/28196557",
volume = 27,
year = 2017
}
Alphonsus C Liew, Claire E Raphael and Raad Mohiaddin.
A 38-year-old man with progressive dyspnoea and ventricular tachycardia.
Heart 103(11):839–839, June 2017.
URL, DOI BibTeX
@article{Liew2017,
abstract = "CLINICAL INTRODUCTION A previously healthy 38-year-old man presented with a 3-month history of progressive dyspnoea and ventricular tachycardia (VT). He suffered a viral illness 4 months earlier. There was no family history of cardiac disease or sudden cardiac death (SCD). ECG showed left bundle branch block (LBBB). Echocardiography revealed a dilated left ventricle with severely impaired systolic function. Coronary angiogram showed angiographically normal coronary arteries. He was diagnosed as having dilated cardiomyopathy and was referred for further assessment with cardiovascular magnetic resonance (CMR) (figure 1) and subsequently CT thorax. QUESTION What is the most likely diagnosis? Dilated cardiomyopathy secondary to HIVGranulomatosis with polyangiitis (GPA)SarcoidosisTuberculosisUnderlying malignancy with lung and cardiac metastases.",
author = "Liew, Alphonsus C and Raphael, Claire E and Mohiaddin, Raad",
doi = "10.1136/heartjnl-2016-310597",
issn = "1355-6037",
journal = "Heart",
month = "jun",
number = 11,
pages = "839--839",
pmid = 27993910,
title = "{A 38-year-old man with progressive dyspnoea and ventricular tachycardia}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27993910 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2016-310597",
volume = 103,
year = 2017
}
Viviana Maestrini, Mun H Cheang, Paul Kotwinski, Stefania Rosmini, Guy Lloyd, Peter Kellman, Dudley J Pennell, Hugh Montgomery, James C Moon and Charlotte Manisty.
Late Anthracycline-Related Cardiotoxicity in Low-Risk Breast Cancer Patients..
Journal of the American College of Cardiology 69(20):2573–2575, May 2017.
URL, DOI BibTeX
@article{Maestrini2017,
author = "Maestrini, Viviana and Cheang, Mun H and Kotwinski, Paul and Rosmini, Stefania and Lloyd, Guy and Kellman, Peter and Pennell, Dudley J and Montgomery, Hugh and Moon, James C and Manisty, Charlotte",
doi = "10.1016/j.jacc.2017.03.560",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
month = "may",
number = 20,
pages = "2573--2575",
pmid = 28521895,
title = "{Late Anthracycline-Related Cardiotoxicity in Low-Risk Breast Cancer Patients.}",
url = "http://linkinghub.elsevier.com/retrieve/pii/S0735109717368134 http://www.ncbi.nlm.nih.gov/pubmed/28521895",
volume = 69,
year = 2017
}
Brian P Halliday, Ankur Gulati, Aamir Ali, Kaushik Guha, Simon Newsome, Monika Arzanauskaite, Vassilios S Vassiliou, Amrit Lota, Cemil Izgi, Upasana Tayal, Zohya Khalique, Colin Stirrat, Dominique Auger, Nilesh Pareek, Tevfik F Ismail, Stuart D Rosen, Ali Vazir, Francisco Alpendurada, John Gregson, Michael P Frenneaux, Martin R Cowie, John G F Cleland, Stuart A Cook, Dudley J Pennell and Sanjay K Prasad.
Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction..
Circulation 135(22):2106–2115, May 2017.
URL, DOI BibTeX
@article{Halliday2017,
abstract = "BACKGROUND Current guidelines only recommend the use of an implantable cardioverter defibrillator in patients with dilated cardiomyopathy for the primary prevention of sudden cardiac death (SCD) in those with a left ventricular ejection fraction (LVEF) {\textless}35{\%}. However, registries of out-of-hospital cardiac arrests demonstrate that 70{\%} to 80{\%} of such patients have an LVEF {\textgreater}35{\%}. Patients with an LVEF {\textgreater}35{\%} also have low competing risks of death from nonsudden causes. Therefore, those at high risk of SCD may gain longevity from successful implantable cardioverter defibrillator therapy. We investigated whether late gadolinium enhancement (LGE) cardiovascular magnetic resonance identified patients with dilated cardiomyopathy without severe LV systolic dysfunction at high risk of SCD. METHODS We prospectively investigated the association between midwall LGE and the prespecified primary composite outcome of SCD or aborted SCD among consecutive referrals with dilated cardiomyopathy and an LVEF ≥40{\%} to our center between January 2000 and December 2011 who did not have a preexisting indication for implantable cardioverter defibrillator implantation. RESULTS Of 399 patients (145 women, median age 50 years, median LVEF 50{\%}, 25.3{\%} with LGE) followed for a median of 4.6 years, 18 of 101 (17.8{\%}) patients with LGE reached the prespecified end point, compared with 7 of 298 (2.3{\%}) without (hazard ratio [HR], 9.2; 95{\%} confidence interval [CI], 3.9-21.8;P{\textless}0.0001). Nine patients (8.9{\%}) with LGE compared with 6 (2.0{\%}) without (HR, 4.9; 95{\%} CI, 1.8-13.5;P=0.002) died suddenly, whereas 10 patients (9.9{\%}) with LGE compared with 1 patient (0.3{\%}) without (HR, 34.8; 95{\%} CI, 4.6-266.6;P{\textless}0.001) had aborted SCD. After adjustment, LGE predicted the composite end point (HR, 9.3; 95{\%} CI, 3.9-22.3;P{\textless}0.0001), SCD (HR, 4.8; 95{\%} CI, 1.7-13.8;P=0.003), and aborted SCD (HR, 35.9; 95{\%} CI, 4.8-271.4;P{\textless}0.001). Estimated HRs for the primary end point for patients with an LGE extent of 0{\%} to 2.5{\%}, 2.5{\%} to 5{\%}, and {\textgreater}5{\%} compared with those without LGE were 10.6 (95{\%} CI, 3.9-29.4), 4.9 (95{\%} CI, 1.3-18.9), and 11.8 (95{\%} CI, 4.3-32.3), respectively. CONCLUSIONS Midwall LGE identifies a group of patients with dilated cardiomyopathy and an LVEF ≥40{\%} at increased risk of SCD and low risk of nonsudden death who may benefit from implantable cardioverter defibrillator implantation. CLINICAL TRIAL REGISTRATION URL: http://clinicaltrials.gov. Unique identifier: NCT00930735.",
author = "Halliday, Brian P and Gulati, Ankur and Ali, Aamir and Guha, Kaushik and Newsome, Simon and Arzanauskaite, Monika and Vassiliou, Vassilios S and Lota, Amrit and Izgi, Cemil and Tayal, Upasana and Khalique, Zohya and Stirrat, Colin and Auger, Dominique and Pareek, Nilesh and Ismail, Tevfik F and Rosen, Stuart D and Vazir, Ali and Alpendurada, Francisco and Gregson, John and Frenneaux, Michael P and Cowie, Martin R and Cleland, John G F and Cook, Stuart A and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1161/CIRCULATIONAHA.116.026910",
issn = "1524-4539",
journal = "Circulation",
keywords = "cardiovascular MRI,dilated cardiomyopathy,implantable cardioverter-defibrillator,late gadolinium enhancement,sudden cardiac death",
month = "may",
number = 22,
pages = "2106--2115",
pmid = 28351901,
title = "{Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction.}",
url = "http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.116.026910 http://www.ncbi.nlm.nih.gov/pubmed/28351901 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5444425",
volume = 135,
year = 2017
}
Vassilios S Vassiliou, Aris Perperoglou, Claire E Raphael, Sanjiv Joshi, Tamir Malley, Russell Everett, Brian Halliday, Dudley J Pennell, Marc R Dweck and Sanjay K Prasad.
Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis.
Journal of the American College of Cardiology 69(13):1755–1756, April 2017.
URL, DOI BibTeX
@article{Vassiliou2017a,
author = "Vassiliou, Vassilios S. and Perperoglou, Aris and Raphael, Claire E. and Joshi, Sanjiv and Malley, Tamir and Everett, Russell and Halliday, Brian and Pennell, Dudley J. and Dweck, Marc R. and Prasad, Sanjay K.",
doi = "10.1016/j.jacc.2017.01.034",
issn = 07351097,
journal = "Journal of the American College of Cardiology",
month = "apr",
number = 13,
pages = "1755--1756",
pmid = 28359524,
title = "{Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28359524 http://linkinghub.elsevier.com/retrieve/pii/S073510971730390X",
volume = 69,
year = 2017
}
Pustika Amalia Wahidiyat, Felix Liauw, Damayanti Sekarsari, Siti Ayu Putriasih, Vasili Berdoukas and Dudley J Pennell.
Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging.
Hematology 22(8):1–7, February 2017.
URL, DOI BibTeX
@article{Wahidiyat2017,
abstract = "OBJECTIVES Recent advancements have promoted the use of T2* magnetic resonance imaging (MRI) in the non-invasive detection of iron overload in various organs for thalassemia major patients. This study aims to determine the iron load in the heart and liver of patients with thalassemia major using T2* MRI and to evaluate its correlation with serum ferritin level and iron chelation therapy. METHODS This cross-sectional study included 162 subjects diagnosed with thalassemia major, who were classified into acceptable, mild, moderate, or severe cardiac and hepatic iron overload following their T2* MRI results, respectively, and these were correlated to their serum ferritin levels and iron chelation therapy. RESULTS The study found that 85.2{\%} of the subjects had normal cardiac iron stores. In contrast, 70.4{\%} of the subjects had severe liver iron overload. A significant but weak correlation (r = -0.28) was found between cardiac T2* MRI and serum ferritin, and a slightly more significant correlation (r = 0.37) was found between liver iron concentration (LIC) and serum ferritin. DISCUSSION The findings of this study are consistent with several other studies, which show that patients generally manifest with liver iron overload prior to cardiac iron overload. Moreover, iron accumulation demonstrated by T2* MRI results also show a significant correlation to serum ferritin levels. CONCLUSION This is the first study of its kind conducted in Indonesia, which supports the fact that T2* MRI is undoubtedly valuable in the early detection of cardiac and hepatic iron overload in thalassemia major patients.",
author = "Wahidiyat, Pustika Amalia and Liauw, Felix and Sekarsari, Damayanti and Putriasih, Siti Ayu and Berdoukas, Vasili and Pennell, Dudley J.",
doi = "10.1080/10245332.2017.1292614",
issn = "1024-5332",
journal = "Hematology",
keywords = "T2* MRI,cardiac iron,hepatic iron,thalassemia major",
month = "feb",
number = 8,
pages = "1--7",
pmid = 28218005,
title = "{Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28218005 https://www.tandfonline.com/doi/full/10.1080/10245332.2017.1292614",
volume = 22,
year = 2017
}
Sonia Nielles-Vallespin, Zohya Khalique, Pedro F Ferreira, Ranil Silva, Andrew D Scott, Philip Kilner, Laura-Ann McGill, Archontis Giannakidis, Peter D Gatehouse, Daniel Ennis, Eric Aliotta, Majid Al-Khalil, Peter Kellman, Dumitru Mazilu, Robert S Balaban, David N Firmin, Andrew E Arai and Dudley J Pennell.
Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance.
Journal of the American College of Cardiology 69(6):661–676, February 2017.
URL, DOI BibTeX
@article{Nielles-Vallespin2017,
abstract = "BACKGROUND Cardiomyocytes are organized in microstructures termed sheetlets that reorientate during left ventricular thickening. Diffusion tensor cardiac magnetic resonance (DT-CMR) may enable noninvasive interrogation of in vivo cardiac microstructural dynamics. Dilated cardiomyopathy (DCM) is a condition of abnormal myocardium with unknown sheetlet function. OBJECTIVES This study sought to validate in vivo DT-CMR measures of cardiac microstructure against histology, characterize microstructural dynamics during left ventricular wall thickening, and apply the technique in hypertrophic cardiomyopathy (HCM) and DCM. METHODS In vivo DT-CMR was acquired throughout the cardiac cycle in healthy swine, followed by in situ and ex vivo DT-CMR, then validated against histology. In vivo DT-CMR was performed in 19 control subjects, 19 DCM, and 13 HCM patients. RESULTS In swine, a DT-CMR index of sheetlet reorientation (E2A) changed substantially (E2A mobility ∼46°). E2A changes correlated with wall thickness changes (in vivo r2 = 0.75; in situ r2 = 0.89), were consistently observed under all experimental conditions, and accorded closely with histological analyses in both relaxed and contracted states. The potential contribution of cyclical strain effects to in vivo E2A was ∼17{\%}. In healthy human control subjects, E2A increased from diastole (18°) to systole (65°; p {\textless} 0.001; E2A mobility = 45°). HCM patients showed significantly greater E2A in diastole than control subjects did (48°; p {\textless} 0.001) with impaired E2A mobility (23°; p {\textless} 0.001). In DCM, E2A was similar to control subjects in diastole, but systolic values were markedly lower (40°; p {\textless} 0.001) with impaired E2A mobility (20°; p {\textless} 0.001). CONCLUSIONS Myocardial microstructure dynamics can be characterized by in vivo DT-CMR. Sheetlet function was abnormal in DCM with altered systolic conformation and reduced mobility, contrasting with HCM, which showed reduced mobility with altered diastolic conformation. These novel insights significantly improve understanding of contractile dysfunction at a level of noninvasive interrogation not previously available in humans.",
author = "Nielles-Vallespin, Sonia and Khalique, Zohya and Ferreira, Pedro F. and de Silva, Ranil and Scott, Andrew D. and Kilner, Philip and McGill, Laura-Ann and Giannakidis, Archontis and Gatehouse, Peter D. and Ennis, Daniel and Aliotta, Eric and Al-Khalil, Majid and Kellman, Peter and Mazilu, Dumitru and Balaban, Robert S. and Firmin, David N. and Arai, Andrew E. and Pennell, Dudley J.",
doi = "10.1016/j.jacc.2016.11.051",
issn = 07351097,
journal = "Journal of the American College of Cardiology",
keywords = ",dilated cardiomyopathy,helical structure,hypertrophic cardiomyopathy,laminar structure,left ventricle,sheetlet structure",
month = "feb",
number = 6,
pages = "661--676",
pmid = 28183509,
title = "{Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28183509 http://linkinghub.elsevier.com/retrieve/pii/S0735109716373272",
volume = 69,
year = 2017
}
D J Pennell, A J Baksi, S K Prasad, R H Mohiaddin, F Alpendurada, S V Babu-Narayan, J E Schneider and D N Firmin.
Review of Journal of Cardiovascular Magnetic Resonance 2015.
Journal of Cardiovascular Magnetic Resonance 18(1):86, January 2017.
URL, DOI BibTeX
@article{Pennell2017,
abstract = "There were 116 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2015, which is a 14 {\%} increase on the 102 articles published in 2014. The quality of the submissions continues to increase. The 2015 JCMR Impact Factor (which is published in June 2016) rose to 5.75 from 4.72 for 2014 (as published in June 2015), which is the highest impact factor ever recorded for JCMR. The 2015 impact factor means that the JCMR papers that were published in 2013 and 2014 were cited on average 5.75 times in 2015. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is {\textless}25 {\%} and has been falling because the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality papers to JCMR for publication.",
author = "Pennell, D. J. and Baksi, A. J. and Prasad, S. K. and Mohiaddin, R. H. and Alpendurada, F. and Babu-Narayan, S. V. and Schneider, J. E. and Firmin, D. N.",
doi = "10.1186/s12968-016-0305-7",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "jan",
number = 1,
pages = 86,
pmid = 27846914,
title = "{Review of Journal of Cardiovascular Magnetic Resonance 2015}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27846914 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5111217 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0305-7",
volume = 18,
year = 2017
}
Claire E Raphael, Jennifer Keegan, Kim H Parker, Robin Simpson, Julian Collinson, Vass Vassiliou, Ricardo Wage, Peter Drivas, Stephen Strain, Robert Cooper, Ranil Silva, Rod H Stables, Carlo Di Mario, Michael Frenneaux, Dudley J Pennell, Justin E Davies, Alun D Hughes, David Firmin and Sanjay K Prasad.
Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis.
Journal of Cardiovascular Magnetic Resonance 18(1):93, January 2017.
URL, DOI BibTeX
@article{Raphael2017,
abstract = "BACKGROUND Wave intensity analysis (WIA) of the coronary arteries allows description of the predominant mechanisms influencing coronary flow over the cardiac cycle. The data are traditionally derived from pressure and velocity changes measured invasively in the coronary artery. Cardiovascular magnetic resonance (CMR) allows measurement of coronary velocities using phase velocity mapping and derivation of central aortic pressure from aortic distension. We assessed the feasibility of WIA of the coronary arteries using CMR and compared this to invasive data. METHODS CMR scans were undertaken in a serial cohort of patients who had undergone invasive WIA. Velocity maps were acquired in the proximal left anterior descending and proximal right coronary artery using a retrospectively-gated breath-hold spiral phase velocity mapping sequence with high temporal resolution (19 ms). A breath-hold segmented gradient echo sequence was used to acquire through-plane cross sectional area changes in the proximal ascending aorta which were used as a surrogate of an aortic pressure waveform after calibration with brachial blood pressure measured with a sphygmomanometer. CMR-derived aortic pressures and CMR-measured velocities were used to derive wave intensity. The CMR-derived wave intensities were compared to invasive data in 12 coronary arteries (8 left, 4 right). Waves were presented as absolute values and as a {\%} of total wave intensity. Intra-study reproducibility of invasive and non-invasive WIA was assessed using Bland-Altman analysis and the intraclass correlation coefficient (ICC). RESULTS The combination of the CMR-derived pressure and velocity data produced the expected pattern of forward and backward compression and expansion waves. The intra-study reproducibility of the CMR derived wave intensities as a {\%} of the total wave intensity (mean ± standard deviation of differences) was 0.0 ± 6.8{\%}, ICC = 0.91. Intra-study reproducibility for the corresponding invasive data was 0.0 ± 4.4{\%}, ICC = 0.96. The invasive and CMR studies showed reasonable correlation (r = 0.73) with a mean difference of 0.0 ± 11.5{\%}. CONCLUSION This proof of concept study demonstrated that CMR may be used to perform coronary WIA non-invasively with reasonable reproducibility compared to invasive WIA. The technique potentially allows WIA to be performed in a wider range of patients and pathologies than those who can be studied invasively.",
author = "Raphael, Claire E. and Keegan, Jennifer and Parker, Kim H. and Simpson, Robin and Collinson, Julian and Vassiliou, Vass and Wage, Ricardo and Drivas, Peter and Strain, Stephen and Cooper, Robert and de Silva, Ranil and Stables, Rod H. and {Di Mario}, Carlo and Frenneaux, Michael and Pennell, Dudley J. and Davies, Justin E. and Hughes, Alun D. and Firmin, David and Prasad, Sanjay K.",
doi = "10.1186/s12968-016-0312-8",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "jan",
number = 1,
pages = 93,
pmid = 27964736,
title = "{Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27964736 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5154155 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0312-8",
volume = 18,
year = 2017
}
Mohammed H Alam, Taigang He, Dominique Auger, Gillian C Smith, Peter Drivas, Rick Wage, Cemil Izgi, Karen Symmonds, Andreas Greiser, Bruce S Spottiswoode, Lisa Anderson, David Firmin and Dudley J Pennell.
Validation of T2* in-line analysis for tissue iron quantification at 1.5 T.
Journal of Cardiovascular Magnetic Resonance 18(1):23, December 2016.
URL, DOI BibTeX
@article{Alam2016a,
abstract = "BACKGROUND There is a need for improved worldwide access to tissue iron quantification using T2* cardiovascular magnetic resonance (CMR). One route to facilitate this would be simple in-line T2* analysis widely available on MR scanners. We therefore compared our clinically validated and established T2* method at Royal Brompton Hospital (RBH T2*) against a novel work-in-progress (WIP) sequence with in-line T2* measurement from Siemens (WIP T2*). METHODS Healthy volunteers (n = 22) and patients with iron overload (n = 78) were recruited (53 males, median age 34 years). A 1.5 T study (Magnetom Avanto, Siemens) was performed on all subjects. The same mid-ventricular short axis cardiac slice and transaxial slice through the liver were used to acquire both RBH T2* images and WIP T2* maps for each participant. Cardiac white blood (WB) and black blood (BB) sequences were acquired. Intraobserver, interobserver and interstudy reproducibility were measured on the same data from a subset of 20 participants. RESULTS Liver T2* values ranged from 0.8 to 35.7 ms (median 5.1 ms) and cardiac T2* values from 6.0 to 52.3 ms (median 31 ms). The coefficient of variance (CoV) values for direct comparison of T2* values by RBH and WIP were 6.1-7.8 {\%} across techniques. Accurate delineation of the septum was difficult on some WIP T2* maps due to artefacts. The inability to manually correct for noise by truncation of erroneous later echo times led to some overestimation of T2* using WIP T2* compared with the RBH T2*. Reproducibility CoV results for RBH T2* ranged from 1.5 to 5.7 {\%} which were better than the reproducibility of WIP T2* values of 4.1-16.6 {\%}. CONCLUSIONS Iron estimation using the T2* CMR sequence in combination with Siemens' in-line data processing is generally satisfactory and may help facilitate global access to tissue iron assessment. The current automated T2* map technique is less good for tissue iron assessment with noisy data at low T2* values.",
author = "Alam, Mohammed H. and He, Taigang and Auger, Dominique and Smith, Gillian C. and Drivas, Peter and Wage, Rick and Izgi, Cemil and Symmonds, Karen and Greiser, Andreas and Spottiswoode, Bruce S. and Anderson, Lisa and Firmin, David and Pennell, Dudley J.",
doi = "10.1186/s12968-016-0243-4",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
keywords = "CMR,Heart,In-line processing,Iron overload,Liver,T2*",
month = "dec",
number = 1,
pages = 23,
pmid = 27121114,
title = "{Validation of T2* in-line analysis for tissue iron quantification at 1.5 T}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27121114 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4847205 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0243-4",
volume = 18,
year = 2016
}
Elisabeth D Burman, Jennifer Keegan and Philip J Kilner.
Pulmonary artery diameters, cross sectional areas and area changes measured by cine cardiovascular magnetic resonance in healthy volunteers.
Journal of Cardiovascular Magnetic Resonance 18(1):12, December 2016.
URL, DOI BibTeX
@article{Burman2016,
abstract = "BACKGROUND We measured by cine cardiovascular magnetic resonance (CMR) main and branch pulmonary artery diameters and cross sectional areas in diastole and systole in order to establish normal ranges and the effects on them of age, gender and body surface area (BSA). Documentation of normal ranges provides a reference for research and clinical investigation in the fields of congenital heart disease, pulmonary hypertension and connective tissue disorders. METHODS We recruited 120 healthy volunteers: ten males (M) and ten females (F) in each decile between 20 and 79 years, imaging them in a 1.5 Tesla CMR system. Scout acquisitions guided the placement of steady state free precession cine acquisitions transecting the main, right and left pulmonary arteries (MPA, RPA and LPA). Cross sections were rarely quite circular. RESULTS From all subjects, the means of the greater and lesser orthogonal diastolic diameters in mm were: MPA, 22.9 ± 2.4 (M) and 21.2 ± 2.1 (F), RPA 16.6 ± 2.8 (M) and 14.7 ± 2.2 (F), and LPA 17.3 ± 2.5 (M) and 15.9 ± 2.0 (F), p {\textless} 0.0001 between genders in each case. The diastolic diameters increased with BSA and age, and plots are provided for reference. From measurements of minimum diastolic and maximum systolic cross sectional areas, the {\%} systolic distensions were: MPA 42.7 ± 17.2 (M) and 41.8 ± 15.7 (F), RPA 50.6 ± 16.9 (M) and 48.2 ± 14.5 (F), LPA 35.6 ± 10.1 (M) and 35.2 ± 10.3 (F), and there was a decrease in distension with age (p {\textless} 0.0001 for the MPA). CONCLUSIONS Measurements of MPA, RPA and LPA by cine CMR are provided for reference, with documentation of their changes with age and BSA.",
author = "Burman, Elisabeth D and Keegan, Jennifer and Kilner, Philip J",
doi = "10.1186/s12968-016-0230-9",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 12,
pmid = 26940894,
title = "{Pulmonary artery diameters, cross sectional areas and area changes measured by cine cardiovascular magnetic resonance in healthy volunteers}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26940894 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4778312 http://jcmr-online.com/content/18/1/12",
volume = 18,
year = 2016
}
Gianni Pedrizzetti, Piet Claus, Philip J Kilner and Eike Nagel.
Principles of cardiovascular magnetic resonance feature tracking and echocardiographic speckle tracking for informed clinical use.
Journal of Cardiovascular Magnetic Resonance 18(1):51, December 2016.
URL, DOI BibTeX
@article{Pedrizzetti2016,
abstract = "Tissue tracking technology of routinely acquired cardiovascular magnetic resonance (CMR) cine acquisitions has increased the apparent ease and availability of non-invasive assessments of myocardial deformation in clinical research and practice. Its widespread availability thanks to the fact that this technology can in principle be applied on images that are part of every CMR or echocardiographic protocol. However, the two modalities are based on very different methods of image acquisition and reconstruction, each with their respective strengths and limitations. The image tracking methods applied are not necessarily directly comparable between the modalities, or with those based on dedicated CMR acquisitions for strain measurement such as tagging or displacement encoding. Here we describe the principles underlying the image tracking methods for CMR and echocardiography, and the translation of the resulting tracking estimates into parameters suited to describe myocardial mechanics. Technical limitations are presented with the objective of suggesting potential solutions that may allow informed and appropriate use in clinical applications.",
author = "Pedrizzetti, Gianni and Claus, Piet and Kilner, Philip J. and Nagel, Eike",
doi = "10.1186/s12968-016-0269-7",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pedrizzetti et al. - 2016 - Principles of cardiovascular magnetic resonance feature tracking and echocardiographic speckle tracking for.pdf:pdf",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
keywords = "Angiology,Cardiology,Imaging / Radiology",
month = "dec",
number = 1,
pages = 51,
publisher = "BioMed Central",
title = "{Principles of cardiovascular magnetic resonance feature tracking and echocardiographic speckle tracking for informed clinical use}",
url = "http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0269-7",
volume = 18,
year = 2016
}
Vassilios S Vassiliou, Ee Ling Heng, Peter D Gatehouse, Jacqueline Donovan, Claire E Raphael, Shivraman Giri, Sonya V Babu-Narayan, Michael A Gatzoulis, Dudley J Pennell, Sanjay K Prasad and David N Firmin.
Magnetic resonance imaging phantoms for quality-control of myocardial T1 and ECV mapping: specific formulation, long-term stability and variation with heart rate and temperature.
Journal of Cardiovascular Magnetic Resonance 18(1):62, December 2016.
URL, DOI BibTeX
@article{Vassiliou2016a,
abstract = "BACKGROUND Magnetic resonance imaging (MRI) phantoms are routinely used for quality assurance in MRI centres; however their long term stability for verification of myocardial T1/ extracellular volume fraction (ECV) mapping has never been investigated. METHODS Nickel-chloride agarose gel phantoms were formulated in a reproducible laboratory procedure to mimic blood and myocardial T1 and T2 values, native and late after Gadolinium administration as used in T1/ECV mapping. The phantoms were imaged weekly with an 11 heart beat MOLLI sequence for T1 and long TR spin-echo sequences for T2, in a carefully controlled reproducible manner for 12 months. RESULTS There were only small relative changes seen in all the native and post gadolinium T1 values (up to 9.0 {\%} maximal relative change in T1 values) or phantom ECV (up to 8.3 {\%} maximal relative change of ECV, up to 2.2 {\%} maximal absolute change in ECV) during this period. All native and post gadolinium T2 values remained stable over time with {\textless}2 {\%} change. Temperature sensitivity testing showed MOLLI T1 values in the long T1 phantoms increasing by 23.9 ms per degree increase and short T1 phantoms increasing by 0.3 ms per degree increase. There was a small absolute increase in ECV of 0.069 {\%} ({\~{}}0.22 {\%} relative increase in ECV) per degree increase. Variation in heart rate testing showed a 0.13 {\%} absolute increase in ECV ({\~{}}0.45 {\%} relative increase in ECV) per 10 heart rate increase. CONCLUSIONS These are the first phantoms reported in the literature modeling T1 and T2 values for blood and myocardium specifically for the T1mapping/ECV mapping application, with stability tested rigorously over a 12 month period. This work has significant implications for the utility of such phantoms in improving the accuracy of serial scans for myocardial tissue characterisation by T1 mapping methods and in multicentre work.",
author = "Vassiliou, Vassilios S. and Heng, Ee Ling and Gatehouse, Peter D. and Donovan, Jacqueline and Raphael, Claire E. and Giri, Shivraman and Babu-Narayan, Sonya V. and Gatzoulis, Michael A. and Pennell, Dudley J. and Prasad, Sanjay K. and Firmin, David N.",
doi = "10.1186/s12968-016-0275-9",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
keywords = "Agarose,Nickel,Phantoms,Stability,T1 mapping",
month = "dec",
number = 1,
pages = 62,
pmid = 27659737,
title = "{Magnetic resonance imaging phantoms for quality-control of myocardial T1 and ECV mapping: specific formulation, long-term stability and variation with heart rate and temperature}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27659737 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5034463 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0275-9",
volume = 18,
year = 2016
}
Mohammed H Alam, Dominique Auger, Laura-Ann McGill, Gillian C Smith, Taigang He, Cemil Izgi, John A Baksi, Rick Wage, Peter Drivas, David N Firmin and Dudley J Pennell.
Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron.
Journal of Cardiovascular Magnetic Resonance 18(1):40, December 2016.
URL, DOI BibTeX
@article{Alam2016,
abstract = "BACKGROUND T2* magnetic resonance of tissue iron concentration has improved the outcome of transfusion dependant anaemia patients. Clinical evaluation is performed at 1.5 T but scanners operating at 3 T are increasing in numbers. There is a paucity of data on the relative merits of iron quantification at 3 T vs 1.5 T. METHODS A total of 104 transfusion dependent anaemia patients and 20 normal volunteers were prospectively recruited to undergo cardiac and liver T2* assessment at both 1.5 T and 3 T. Intra-observer, inter-observer and inter-study reproducibility analysis were performed on 20 randomly selected patients for cardiac and liver T2*. RESULTS Association between heart and liver T2* at 1.5 T and 3 T was non-linear with good fit (R (2) = 0.954, p {\textless} 0.001 for heart white-blood (WB) imaging; R (2) = 0.931, p {\textless} 0.001 for heart black-blood (BB) imaging; R (2) = 0.993, p {\textless} 0.001 for liver imaging). R2* approximately doubled between 1.5 T and 3 T with linear fits for both heart and liver (94, 94 and 105 {\%} respectively). Coefficients of variation for intra- and inter-observer reproducibility, as well as inter-study reproducibility trended to be less good at 3 T (3.5 to 6.5 {\%}) than at 1.5 T (1.4 to 5.7 {\%}) for both heart and liver T2*. Artefact scores for the heart were significantly worse with the 3 T BB sequence (median 4, IQR 2-5) compared with the 1.5 T BB sequence (4 [3-5], p = 0.007). CONCLUSION Heart and liver T2* and R2* at 3 T show close association with 1.5 T values, but there were more artefacts at 3 T and trends to lower reproducibility causing difficulty in quantifying low T2* values with high tissue iron. Therefore T2* imaging at 1.5 T remains the gold standard for clinical practice. However, in centres where only 3 T is available, equivalent values at 1.5 T may be approximated by halving the 3 T tissue R2* with subsequent conversion to T2*.",
author = "Alam, Mohammed H. and Auger, Dominique and McGill, Laura-Ann and Smith, Gillian C. and He, Taigang and Izgi, Cemil and Baksi, A. John and Wage, Rick and Drivas, Peter and Firmin, David N. and Pennell, Dudley J.",
doi = "10.1186/s12968-016-0259-9",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
keywords = "3 T,Heart,Iron overload,Liver,Magnetic resonance,Siderosis,T2*",
month = "dec",
number = 1,
pages = 40,
pmid = 27391316,
title = "{Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27391316 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4938967 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0259-9",
volume = 18,
year = 2016
}
Alicia M Maceira, Juan Cosin-Sales, Sanjay K Prasad and Dudley J Pennell.
Characterization of left and right atrial function in healthy volunteers by cardiovascular magnetic resonance.
Journal of Cardiovascular Magnetic Resonance 18(1):64, December 2016.
URL, DOI BibTeX
@article{Maceira2016,
abstract = "BACKGROUND Left and right atrial function show a different pattern in advanced age in order to maintain adequate ventricular filling. It has been shown that left atrial (LA) function has a prognostic value in a number of heart conditions. Cardiovascular magnetic resonance (CMR) provides high quality images of the left and right atria using high temporal resolution steady state free precession (SSFP) cine sequences. We used SSFP cines to characterize atrial function in healthy, normotensive, volunteers. METHODS We measured maximum, preatrial contraction and minimum left and right atrial volumes in 120 healthy subjects after careful exclusion of cardiovascular abnormality (60 men, 60 women; 20 subjects per age decile from 20 to 80 years). Data were generated from 3-dimensional modeling, including tracking of the atrioventricular ring motion and time-volume curves analysis. With those measurements, all the usual parameters for left and right atrial function were calculated. RESULTS Gender had significant influence on some parameters of left and right atrial conduit and booster pump function. Age significantly influenced the majority of parameters of both left and right atrial function, with typically lower reservoir and conduit functions and higher booster pump function, both in males and females belonging to older age groups. CMR normal ranges were modelled for clinical use with normalization, where appropriate, for body surface area and gender, displaying parameters with respect to age. CONCLUSIONS CMR normal reference ranges for components of left and right atrial function are provided for males and females for a wide age range.",
author = "Maceira, Alicia M. and Cosin-Sales, Juan and Prasad, Sanjay K. and Pennell, Dudley J.",
doi = "10.1186/s12968-016-0284-8",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
keywords = "Cardiovascular magnetic resonance,Conduit,Heart,Left atrium,Pump function,Reference values,Reservoir,Right atrium",
month = "dec",
number = 1,
pages = 64,
pmid = 27719670,
title = "{Characterization of left and right atrial function in healthy volunteers by cardiovascular magnetic resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27719670 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5056480 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-016-0284-8",
volume = 18,
year = 2016
}
Paul Kotwinski, Gillian Smith, Jackie Cooper, Julie Sanders, Louise Ma, Albert Teis, David Kotwinski, Michael Mythen, Dudley J Pennell, Alison Jones, Hugh Montgomery, Breast Early Toxicity Therapy Epirubicin Regimens–Cardiac Assessment and Risk Evaluation (BETTER-CARE) Study Investigators.
Body Surface Area and Baseline Blood Pressure Predict Subclinical Anthracycline Cardiotoxicity in Women Treated for Early Breast Cancer.
PLOS ONE 11(12):e0165262, December 2016.
URL, DOI BibTeX
@article{Kotwinski2016,
abstract = "BACKGROUND AND AIMS Anthracyclines are highly effective chemotherapeutic agents which may cause long-term cardiac damage (chronic anthracycline cardiotoxicity) and heart failure. The pathogenesis of anthracycline cardiotoxicity remains incompletely understood and individual susceptibility difficult to predict. We sought clinical features which might contribute to improved risk assessment. METHODS Subjects were women with early breast cancer, free of pre-existing cardiac disease. Left ventricular ejection fraction was measured using cardiovascular magnetic resonance before and {\textgreater}12 months after anthracycline-based chemotherapy ({\textgreater}3 months post-Trastuzumab). Variables associated with subclinical cardiotoxicity (defined as a fall in left ventricular ejection fraction of ≥5{\%}) were identified by logistic regression. RESULTS One hundred and sixty-five women (mean age 48.3 years at enrollment) completed the study 21.7 months [IQR 18.0-26.8] after starting chemotherapy. All received anthracyclines (98.8{\%} epirubicin, cumulative dose 400 [300-450] mg/m2); 18{\%} Trastuzumab. Baseline blood pressure was elevated (≥140/90mmHg, mean 147.3/86.1mmHg) in 18 subjects. Thirty-four subjects (20.7{\%}) were identified with subclinical cardiotoxicity, independent predictors of which were the number of anthracycline cycles (odds ratio, OR 1.64 [1.17-2.30] per cycle), blood pressure ≥140/90mmHg (OR 5.36 [1.73-17.61]), body surface area (OR 2.08 [1.36-3.20] per standard deviation (0.16m2) increase), and Trastuzumab therapy (OR 3.35 [1.18-9.51]). The resultant predictive-model had an area under the receiver operating characteristics curve of 0.78 [0.70-0.86]. CONCLUSIONS We found subclinical cardiotoxicity to be common even within this low risk cohort. Risk of cardiotoxicity was associated with modestly elevated baseline blood pressure-indicating that close attention should be paid to blood pressure in patients considered for anthracycline based chemotherapy. The association with higher body surface area suggests that indexing of anthracycline doses to surface area may not be appropriate for all, and points to the need for additional research in this area.",
author = "Kotwinski, Paul and Smith, Gillian and Cooper, Jackie and Sanders, Julie and Ma, Louise and Teis, Albert and Kotwinski, David and Mythen, Michael and Pennell, Dudley J. and Jones, Alison and Montgomery, Hugh and {Breast cancer Early disease: Toxicity from Therapy with Epirubicin Regimens–Cardiac Assessment and Risk Evaluation (BETTER-CARE) Study Investigators}",
doi = "10.1371/journal.pone.0165262",
editor = "Bishopric, Nanette H.",
issn = "1932-6203",
journal = "PLOS ONE",
month = "dec",
number = 12,
pages = "e0165262",
pmid = 27911951,
title = "{Body Surface Area and Baseline Blood Pressure Predict Subclinical Anthracycline Cardiotoxicity in Women Treated for Early Breast Cancer}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27911951 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5135038 http://dx.plos.org/10.1371/journal.pone.0165262",
volume = 11,
year = 2016
}
Claire E Raphael, Robert Cooper, Kim H Parker, Julian Collinson, Vassilis Vassiliou, Dudley J Pennell, Ranil Silva, Li Yueh Hsu, Anders M Greve, Sukh Nijjer, Chris Broyd, Aamir Ali, Jennifer Keegan, Darrel P Francis, Justin E Davies, Alun D Hughes, Andrew Arai, Michael Frenneaux, Rod H Stables, Carlo Di Mario and Sanjay K Prasad.
Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy.
Journal of the American College of Cardiology 68(15):1651–1660, October 2016.
URL, DOI BibTeX
@article{Raphael2016a,
abstract = "BACKGROUND Angina is common in hypertrophic cardiomyopathy (HCM) and is associated with abnormal myocardial perfusion. Wave intensity analysis improves the understanding of the mechanics of myocardial ischemia. OBJECTIVES Wave intensity analysis was used to describe the mechanisms underlying perfusion abnormalities in patients with HCM. METHODS Simultaneous pressure and flow were measured in the proximal left anterior descending artery in 33 patients with HCM and 20 control patients at rest and during hyperemia, allowing calculation of wave intensity. Patients also underwent quantitative first-pass perfusion cardiac magnetic resonance to measure myocardial perfusion reserve. RESULTS Patients with HCM had a lower coronary flow reserve than control subjects (1.9 ± 0.8 vs. 2.7 ± 0.9; p = 0.01). Coronary hemodynamics in HCM were characterized by a very large backward compression wave during systole (38 ± 11{\%} vs. 21 ± 6{\%}; p {\textless} 0.001) and a proportionately smaller backward expansion wave (27{\%} ± 8{\%} vs. 33 ± 6{\%}; p = 0.006) compared with control subjects. Patients with severe left ventricular outflow tract obstruction had a bisferiens pressure waveform resulting in an additional proximally originating deceleration wave during systole. The proportion of waves acting to accelerate coronary flow increased with hyperemia, and the magnitude of change was proportional to the myocardial perfusion reserve (rho = 0.53; p {\textless} 0.01). CONCLUSIONS Coronary flow in patients with HCM is deranged. Distally, compressive deformation of intramyocardial blood vessels during systole results in an abnormally large backward compression wave, whereas proximally, severe left ventricular outflow tract obstruction is associated with an additional deceleration wave. Perfusion abnormalities in HCM are not simply a consequence of supply/demand mismatch or remodeling of the intramyocardial blood vessels; they represent a dynamic interaction with the mechanics of myocardial ischemia that may be amenable to treatment.",
author = "Raphael, Claire E. and Cooper, Robert and Parker, Kim H. and Collinson, Julian and Vassiliou, Vassilis and Pennell, Dudley J. and de Silva, Ranil and Hsu, Li Yueh and Greve, Anders M. and Nijjer, Sukh and Broyd, Chris and Ali, Aamir and Keegan, Jennifer and Francis, Darrel P. and Davies, Justin E. and Hughes, Alun D. and Arai, Andrew and Frenneaux, Michael and Stables, Rod H. and {Di Mario}, Carlo and Prasad, Sanjay K.",
doi = "10.1016/j.jacc.2016.07.751",
issn = 07351097,
journal = "Journal of the American College of Cardiology",
keywords = "CMR,angina,cardiovascular magnetic resonance,left ventricular outflow tract obstruction,perfusion",
month = "oct",
number = 15,
pages = "1651--1660",
pmid = 27712778,
title = "{Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27712778 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5054113 http://linkinghub.elsevier.com/retrieve/pii/S0735109716348860",
volume = 68,
year = 2016
}
Veronica Spadotto, Inga Voges, Philip J Kilner, Magdi H Yacoub, Sabine Ernst, Siew Yen Ho and Sonya V Babu-Narayan.
Juxtaposition of the atrial appendages: A nidus for thrombus in atriopulmonary Fontan?.
Global Cardiology Science and Practice 2016(2):e201619, October 2016.
URL, DOI BibTeX
@article{Spadotto2016,
abstract = "{\textless}p{\textgreater}Juxtaposition of atrial appendages is a rare cardiac congenital anomaly, usually associated with other cardiac malformations. Until now, it has not been linked to any significant clinical implications. We report cardiovascular magnetic resonance (CMR) findings of two adult patients who underwent atriopulmonary Fontan operation in the setting of left juxtaposition of the atrial appendages. The patients were in sinus rhythm at the time of the CMR study. Both patients had episodes of sustained atrial tachyarrhythmia requiring electrical cardioversion and were anticoagulated with warfarin with target INR 2-3. CMR images showed a thrombus located in the enlarged and juxtaposed right appendage in both patients. Blood flow frequently appears slow or sluggish in the dilated right atrium following atriopulmonary Fontan surgery. In addition, cine CMR suggested that blood flow reaches very low velocities in the massively dilated juxtaposed right atrial appendage cul-de-sac, thus potentially creating a substrate for clot formation. These findings propose that juxtaposed atrial appendages in atriopulmonary Fontan is an additional risk factor for clot formation, specifically in the dilated right atrial appendage on the left side juxtaposed with the left atrial appendage and that prophylactic anticoagulation is highly justified in these patients. {\textless}/p{\textgreater}",
author = "Spadotto, Veronica and Voges, Inga and Kilner, Philip J and Yacoub, Magdi H and Ernst, Sabine and Ho, Siew Yen and Babu-Narayan, Sonya V",
doi = "10.21542/gcsp.2016.19",
issn = 23057823,
journal = "Global Cardiology Science and Practice",
month = "oct",
number = 2,
pages = "e201619",
pmid = 29043267,
title = "{Juxtaposition of the atrial appendages: A nidus for thrombus in atriopulmonary Fontan?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/29043267 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5642832 https://globalcardiologyscienceandpractice.com/index.php/gcsp/article/view/23",
volume = 2016,
year = 2016
}
Sonya V Babu-Narayan, Daniele Prati, Riikka Rydman, Konstantinos Dimopoulos, Gerhard-Paul Diller, Anselm Uebing, Michael Y Henein, Philip J Kilner, Michael A Gatzoulis and Wei Li.
Dyssynchrony and electromechanical delay are associated with focal fibrosis in the systemic right ventricle — Insights from echocardiography.
International Journal of Cardiology 220:382–388, October 2016.
URL, DOI BibTeX
@article{Babu-Narayan2016,
abstract = "{BACKGROUND Systemic right ventricular (RV) dysfunction and sudden cardiac death remain problematic late after Mustard operation for transposition of the great arteries. The exact mechanism for that relationship is likely to be multifactorial including myocardial fibrosis. Doppler echocardiography gives further insights into the role of fibrosis shown by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in late morbidity. METHODS AND RESULTS Twenty-two consecutive patients, mean age 28±8years, were studied with 2D echocardiography, and also assessed by LGE CMR. The presence of LGE in 13/22 patients (59{\%}) was related to delayed septal shortening and lengthening (P=0.002 {\&}P=0.049), prolonged systemic RV isovolumic contraction time (P=0.024) and reduced systemic RV free wall and septal excursion (P=0.027 {\&}P=0.005). The systemic RV total isovolumic time was prolonged but not related to extent of LGE. LGE extent was related to markers of electromechanical delay and dyssynchrony (delayed onset of RV free wall shortening and lengthening; r=0.73 {\&}P=0.004 and r=0.62 {\&}P=0.041, respectively, and QRS duration r=0.68, P{\textless}0.01) and was inversely related to systolic RV free wall shortening velocity (r=-0.59 {\&}P=0.042). The presence of LGE was also related to lower exercise capacity, ≥mild tricuspid regurgitation and more arrhythmia (P=0.008",
p = "\textless}0.001, respectively). CONCLUSION Post Mustard repair, myocardial fibrosis is related to dyssynchrony, RV long axis dysfunction and tricuspid regurgitation. Echocardiographic measurements of systemic RV function can be confidently used in serial follow-up following Mustard operation.",
author = "Babu-Narayan, Sonya V. and Prati, Daniele and Rydman, Riikka and Dimopoulos, Konstantinos and Diller, Gerhard-Paul and Uebing, Anselm and Henein, Michael Y. and Kilner, Philip J. and Gatzoulis, Michael A. and Li, Wei",
doi = "10.1016/j.ijcard.2016.06.090",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Fibrosis,Late gadolinium enhancement,Long axis function,Systemic right ventricle,Tissue Doppler imaging,Transposition of the great arteries",
month = "oct",
pages = "382--388",
pmid = 27390959,
title = "{Dyssynchrony and electromechanical delay are associated with focal fibrosis in the systemic right ventricle — Insights from echocardiography}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27390959 http://linkinghub.elsevier.com/retrieve/pii/S0167527316311007",
volume = 220,
year = 2016
}
Claire E Raphael, Vassilis Vassiliou, Francisco Alpendurada, Sanjay K Prasad, Dudley J Pennell and Raad H Mohiaddin.
Clinical value of cardiovascular magnetic resonance in patients with MR-conditional pacemakers.
European Heart Journal - Cardiovascular Imaging 17(10):1178–1185, October 2016.
URL, DOI BibTeX
@article{Raphael2016,
abstract = "AIMS Magnetic resonance (MR) conditional pacemakers are increasingly implanted into patients who may need cardiovascular MR (CMR) subsequent to device implantation. We assessed the added value of CMR for diagnosis and management in this population. METHODS AND RESULTS CMR and pacing data from consecutive patients with MR conditional pacemakers were retrospectively reviewed. Images were acquired at 1.5 T (Siemens Magnetom Avanto). The indication for CMR and any resulting change in management was recorded. The quality of CMR was rated by an observer blinded to clinical details, and data on pacemaker and lead parameters were collected pre- and post-CMR. Seventy-two CMR scans on 69 patients performed between 2011 and 2015 were assessed. All scans were completed successfully with no significant change in lead thresholds or pacing parameters. Steady-state free precession (SSFP) cine imaging resulted in a greater frequency of non-diagnostic imaging (22 vs. 1{\%}, P {\textless} 0.01) compared with gradient echo sequences (GRE). Right-sided pacemakers were associated with less artefact than left-sided pacemakers. Late gadolinium enhancement imaging was performed in 59 scans with only 2{\%} of segments rated of non-diagnostic quality. The CMR data resulted in a new diagnosis in 27 (38{\%}) of examinations; clinical management was changed in a further 18 (25{\%}). CONCLUSIONS CMR in patients with MR conditional pacemakers provided diagnostic or management-changing information in the majority (63{\%}) of our cohort. The use of gradient echo cine sequences can reduce rates of non-diagnostic imaging. Right-sided device implantation may be considered in patients likely to require CMR examination.",
author = "Raphael, Claire E. and Vassiliou, Vassilis and Alpendurada, Francisco and Prasad, Sanjay K. and Pennell, Dudley J. and Mohiaddin, Raad H.",
doi = "10.1093/ehjci/jev305",
issn = "2047-2412",
journal = "European Heart Journal - Cardiovascular Imaging",
keywords = "CMR,PPM,cardiovascular magnetic resonance,conditional,pacemaker",
month = "oct",
number = 10,
pages = "1178--1185",
pmid = 26588986,
title = "{Clinical value of cardiovascular magnetic resonance in patients with MR-conditional pacemakers}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26588986 https://academic.oup.com/ehjcimaging/article/17/10/1178/2389105",
volume = 17,
year = 2016
}
Maude Pagé, Cesare Quarto, Enrico Mancuso and Raad H Mohiaddin.
Metabolically Active Brown Fat Mimicking Pericardial Metastasis on PET/CT: The Discriminating Role of Cardiac Magnetic Resonance Imaging.
Canadian Journal of Cardiology 32(8):1039.e15–1039.e17, August 2016.
URL, DOI BibTeX
@article{Page2016,
abstract = "Metabolically active mediastinal brown adipose tissue may be mistakenly diagnosed as a malignancy on 18F-fluoro-2-deoxy-D-glucose (FDG)/positron emission tomography (PET). We report the case of a patient with locally recurrent breast carcinoma in which staging PET/CT revealed a suspicious pericardial lesion for which the patient was referred to our centre. The novelty of this case resides in the fact that by tissue characterization, cardiac magnetic resonance imaging allowed the determination that the lesion corresponded to brown fat, a reassuring finding with important impact on management, because the presence of pericardial metastasis would have disqualified this patient for curative resection of her cancer recurrence.",
author = "Pag{\'{e}}, Maude and Quarto, Cesare and Mancuso, Enrico and Mohiaddin, Raad H.",
doi = "10.1016/j.cjca.2015.10.009",
issn = "0828282X",
journal = "Canadian Journal of Cardiology",
month = "aug",
number = 8,
pages = "1039.e15--1039.e17",
pmid = 26860773,
title = "{Metabolically Active Brown Fat Mimicking Pericardial Metastasis on PET/CT: The Discriminating Role of Cardiac Magnetic Resonance Imaging}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26860773 http://linkinghub.elsevier.com/retrieve/pii/S0828282X15015007",
volume = 32,
year = 2016
}
Archontis Giannakidis, Grant T Gullberg, Dudley J Pennell and David N Firmin.
Value of Formalin Fixation for the Prolonged Preservation of Rodent Myocardial Microanatomical Organization: Evidence by MR Diffusion Tensor Imaging.
The Anatomical Record 299(7):878–887, July 2016.
URL, DOI BibTeX
@article{Giannakidis2016,
abstract = "Previous ex vivo diffusion tensor imaging (DTI) studies on formalin-fixed myocardial tissue assumed that, after some initial changes in the first 48 hr since the start of fixation, DTI parameters remain stable over time. Prolonged preservation of cardiac tissue in formalin prior to imaging has been seen many times in the DTI literature as it is considered orderly. Our objective is to define the effects of the prolonged cardiac tissue exposure to formalin on tissue microanatomical organization, as this is assessed by DTI parameters. DTI experiments were conducted on eight excised rodent hearts that were fixed by immersion in formalin. The samples were randomly divided into two equinumerous groups corresponding to shorter (∼2 weeks) and more prolonged (∼6-8 weeks) durations of tissue exposure to formalin prior to imaging. We found that when the duration of cardiac tissue exposure to formalin before imaging increased, water diffusion became less restricted, helix angle (HA) histograms flattened out and exhibited heavier tails (even though the classic HA transmural variation was preserved), and a significant loss of inter-voxel primary diffusion orientation integrity was introduced. The prolonged preservation of cardiac tissue in formalin profoundly affected its microstructural organization, as this was assessed by DTI parameters. The accurate interpretation of diffusivity profiles necessitates awareness of the pitfalls of prolonged cardiac tissue exposure duration to formalin. The acquired knowledge works to the advantage of a proper experimental design of DTI studies of fixed hearts. Anat Rec, 299:878-887, 2016. {\textcopyright} 2016 Wiley Periodicals, Inc.",
author = "Giannakidis, Archontis and Gullberg, Grant T. and Pennell, Dudley J. and Firmin, David N.",
doi = "10.1002/ar.23359",
issn = 19328486,
journal = "The Anatomical Record",
keywords = "diffusion anisotropy,diffusivity,fixation,formalin,helix angle,inter-voxel diffusion coherence,magnetic resonance diffusion tensor imaging,rat myocardial microanatomy",
month = "jul",
number = 7,
pages = "878--887",
pmid = 27111575,
title = "{Value of Formalin Fixation for the Prolonged Preservation of Rodent Myocardial Microanatomical Organization: Evidence by MR Diffusion Tensor Imaging}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27111575 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4907831 http://doi.wiley.com/10.1002/ar.23359",
volume = 299,
year = 2016
}
Maude Pagé, Agata E Grasso, John-Paul Carpenter, Mary N Sheppard, Stefan P Karwatowski and Raad H Mohiaddin.
Primary Cardiac Lymphoma: Diagnosis and the Impact of Chemotherapy on Cardiac Structure and Function.
Canadian Journal of Cardiology 32(7):931.e1–931.e3, July 2016.
URL, DOI BibTeX
@article{Page2016a,
abstract = "We report a case of primary cardiac lymphoma presenting as myopericarditis and rapidly deteriorating into biventricular heart failure and ventricular arrhythmias. Computed tomography and cardiac magnetic resonance (CMR) imaging showed extensive myocardial infiltration with typical patterns on tissue characterization CMR images, raising clinical suspicion. Diagnosis was confirmed by myocardial histologic examination. Marked regression of tumor burden was apparent after 6 cycles of anthracycline-based chemotherapy. This case illustrates that a high degree of suspicion for this rare entity is mandated to institute timely treatment. Rapid tumor lysis may induce life-threatening acute cardiac decompensation that requires intensive monitoring and support therapy.",
author = "Pag{\'{e}}, Maude and Grasso, Agata E. and Carpenter, John-Paul and Sheppard, Mary N. and Karwatowski, Stefan P. and Mohiaddin, Raad H.",
doi = "10.1016/j.cjca.2015.09.002",
issn = "0828282X",
journal = "Canadian Journal of Cardiology",
month = "jul",
number = 7,
pages = "931.e1--931.e3",
pmid = 26755242,
title = "{Primary Cardiac Lymphoma: Diagnosis and the Impact of Chemotherapy on Cardiac Structure and Function}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26755242 http://linkinghub.elsevier.com/retrieve/pii/S0828282X15013999",
volume = 32,
year = 2016
}
Alistair C Lindsay, Katie Harron, Richard J Jabbour, Ritesh Kanyal, Thomas M Snow, Paramvir Sawhney, Francisco Alpendurada, Michael Roughton, Dudley J Pennell, Alison Duncan, Carlo Di Mario, Simon W Davies, Raad H Mohiaddin and Neil E Moat.
Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Patients Undergoing Transcatheter Aortic Valve Implantation.
Circulation: Cardiovascular Interventions 9(7):e003486, July 2016.
URL, DOI BibTeX
@article{Lindsay2016,
abstract = "BACKGROUND Cardiovascular magnetic resonance (CMR) can provide important structural information in patients undergoing transcatheter aortic valve implantation. Although CMR is considered the standard of reference for measuring ventricular volumes and mass, the relationship between CMR findings of right ventricular (RV) function and outcomes after transcatheter aortic valve implantation has not previously been reported. METHODS AND RESULTS A total of 190 patients underwent 1.5 Tesla CMR before transcatheter aortic valve implantation. Steady-state free precession sequences were used for aortic valve planimetry and to assess ventricular volumes and mass. Semiautomated image analysis was performed by 2 specialist reviewers blinded to patient treatment. Patient follow-up was obtained from the Office of National Statistics mortality database. The median age was 81.0 (interquartile range, 74.9-85.5) years; 50.0{\%} were women. Impaired RV function (RV ejection fraction ≤50{\%}) was present in 45 (23.7{\%}) patients. Patients with RV dysfunction had poorer left ventricular ejection fractions (42{\%} versus 69{\%}), higher indexed left ventricular end-systolic volumes (96 versus 40 mL), and greater indexed left ventricular mass (101 versus 85 g/m(2); P{\textless}0.01 for all) than those with normal RV function. Median follow-up was 850 days; 21 of 45 (46.7{\%}) patients with RV dysfunction died, compared with 43 of 145 (29.7{\%}) patients with normal RV function (P=0.035). After adjustment for significant baseline variables, both RV ejection fraction ≤50{\%} (hazard ratio, 2.12; P=0.017) and indexed aortic valve area (hazard ratio, 4.16; P=0.025) were independently associated with survival. CONCLUSIONS RV function, measured on preprocedural CMR, is an independent predictor of mortality after transcatheter aortic valve implantation. CMR assessment of RV function may be important in the risk stratification of patients undergoing transcatheter aortic valve implantation.",
author = "Lindsay, Alistair C. and Harron, Katie and Jabbour, Richard J. and Kanyal, Ritesh and Snow, Thomas M. and Sawhney, Paramvir and Alpendurada, Francisco and Roughton, Michael and Pennell, Dudley J. and Duncan, Alison and {Di Mario}, Carlo and Davies, Simon W. and Mohiaddin, Raad H. and Moat, Neil E.",
doi = "10.1161/CIRCINTERVENTIONS.115.003486",
issn = "1941-7640",
journal = "Circulation: Cardiovascular Interventions",
keywords = "magnetic resonance imaging,prognosis,transcatheter aortic valve replacement,ventricular ejection fraction,ventricular function, right",
month = "jul",
number = 7,
pages = "e003486",
pmid = 27418610,
title = "{Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Patients Undergoing Transcatheter Aortic Valve Implantation}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27418610 http://circinterventions.ahajournals.org/lookup/doi/10.1161/CIRCINTERVENTIONS.115.003486",
volume = 9,
year = 2016
}
S D Singh, X Y Xu, J R Pepper, C Izgi, T Treasure and R H Mohiaddin.
Effects of aortic root motion on wall stress in the Marfan aorta before and after personalised aortic root support (PEARS) surgery.
Journal of Biomechanics 49(10):2076–2084, July 2016.
URL, DOI BibTeX
@article{Singh2016a,
abstract = "Aortic root motion was previously identified as a risk factor for aortic dissection due to increased longitudinal stresses in the ascending aorta. The aim of this study was to investigate the effects of aortic root motion on wall stress and strain in the ascending aorta and evaluate changes before and after implantation of personalised external aortic root support (PEARS). Finite element (FE) models of the aortic root and thoracic aorta were developed using patient-specific geometries reconstructed from pre- and post-PEARS cardiovascular magnetic resonance (CMR) images in three Marfan patients. The wall and PEARS materials were assumed to be isotropic, incompressible and linearly elastic. A static load on the inner wall corresponding to the patients' pulse pressure was applied. Cardiovascular MR cine images were used to quantify aortic root motion, which was imposed at the aortic root boundary of the FE model, with zero-displacement constraints at the distal ends of the aortic branches and descending aorta. Measurements of the systolic downward motion of the aortic root revealed a significant reduction in the axial displacement in all three patients post-PEARS compared with its pre-PEARS counterparts. Higher longitudinal stresses were observed in the ascending aorta when compared with models without the root motion. Implantation of PEARS reduced the longitudinal stresses in the ascending aorta by up to 52{\%}. In contrast, the circumferential stresses at the interface between the supported and unsupported aorta were increase by up to 82{\%}. However, all peak stresses were less than half the known yield stress for the dilated thoracic aorta.",
author = "Singh, S.D. and Xu, X.Y. and Pepper, J.R. and Izgi, C. and Treasure, T. and Mohiaddin, R.H.",
doi = "10.1016/j.jbiomech.2016.05.011",
issn = 00219290,
journal = "Journal of Biomechanics",
keywords = "Aortic root motion,Finite element (FE),Marfan syndrome,Personalised external aortic root support (PEARS)",
month = "jul",
number = 10,
pages = "2076--2084",
pmid = 27255604,
title = "{Effects of aortic root motion on wall stress in the Marfan aorta before and after personalised aortic root support (PEARS) surgery}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27255604 http://linkinghub.elsevier.com/retrieve/pii/S0021929016305784",
volume = 49,
year = 2016
}
Mihaela A M Constantinescu, Su-Lin Lee, Nikhil V Navkar, Weimin Yu, Saifedeen Al-Rawas, Julien Abinahed, Guoyan Zheng, Jennifer Keegan, Abdulla Al-Ansari, Nabil Jomaah, Philippe Landreau and Guang-Zhong Yang.
Constrained Statistical Modelling of Knee Flexion From Multi-Pose Magnetic Resonance Imaging.
IEEE Transactions on Medical Imaging 35(7):1686–1695, July 2016.
URL, DOI BibTeX
@article{Constantinescu2016,
author = "Constantinescu, Mihaela A. M. and Lee, Su-Lin and Navkar, Nikhil V. and Yu, Weimin and Al-Rawas, Saifedeen and Abinahed, Julien and Zheng, Guoyan and Keegan, Jennifer and Al-Ansari, Abdulla and Jomaah, Nabil and Landreau, Philippe and Yang, Guang-Zhong",
doi = "10.1109/TMI.2016.2524587",
issn = "0278-0062",
journal = "IEEE Transactions on Medical Imaging",
month = "jul",
number = 7,
pages = "1686--1695",
title = "{Constrained Statistical Modelling of Knee Flexion From Multi-Pose Magnetic Resonance Imaging}",
url = "http://ieeexplore.ieee.org/document/7398103/",
volume = 35,
year = 2016
}
Najveen Alvi, Fateh A Tipoo, Ahmed Imran, Muhammad N Ashraf, Asim Qidwai, Mohammed Khursheed, Bushra Moiz, Salman N Adil, Zehra Fadoo, Sadaf Altaf, Dudley J Pennell and Babar S Hasan.
Burden of Cardiac Siderosis in a Thalassemia-Major Endemic Population.
Journal of Pediatric Hematology/Oncology 38(5):378–383, July 2016.
URL, DOI BibTeX
@article{Alvi2016,
abstract = "{OBJECTIVE To describe the initial experience and demographics of T2* cardiac magnetic resonance-based myocardial-iron quantification of transfusion-dependent thalassemia-major (TM) patients from Pakistan and the correlation with serum ferritin. METHODS Eligible TM patients presenting between April 2014 and April 2015 to Aga Khan University Hospital, Pakistan, for T2*CMR were included. The severity of myocardial-iron deposition was defined as follows: normal T2*{\textgreater}20 ms, mild-moderate T2*10 to 20 ms, and severe T2*{\textless}10 ms. Cardiac symptoms were classified using the NYHA functional classification. Echocardiographic systolic and diastolic functions were performed. Continuous variables were presented as the median (minimum-maximum value). Correlation was measured using the Spearman rank correlation. Multivariate logistic regression was used to determine factors associated with the NYHA functional class. RESULTS A total of 83 patients (49 male and 34 female) with TM, age 19 (5 to 45) years at presentation for T2*CMR, were reviewed. At presentation, 70{\%} of the patients were classified as NYHA class II or worse. T2*{\textless}20 ms was observed in 62.6{\%} of the patients, with 47{\%} showing severe iron deposition (T2{\textless}10 ms). No correlation of T2*{\textless}20 ms (r=-0.157",
p = "",
author = "Alvi, Najveen and Tipoo, Fateh A. and Imran, Ahmed and Ashraf, Muhammad N. and Qidwai, Asim and Khursheed, Mohammed and Moiz, Bushra and Adil, Salman N. and Fadoo, Zehra and Altaf, Sadaf and Pennell, Dudley J. and Hasan, Babar S.",
doi = "10.1097/MPH.0000000000000574",
issn = "1077-4114",
journal = "Journal of Pediatric Hematology/Oncology",
month = "jul",
number = 5,
pages = "378--383",
pmid = 27164519,
title = "{Burden of Cardiac Siderosis in a Thalassemia-Major Endemic Population}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27164519 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage{\&}an=00043426-201607000-00010",
volume = 38,
year = 2016
}
Alan G Japp, Ankur Gulati, Stuart A Cook, Martin R Cowie and Sanjay K Prasad.
The Diagnosis and Evaluation of Dilated Cardiomyopathy.
Journal of the American College of Cardiology 67(25):2996–3010, June 2016.
URL, DOI BibTeX
@article{Japp2016,
abstract = "Dilated cardiomyopathy (DCM) is best understood as the final common response of myocardium to diverse genetic and environmental insults. A rigorous work-up can exclude alternative causes of left ventricular (LV) dilation and dysfunction, identify etiologies that may respond to specific treatments, and guide family screening. A significant proportion of DCM cases have an underlying genetic or inflammatory basis. Measurement of LV size and ejection fraction remain central to diagnosis, risk stratification, and treatment, but other aspects of cardiac remodeling inform prognosis and carry therapeutic implications. Assessment of myocardial fibrosis predicts both risk of sudden cardiac death and likelihood of LV functional recovery, and has significant potential to guide patient selection for cardioverter-defibrillator implantation. Detailed mitral valve assessment is likely to assume increasing importance with the emergence of percutaneous interventions for functional mitral regurgitation. Detection of pre-clinical DCM could substantially reduce morbidity and mortality by allowing early instigation of cardioprotective therapy.",
author = "Japp, Alan G. and Gulati, Ankur and Cook, Stuart A. and Cowie, Martin R. and Prasad, Sanjay K.",
doi = "10.1016/j.jacc.2016.03.590",
issn = 07351097,
journal = "Journal of the American College of Cardiology",
keywords = "imaging,implantable cardioverter-defibrillator,remodeling",
month = "jun",
number = 25,
pages = "2996--3010",
pmid = 27339497,
title = "{The Diagnosis and Evaluation of Dilated Cardiomyopathy}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27339497 http://linkinghub.elsevier.com/retrieve/pii/S0735109716329187",
volume = 67,
year = 2016
}
Ahmad Falahatpisheh, Carsten Rickers, Dominik Gabbert, Ee Ling Heng, Aurelien Stalder, Hans-Heiner Kramer, Philip J Kilner and Arash Kheradvar.
Simplified Bernoulli's method significantly underestimates pulmonary transvalvular pressure drop.
Journal of Magnetic Resonance Imaging 43(6):1313–1319, June 2016.
URL, DOI BibTeX
@article{Falahatpisheh2016,
abstract = "PURPOSE To determine whether neglecting the flow unsteadiness in simplified Bernoulli's equation significantly affects the pulmonary transvalvular pressure drop estimation. MATERIALS AND METHODS 3.0T magnetic resonance imaging (MRI) 4D velocity mapping was performed on four healthy volunteers, seven patients with repaired tetralogy of Fallot, and thirteen patients with transposition of the great arteries repaired by arterial switch. Pulmonary transvalvular pressure drop was estimated based on two methods: General Bernoulli's Equation (GBE), ie, the most complete form; and Simplified Bernoulli's Equation (SBE), known as 4V(2) . More than 2300 individual pressure drop measurements were used to compare the simplified and the general Bernoulli's methods. A linear mixed-effects model was employed for statistical analyses, fully accounting for clustering of observations among the methods and systolic phases. RESULTS The simplified Bernoulli's method systematically underestimated the pressure drop compared to general Bernoulli's method during the entire systolic phase (P {\textless} 0.05), including the peak systole, where on average $\Delta$pSBE/$\Delta$pGBE=78{\%}. CONCLUSION The simplified Bernoulli method underestimated the pressure drop during all systolic phases in all the studied subjects. Therefore, it is necessary to take into account the flow unsteadiness for more accurate estimation of the pressure drop. J. Magn. Reson. Imaging 2016;43:1313-1319.",
author = "Falahatpisheh, Ahmad and Rickers, Carsten and Gabbert, Dominik and Heng, Ee Ling and Stalder, Aurelien and Kramer, Hans-Heiner and Kilner, Philip J. and Kheradvar, Arash",
doi = "10.1002/jmri.25097",
issn = 10531807,
journal = "Journal of Magnetic Resonance Imaging",
keywords = "Bernoulli equation,pulmonary transvalvular pressure drop,pulmonary valve stenosis,unsteady Bernoulli equation",
month = "jun",
number = 6,
pages = "1313--1319",
pmid = 26584006,
title = "{Simplified Bernoulli's method significantly underestimates pulmonary transvalvular pressure drop}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26584006 http://doi.wiley.com/10.1002/jmri.25097",
volume = 43,
year = 2016
}
Hitesh C Patel, Stuart D Rosen, Carl Hayward, Vassilios Vassiliou, Gillian C Smith, Ricardo R Wage, James Bailey, Ronak Rajani, Alistair C Lindsay, Dudley J Pennell, Richard S Underwood, Sanjay K Prasad, Raad Mohiaddin, Simon J R Gibbs, Alexander R Lyon and Carlo Di Mario.
Renal denervation in heart failure with preserved ejection fraction (RDT-PEF): a randomized controlled trial.
European Journal of Heart Failure 18(6):703–712, June 2016.
URL, DOI BibTeX
@article{Patel2016,
abstract = "AIM Heart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RDT) might be helpful and there are no data currently in humans with HFpEF. METHODS AND RESULTS In this single-centre, randomized, open-controlled study we included 25 patients with HFpEF [preserved left ventricular (LV) ejection fraction, left atrial (LA) dilatation or LV hypertrophy and raised B-type natriuretic peptide (BNP) or echocardiographic assessment of filling pressures]. Patients were randomized (2:1) to RDT with the Symplicity™ catheter or continuing medical therapy. The primary success criterion was not met in that there were no differences between groups at 12 months for Minnesota Living with Heart Failure Questionnaire score, peak oxygen uptake (VO2 ) on exercise, BNP, E/e', LA volume index or LV mass index. A greater proportion of patients improved at 3 months in the RDT group with respect to VO2 peak (56{\%} vs. 13{\%}, P = 0.025) and E/e' (31{\%} vs. 13{\%}, P = 0.04). Change in estimated glomerular filtration rate was comparable between groups. Two patients required plain balloon angioplasty during the RDT procedure to treat renal artery wall oedema. CONCLUSION This study was terminated early because of difficulties in recruitment and was underpowered to detect whether RD improved the endpoints of quality of life, exercise function, biomarkers, and left heart remodelling. The procedure was safe in patients with HFpEF, although two patients did require intraprocedure renal artery dilatation.",
author = "Patel, Hitesh C. and Rosen, Stuart D. and Hayward, Carl and Vassiliou, Vassilios and Smith, Gillian C. and Wage, Ricardo R. and Bailey, James and Rajani, Ronak and Lindsay, Alistair C. and Pennell, Dudley J. and Underwood, S. Richard and Prasad, Sanjay K. and Mohiaddin, Raad and Gibbs, J. Simon R. and Lyon, Alexander R. and {Di Mario}, Carlo",
doi = "10.1002/ejhf.502",
issn = 13889842,
journal = "European Journal of Heart Failure",
keywords = "Heart failure with preserved ejection fraction,Meta-iodo-benzyl-guanidine,Noradrenaline,Renal denervation,Sympathetic nervous system",
month = "jun",
number = 6,
pages = "703--712",
pmid = 26990920,
title = "{Renal denervation in heart failure with preserved ejection fraction (RDT-PEF): a randomized controlled trial}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26990920 http://doi.wiley.com/10.1002/ejhf.502",
volume = 18,
year = 2016
}
Saul G Myerson, Joanna D'Arcy, Jonathan P Christiansen, Laura E Dobson, Raad Mohiaddin, Jane M Francis, Bernard Prendergast, John P Greenwood, Theodoros D Karamitsos and Stefan Neubauer.
Determination of Clinical Outcome in Mitral Regurgitation With Cardiovascular Magnetic Resonance QuantificationCLINICAL PERSPECTIVE.
Circulation 133(23):2287–2296, June 2016.
URL, DOI BibTeX
@article{Myerson2016,
abstract = "BACKGROUND Surgery for severe mitral regurgitation is indicated if symptoms or left ventricular dilation or dysfunction occur. However, prognosis is already reduced by this stage, and earlier surgery on asymptomatic patients has been advocated if valve repair is likely, but identifying suitable patients for early surgery is difficult. Quantifying the regurgitation may help, but evidence for its link with outcome is limited. Cardiovascular magnetic resonance (CMR) can accurately quantify mitral regurgitation, and we examined whether this was associated with the future need for surgery. METHODS AND RESULTS One hundred nine asymptomatic patients with echocardiographic moderate or severe mitral regurgitation had baseline CMR scans and were followed up for up to 8 years (mean, 2.5±1.9 years). CMR quantification accurately identified patients who progressed to symptoms or other indications for surgery: 91{\%} of subjects with regurgitant volume ≤55 mL survived to 5 years without surgery compared with only 21{\%} with regurgitant volume {\textgreater}55 mL (P{\textless}0.0001). A similar separation was observed for regurgitant fraction ≤40{\%} and {\textgreater}40{\%}. CMR-derived end-diastolic volume index showed a weaker association with outcome (proportions surviving without surgery at 5 years, 90{\%} for left ventricular end-diastolic volume index {\textless}100 mL/m(2) versus 48{\%} for ≥100 mL/m(2)) and added little to the discriminatory power of regurgitant fraction/volume alone. CONCLUSIONS CMR quantification of mitral regurgitation was associated with the development of symptoms or other indications for surgery and showed better discriminatory ability than the reference-standard CMR-derived ventricular volumes. CMR may be able to identify appropriate patients for early surgery, with the potential to change clinical practice, although the clinical benefits of early surgery require confirmation in a clinical trial.",
author = "Myerson, Saul G. and D'Arcy, Joanna and Christiansen, Jonathan P. and Dobson, Laura E. and Mohiaddin, Raad and Francis, Jane M. and Prendergast, Bernard and Greenwood, John P. and Karamitsos, Theodoros D. and Neubauer, Stefan",
doi = "10.1161/CIRCULATIONAHA.115.017888",
issn = "0009-7322",
journal = "Circulation",
keywords = "magnetic resonance imaging,mitral valve,mitral valve insufficiency,outcome assessment (health care),prognosis",
month = "jun",
number = 23,
pages = "2287--2296",
pmid = 27189033,
title = "{Determination of Clinical Outcome in Mitral Regurgitation With Cardiovascular Magnetic Resonance QuantificationCLINICAL PERSPECTIVE}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27189033 http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.115.017888",
volume = 133,
year = 2016
}
Guang Yang, Xujiong Ye, Greg Slabaugh, Jennifer Keegan, Raad Mohiaddin and David Firmin.
Super-Resolved Enhancement of a Single Image and Its Application in Cardiac MRI.
Springer, Cham, May 2016, pages 179–190.
URL, DOI BibTeX
@incollection{Yang2016,
author = "Yang, Guang and Ye, Xujiong and Slabaugh, Greg and Keegan, Jennifer and Mohiaddin, Raad and Firmin, David",
doi = "10.1007/978-3-319-33618-3_19",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Yang et al. - 2016 - Super-Resolved Enhancement of a Single Image and Its Application in Cardiac MRI.pdf:pdf",
month = "may",
pages = "179--190",
publisher = "Springer, Cham",
title = "{Super-Resolved Enhancement of a Single Image and Its Application in Cardiac MRI}",
url = "http://link.springer.com/10.1007/978-3-319-33618-3{\_}19",
year = 2016
}
Vassilios S Vassiliou, Hitesh C Patel, Stuart D Rosen, Dominique Auger, Carl Hayward, Francisco Alpendurada, Alexander R Lyon, Dudley J Pennell, Carlo Di Mario and Sanjay K Prasad.
Left atrial dilation in patients with heart failure and preserved ejection fraction: Insights from cardiovascular magnetic resonance.
International Journal of Cardiology 210:158–160, May 2016.
URL, DOI BibTeX
@article{Vassiliou2016,
author = "Vassiliou, Vassilios S. and Patel, Hitesh C. and Rosen, Stuart D. and Auger, Dominique and Hayward, Carl and Alpendurada, Francisco and Lyon, Alexander R. and Pennell, Dudley J. and {Di Mario}, Carlo and Prasad, Sanjay K.",
doi = "10.1016/j.ijcard.2016.02.101",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Atrial volume,CMR,Echocardiography,HFpEF",
month = "may",
pages = "158--160",
pmid = 26946043,
title = "{Left atrial dilation in patients with heart failure and preserved ejection fraction: Insights from cardiovascular magnetic resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26946043 http://linkinghub.elsevier.com/retrieve/pii/S016752731630331X",
volume = 210,
year = 2016
}
Chiara Bucciarelli-Ducci, Dominique Auger, Carlo Di Mario, Didier Locca, Joanna Petryka, Rory O'Hanlon, Agata Grasso, Christine Wright, Karen Symmonds, Ricardo Wage, Eleni Asimacopoulos, Francesca Del Furia, Jonathan C Lyne, Peter D Gatehouse, Kim M Fox and Dudley J Pennell.
CMR Guidance for Recanalization of Coronary Chronic Total Occlusion.
JACC: Cardiovascular Imaging 9(5):547–556, May 2016.
URL, DOI BibTeX
@article{Bucciarelli-Ducci2016,
abstract = "OBJECTIVES This study explored whether cardiac magnetic resonance (CMR) could help select patients who could benefit from revascularization by identifying inducible myocardial ischemia and viability in the perfusion territory of the artery with chronic total occlusion (CTO). BACKGROUND The benefit of revascularization using percutaneous coronary intervention (PCI) in CTO is controversial. CMR offers incomparable left ventricular (LV) systolic function assessment in addition to potent ischemic burden quantification and reliable myocardial viability analysis. Whether CMR guided CTO revascularization would be helpful to such patients has not yet been explored fully. METHODS A prospective study of 50 consecutive CTO patients was conducted. Of 50 patients undergoing baseline stress CMR, 32 (64{\%}) were selected for recanalization based on the presence of significant inducible perfusion deficit and myocardial viability within the CTO arterial territory. Patients were rescanned 3 months after successful CTO recanalization. RESULTS At baseline, myocardial perfusion reserve (MPR) in the CTO territory was significantly reduced compared with the remote region (1.8 ± 0.72 vs. 2.2 ± 0.7; p = 0.01). MPR in the CTO region improved significantly after PCI (to 2.3 ± 0.9; p = 0.02 vs. baseline) with complete or near-complete resolution of CTO related perfusion defect in 90{\%} of patients. Remote territory MPR was unchanged after PCI (2.5 ± 1.2; p = NS vs. baseline). The LV ejection fraction increased from 63 ± 13{\%} to 67 ± 12{\%} (p {\textless} 0.0001) and end-systolic volume decreased from 65 ± 38 to 56 ± 38 ml (p {\textless} 0.001) 3 months after CTO PCI. Importantly, despite minimal post-procedural infarction due to distal embolization and side branch occlusion in 8 of 32 patients (25{\%}), the total Seattle Angina Questionnaire score improved from a median of 54 (range 45 to 74) at baseline to 89 (range 77 to 98) after CTO recanalization (p {\textless} 0.0001). CONCLUSIONS In this small group of patients showing CMR evidence of significant myocardial inducible perfusion defect and viability, CTO recanalization reduces ischemic burden, favors reverse remodeling, and ameliorates quality of life.",
author = "Bucciarelli-Ducci, Chiara and Auger, Dominique and {Di Mario}, Carlo and Locca, Didier and Petryka, Joanna and O'Hanlon, Rory and Grasso, Agata and Wright, Christine and Symmonds, Karen and Wage, Ricardo and Asimacopoulos, Eleni and {Del Furia}, Francesca and Lyne, Jonathan C. and Gatehouse, Peter D. and Fox, Kim M. and Pennell, Dudley J.",
doi = "10.1016/j.jcmg.2015.10.025",
issn = "1936878X",
journal = "JACC: Cardiovascular Imaging",
keywords = "cardiac magnetic resonance,chronic total occlusion,coronary artery disease",
month = "may",
number = 5,
pages = "547--556",
pmid = 27085432,
title = "{CMR Guidance for Recanalization of Coronary Chronic Total Occlusion}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/27085432 http://linkinghub.elsevier.com/retrieve/pii/S1936878X16300109",
volume = 9,
year = 2016
}
S S M Chen, K Dimopoulos, F H Sheehan, M A Gatzoulis and P J Kilner.
On the question of adjustment for multiple testing.
International Journal of Cardiology 209:347, April 2016.
URL, DOI BibTeX
@article{Chen2016,
author = "Chen, S.S.M. and Dimopoulos, K. and Sheehan, F.H. and Gatzoulis, M.A. and Kilner, P.J.",
doi = "10.1016/j.ijcard.2015.12.020",
issn = 01675273,
journal = "International Journal of Cardiology",
month = "apr",
pages = 347,
pmid = 26875607,
title = "{On the question of adjustment for multiple testing}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26875607 http://linkinghub.elsevier.com/retrieve/pii/S0167527315310147",
volume = 209,
year = 2016
}
Sonya V Babu-Narayan, George Giannakoulas, Anne Marie Valente, Wei Li and Michael A Gatzoulis.
Imaging of congenital heart disease in adults.
European Heart Journal 37(15):1182–1195, April 2016.
URL, DOI BibTeX
@article{Babu-Narayan2016a,
abstract = "Imaging is fundamental to the lifelong care of adult congenital heart disease (ACHD) patients. Echocardiography remains the first line imaging for inpatient, outpatient, or perioperative care. Cross-sectional imaging with cardiovascular magnetic resonance (CMR) or computed tomography (CT) provides complementary and invaluable information on cardiac and vascular anatomy and other intra-thoracic structures. Furthermore, CMR provides quantification of cardiac function and vascular flow. Cardiac catheterization is mostly reserved for assessment of pulmonary vascular resistance, ventricular end-diastolic pressure, and percutaneous interventions. There have been further advances in non-invasive imaging for ACHD including the application of advanced echocardiographic techniques, faster automated CMR imaging, and radiation dose reduction in CT. As a result ACHD, a heterogeneous population, benefit from appropriate application of multiple imaging modalities matched with tertiary ACHD expertise.",
author = "Babu-Narayan, Sonya V. and Giannakoulas, George and Valente, Anne Marie and Li, Wei and Gatzoulis, Michael A.",
doi = "10.1093/eurheartj/ehv519",
issn = "0195-668X",
journal = "European Heart Journal",
keywords = "Chest X-ray,Computed tomography,Congenital heart disease,Echocardiography,Imaging,Magnetic resonance imaging",
month = "apr",
number = 15,
pages = "1182--1195",
pmid = 26424866,
title = "{Imaging of congenital heart disease in adults}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26424866 https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehv519",
volume = 37,
year = 2016
}
Theodoros Karonis, Giancarlo Scognamiglio, Sonya V Babu-Narayan, Claudia Montanaro, Anselm Uebing, Gerhard P Diller, Rafael Alonso-Gonzalez, Lorna Swan, Konstantinos Dimopoulos, Michael A Gatzoulis and Wei Li.
Clinical course and potential complications of small ventricular septal defects in adulthood: Late development of left ventricular dysfunction justifies lifelong care.
International Journal of Cardiology 208:102–106, April 2016.
URL, DOI BibTeX
@article{Karonis2016,
abstract = "BACKGROUND Patients with small ventricular septal defects (VSDs) are thought to have excellent long-term survival, although complications may not be uncommon. METHODS We identified all patients aged ≥ 16 years with native isolated VSD between January 2000 and September 2013. Clinical outcomes were retrospectively reviewed. Transthoracic echocardiograms performed within 2 years of last assessment were reviewed for hemodynamic sequelae. RESULTS Two-hundred-and-thirty-one patients, 100 (43{\%}) male, mean age at last follow-up 34 ± 13 years were studied. During the recorded period there were no deaths. The majority (224/231; 97{\%}) were asymptomatic. Documented arrhythmias occurred in 7 patients (3{\%}), double-chamber right ventricle (DCRV) in 29 (13{\%}), more than mild aortic regurgitation in 6 (3{\%}) and infective endocarditis in 24 (10{\%}) patients. Surgery due to complications associated with VSD was performed in 26 (11{\%}) patients at a median age of 27.6 years (IQR: 16.1-38.7) due to DCRV (n=17, 65{\%}), infective endocarditis (n=6, 23{\%}), progression of left-right shunt (n=2, 8{\%}) and aortic regurgitation (n=1, 4{\%}). At most recent echocardiography (n=164), 10 (6{\%}), had reduced LVEF, 34 (21{\%}) had increased LVEDD and 17 (10{\%}) had LVESD {\textgreater}4.0 cm. Thirty-two patients (25{\%}) with normal LV dimensions had LA enlargement suggesting LV diastolic dysfunction. CONCLUSIONS We report a non-negligible incidence of major complications or clinical events during late follow-up of adult patients with restrictive VSDs. Furthermore, we show co-existing LV dysfunction, systolic or diastolic in a subset of patients. Indication for VSD closure in childhood may be recognized, whereas lifelong follow-up for adult with restrictive VSDs is clearly warranted.",
author = "Karonis, Theodoros and Scognamiglio, Giancarlo and Babu-Narayan, Sonya V. and Montanaro, Claudia and Uebing, Anselm and Diller, Gerhard P. and Alonso-Gonzalez, Rafael and Swan, Lorna and Dimopoulos, Konstantinos and Gatzoulis, Michael A. and Li, Wei",
doi = "10.1016/j.ijcard.2016.01.208",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Adult,Congenital,Double chamber right ventricle,Endocarditis,Heart defects,Ventricular septal defect",
month = "apr",
pages = "102--106",
pmid = 26844920,
title = "{Clinical course and potential complications of small ventricular septal defects in adulthood: Late development of left ventricular dysfunction justifies lifelong care}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26844920 http://linkinghub.elsevier.com/retrieve/pii/S0167527316302078",
volume = 208,
year = 2016
}
Kathleen A M Rose, Jaime H Vera, Peter Drivas, Winston Banya, Niall Keenan, Dudley J Pennell and Alan Winston.
Atherosclerosis is Evident in Treated HIV-Infected Subjects With Low Cardiovascular Risk by Carotid Cardiovascular Magnetic Resonance.
JAIDS Journal of Acquired Immune Deficiency Syndromes 71(5):514–521, April 2016.
URL, DOI BibTeX
@article{Rose2016,
abstract = "OBJECTIVE Premature atherosclerosis has been observed among HIV-infected individuals with high cardiovascular risk using one-dimensional ultrasound carotid intima-media thickness. We evaluated the assessment of HIV-infected individuals with low traditional cardiovascular disease risk using cardiovascular magnetic resonance, which allows three-dimensional assessment of the carotid artery wall. METHODS Carotid cardiovascular magnetic resonance was performed in 33 HIV-infected individuals (cases) (19 male, 14 female), and 35 HIV-negative controls (20 male, 15 female). Exclusion criteria included smoking, hypertension, hyperlipidemia (total cholesterol/HDL ratio {\textgreater} 5) or family history of premature atherosclerosis. Cases were stable on combination antiretroviral therapy with plasma HIV-1 RNA {\textless}50 copies per milliliter. Using computer modeling, the arterial wall, lumen, and total vessel volumes were calculated for a 4-cm length of each carotid artery centered on the bifurcation. The wall/outer-wall ratio (W/OW), an index of vascular thickening, was compared between the groups. RESULTS Cases had a median CD4 cell count of 690 cells per microliter. Mean (±SD) age and 10-year Framingham coronary risk scores were similar for cases and controls (45.2 ± 9.7 years versus 46.9 ± 11.6 years and 3.97{\%} ± 3.9{\%} versus 3.72{\%} ± 3.5{\%}, respectively). W/OW was significantly increased in cases compared with controls (36.7{\%} versus 32.5{\%}, P {\textless} 0.0001); this was more marked in HIV-infected females. HIV status was significantly associated with increased W/OW after adjusting for age (P {\textless} 0.0001). No significant association between antiretroviral type and W/OW was found-W/OW lowered comparing abacavir to zidovudine (P = 0.038), but statistical model fits poorly. CONCLUSIONS In a cohort of treated HIV-infected individuals with low measurable cardiovascular risk, we have observed evidence of premature subclinical atherosclerosis.",
author = "Rose, Kathleen A. M. and Vera, Jaime H. and Drivas, Peter and Banya, Winston and Keenan, Niall and Pennell, Dudley J. and Winston, Alan",
doi = "10.1097/QAI.0000000000000900",
issn = "1525-4135",
journal = "JAIDS Journal of Acquired Immune Deficiency Syndromes",
month = "apr",
number = 5,
pages = "514--521",
pmid = 26579986,
title = "{Atherosclerosis is Evident in Treated HIV-Infected Subjects With Low Cardiovascular Risk by Carotid Cardiovascular Magnetic Resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26579986 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4782218 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage{\&}an=00126334-201604150-00007",
volume = 71,
year = 2016
}
Matthew Cauldwell, Kate Von Klemperer, Anselm Uebing, Lorna Swan, Philip J Steer, Sonya V Babu-Narayan, Michael A Gatzoulis and Mark R Johnson.
A cohort study of women with a Fontan circulation undergoing preconception counselling.
Heart 102(7):534–540, April 2016.
URL, DOI BibTeX
@article{Cauldwell2016,
abstract = "OBJECTIVE To describe outcomes for women with a Fontan circulation attending preconception counselling (PCC). Exploring (1) impact of counselling on decision to become pregnant; (2) pregnancy rates in those opting for pregnancy and (3) short-term and long-term outcome of those who succeeded in becoming pregnant. METHODS Retrospective review of women aged 16-45 years with a Fontan circulation from 1994 to 2014. RESULTS 58 women were offered PCC, 3 declined and 55 received PCC. Following PCC, 15 opted against conception, 16 decided to delay pregnancy, 19 attempted pregnancy and 5 were lost to follow-up. Of the 19 women, 14 succeeded, becoming pregnant a total of 43 times (median 1, range 1-9). Of these, 6 miscarried all pregnancies. 8 carried 14 pregnancies to viability. Baseline hypoxaemia and cardiac disease in pregnancy (CARPREG) score was similar in those opting for and against pregnancy, but CARPREG score was better in those delaying conception. Women exclusively miscarrying or unable to conceive were more likely to have baseline hypoxaemia and greater CARPREG score. Cardiac complications included arrhythmia requiring treatment (n = 4) and one thromboembolism. Obstetric complications were greater in women with a Fontan circulation, 10 preterm births ({\textless} 37 weeks) and 8 small for gestational age babies ({\textless} 10th centile). There was one neonatal death. At follow-up, there was no deterioration in clinical status as determined by echo. CONCLUSIONS Most women accept PCC and decided to pursue pregnancy; in some cases, this was despite being advised of a poor prognosis. Pregnancy outcome was related to baseline hypoxia and CARPREG scores.",
author = "Cauldwell, Matthew and {Von Klemperer}, Kate and Uebing, Anselm and Swan, Lorna and Steer, Philip J and Babu-Narayan, Sonya V and Gatzoulis, Michael A and Johnson, Mark R",
doi = "10.1136/heartjnl-2015-308788",
issn = "1355-6037",
journal = "Heart",
month = "apr",
number = 7,
pages = "534--540",
pmid = 26786817,
title = "{A cohort study of women with a Fontan circulation undergoing preconception counselling}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26786817 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2015-308788",
volume = 102,
year = 2016
}
Gerhard-Paul Diller, Andrea Bräutigam, Aleksander Kempny, Anselm Uebing, Rafael Alonso-Gonzalez, Lorna Swan, Sonya V Babu-Narayan, Helmut Baumgartner, Konstantinos Dimopoulos and Michael A Gatzoulis.
Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value.
European Heart Journal 37(9):771–782, March 2016.
URL, DOI BibTeX
@article{Diller2016,
abstract = "BACKGROUND Depression is prevalent in adults with congenital heart disease (ACHD), but limited data on the frequency of anti-depressant drug (ADD) therapy and its impact on outcome are available. METHODS AND RESULTS We identified all ACHD patients treated with ADDs between 2000 and 2011 at our centre. Of 6162 patients under follow-up, 204 (3.3{\%}) patients were on ADD therapy. The majority of patients were treated with selective serotonin-reuptake inhibitors (67.4{\%}), while only 17.0{\%} of patients received tricyclic anti-depressants. Twice as many female patients used ADDs compared with males (4.4 vs. 2.2{\%}, P {\textless} 0.0001). The percentage of patients on ADDs increased with disease complexity (P {\textless} 0.0001) and patient age (P {\textless} 0.0001). Over a median follow-up of 11.1 years, 507 (8.2{\%}) patients died. After propensity score matching, ADD use was found to be significantly associated with worse outcome in male ACHD patients [hazard ratio 1.44 (95{\%} confidence interval 1.17-1.84)]. There was no evidence that this excess mortality was directly related to ADD therapy, QT-prolongation, or malignant arrhythmias. However, males taking ADDs were also more likely to miss scheduled follow-up appointments compared with untreated counterparts, while no such difference in clinic attendance was seen in females. CONCLUSIONS The use of ADD therapy in ACHD relates to gender, age, and disease complexity. Although, twice as many female patients were on ADDs, it were their male counterparts, who were at increased mortality risk on therapy. Furthermore, males on ADDs had worse adherence to scheduled appointments suggesting the need for special medical attention and possibly psychosocial intervention for this group of patients.",
author = {Diller, Gerhard-Paul and Br{\"{a}}utigam, Andrea and Kempny, Aleksander and Uebing, Anselm and Alonso-Gonzalez, Rafael and Swan, Lorna and Babu-Narayan, Sonya V. and Baumgartner, Helmut and Dimopoulos, Konstantinos and Gatzoulis, Michael A.},
doi = "10.1093/eurheartj/ehv386",
issn = "0195-668X",
journal = "European Heart Journal",
keywords = ",Adult congenital heart disease,Depression,Mortality,Outcome",
month = "mar",
number = 9,
pages = "771--782",
pmid = 26314687,
title = "{Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26314687 https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehv386",
volume = 37,
year = 2016
}
Dominique Auger and Dudley J Pennell.
Cardiac complications in thalassemia major.
Annals of the New York Academy of Sciences 1368(1):56–64, March 2016.
URL, DOI BibTeX
@article{Auger2016,
abstract = "The myocardium is particularly susceptible to complications from iron loading in thalassemia major. In the first years of life, severe anemia leads to high-output cardiac failure and death if not treated. The necessary supportive blood transfusions create loading of iron that cannot be naturally excreted, and this iron accumulates within tissues, including the heart. Free unbound iron catalyzes the formation of toxic hydroxyl radicals, which damage cells and cause cardiac dysfunction. Significant cardiac siderosis may present by the age of 10 and may lead to acute clinical heart failure, which must be treated urgently. Atrial fibrillation is the most frequently encountered iron-related arrhythmia. Iron chelation is effective at removing iron from the myocardium, at the expense of side effects that hamper compliance to therapy. Monitoring of myocardial iron content is mandatory for clinical management of cardiac risk. T2* cardiac magnetic resonance measures myocardial iron and is the strongest biomarker for prediction of heart failure and arrhythmic events. It has been calibrated to human myocardial tissue iron concentration and is highly reproducible across all magnetic resonance scanner vendors. As survival and patient age increases, endothelial dysfunction and diabetes may become new factors in the cardiovascular health of thalassemia patients. Promising new imaging technology and therapies could ameliorate the long-term prognosis.",
author = "Auger, Dominique and Pennell, Dudley J.",
doi = "10.1111/nyas.13026",
issn = 00778923,
journal = "Annals of the New York Academy of Sciences",
keywords = "arrhythmia,cardiac siderosis,heart failure,thalassemia",
month = "mar",
number = 1,
pages = "56--64",
pmid = 26963698,
title = "{Cardiac complications in thalassemia major}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26963698 http://doi.wiley.com/10.1111/nyas.13026",
volume = 1368,
year = 2016
}
S S M Chen, K Dimopoulos, F H Sheehan, M A Gatzoulis and P J Kilner.
Physiologic determinants of exercise capacity in patients with different types of right-sided regurgitant lesions: Ebstein's malformation with tricuspid regurgitation and repaired tetralogy of Fallot with pulmonary regurgitation.
International Journal of Cardiology 205:1–5, February 2016.
URL, DOI BibTeX
@article{Chen2016a,
abstract = "BACKGROUND Exercise capacity relates to right ventricular (RV) volume overload in congenital heart disease and may improve after surgery. We herewith investigate the relation between exercise capacity, cardiac index, and RV volume overload due to tricuspid regurgitation (TR) in Ebstein's malformation and pulmonary regurgitation (PR) after repair of tetralogy of Fallot (rToF). METHODS We measured cardiac index and tricuspid/pulmonary regurgitant fraction by cardiovascular magnetic resonance in patients with Ebstein's malformation (n = 40) or rTOF (n = 53) with at least moderate TR/PR and 24 healthy controls. Exercise tolerance was determined by peak oxygen consumption (peak VO2) during cardiopulmonary exercise testing. RESULTS TR and PR fraction were similar in Ebstein and rTOF patients (43 ± 17{\%} versus 39 ± 12{\%}, respectively). Cardiac index was reduced in Ebstein (2.7 ± 0.6L/min/m(2) compared to controls 3.5 ± 0.9L/min/m(2), p {\textless} 0.001) but not in rToF patients (3.2 ± 0.5L/min/m(2)). Multiple regression analysis revealed a significant correlation between peak VO2 and cardiac index in Ebstein. Furthermore, peak VO2 correlated with peak heart rate in both groups but not with regurgitation fraction. CONCLUSIONS Despite comparable amounts of regurgitation from a right sided heart valve in patients with Ebstein and rToF, reduction of cardiac index was observed only in the former group. Greater physiologic complexity and adverse ventricular interaction with chronotropic incompetence in Ebstein's malformation may account for this.",
author = "Chen, S.S.M. and Dimopoulos, K. and Sheehan, F.H. and Gatzoulis, M.A. and Kilner, P.J.",
doi = "10.1016/j.ijcard.2015.10.175",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Cardiac MRI,Cardiac index,Ebstein's,Exercise tolerance,Tetralogy of fallot",
month = "feb",
pages = "1--5",
pmid = 26703376,
title = "{Physiologic determinants of exercise capacity in patients with different types of right-sided regurgitant lesions: Ebstein's malformation with tricuspid regurgitation and repaired tetralogy of Fallot with pulmonary regurgitation}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26703376 http://linkinghub.elsevier.com/retrieve/pii/S0167527315307397",
volume = 205,
year = 2016
}
W C Lam and D J Pennell.
Imaging of the heart: historical perspective and recent advances.
Postgraduate Medical Journal 92(1084):99–104, February 2016.
URL, DOI BibTeX
@article{Lam2016,
abstract = "Correct diagnosis must be made before appropriate treatment can be given. The aim of cardiac imaging is to establish cardiac diagnosis as accurate as possible and to avert unnecessary invasive procedures. There are many different modalities of cardiac imaging and each of them has advanced tremendously throughout the past decades. Echocardiography, as the first-line modality in most clinical circumstances, has progressed from two-dimensional, single-planed M-mode in the 1960s to three-dimensional speckle tracking echocardiography nowadays. Cardiac computed tomography angiogram (CCTA) has revolutionised the management of coronary artery disease as it allows clinicians to visualise the coronary arteries without performing an invasive angiogram. Because of the high negative predictive value, CCTA plays an important reassuring role in acute chest pain management. The greatest strength of cardiovascular magnetic resonance (CMR) is that it provides information in tissue characterization. It is the modality of choice in assessing myocardial viability and myocardial infiltration such as haemochromatosis or amyloidosis. Each of these modalities has its own strengths and limitations. In fact, they are complementing each other in different clinical settings. Cardiac imaging will continue to advance and, not long from now, we will not need invasive procedures to make an accurate cardiac diagnosis.",
author = "Lam, W C and Pennell, D J",
doi = "10.1136/postgradmedj-2015-133831",
issn = "0032-5473",
journal = "Postgraduate Medical Journal",
month = "feb",
number = 1084,
pages = "99--104",
pmid = 26647305,
title = "{Imaging of the heart: historical perspective and recent advances}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26647305 http://pmj.bmj.com/lookup/doi/10.1136/postgradmedj-2015-133831",
volume = 92,
year = 2016
}
Frances M Mitchell, Sanjay K Prasad, Gerald F Greil, Peter Drivas, Vassilios S Vassiliou and Claire E Raphael.
Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population.
World Journal of Clinical Pediatrics 5(1):1, February 2016.
URL, DOI BibTeX
@article{Mitchell2016,
abstract = "Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field.",
author = "Mitchell, Frances M and Prasad, Sanjay K and Greil, Gerald F and Drivas, Peter and Vassiliou, Vassilios S and Raphael, Claire E",
doi = "10.5409/wjcp.v5.i1.1",
issn = "2219-2808",
journal = "World Journal of Clinical Pediatrics",
keywords = "Cardiology,Cardiovascular magnetic resonance,Diagnosis,Imaging,Pediatrics",
month = "feb",
number = 1,
pages = 1,
pmid = 26862497,
title = "{Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26862497 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4737683 http://www.wjgnet.com/2219-2808/full/v5/i1/1.htm",
volume = 5,
year = 2016
}
James S Ware, Jian Li, Erica Mazaika, Christopher M Yasso, Tiffany DeSouza, Thomas P Cappola, Emily J Tsai, Denise Hilfiker-Kleiner, Chizuko A Kamiya, Francesco Mazzarotto, Stuart A Cook, Indrani Halder, Sanjay K Prasad, Jessica Pisarcik, Karen Hanley-Yanez, Rami Alharethi, Julie Damp, Eileen Hsich, Uri Elkayam, Richard Sheppard, Angela Kealey, Jeffrey Alexis, Gautam Ramani, Jordan Safirstein, John Boehmer, Daniel F Pauly, Ilan S Wittstein, Vinay Thohan, Mark J Zucker, Peter Liu, John Gorcsan, Dennis M McNamara, Christine E Seidman, Jonathan G Seidman, Zoltan Arany, IMAC-2 and IPAC Investigators.
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.
New England Journal of Medicine 374(3):233–241, January 2016.
URL, DOI BibTeX
@article{Ware2016,
abstract = "Background Peripartum cardiomyopathy shares some clinical features with idiopathic dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including TTN, which encodes the sarcomere protein titin. Methods In 172 women with peripartum cardiomyopathy, we sequenced 43 genes with variants that have been associated with dilated cardiomyopathy. We compared the prevalence of different variant types (nonsense, frameshift, and splicing) in these women with the prevalence of such variants in persons with dilated cardiomyopathy and with population controls. Results We identified 26 distinct, rare truncating variants in eight genes among women with peripartum cardiomyopathy. The prevalence of truncating variants (26 in 172 [15{\%}]) was significantly higher than that in a reference population of 60,706 persons (4.7{\%",
p = "",
author = "Ware, James S. and Li, Jian and Mazaika, Erica and Yasso, Christopher M. and DeSouza, Tiffany and Cappola, Thomas P. and Tsai, Emily J. and Hilfiker-Kleiner, Denise and Kamiya, Chizuko A. and Mazzarotto, Francesco and Cook, Stuart A. and Halder, Indrani and Prasad, Sanjay K. and Pisarcik, Jessica and Hanley-Yanez, Karen and Alharethi, Rami and Damp, Julie and Hsich, Eileen and Elkayam, Uri and Sheppard, Richard and Kealey, Angela and Alexis, Jeffrey and Ramani, Gautam and Safirstein, Jordan and Boehmer, John and Pauly, Daniel F. and Wittstein, Ilan S. and Thohan, Vinay and Zucker, Mark J. and Liu, Peter and Gorcsan, John and McNamara, Dennis M. and Seidman, Christine E. and Seidman, Jonathan G. and Arany, Zoltan and {IMAC-2 and IPAC Investigators}",
doi = "10.1056/NEJMoa1505517",
issn = "0028-4793",
journal = "New England Journal of Medicine",
month = "jan",
number = 3,
pages = "233--241",
pmid = 26735901,
title = "{Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26735901 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4797319 http://www.nejm.org/doi/10.1056/NEJMoa1505517",
volume = 374,
year = 2016
}
Aleksander Kempny, Gerhard-Paul Diller, Konstantinos Dimopoulos, Rafael Alonso-Gonzalez, Anselm Uebing, Wei Li, Sonya Babu-Narayan, Lorna Swan, Stephen J Wort and Michael A Gatzoulis.
Determinants of outpatient clinic attendance amongst adults with congenital heart disease and outcome.
International Journal of Cardiology 203:245–250, January 2016.
URL, DOI BibTeX
@article{Kempny2016,
abstract = "{BACKGROUND Adult congenital heart disease (ACHD) guidelines advise life-long, regular, follow up in predefined intervals for ACHD patients. However, limited data exist to support this position. We examine, herewith, compliance to scheduled outpatient clinic appointments and its impact on outcome. METHODS AND RESULTS We examined 4461 ACHD patients (median age at entry 26.4years, 51{\%} female) and their follow up records at our tertiary centre between 1991 and 2008. Clinic attendance was quantified from electronic hospital records. For survival analysis we employed the last clinic attendance before 2008 as starting of follow-up. Overall 23{\%} of scheduled clinic appointments were not attended. The main predictors of clinic non-attendance (CNA) were younger age, non-Caucasian ethnicity, lower socioeconomic status, number of previous CNAs and the lack of planned additional investigation/s (e.g. echocardiography) scheduled on the same day. During a cumulative follow-up time of 48,828 patient-years, 366 (8.2{\%}) patients died. Both, the number of CNAs (HR=1.08, 95{\%} CI 1.05-1.12 per CNA, P{\textless}0.001) and the ratio of CNA to follow up period (HR=1.23, 95{\%} CI 1.04-1.44 per CNA/year",
p = "",
author = "Kempny, Aleksander and Diller, Gerhard-Paul and Dimopoulos, Konstantinos and Alonso-Gonzalez, Rafael and Uebing, Anselm and Li, Wei and Babu-Narayan, Sonya and Swan, Lorna and Wort, Stephen J. and Gatzoulis, Michael A.",
doi = "10.1016/j.ijcard.2015.10.081",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Adult congenital heart disease,Congenital heart disease,Outcome",
month = "jan",
pages = "245--250",
pmid = 26519677,
title = "{Determinants of outpatient clinic attendance amongst adults with congenital heart disease and outcome}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26519677 http://linkinghub.elsevier.com/retrieve/pii/S0167527315306471",
volume = 203,
year = 2016
}
S D Singh, X Y Xu, N B Wood, J R Pepper, C Izgi, T Treasure and R H Mohiaddin.
Aortic flow patterns before and after personalised external aortic root support implantation in Marfan patients.
Journal of Biomechanics 49(1):100–111, January 2016.
URL, DOI BibTeX
@article{Singh2016,
abstract = "Implantation of a personalised external aortic root support (PEARS) in the Marfan aorta is a new procedure that has emerged recently, but its haemodynamic implication has not been investigated. The objective of this study was to compare the flow characteristics and hemodynamic indices in the aorta before and after insertion of PEARS, using combined cardiovascular magnetic resonance imaging (CMR) and computational fluid dynamics (CFD). Pre- and post-PEARS MR images were acquired from 3 patients and used to build patient-specific models and upstream flow conditions, which were incorporated into the CFD simulations. The results revealed that while the qualitative patterns of the haemodynamics were similar before and after PEARS implantation, the post-PEARS aortas had slightly less disturbed flow at the sinuses, as a result of reduced diameters in the post-PEARS aortic roots. Quantitative differences were observed between the pre- and post-PEARS aortas, in that the mean values of helicity flow index (HFI) varied by -10{\%}, 35{\%} and 20{\%} in post-PEARS aortas of Patients 1, 2 and 3, respectively, but all values were within the range reported for normal aortas. Comparisons with MR measured velocities in the descending aorta of Patient 2 demonstrated that the computational models were able to reproduce the important flow features observed in vivo.",
author = "Singh, S.D. and Xu, X.Y. and Wood, N.B. and Pepper, J.R. and Izgi, C. and Treasure, T. and Mohiaddin, R.H.",
doi = "10.1016/j.jbiomech.2015.11.040",
issn = 00219290,
journal = "Journal of Biomechanics",
keywords = ",Computational fluid dynamics (CFD),Helicity flow index (HFI),Marfan syndrome,Personalised external aortic root support (PEARS),Wall shear stress (WSS)",
month = "jan",
number = 1,
pages = "100--111",
pmid = 26654673,
title = "{Aortic flow patterns before and after personalised external aortic root support implantation in Marfan patients}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26654673 http://linkinghub.elsevier.com/retrieve/pii/S002192901500682X",
volume = 49,
year = 2016
}
Jennifer Keegan, Claire E Raphael, Kim Parker, Robin M Simpson, Stephen Strain, Ranil Silva, Carlo Di Mario, Julian Collinson, Rod H Stables, Ricardo Wage, Peter Drivas, Malindie Sugathapala, Sanjay K Prasad and David N Firmin.
Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire.
Journal of Cardiovascular Magnetic Resonance 17(1):85, December 2015.
URL, DOI BibTeX
@article{Keegan2015c,
abstract = "BACKGROUND Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning. METHODS A retrospectively-gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data. RESULTS When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PDV) were approximately 40 {\%} of the peak Doppler values with a moderate - good linear relationship between the two techniques (R(2): 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13). CONCLUSIONS High temporal resolution breath-hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.",
author = "Keegan, Jennifer and Raphael, Claire E and Parker, Kim and Simpson, Robin M and Strain, Stephen and de Silva, Ranil and {Di Mario}, Carlo and Collinson, Julian and Stables, Rod H and Wage, Ricardo and Drivas, Peter and Sugathapala, Malindie and Prasad, Sanjay K and Firmin, David N",
doi = "10.1186/s12968-015-0189-y",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 85,
pmid = 26428627,
title = "{Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26428627 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4591589 http://jcmr-online.com/content/17/1/85",
volume = 17,
year = 2015
}
Mohammed H Alam, Dominique Auger, Gillian C Smith, Taigang He, Vassilis Vassiliou, John A Baksi, Rick Wage, Peter Drivas, Yanqiu Feng, David N Firmin and Dudley J Pennell.
T1 at 1.5T and 3T compared with conventional T2* at 1.5T for cardiac siderosis.
Journal of Cardiovascular Magnetic Resonance 17(1):102, December 2015.
URL, DOI BibTeX
@article{Alam2015,
abstract = "BACKGROUND Myocardial black blood (BB) T2* relaxometry at 1.5T provides robust, reproducible and calibrated non-invasive assessment of cardiac iron burden. In vitro data has shown that like T2*, novel native Modified Look-Locker Inversion recovery (MOLLI) T1 shortens with increasing tissue iron. The relative merits of T1 and T2* are largely unexplored. We compared the established 1.5T BB T2* technique against native T1 values at 1.5T and 3T in iron overload patients and in normal volunteers. METHODS A total of 73 subjects (42 male) were recruited, comprising 20 healthy volunteers (controls) and 53 patients (thalassemia major 22, sickle cell disease 9, hereditary hemochromatosis 9, other iron overload conditions 13). Single mid-ventricular short axis slices were acquired for BB T2* at 1.5T and MOLLI T1 quantification at 1.5T and 3T. RESULTS In healthy volunteers, median T1 was 1014 ms (full range 939-1059 ms) at 1.5T and modestly increased to 1165ms (full range 1056-1224 ms) at 3T. All patients with significant cardiac iron overload (1.5T T2* values {\textless}20 ms) had T1 values {\textless}939 ms at 1.5T, and {\textless}1056 ms at 3T. Associations between T2* and T1 were found to be moderate with y =377 {\textperiodcentered} x(0.282) at 1.5T (R(2) = 0.717), and y =406 {\textperiodcentered} x(0.294) at 3T (R(2) = 0.715). Measures of reproducibility of T1 appeared superior to T2*. CONCLUSIONS T1 mapping at 1.5T and at 3T can identify individuals with significant iron loading as defined by the current gold standard T2* at 1.5T. However, there is significant scatter between results which may reflect measurement error, but it is also possible that T1 interacts with T2*, or is differentially sensitive to aspects of iron chemistry or other biology. Hurdles to clinical implementation of T1 include the lack of calibration against human myocardial iron concentration, no demonstrated relation to cardiac outcomes, and variation in absolute T1 values between scanners, which makes inter-centre comparisons difficult. The relative merits of T1 at 3T versus T2* at 3T require further consideration.",
author = "Alam, Mohammed H. and Auger, Dominique and Smith, Gillian C. and He, Taigang and Vassiliou, Vassilis and Baksi, A. John and Wage, Rick and Drivas, Peter and Feng, Yanqiu and Firmin, David N. and Pennell, Dudley J.",
doi = "10.1186/s12968-015-0207-0",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 102,
pmid = 26602203,
title = "{T1 at 1.5T and 3T compared with conventional T2* at 1.5T for cardiac siderosis}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26602203 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4659152 http://jcmr-online.com/content/17/1/102",
volume = 17,
year = 2015
}
Gerhard-Paul Diller, Aleksander Kempny, Rafael Alonso-Gonzalez, Lorna Swan, Anselm Uebing, Wei Li, Sonya Babu-Narayan, Stephen J Wort, Konstantinos Dimopoulos and Michael A Gatzoulis.
Survival Prospects and Circumstances of Death in Contemporary Adult Congenital Heart Disease Patients Under Follow-Up at a Large Tertiary CentreCLINICAL PERSPECTIVE.
Circulation 132(22):2118–2125, December 2015.
URL, DOI BibTeX
@article{Diller2015,
abstract = "BACKGROUND Adult congenital heart disease (ACHD) patients have ongoing morbidity and reduced long-term survival. Recently, the importance of specialized follow-up at tertiary ACHD centers has been highlighted. We aimed to assess survival prospects and clarify causes of death in a large cohort of patients at a single, tertiary center. METHODS AND RESULTS We included 6969 adult patients (age 29.9 ± 15.4 years) under follow-up at our institution between 1991 and 2013. Causes of death were ascertained from official death certificates. Survival was compared with the expected survival in the general age- and sex-matched population, and standardized mortality rates were calculated. Over a median follow-up time of 9.1 years (interquartile range, 5.2-14.5), 524 patients died. Leading causes of death were chronic heart failure (42{\%}), pneumonia (10{\%}), sudden-cardiac death (7{\%}), cancer (6{\%}), and hemorrhage (5{\%}), whereas perioperative mortality was comparatively low. Isolated simple defects exhibited mortality rates similar to those in the general population, whereas patients with Eisenmenger syndrome, complex congenital heart disease, and Fontan physiology had much poorer long-term survival (P{\textless}0.0001 for all). The probability of cardiac death decreased with increasing patient's age, whereas the proportion of patients dying from noncardiac causes, such as cancer, increased. CONCLUSIONS ACHD patients continue to be afflicted by increased mortality in comparison with the general population as they grow older. Highest mortality rates were observed among patients with complex ACHD, Fontan physiology, and Eisenmenger syndrome. Our data provide an overview over causes of mortality and especially the spectrum of noncardiac causes of death in contemporary ACHD patients.",
author = "Diller, Gerhard-Paul and Kempny, Aleksander and Alonso-Gonzalez, Rafael and Swan, Lorna and Uebing, Anselm and Li, Wei and Babu-Narayan, Sonya and Wort, Stephen J. and Dimopoulos, Konstantinos and Gatzoulis, Michael A.",
doi = "10.1161/CIRCULATIONAHA.115.017202",
issn = "0009-7322",
journal = "Circulation",
keywords = "heart defects, congenital,heart failure,mortality,sudden cardiac death,survival",
month = "dec",
number = 22,
pages = "2118--2125",
pmid = 26369353,
title = "{Survival Prospects and Circumstances of Death in Contemporary Adult Congenital Heart Disease Patients Under Follow-Up at a Large Tertiary CentreCLINICAL PERSPECTIVE}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26369353 http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.115.017202",
volume = 132,
year = 2015
}
D J Pennell, A J Baksi, S K Prasad, C E Raphael, P J Kilner, R H Mohiaddin, F Alpendurada, S V Babu-Narayan, J Schneider and D N Firmin.
Review of Journal of Cardiovascular Magnetic Resonance 2014.
Journal of Cardiovascular Magnetic Resonance 17(1):99, December 2015.
URL, DOI BibTeX
@article{Pennell2015,
abstract = "There were 102 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2014, which is a 6{\%} decrease on the 109 articles published in 2013. The quality of the submissions continues to increase. The 2013 JCMR Impact Factor (which is published in June 2014) fell to 4.72 from 5.11 for 2012 (as published in June 2013). The 2013 impact factor means that the JCMR papers that were published in 2011 and 2012 were cited on average 4.72 times in 2013. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is {\textless}25{\%} and has been falling because the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality papers to JCMR for publication.",
author = "Pennell, D. J. and Baksi, A. J. and Prasad, S. K. and Raphael, C. E. and Kilner, P. J. and Mohiaddin, R. H. and Alpendurada, F. and Babu-Narayan, S. V. and Schneider, J. and Firmin, D. N.",
doi = "10.1186/s12968-015-0203-4",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 99,
pmid = 26589839,
title = "{Review of Journal of Cardiovascular Magnetic Resonance 2014}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26589839 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4654908 http://jcmr-online.com/content/17/1/99",
volume = 17,
year = 2015
}
L A McGill, P F Ferreira, A D Scott, S Nielles-Vallespin, A Giannakidis, P J Kilner, P D Gatehouse, R Silva, D N Firmin and D J Pennell.
Relationship between cardiac diffusion tensor imaging parameters and anthropometrics in healthy volunteers.
Journal of Cardiovascular Magnetic Resonance 18(1):2, December 2015.
URL, DOI BibTeX
@article{McGill2015a,
abstract = "BACKGROUND In vivo cardiac diffusion tensor imaging (cDTI) is uniquely capable of interrogating laminar myocardial dynamics non-invasively. A comprehensive dataset of quantative parameters and comparison with subject anthropometrics is required. METHODS cDTI was performed at 3T with a diffusion weighted STEAM sequence. Data was acquired from the mid left ventricle in 43 subjects during the systolic and diastolic pauses. Global and regional values were determined for fractional anisotropy (FA), mean diffusivity (MD), helix angle gradient (HAg, degrees/{\%}depth) and the secondary eigenvector angulation (E2A). Regression analysis was performed between global values and subject anthropometrics. RESULTS All cDTI parameters displayed regional heterogeneity. The RR interval had a significant, but clinically small effect on systolic values for FA, HAg and E2A. Male sex and increasing left ventricular end diastolic volume were associated with increased systolic HAg. Diastolic HAg and systolic E2A were both directly related to left ventricular mass and body surface area. There was an inverse relationship between E2A mobility and both age and ejection fraction. CONCLUSIONS Future interpretations of quantitative cDTI data should take into account anthropometric variations observed with patient age, body surface area and left ventricular measurements. Further work determining the impact of technical factors such as strain and SNR is required.",
author = "McGill, L.A. and Ferreira, P.F. and Scott, A.D. and Nielles-Vallespin, S. and Giannakidis, A. and Kilner, P.J. and Gatehouse, P.D. and de Silva, R. and Firmin, D.N. and Pennell, D.J.",
doi = "10.1186/s12968-015-0215-0",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 2,
pmid = 26738482,
title = "{Relationship between cardiac diffusion tensor imaging parameters and anthropometrics in healthy volunteers}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26738482 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4704390 http://jcmr-online.com/content/18/1/2",
volume = 18,
year = 2015
}
Archontis Giannakidis, Eva Nyktari, Jennifer Keegan, Iain Pierce, Irina Suman Horduna, Shouvik Haldar, Dudley J Pennell, Raad Mohiaddin, Tom Wong and David N Firmin.
Rapid automatic segmentation of abnormal tissue in late gadolinium enhancement cardiovascular magnetic resonance images for improved management of long-standing persistent atrial fibrillation.
BioMedical Engineering OnLine 14(1):88, December 2015.
URL, DOI BibTeX
@article{Giannakidis2015,
abstract = "BACKGROUND Atrial fibrillation (AF) is the most common heart rhythm disorder. In order for late Gd enhancement cardiovascular magnetic resonance (LGE CMR) to ameliorate the AF management, the ready availability of the accurate enhancement segmentation is required. However, the computer-aided segmentation of enhancement in LGE CMR of AF is still an open question. Additionally, the number of centres that have reported successful application of LGE CMR to guide clinical AF strategies remains low, while the debate on LGE CMR's diagnostic ability for AF still holds. The aim of this study is to propose a method that reliably distinguishes enhanced (abnormal) from non-enhanced (healthy) tissue within the left atrial wall of (pre-ablation and 3 months post-ablation) LGE CMR data-sets from long-standing persistent AF patients studied at our centre. METHODS Enhancement segmentation was achieved by employing thresholds benchmarked against the statistics of the whole left atrial blood-pool (LABP). The test-set cross-validation mechanism was applied to determine the input feature representation and algorithm that best predict enhancement threshold levels. RESULTS Global normalized intensity threshold levels T PRE = 1 1/4 and T POST = 1 5/8 were found to segment enhancement in data-sets acquired pre-ablation and at 3 months post-ablation, respectively. The segmentation results were corroborated by using visual inspection of LGE CMR brightness levels and one endocardial bipolar voltage map. The measured extent of pre-ablation fibrosis fell within the normal range for the specific arrhythmia phenotype. 3D volume renderings of segmented post-ablation enhancement emulated the expected ablation lesion patterns. By comparing our technique with other related approaches that proposed different threshold levels (although they also relied on reference regions from within the LABP) for segmenting enhancement in LGE CMR data-sets of AF patients, we illustrated that the cut-off levels employed by other centres may not be usable for clinical studies performed in our centre. CONCLUSIONS The proposed technique has great potential for successful employment in the AF management within our centre. It provides a highly desirable validation of the LGE CMR technique for AF studies. Inter-centre differences in the CMR acquisition protocol and image analysis strategy inevitably impede the selection of a universally optimal algorithm for segmentation of enhancement in AF studies.",
author = "Giannakidis, Archontis and Nyktari, Eva and Keegan, Jennifer and Pierce, Iain and {Suman Horduna}, Irina and Haldar, Shouvik and Pennell, Dudley J. and Mohiaddin, Raad and Wong, Tom and Firmin, David N.",
doi = "10.1186/s12938-015-0083-8",
issn = "1475-925X",
journal = "BioMedical Engineering OnLine",
month = "dec",
number = 1,
pages = 88,
pmid = 26445883,
title = "{Rapid automatic segmentation of abnormal tissue in late gadolinium enhancement cardiovascular magnetic resonance images for improved management of long-standing persistent atrial fibrillation}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26445883 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4596471 http://www.biomedical-engineering-online.com/content/14/1/88",
volume = 14,
year = 2015
}
Annette S Jensen, Craig S Broberg, Riikka Rydman, Gerhard-Paul Diller, Wei Li, Konstantinos Dimopoulos, Stephen J Wort, Dudley J Pennell, Gatzoulis Michael A and Sonya V Babu-Narayan.
Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated With Mortality in Eisenmenger SyndromeCLINICAL PERSPECTIVE.
Circulation: Cardiovascular Imaging 8(12):e003596, December 2015.
URL, DOI BibTeX
@article{Jensen2015,
abstract = "BACKGROUND Patients with Eisenmenger syndrome (ES) have better survival, despite similar pulmonary vascular pathology, compared with other patients with pulmonary arterial hypertension. Cardiovascular magnetic resonance (CMR) is useful for risk stratification in idiopathic pulmonary arterial hypertension, whereas it has not been evaluated in ES. We studied CMR together with other noninvasive measurements in ES to evaluate its potential role as a noninvasive risk stratification test. METHODS AND RESULTS Between 2003 and 2005, 48 patients with ES, all with a post-tricuspid shunt, were enrolled in a prospective, longitudinal, single-center study. All patients underwent a standardized baseline assessment with CMR, blood test, echocardiography, and 6-minute walk test and were followed up for mortality until the end of December 2013. Twelve patients (25{\%}) died during follow-up, mostly from heart failure (50{\%}). Impaired ventricular function (right or left ventricular ejection fraction) was associated with increased risk of mortality (lowest quartile: right ventricular ejection fraction, {\textless}40{\%}; hazard ratio, 4.4 [95{\%} confidence interval, 1.4-13.5]; P=0.01 and left ventricular ejection fraction, {\textless}50{\%}; hazard ratio, 6.6 [95{\%} confidence interval, 2.1-20.8]; P=0.001). Biventricular impairment (lowest quartile left ventricular ejection fraction, {\textless}50{\%} and right ventricular ejection fraction, {\textless}40{\%}) conveyed an even higher risk of mortality (hazard ratio, 8.0 [95{\%} confidence interval, 2.5-25.1]; P=0.0004). No other CMR or noninvasive measurement besides resting oxygen saturation (hazard ratio, 0.90 [0.83-0.97]/{\%}; P=0.007) was associated with mortality. CONCLUSIONS Impaired right, left, or biventricular systolic function derived from baseline CMR and resting oxygen saturation are associated with mortality in adult patients with ES. CMR is a useful noninvasive tool, which may be incorporated in the risk stratification assessment of ES during lifelong follow-up.",
author = "Jensen, Annette S. and Broberg, Craig S. and Rydman, Riikka and Diller, Gerhard-Paul and Li, Wei and Dimopoulos, Konstantinos and Wort, Stephen J. and Pennell, Dudley J. and Gatzoulis, Michael A, and Babu-Narayan, Sonya V.",
doi = "10.1161/CIRCIMAGING.115.003596",
issn = "1941-9651",
journal = "Circulation: Cardiovascular Imaging",
keywords = "Eisenmenger syndrome,follow-up studies,magnetic resonance imaging,mortality",
month = "dec",
number = 12,
pages = "e003596",
pmid = 26659374,
title = "{Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated With Mortality in Eisenmenger SyndromeCLINICAL PERSPECTIVE}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26659374 http://circimaging.ahajournals.org/lookup/doi/10.1161/CIRCIMAGING.115.003596",
volume = 8,
year = 2015
}
Ning Jin, Juliana Serafim Silveira, Marie-Pierre Jolly, David N Firmin, George Mathew, Nathan Lamba, Sharath Subramanian, Dudley J Pennell, Subha V Raman and Orlando P Simonetti.
Free-breathing myocardial T2* mapping using GRE-EPI and automatic Non-rigid motion correction.
Journal of Cardiovascular Magnetic Resonance 17(1):113, December 2015.
URL, DOI BibTeX
@article{Jin2015,
abstract = "BACKGROUND Measurement of myocardial T2* is becoming widely used in the assessment of patients at risk for cardiac iron overload. The conventional breath-hold, ECG-triggered, segmented, multi-echo gradient echo (MGRE) sequence used for myocardial T2* quantification is very sensitive to respiratory motion and may not be feasible in patients who are unable to breath-hold. We propose a free-breathing myocardial T2* mapping approach that combines a single-shot gradient-echo echo-planar imaging (GRE-EPI) sequence for T2*-weighted image acquisition with automatic non-rigid motion correction (MOCO) of respiratory motion between single-shot images. METHODS ECG-triggered T2*-weighted images at different echo times were acquired by a black-blood, single-shot GRE-EPI sequence during free-breathing. A single image at a single TE is acquired in each heartbeat. Automatic non-rigid MOCO was applied to correct for in-plane respiratory motion before pixel-wise T2* mapping. In a total of 117 patients referred for clinical cardiac magnetic resonance exams, the free-breathing MOCO GRE-EPI sequence was compared to the breath-hold segmented MGRE approach. Image quality was scored independently by 2 experienced observers blinded to the particular image acquisition strategy. T2* measurements in the interventricular septum and in the liver were compared for the two methods in all cases with adequate image quality. RESULTS T2* maps were acquired in all 117 patients using the breath-hold MGRE and the free-breathing MOCO GRE-EPI approaches, including 8 patients with myocardial iron overload and 25 patients with hepatic iron overload. The mean image quality of the free-breathing MOCO GRE-EPI images was scored significantly higher than that of the breath-hold MGRE images by both reviewers. Out of the 117 studies, 21 breath-hold MGRE studies (17.9{\%} of all the patients) were scored to be less than adequate or very poor by both reviewers, while only 2 free-breathing MOCO GRE-EPI studies were scored to be less than adequate image quality. In a comparative evaluation of the images with at least adequate quality, the intra-class correlation coefficients for myocardial and liver T2* were 0.868 and 0.986 respectively (p {\textless} 0.001), indicating that the T2* measured by breath-hold MGRE and free-breathing MOCO GRE-EPI were in close agreement. The coefficient of variation between the breath-hold and free-breathing approaches for myocardial and liver T2* were 9.88{\%} and 9.38{\%} respectively. Bland-Altman plots demonstrated good absolute agreement of T2* in the interventricular septum and the liver from the free-breathing and breath-hold approaches (mean differences -0.03 and 0.16 ms, respectively). CONCLUSION The free-breathing approach described for T2* mapping using MOCO GRE-EPI enables accurate myocardial and liver T2* measurements and is insensitive to respiratory motion.",
author = "Jin, Ning and da Silveira, Juliana Serafim and Jolly, Marie-Pierre and Firmin, David N. and Mathew, George and Lamba, Nathan and Subramanian, Sharath and Pennell, Dudley J. and Raman, Subha V. and Simonetti, Orlando P.",
doi = "10.1186/s12968-015-0216-z",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 113,
pmid = 26699850,
title = "{Free-breathing myocardial T2* mapping using GRE-EPI and automatic Non-rigid motion correction}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26699850 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4690363 http://jcmr-online.com/content/17/1/113",
volume = 17,
year = 2015
}
Huaibing Cheng, Minjie Lu, Cuihong Hou, Xuhua Chen, Li Li, Jing Wang, Gang Yin, Xiuyu Chen, Wei Xiangli, Chen Cui, Jianmin Chu, Shu Zhang, Sanjay K Prasad, Jielin Pu and Shihua Zhao.
Comparison of cardiovascular magnetic resonance characteristics and clinical consequences in children and adolescents with isolated left ventricular non-compaction with and without late gadolinium enhancement.
Journal of Cardiovascular Magnetic Resonance 17(1):44, December 2015.
URL, DOI BibTeX
@article{Cheng2015,
abstract = "BACKGROUND Although cardiovascular magnetic resonance (CMR) is showing increasingly diagnostic potential in left ventricular non-compaction (LVNC), relatively little research relevant to CMR is conducted in children with LVNC. This study was performed to characterize and compare CMR features and clinical outcomes in children with LVNC with and without late gadolinium enhancement (LGE). METHODS A cohort of 40 consecutive children (age, 13.7 ± 3.3 years; 29 boys and 11 girls) with isolated LVNC underwent a baseline CMR scan with subsequent clinical follow-up. Short-axis cine images were used to calculate left ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), myocardial mass, ratio of non-compacted-to-compacted myocardial thickness (NC/C ratio), and number of non-compacted segments. The LGE images were analyzed to assess visually presence and patterns of LGE. The primary end point was a composite of cardiac death and heart transplantation. RESULTS The LGE was present in 10 (25{\%}) children, and 46 (27{\%}) segments were involved, including 23 non-compacted segments and 23 normal segments. Compared with LGE- cohort, LGE+ cohort had significantly lower LVEF (23.8 ± 10.7{\%} vs. 42.9 ± 16.7{\%}, p {\textless} 0.001) and greater LVEDV (169.2 ± 65.1 vs. 118.2 ± 48.9 mL/m2, p = 0.010), LVESV (131.3 ± 55.5 vs. 73.3 ± 46.7 mL/m2, p = 0.002), and sphericity indices (0.75 ± 0.19 vs. 0.60 ± 0.20, p = 0.045). There were no differences in terms of number and distribution of non-compacted segments, NC/C ratio, and myocardial mass index between LGE+ and LGE- cohort. In the LGE+ cohort, adverse events occurred in 6 patients compared to 2 events in the LGE- cohort. Kaplan-Meier analysis showed a significant difference in outcome between LGE+ and LGE- cohort for cardiac death and heart transplantation (p = 0.011). CONCLUSIONS The LGE was present in up to one-fourth of children with LVNC, and the LGE+ children exhibited a more maladaptive LV remodeling and a higher incidence of cardiovascular death and heart transplantation.",
author = "Cheng, Huaibing and Lu, Minjie and Hou, Cuihong and Chen, Xuhua and Li, Li and Wang, Jing and Yin, Gang and Chen, Xiuyu and Xiangli, Wei and Cui, Chen and Chu, Jianmin and Zhang, Shu and Prasad, Sanjay K and Pu, Jielin and Zhao, Shihua",
doi = "10.1186/s12968-015-0148-7",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 44,
pmid = 26024839,
title = "{Comparison of cardiovascular magnetic resonance characteristics and clinical consequences in children and adolescents with isolated left ventricular non-compaction with and without late gadolinium enhancement}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26024839 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4449588 http://jcmr-online.com/content/17/1/44",
volume = 17,
year = 2015
}
Merlin J Fair, Peter D Gatehouse, Edward V R DiBella and David N Firmin.
A review of 3D first-pass, whole-heart, myocardial perfusion cardiovascular magnetic resonance.
Journal of Cardiovascular Magnetic Resonance 17(1):68, December 2015.
URL, DOI BibTeX
@article{Fair2015,
abstract = "A comprehensive review is undertaken of the methods available for 3D whole-heart first-pass perfusion (FPP) and their application to date, with particular focus on possible acceleration techniques. Following a summary of the parameters typically desired of 3D FPP methods, the review explains the mechanisms of key acceleration techniques and their potential use in FPP for attaining 3D acquisitions. The mechanisms include rapid sequences, non-Cartesian k-space trajectories, reduced k-space acquisitions, parallel imaging reconstructions and compressed sensing. An attempt is made to explain, rather than simply state, the varying methods with the hope that it will give an appreciation of the different components making up a 3D FPP protocol. Basic estimates demonstrating the required total acceleration factors in typical 3D FPP cases are included, providing context for the extent that each acceleration method can contribute to the required imaging speed, as well as potential limitations in present 3D FPP literature. Although many 3D FPP methods are too early in development for the type of clinical trials required to show any clear benefit over current 2D FPP methods, the review includes the small but growing quantity of clinical research work already using 3D FPP, alongside the more technical work. Broader challenges concerning FPP such as quantitative analysis are not covered, but challenges with particular impact on 3D FPP methods, particularly with regards to motion effects, are discussed along with anticipated future work in the field.",
author = "Fair, Merlin J. and Gatehouse, Peter D. and DiBella, Edward V. R. and Firmin, David N.",
doi = "10.1186/s12968-015-0162-9",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 68,
pmid = 26231784,
title = "{A review of 3D first-pass, whole-heart, myocardial perfusion cardiovascular magnetic resonance}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26231784 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4522116 http://jcmr-online.com/content/17/1/68",
volume = 17,
year = 2015
}
Petter Dyverfeldt, Malenka Bissell, Alex J Barker, Ann F Bolger, Carl-Johan Carlhäll, Tino Ebbers, Christopher J Francios, Alex Frydrychowicz, Julia Geiger, Daniel Giese, Michael D Hope, Philip J Kilner, Sebastian Kozerke, Saul Myerson, Stefan Neubauer, Oliver Wieben and Michael Markl.
4D flow cardiovascular magnetic resonance consensus statement.
Journal of Cardiovascular Magnetic Resonance 17(1):72, December 2015.
URL, DOI BibTeX
@article{Dyverfeldt2015,
abstract = "Pulsatile blood flow through the cavities of the heart and great vessels is time-varying and multidirectional. Access to all regions, phases and directions of cardiovascular flows has formerly been limited. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has enabled more comprehensive access to such flows, with typical spatial resolution of 1.5×1.5×1.5 - 3×3×3 mm(3), typical temporal resolution of 30-40 ms, and acquisition times in the order of 5 to 25 min. This consensus paper is the work of physicists, physicians and biomedical engineers, active in the development and implementation of 4D Flow CMR, who have repeatedly met to share experience and ideas. The paper aims to assist understanding of acquisition and analysis methods, and their potential clinical applications with a focus on the heart and greater vessels. We describe that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy. We also specify research and development goals that have yet to be satisfactorily achieved. Derived flow parameters, generally needing further development or validation for clinical use, include measurements of wall shear stress, pressure difference, turbulent kinetic energy, and intracardiac flow components. The dependence of measurement accuracy on acquisition parameters is considered, as are the uses of different visualization strategies for appropriate representation of time-varying multidirectional flow fields. Finally, we offer suggestions for more consistent, user-friendly implementation of 4D Flow CMR acquisition and data handling with a view to multicenter studies and more widespread adoption of the approach in routine clinical investigations.",
author = {Dyverfeldt, Petter and Bissell, Malenka and Barker, Alex J. and Bolger, Ann F. and Carlh{\"{a}}ll, Carl-Johan and Ebbers, Tino and Francios, Christopher J. and Frydrychowicz, Alex and Geiger, Julia and Giese, Daniel and Hope, Michael D. and Kilner, Philip J. and Kozerke, Sebastian and Myerson, Saul and Neubauer, Stefan and Wieben, Oliver and Markl, Michael},
doi = "10.1186/s12968-015-0174-5",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "dec",
number = 1,
pages = 72,
pmid = 26257141,
title = "{4D flow cardiovascular magnetic resonance consensus statement}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26257141 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4530492 http://jcmr-online.com/content/17/1/72",
volume = 17,
year = 2015
}
Ee Ling Heng, Michael A Gatzoulis and Sonya V Babu-Narayan.
Tailoring counselling after pulmonary valve surgery in repaired tetralogy of Fallot.
Heart 101(21):1695–1696, November 2015.
URL, DOI BibTeX
@article{Heng2015a,
author = "Heng, Ee Ling and Gatzoulis, Michael A and Babu-Narayan, Sonya V",
doi = "10.1136/heartjnl-2015-308294",
issn = "1355-6037",
journal = "Heart",
month = "nov",
number = 21,
pages = "1695--1696",
pmid = 26220813,
title = "{Tailoring counselling after pulmonary valve surgery in repaired tetralogy of Fallot}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26220813 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2015-308294",
volume = 101,
year = 2015
}
Rachel M Wald, Anne Marie Valente, Kimberlee Gauvreau, Sonya V Babu-Narayan, Gabriele Egidy Assenza, Jenna Schreier, Michael A Gatzoulis, Philip J Kilner, Zeliha Koyak, Barbara Mulder, Andrew J Powell and Tal Geva.
Cardiac magnetic resonance markers of progressive RV dilation and dysfunction after tetralogy of Fallot repair.
Heart 101(21):1724–1730, November 2015.
URL, DOI BibTeX
@article{Wald2015,
abstract = "OBJECTIVE Patients with repaired tetralogy of Fallot (TOF) are followed serially by cardiac magnetic resonance (CMR) for surveillance of RV dilation and dysfunction. We sought to define the prevalence of progressive RV disease and the optimal time interval between CMR evaluations. METHODS Candidates were selected from a multicentre TOF registry and were included if ≥2 CMR studies performed ≥6 months apart were available without interval cardiovascular interventions. Patients with 'disease progression' (defined as increase in RV end-diastolic volume index (RVEDVi) ≥30 mL/m(2), decrease in RVEF ≥10{\%} or decrease in LVEF ≥10{\%}) were compared with those with 'disease non-progression' (defined as RVEDVi increase ≤5 mL/m(2), RVEF decrease ≤3{\%} and LVEF decrease ≤3{\%}). RESULTS A total of 849 CMR studies in 339 patients (median age at first CMR 23.6 years) were analysed. Over a median interval of 2.2 years between CMR pairs, RVEDVi increased 4±18 mL/m(2) (p{\textless}0.001), RV end-systolic volume index increased 3±13 mL/m(2) (p{\textless}0.001), RVEF decreased 1{\%}±6{\%} (p=0.02) and LVEF decreased 1{\%}±6{\%} (p=0.001). Disease progression was observed in 15{\%} (n=76) and non-progression in 26{\%} (n=133). There were no significant differences between those with and without progression in baseline demographic, anatomic, ECG, exercise or baseline CMR characteristics. The optimal time interval between CMR studies for detection of progression was a 3-year interval (63{\%} sensitivity, 65{\%} specificity, area under the receiver operating characteristic curve 0.65). CONCLUSIONS Although progressive RV dilation and decline in biventricular systolic function occur at a slow pace in the majority of adults with repaired TOF, 15{\%} of patients experience rapid disease progression. The results of this study support the practice of serial CMR examinations to identify progressive disease at a time interval of up to 3 years.",
author = "Wald, Rachel M and Valente, Anne Marie and Gauvreau, Kimberlee and Babu-Narayan, Sonya V and Assenza, Gabriele Egidy and Schreier, Jenna and Gatzoulis, Michael A and Kilner, Philip J and Koyak, Zeliha and Mulder, Barbara and Powell, Andrew J and Geva, Tal",
doi = "10.1136/heartjnl-2015-308014",
issn = "1355-6037",
journal = "Heart",
month = "nov",
number = 21,
pages = "1724--1730",
pmid = 26276804,
title = "{Cardiac magnetic resonance markers of progressive RV dilation and dysfunction after tetralogy of Fallot repair}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26276804 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2015-308014",
volume = 101,
year = 2015
}
Conal Austin, Tal Golesworthy, Cemil Izgi, Raad Mohiaddin, John Pepper, Mario Petrou, Filip Rega, Ulrich Rosendahl, Michael Rubens and Tom Treasure.
Personalized Aortic Root Support With Mesh Provides Optimal Valve Conservation.
The Annals of Thoracic Surgery 100(4):1509–1510, October 2015.
URL, DOI BibTeX
@article{Austin2015,
author = "Austin, Conal and Golesworthy, Tal and Izgi, Cemil and Mohiaddin, Raad and Pepper, John and Petrou, Mario and Rega, Filip and Rosendahl, Ulrich and Rubens, Michael and Treasure, Tom",
doi = "10.1016/j.athoracsur.2015.03.027",
issn = 00034975,
journal = "The Annals of Thoracic Surgery",
month = "oct",
number = 4,
pages = "1509--1510",
pmid = 26434468,
title = "{Personalized Aortic Root Support With Mesh Provides Optimal Valve Conservation}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26434468 http://linkinghub.elsevier.com/retrieve/pii/S0003497515004087",
volume = 100,
year = 2015
}
Cemil Izgi, Evangelia Nyktari, Francisco Alpendurada, Annina Studer Bruengger, John Pepper, Tom Treasure and Raad Mohiaddin.
Effect of personalized external aortic root support on aortic root motion and distension in Marfan syndrome patients.
International Journal of Cardiology 197:154–160, October 2015.
URL, DOI BibTeX
@article{Izgi2015,
abstract = "OBJECTIVE Personalized external aortic root support (PEARS) is a novel surgical approach with the aim of stabilizing the aortic root size and decreasing risk of dissection in Marfan syndrome patients. A bespoke polymer mesh tailored to each patient's individual aorta shape is produced by modeling and then surgically implanted. The aim of this study is to assess the mechanical effects of PEARS on the aortic root systolic downward motion (an important determinant of aortic wall stress), aortic root distension and on the left ventricle (LV). METHODS/RESULTS A cohort of 27 Marfan patients had a prophylactic PEARS surgery between 2004 and 2012 with 24 having preoperative and follow-up cardiovascular magnetic resonance imaging studies. Systolic downward aortic root motion, aortic root distension, LV volumes/mass and mitral annular systolic excursion before the operation and in the latest follow-up were measured randomly and blinded. After a median follow-up of 50.5 (IQR 25.5-72) months following implantation of PEARS, systolic downward motion of aortic root was significantly decreased (12.6±3.6mm pre-operation vs 7.9±2.9mm latest follow-up, p{\textless}0.00001). There was a tendency for a decrease in systolic aortic root distension but this was not significant (median 4.5{\%} vs 2{\%",
p = "",
author = "Izgi, Cemil and Nyktari, Evangelia and Alpendurada, Francisco and Bruengger, Annina Studer and Pepper, John and Treasure, Tom and Mohiaddin, Raad",
doi = "10.1016/j.ijcard.2015.06.015",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Aneurysm,Aorta,Elasticity,Magnetic resonance imaging,Marfan syndrome,Prevention",
month = "oct",
pages = "154--160",
pmid = 26134372,
title = "{Effect of personalized external aortic root support on aortic root motion and distension in Marfan syndrome patients}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26134372 http://linkinghub.elsevier.com/retrieve/pii/S0167527315013169",
volume = 197,
year = 2015
}
Hitesh C Patel, Sofia Otero, Joanna B Moser, Carl Hayward, Stuart D Rosen, Alexander R Lyon, Raad Mohiaddin, Carlo Mario and Simon Padley.
A cross-sectional imaging study to identify organs at risk of thermal injury during renal artery sympathetic denervation.
International Journal of Cardiology 197:235–240, October 2015.
URL, DOI BibTeX
@article{Patel2015,
abstract = "BACKGROUND The technology used to perform catheter-based renal artery sympathetic denervation has evolved: catheters can now access arteries as small as 3mm in diameter and create ablation zones of up to 10mm in depth. Recent evidence suggests that the procedure may be more effective if a more thorough ablation strategy is employed. Limited data are available regarding inadvertent soft tissue thermal injury during such procedures. We used computed tomography (CT) to identify structures lying within the expected thermal ablation field or the 'at risk zone' (ARZ). METHODS 63 consecutive CT aortograms were reviewed, yielding 100 renal arteries anatomically eligible for treatment. Structures lying within a predefined ARZ (within 10mm of the renal artery wall) were recorded. RESULTS The 63 subjects had a mean age of 74.6years, 48{\%} were males and 88{\%} had hypertension. The inferior vena cava and renal veins were in the ARZ in all cases. Psoas muscles and small bowel were within the ARZ in at least a fifth of the kidneys. Other structures found in the ARZ included the liver, pancreas, adrenal glands and diaphragm. CONCLUSIONS This study describes the variable anatomical relationship between renal arteries and important abdominal structures that may be exposed to thermal energy during modern denervation procedures. The consequence of delivering such thermal energy to these structures is unknown but clinicians should be alert to the presenting symptoms if these structures are damaged. CT may have a pre-procedure role in assessing this risk.",
author = "Patel, Hitesh C. and Otero, Sofia and Moser, Joanna B. and Hayward, Carl and Rosen, Stuart D. and Lyon, Alexander R. and Mohiaddin, Raad and di Mario, Carlo and Padley, Simon",
doi = "10.1016/j.ijcard.2015.06.068",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Ablation,Anatomy,Cross-sectional imaging,Renal denervation,Safety",
month = "oct",
pages = "235--240",
pmid = 26151591,
title = "{A cross-sectional imaging study to identify organs at risk of thermal injury during renal artery sympathetic denervation}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26151591 http://linkinghub.elsevier.com/retrieve/pii/S0167527315300012",
volume = 197,
year = 2015
}
Byambajav Buyandelger, Catherine Mansfield, Sawa Kostin, Onjee Choi, Angharad M Roberts, James S Ware, Francesco Mazzarotto, Francesco Pesce, Rachel Buchan, Rivka L Isaacson, Josée Vouffo, Sylvia Gunkel, Gudrun Knöll, Sara J McSweeney, Heming Wei, Andreas Perrot, Conny Pfeiffer, Mohammad Reza Toliat, Kristina Ilieva, Ewelina Krysztofinska, Marina M López-Olañeta, Jesús M Gómez-Salinero, Albrecht Schmidt, Keat-Eng Ng, Niels Teucher, Ju Chen, Martin Teichmann, Martin Eilers, Wilhelm Haverkamp, Vera Regitz-Zagrosek, Gerd Hasenfuss, Thomas Braun, Dudley J Pennell, Ian Gould, Paul J R Barton, Enrique Lara-Pezzi, Sebastian Schäfer, Norbert Hübner, Leanne E Felkin, Declan P O'Regan, Thomas Brand, Hendrik Milting, Peter Nürnberg, Michael D Schneider, Sanjay Prasad, Enrico Petretto and Ralph Knöll.
{\textlessi\textgreaterZBTB17\textless/i\textgreater ( \textlessi\textgreaterMIZ1\textless/i\textgreater ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart FailureCLINICAL PERSPECTIVE}.
Circulation: Cardiovascular Genetics 8(5):643–652, October 2015.
URL, DOI BibTeX
@article{Buyandelger2015,
abstract = "BACKGROUND Mutations in sarcomeric and cytoskeletal proteins are a major cause of hereditary cardiomyopathies, but our knowledge remains incomplete as to how the genetic defects execute their effects. METHODS AND RESULTS We used cysteine and glycine-rich protein 3, a known cardiomyopathy gene, in a yeast 2-hybrid screen and identified zinc-finger and BTB domain-containing protein 17 (ZBTB17) as a novel interacting partner. ZBTB17 is a transcription factor that contains the peak association signal (rs10927875) at the replicated 1p36 cardiomyopathy locus. ZBTB17 expression protected cardiac myocytes from apoptosis in vitro and in a mouse model with cardiac myocyte-specific deletion of Zbtb17, which develops cardiomyopathy and fibrosis after biomechanical stress. ZBTB17 also regulated cardiac myocyte hypertrophy in vitro and in vivo in a calcineurin-dependent manner. CONCLUSIONS We revealed new functions for ZBTB17 in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene.",
author = {Buyandelger, Byambajav and Mansfield, Catherine and Kostin, Sawa and Choi, Onjee and Roberts, Angharad M. and Ware, James S. and Mazzarotto, Francesco and Pesce, Francesco and Buchan, Rachel and Isaacson, Rivka L. and Vouffo, Jos{\'{e}}e and Gunkel, Sylvia and Kn{\"{o}}ll, Gudrun and McSweeney, Sara J. and Wei, Heming and Perrot, Andreas and Pfeiffer, Conny and Toliat, Mohammad Reza and Ilieva, Kristina and Krysztofinska, Ewelina and L{\'{o}}pez-Ola{\~{n}}eta, Marina M. and G{\'{o}}mez-Salinero, Jes{\'{u}}s M. and Schmidt, Albrecht and Ng, Keat-Eng and Teucher, Niels and Chen, Ju and Teichmann, Martin and Eilers, Martin and Haverkamp, Wilhelm and Regitz-Zagrosek, Vera and Hasenfuss, Gerd and Braun, Thomas and Pennell, Dudley J. and Gould, Ian and Barton, Paul J.R. and Lara-Pezzi, Enrique and Sch{\"{a}}fer, Sebastian and H{\"{u}}bner, Norbert and Felkin, Leanne E. and O'Regan, Declan P. and Brand, Thomas and Milting, Hendrik and N{\"{u}}rnberg, Peter and Schneider, Michael D. and Prasad, Sanjay and Petretto, Enrico and Kn{\"{o}}ll, Ralph},
doi = "10.1161/CIRCGENETICS.113.000690",
issn = "1942-325X",
journal = "Circulation: Cardiovascular Genetics",
keywords = "cardiomyopathies,genetics,heart failure,models, animal,mutation",
month = "oct",
number = 5,
pages = "643--652",
pmid = 26175529,
title = "{{\textless}i{\textgreater}ZBTB17{\textless}/i{\textgreater} ( {\textless}i{\textgreater}MIZ1{\textless}/i{\textgreater} ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart FailureCLINICAL PERSPECTIVE}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26175529 http://circgenetics.ahajournals.org/lookup/doi/10.1161/CIRCGENETICS.113.000690",
volume = 8,
year = 2015
}
Yesim Aydinok, John B Porter, Antonio Piga, Mohsen Elalfy, Amal El-Beshlawy, Yurdanur Kilinç, Vip Viprakasit, Akif Yesilipek, Dany Habr, Erhard Quebe-Fehling and Dudley J Pennell.
Prevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study.
European Journal of Haematology 95(3):244–253, September 2015.
URL, DOI BibTeX
@article{Aydinok2015,
abstract = "OBJECTIVES The randomized comparison of deferasirox to deferoxamine for myocardial iron removal in patients with transfusion-dependent anemias (CORDELIA) gave the opportunity to assess relative prevalence and body distribution of iron overload in screened patients. METHODS Patients aged ≥ 10 yr with transfusion-dependent anemias from 11 countries were screened. Data were summarized descriptively, overall and across regions. RESULTS Among 925 patients (99.1{\%} with $\beta$-thalassemia major; 98.5{\%} receiving prior chelation; mean age 19.2 yr), 36.7{\%} had myocardial iron overload (myocardial T2* ≤ 20 ms), 12.1{\%} had low left ventricular ejection fraction. Liver iron concentration (LIC) (mean 25.8 mg Fe/g dw) and serum ferritin (median 3702 ng/mL) were high. Fewer patients in the Middle East (ME; 28.5{\%}) had myocardial T2* ≤ 20 ms vs. patients in the West (45.9{\%}) and Far East (FE, 40.9{\%}). Patients in the West had highest myocardial iron burden, but lowest LIC (26.9{\%} with LIC {\textless} 7 mg Fe/g dw) and serum ferritin. Among patients with normal myocardial iron, a higher proportion of patients from the ME and FE had LIC ≥ 15 than {\textless} 7 mg Fe/g dw (ME, 56.7{\%} vs. 17.2{\%}; FE, 78.6{\%} vs. 7.8{\%}, respectively), a trend which was less evident in the West (44.6{\%} vs. 33.9{\%}, respectively). Transfusion and chelation practices differed between regions. CONCLUSIONS Evidence of substantial myocardial and liver iron burden across regions revealed a need for optimization of effective, convenient iron chelation regimens. Significant regional variation exists in myocardial and liver iron loading that are not well explained; improved understanding of factors contributing to differences in body iron distribution may be of clinical benefit.",
author = "Aydinok, Yesim and Porter, John B. and Piga, Antonio and Elalfy, Mohsen and El-Beshlawy, Amal and Kilin{\c{c}}, Yurdanur and Viprakasit, Vip and Yesilipek, Akif and Habr, Dany and Quebe-Fehling, Erhard and Pennell, Dudley J.",
doi = "10.1111/ejh.12487",
issn = 09024441,
journal = "European Journal of Haematology",
keywords = "distribution,heart,iron,liver,prevalence,thalassemia",
month = "sep",
number = 3,
pages = "244--253",
pmid = 25418187,
title = "{Prevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25418187 http://doi.wiley.com/10.1111/ejh.12487",
volume = 95,
year = 2015
}
S D Singh, X Y Xu, J R Pepper, T Treasure and R H Mohiaddin.
Biomechanical properties of the Marfan's aortic root and ascending aorta before and after personalised external aortic root support surgery.
Medical Engineering & Physics 37(8):759–766, August 2015.
URL, DOI BibTeX
@article{Singh2015,
abstract = "Marfan syndrome is an inherited systemic connective tissue disease which may lead to aortic root disease causing dilatation, dissection and rupture of the aorta. The standard treatment is a major operation involving either an artificial valve and aorta or a complex valve repair. More recently, a personalised external aortic root support (PEARS) has been used to strengthen the aorta at an earlier stage of the disease avoiding risk of both rupture and major surgery. The aim of this study was to compare the stress and strain fields of the Marfan aortic root and ascending aorta before and after insertion of PEARS in order to understand its biomechanical implications. Finite element (FE) models were developed using patient-specific aortic geometries reconstructed from pre and post-PEARS magnetic resonance images in three Marfan patients. For the post-PEARS model, two scenarios were investigated-a bilayer model where PEARS and the aortic wall were treated as separate layers, and a single-layer model where PEARS was incorporated into the aortic wall. The wall and PEARS materials were assumed to be isotropic, incompressible and linearly elastic. A static load on the inner wall corresponding to the patients' pulse pressure was applied. Results from our FE models with patient-specific geometries show that peak aortic stresses and displacements before PEARS were located at the sinuses of Valsalva but following PEARS surgery, these peak values were shifted to the aortic arch, particularly at the interface between the supported and unsupported aorta. Further studies are required to assess the statistical significance of these findings and how PEARS compares with the standard treatment.",
author = "Singh, S.D. and Xu, X.Y. and Pepper, J.R. and Treasure, T. and Mohiaddin, R.H.",
doi = "10.1016/j.medengphy.2015.05.010",
issn = 13504533,
journal = "Medical Engineering {\&} Physics",
keywords = "Aortic root dilatation,Finite element modelling,Marfan syndrome,Vascular prosthetics",
month = "aug",
number = 8,
pages = "759--766",
pmid = 26054807,
title = "{Biomechanical properties of the Marfan's aortic root and ascending aorta before and after personalised external aortic root support surgery}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26054807 http://linkinghub.elsevier.com/retrieve/pii/S1350453315001289",
volume = 37,
year = 2015
}
Laura-Ann McGill, Andrew D Scott, Pedro F Ferreira, Sonia Nielles-Vallespin, Tevfik Ismail, Philip J Kilner, Peter D Gatehouse, Ranil Silva, Sanjay K Prasad, Archontis Giannakidis, David N Firmin and Dudley J Pennell.
Heterogeneity of Fractional Anisotropy and Mean Diffusivity Measurements by In Vivo Diffusion Tensor Imaging in Normal Human Hearts.
PLOS ONE 10(7):e0132360, July 2015.
URL, DOI BibTeX
@article{McGill2015,
abstract = "{BACKGROUND Cardiac diffusion tensor imaging (cDTI) by cardiovascular magnetic resonance has the potential to assess microstructural changes through measures of fractional anisotropy (FA) and mean diffusivity (MD). However, normal variation in regional and transmural FA and MD is not well described. METHODS Twenty normal subjects were scanned using an optimised cDTI sequence at 3T in systole. FA and MD were quantified in 3 transmural layers and 4 regional myocardial walls. RESULTS FA was higher in the mesocardium (0.46 ±0.04) than the endocardium (0.40 ±0.04, p≤0.001) and epicardium (0.39 ±0.04, p≤0.001). On regional analysis, the FA in the septum was greater than the lateral wall (0.44 ±0.03 vs 0.40 ±0.05 p = 0.04). There was a transmural gradient in MD increasing towards the endocardium (epicardium 0.87 ±0.07 vs endocardium 0.91 ±0.08×10-3 mm2/s",
p = "",
author = "McGill, Laura-Ann and Scott, Andrew D. and Ferreira, Pedro F. and Nielles-Vallespin, Sonia and Ismail, Tevfik and Kilner, Philip J. and Gatehouse, Peter D. and de Silva, Ranil and Prasad, Sanjay K. and Giannakidis, Archontis and Firmin, David N. and Pennell, Dudley J.",
doi = "10.1371/journal.pone.0132360",
editor = "Panfilov, Alexander V",
issn = "1932-6203",
journal = "PLOS ONE",
month = "jul",
number = 7,
pages = "e0132360",
pmid = 26177211,
title = "{Heterogeneity of Fractional Anisotropy and Mean Diffusivity Measurements by In Vivo Diffusion Tensor Imaging in Normal Human Hearts}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26177211 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4503691 http://dx.plos.org/10.1371/journal.pone.0132360",
volume = 10,
year = 2015
}
Alistair C Lindsay and Raad H Mohiaddin.
The emerging roles of cardiovascular magnetic resonance imaging in transcatheter aortic valve implantation (TAVI).
EuroIntervention 11(2):137–139, June 2015.
URL, DOI BibTeX
@article{Lindsay2015,
author = "Lindsay, Alistair C. and Mohiaddin, Raad H.",
doi = "10.4244/EIJV11I2A26",
issn = "1774-024X",
journal = "EuroIntervention",
month = "jun",
number = 2,
pages = "137--139",
pmid = 26093836,
title = "{The emerging roles of cardiovascular magnetic resonance imaging in transcatheter aortic valve implantation (TAVI)}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26093836 http://www.pcronline.com/eurointervention/85th{\_}issue/26",
volume = 11,
year = 2015
}
John A Baksi, Sunthar G Kanaganayagam and Sanjay K Prasad.
Arrhythmias in Viral Myocarditis and Pericarditis.
Cardiac Electrophysiology Clinics 7(2):269–281, June 2015.
URL, DOI BibTeX
@article{Baksi2015,
abstract = "Acute viral myocarditis and acute pericarditis are self-limiting conditions that run a benign course and that may not involve symptoms that lead to medical assessment. However, ventricular arrhythmia is frequent in viral myocarditis. Myocarditis is thought to account for a large proportion of sudden cardiac deaths in young people without prior structural heart disease. Identification of acute myocarditis either with or without pericarditis is therefore important. However, therapeutic interventions are limited and nonspecific. Identifying those at greatest risk of a life-threatening arrhythmia is critical to reducing the mortality. This review summarizes current understanding of this challenging area in which many questions remain.",
author = "Baksi, A. John and Kanaganayagam, G. Sunthar and Prasad, Sanjay K.",
doi = "10.1016/j.ccep.2015.03.009",
issn = 18779182,
journal = "Cardiac Electrophysiology Clinics",
keywords = "Acute pericarditis,CMR,Ventricular arrhythmia,Viral myocarditis",
month = "jun",
number = 2,
pages = "269--281",
pmid = 26002391,
title = "{Arrhythmias in Viral Myocarditis and Pericarditis}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26002391 http://linkinghub.elsevier.com/retrieve/pii/S1877918215000386",
volume = 7,
year = 2015
}
Tina Z Khan, Alison Pottle, Dudley J Pennell and Mahmoud S Barbir.
The impact of lipoprotein apheresis in patients with refractory angina and raised lipoprotein(a): Objectives and methods of a randomised controlled trial.
Atherosclerosis Supplements 18:103–108, May 2015.
URL, DOI BibTeX
@article{Khan2015a,
abstract = "It is well established that Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk factor and predictor of major adverse cardiovascular events. Lipoprotein apheresis is currently the most effective approved treatment available, with minimal effect conferred by conventional lipid lowering agents. A growing body of evidence suggests that aggressively lowering raised Lp(a) may improve cardiovascular and clinical outcomes, although more prospective research is required in this field. Angina which is refractory to conventional medical therapy and revascularisation is extremely challenging to manage. There is a significant unmet need to establish therapeutic options. Our goal is to determine the impact of lipoprotein apheresis on clinical parameters and symptoms of patients with refractory angina secondary to advanced coronary disease and raised Lp(a). Determining whether we should aggressively lower Lp(a) in such patients remains a very important question, which could potentially impact on the management of a large population. We will also gain insight into how this treatment works and the mechanisms via which Lp(a) increases cardiovascular risk. We are currently conducting a prospective, randomised controlled crossover study of patients with refractory angina and raised Lp(a), randomised to undergoing three months of weekly lipoprotein apheresis or sham apheresis. Patients will then crossover to the opposite study arm after a 1 month wash-out phase. We will assess myocardial perfusion, carotid atherosclerosis, endothelial vascular function, thrombogenesis, oxidised LDL and their antibodies, exercise capacity, angina and quality of life at the beginning and end of treatment, to determine the net true treatment effect on the above parameters. This is a novel area of research, as previous studies have not assessed the role of lipoprotein apheresis in patients with refractory angina and raised Lp(a) in a prospective randomised controlled manner.",
author = "Khan, Tina Z. and Pottle, Alison and Pennell, Dudley J. and Barbir, Mahmoud S.",
doi = "10.1016/j.atherosclerosissup.2015.02.019",
issn = 15675688,
journal = "Atherosclerosis Supplements",
keywords = "Ischaemic heart disease,Lipoprotein apheresis,Lipoprotein(a),Refractory angina",
month = "may",
pages = "103--108",
pmid = 25936312,
title = "{The impact of lipoprotein apheresis in patients with refractory angina and raised lipoprotein(a): Objectives and methods of a randomised controlled trial}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25936312 http://linkinghub.elsevier.com/retrieve/pii/S1567568815000203",
volume = 18,
year = 2015
}
R Rydman, M A Gatzoulis, S Y Ho, S Ernst, L Swan, W Li, T Wong, M Sheppard, K P McCarthy, M Roughton, P J Kilner, D J Pennell and S V Babu-Narayan.
Systemic Right Ventricular Fibrosis Detected by Cardiovascular Magnetic Resonance Is Associated With Clinical Outcome, Mainly New-Onset Atrial Arrhythmia, in Patients After Atrial Redirection Surgery for Transposition of the Great Arteries.
Circulation: Cardiovascular Imaging 8(5):e002628–e002628, May 2015.
URL, DOI BibTeX
@article{Rydman2015,
abstract = "BACKGROUND We hypothesized that fibrosis detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance predicts outcomes in patients with transposition of the great arteries post atrial redirection surgery. These patients have a systemic right ventricle (RV) and are at risk of arrhythmia, premature RV failure, and sudden death. METHODS AND RESULTS Fifty-five patients (aged 27±7 years) underwent LGE cardiovascular magnetic resonance and were followed for a median 7.8 (interquartile range, 3.8-9.6) years in a prospective single-center cohort study. RV LGE was present in 31 (56{\%}) patients. The prespecified composite clinical end point comprised new-onset sustained tachyarrhythmia (atrial/ventricular) or decompensated heart failure admission/transplantation/death. Univariate predictors of the composite end point (n=22 patients; 19 atrial/2 ventricular tachyarrhythmia, 1 death) included RV LGE presence and extent, RV volumes/mass/ejection fraction, right atrial area, peak Vo(2), and age at repair. In bivariate analysis, RV LGE presence was independently associated with the composite end point (hazard ratio, 4.95 [95{\%} confidence interval, 1.60-15.28]; P=0.005), and only percent predicted peak Vo(2) remained significantly associated with cardiac events after controlling for RV LGE (hazard ratio, 0.80 [95{\%} confidence interval, 0.68-0.95]; P=0.009/5{\%}). In 8 of 9 patients with {\textgreater}1 event, atrial tachyarrhythmia, itself a known risk factor for mortality, occurred first. There was agreement between location and extent of RV LGE at in vivo cardiovascular magnetic resonance and histologically documented focal RV fibrosis in an explanted heart. There was RV LGE progression in a different case restudied for clinical indications. CONCLUSIONS Systemic RV LGE is strongly associated with adverse clinical outcome especially arrhythmia in transposition of the great arteries, thus LGE cardiovascular magnetic resonance should be incorporated in risk stratification of these patients.",
author = "Rydman, R. and Gatzoulis, M. A. and Ho, S. Y. and Ernst, S. and Swan, L. and Li, W. and Wong, T. and Sheppard, M. and McCarthy, K. P. and Roughton, M. and Kilner, P. J. and Pennell, D. J. and Babu-Narayan, S. V.",
doi = "10.1161/CIRCIMAGING.114.002628",
issn = "1941-9651",
journal = "Circulation: Cardiovascular Imaging",
keywords = "arrhythmias, cardiac,fibrosis,magnetic resonance imaging,prognosis,transposition of great vessels",
month = "may",
number = 5,
pages = "e002628--e002628",
pmid = 25948241,
title = "{Systemic Right Ventricular Fibrosis Detected by Cardiovascular Magnetic Resonance Is Associated With Clinical Outcome, Mainly New-Onset Atrial Arrhythmia, in Patients After Atrial Redirection Surgery for Transposition of the Great Arteries}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25948241 http://circimaging.ahajournals.org/cgi/doi/10.1161/CIRCIMAGING.114.002628",
volume = 8,
year = 2015
}
Sanjay K Prasad and Vassilios S Vassiliou.
Rheumatoid Arthritis: Mapping the Future ∗.
JACC: Cardiovascular Imaging 8(5):537–539, May 2015.
URL, DOI BibTeX
@article{Prasad2015,
abstract = "Prediction is very difficult. Especially if it is about the future. —Niels Bohr [(1)][1] Rheumatoid arthritis (RA) is a common autoimmune condition presenting with symmetric polyarticular arthritis and affecting 0.5{\%} to 1.0{\%} of the population [(2)][2]. It is associated with significant and",
author = "Prasad, Sanjay K. and Vassiliou, Vassilios S.",
doi = "10.1016/j.jcmg.2014.12.024",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Prasad, Vassiliou - 2015 - Rheumatoid Arthritis Mapping the Future ∗.pdf:pdf",
issn = "1936878X",
journal = "JACC: Cardiovascular Imaging",
month = "may",
number = 5,
pages = "537--539",
publisher = "JACC: Cardiovascular Imaging",
title = "{Rheumatoid Arthritis: Mapping the Future ∗}",
url = "http://linkinghub.elsevier.com/retrieve/pii/S1936878X15001278",
volume = 8,
year = 2015
}
Jennifer Keegan.
Coronary artery wall imaging.
Journal of Magnetic Resonance Imaging 41(5):1190–1202, May 2015.
URL, DOI BibTeX
@article{Keegan2015,
abstract = "Like X-Ray contrast angiography, MR coronary angiograms show the vessel lumens rather than the vessels themselves. Consequently, outward remodeling of the vessel wall, which occurs in subclinical coronary disease before luminal narrowing, cannot be seen. The current gold standard for assessing the coronary vessel wall is intravascular ultrasound, and more recently, optical coherence tomography, both of which are invasive and use ionizing radiation. A noninvasive, low-risk technique for assessing the vessel wall would be beneficial to cardiologists interested in the early detection of preclinical disease and for the safe monitoring of the progression or regression of disease in longitudinal studies. In this review article, the current state of the art in MR coronary vessel wall imaging is discussed, together with validation studies and recent developments.",
author = "Keegan, Jennifer",
doi = "10.1002/jmri.24766",
issn = 10531807,
journal = "Journal of Magnetic Resonance Imaging",
keywords = "coronary vessel wall,magnetic resonance,review",
month = "may",
number = 5,
pages = "1190--1202",
pmid = 25303707,
title = "{Coronary artery wall imaging}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25303707 http://doi.wiley.com/10.1002/jmri.24766",
volume = 41,
year = 2015
}
Tina Z Khan, Samantha Rhodes, Alison Pottle, Winston Banya, Robert Smith, Tito Kabir, Charles Ilsley, Dudley J Pennell and Mahmoud Barbir.
High prevalence of raised lipoprotein(a) in patients with refractory angina.
Global Cardiology Science and Practice 2015(2):28, April 2015.
URL, DOI BibTeX
@article{Khan2015,
abstract = "BACKGROUND Angina that is refractory to conventional medical therapy and revascularisation, remains challenging to manage and poses significant burden to patients. Elevated lipoprotein(a) [Lp(a)] has emerged as an important independent cardiovascular risk factor and predictor of adverse outcomes in atherosclerotic disease. The prevalence of raised Lp(a) amongst patients with refractory angina has not yet been defined. OBJECTIVE To establish the prevalence of raised [Lp(a)] {\textgreater}500 mg/L in patients with refractory angina. METHODS We conducted an epidemiological screening pilot study in 75 patients with refractory angina from a UK tertiary cardiac centre. We determined the proportion of the cohort with raised Lp(a) {\textgreater}500 mg/L using an isoform-insensitive method. In addition, a full fasting lipid profile (including: LDL cholesterol, HDL cholesterol, total cholesterol to HDL ratio and triglycerides) was obtained. Patients were also asked about the presence of conventional cardiovascular risk factors. RESULTS Our study demonstrated that 60{\%} of the 75 patients with refractory angina had raised Lp(a) levels of {\textgreater}500 mg/L. The median and inter-quartile range of Lp(a) values were 771 mg/L (162 mg/L,1260 mg/L) respectively. CONCLUSIONS This high prevalence of raised Lp(a) detected in our cohort with refractory angina may suggest a causal role. Further research is necessary to confirm this association and prospective studies are needed to explore the potential therapeutic benefit of Lp(a) reduction in patients with refractory angina.",
author = "Khan, Tina Z and Rhodes, Samantha and Pottle, Alison and Banya, Winston and Smith, Robert and Kabir, Tito and Ilsley, Charles and Pennell, Dudley J and Barbir, Mahmoud",
doi = "10.5339/gcsp.2015.28",
issn = "2305-7823",
journal = "Global Cardiology Science and Practice",
keywords = "Coronary artery disease,Lipoprotein (a),Refractory angina,Risk factors",
month = "apr",
number = 2,
pages = 28,
pmid = 26779510,
title = "{High prevalence of raised lipoprotein(a) in patients with refractory angina}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26779510 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4614330 http://www.qscience.com/doi/10.5339/gcsp.2015.28",
volume = 2015,
year = 2015
}
Iain T Pierce, Jennifer Keegan, Peter Drivas, Peter D Gatehouse and David N Firmin.
Free-breathing 3D late gadolinium enhancement imaging of the left ventricle using a stack of spirals at 3T..
Journal of magnetic resonance imaging : JMRI 41(4):1030–7, April 2015.
URL, DOI BibTeX
@article{Pierce2015,
abstract = "PURPOSE: To develop navigator-gated free-breathing 3D spiral late gadolinium enhancement (LGE) imaging of the left ventricle at 3T and compare it with conventional breath-hold 2D Cartesian imaging. MATERIALS AND METHODS: Equivalent slices from 3D spiral and multislice 2D Cartesian acquisitions were compared in 15 subjects in terms of image quality (1, nondiagnostic to 5, excellent), sharpness (1-3), and presence of artifacts (0-2). Blood signal-to-noise ratio (SNR), blood/myocardium contrast-to-noise ratio (CNR), and quantitative sharpness were also compared. RESULTS: All 3D spiral scans were completed faster than an equivalent 2D Cartesian short-axis stack (85 vs. 230 sec, P {\textless} 0.001). Image quality was significantly higher for 2D Cartesian images than 3D spiral images (3.7 ± 0.87 vs. 3.4 ± 1.05, P = 0.03) but not for mid or apical slices specifically. There were no significant differences in qualitative and quantitative sharpness (95{\%} confidence interval [CI]: 1.91 ± 0.67 vs. 1.93 ± 0.69, P = 0.83 and 95{\%} CI: 0.41 ± 0.07 vs. 0.40 ± 0.09, P = 0.25, respectively), artifact scores (95{\%} CI: 0.16 ± 0.37 vs. 0.40 ± 0.58, P = 0.16), SNR (95{\%} CI: 121.5 ± 55.3 vs. 136.4 ± 77.9, P = 0.13), and CNR (95{\%} CI: 101.6 ± 48.4 vs. 102.7 ± 61.8, P = 0.98). Similar enhancement ratios (0.65 vs. 0.62) and volumes (13.8 vs. 14.1cm(3) ) were measured from scar regions of three patients. CONCLUSIO: Navigator-gated 3D spiral LGE imaging can be performed in significantly and substantially shorter acquisition durations, although with some reduced image quality, than multiple breath-hold 2D Cartesian imaging while providing higher resolution and contiguous coverage.",
author = "Pierce, Iain T. and Keegan, Jennifer and Drivas, Peter and Gatehouse, Peter D. and Firmin, David N.",
doi = "10.1002/jmri.24643",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pierce et al. - 2015 - Free-breathing 3D late gadolinium enhancement imaging of the left ventricle using a stack of spirals at 3T(2).pdf:pdf",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = ",3D,free-breathing,late gadolinium enhancement,spiral,stack of spirals",
month = "apr",
number = 4,
pages = "1030--7",
pmid = 24796700,
publisher = "Wiley-Blackwell",
title = "{Free-breathing 3D late gadolinium enhancement imaging of the left ventricle using a stack of spirals at 3T.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24796700 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4377106 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4377106{\&}tool=pmcentrez{\&}rendertype=abstract http://doi.wiley.com/10.1002/jmri.24643",
volume = 41,
year = 2015
}
Olivier Ghez, Konstantinos Dimopoulos, Sonya V Babu-Narayan and Michael Gatzoulis.
Repair of tetralogy of Fallot—how much can we achieve with a single operation?.
European Journal of Cardio-Thoracic Surgery 47(3):535–536, March 2015.
URL, DOI BibTeX
@article{Ghez2015a,
author = "Ghez, Olivier and Dimopoulos, Konstantinos and Babu-Narayan, Sonya V. and Gatzoulis, Michael",
doi = "10.1093/ejcts/ezu218",
issn = "1873-734X",
journal = "European Journal of Cardio-Thoracic Surgery",
keywords = ",Cardiac surgery,Long-term effects,Tetralogy of Fallot",
month = "mar",
number = 3,
pages = "535--536",
pmid = 24872476,
title = "{Repair of tetralogy of Fallot—how much can we achieve with a single operation?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24872476 https://academic.oup.com/ejcts/article-lookup/doi/10.1093/ejcts/ezu218",
volume = 47,
year = 2015
}
Olivier Ghez, Konstantinos Dimopoulos, Sonya V Babu-Narayan and Michael Gatzoulis.
Repair of tetralogy of Fallot-how much can we achieve with a single operation?.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 47(3):535–6, March 2015.
URL, DOI BibTeX
@article{Ghez2015,
author = "Ghez, Olivier and Dimopoulos, Konstantinos and Babu-Narayan, Sonya V and Gatzoulis, Michael",
doi = "10.1093/ejcts/ezu218",
issn = "1873-734X",
journal = "European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery",
month = "mar",
number = 3,
pages = "535--6",
pmid = 24872476,
title = "{Repair of tetralogy of Fallot-how much can we achieve with a single operation?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24872476",
volume = 47,
year = 2015
}
Ee Ling Heng, Aidan P Bolger, Alexander Kempny, Periklis A Davlouros, Simon Davidson, Lorna Swan, Anselm Uebing, Dudley J Pennell, Michael A Gatzoulis and Sonya V Babu-Narayan.
Neurohormonal activation and its relation to outcomes late after repair of tetralogy of Fallot..
Heart (British Cardiac Society) 101(6):447–54, March 2015.
URL, DOI BibTeX
@article{Heng2015,
abstract = "BACKGROUND: Brain natriuretic peptide (BNP) levels are elevated in patients with repaired Tetralogy of Fallot (rTOF), the clinical significance of which remains uncertain. METHODS AND RESULTS: Ninety consecutive adults (≥ 16 years) with rTOF (mean age 32.7 ± 11.3 years, 64{\%} men) were prospectively recruited from a single tertiary centre, together with 15 age-matched and gender-matched controls. Patients with rTOF had elevated BNP (8.9 (5.9-14.6) vs 5.4 (2.2-7.5) pmol/L; p{\textless}0.01), and BNP activation was common even in asymptomatic patients. Also, atrial natriuretic peptide (6.9 (4.0-9.9) vs 3.3 (1.0-4.0) pmol/L; p{\textless}0.01), endothelin-1 (1.14 (0.94-1.48) vs 0.75 (0.44-0.93) pmol/L; p{\textless}0.01) and renin (55.0 (45.5-66.5) vs 18.6 (12.0-22.7) pmol/L; p{\textless}0.01) were elevated at baseline compared with controls. Interactions between BNP with endothelin-1, cardiothoracic ratio and right atrial area were evident. Eight deaths occurred over a median follow-up of 10 years. On Cox regression analysis, BNP emerged as a strong predictor of death (HR 1.16 per 10 pmol/L, 95{\%} CI 1.05 to 1.29; p{\textless}0.01). Survival receiver operating curve analysis revealed an optimum cut-off of BNP ≥ 15 pmol/L (=52 pg/mL), above which BNP was related to significantly increased mortality (HR 5.40, 95{\%} CI 1.29 to 22.6; p{\textless}0.01); absolute mortality at 5 years 19{\%} vs 3{\%} in patients with BNP ≤ 15 pmol/L. BNP was also a predictor of sustained arrhythmia (HR 2.06 per 10 pmol/L, 95{\%} CI 1.32 to 3.21; p{\textless}0.05). CONCLUSIONS: Neurohormonal activation is present in adults with rTOF including asymptomatic patients. BNP level ≥ 15 pmol/L is associated with a fivefold increased risk of death. These data suggest that BNP measurement in patients with rTOF should be incorporated in the periodic risk stratification assessment of these patients under lifelong follow-up.",
author = "Heng, Ee Ling and Bolger, Aidan P and Kempny, Alexander and Davlouros, Periklis A and Davidson, Simon and Swan, Lorna and Uebing, Anselm and Pennell, Dudley J and Gatzoulis, Michael A and Babu-Narayan, Sonya V",
doi = "10.1136/heartjnl-2014-306398",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = ",CONGENITAL HEART DISEASE",
month = "mar",
number = 6,
pages = "447--54",
pmid = 25351509,
title = "{Neurohormonal activation and its relation to outcomes late after repair of tetralogy of Fallot.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25351509 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2014-306398",
volume = 101,
year = 2015
}
Hala Mounir Agha, Amal Beshlawy, Mona Hamdy, Alae Sobeih, Fatma El Zahrae, Inas Abd Abd El Satar, Antoine AbdelMassih, Fadwa Said, Ossama Abd El Aziz, Mona El Tagui, Dudley J Pennell, Fatma El Zahrae, Inas Abd El Satar, Antoine AbdelMassih, Fadwa Said, Ossama Abd El Aziz, Mona El Tagui and Dudley J Pennell.
Early detection of right ventricular diastolic dysfunction by pulsed tissue Doppler echocardiography in iron loaded beta thalassemia patients..
Pediatric cardiology 36(3):468–74, March 2015.
URL, DOI BibTeX
@article{Agha2015,
abstract = "Early heart iron overload in beta thalassemia major patients can be quantified through T2* cardiovascular magnetic resonance (CMR). To clarify the value of tissue Doppler imaging (TDI) in early detection of myocardial dysfunction in iron loaded thalassemia patients diagnosed by CMR. Two groups were included in the study; Group I: 69 asymptomatic thalassemia patients (28 females, 41 males), mean age 18.1 ± 7.03 years (range 6-39 years); Group II (n = 41) healthy normal controls matched for age and sex. Serum ferritin and CMR were performed to assess the cardiac siderosis (T2* {\textless} 20 ms). Group I was subdivided into two subgroups; Group Ia (n = 26) T2* {\textless} 20 ms and Group Ib (n = 43) T2* {\textgreater} 20 ms. Conventional and Doppler echocardiography of LV, RV dimensions and functions and pulmonary artery pressure were evaluated. Right ventricular diastolic function assessed by tricuspid annular E'/A' was positively correlated with T2* value; lower tricuspid E'/A' ratios were correlated with lower T2* values (r = 0.366, P = 0.002). Tricuspid annular A' was significantly higher in group Ia compared to group Ib (16.7 ± 5.2 vs 12.1 ± 4.0 cm/s, P {\textless} 0.001). Tricuspid E'/A' {\textless} 1 was common in group Ia compared to group Ib (19/26 (73.0) vs 3/43 (6.97{\%}), P {\textless} 0.001). By multivariate analysis, right ventricular diastolic dysfunction (tricuspid E'/A' {\textless} 1) was associated with serum ferritin and T2* level of the thalassemia patients. TDI is a promising tool for quantitative assessment of myocardial function and early detection of right ventricular diastolic dysfunction in iron loaded beta thalassemia major patients.",
author = "Agha, Hala Mounir and Beshlawy, Amal and Hamdy, Mona and Sobeih, Alae and {El Zahrae}, Fatma and {Abd El Satar}, Inas Abd and AbdelMassih, Antoine and Said, Fadwa and {Abd El Aziz}, Ossama and {El Tagui}, Mona and Pennell, Dudley J. and Zahrae, Fatma El and Satar, Inas Abd El and AbdelMassih, Antoine and Said, Fadwa and Aziz, Ossama Abd El and Tagui, Mona El and Pennell, Dudley J.",
doi = "10.1007/s00246-014-1035-y",
issn = "1432-1971",
journal = "Pediatric cardiology",
month = "mar",
number = 3,
pages = "468--74",
pmid = 25293426,
title = "{Early detection of right ventricular diastolic dysfunction by pulsed tissue Doppler echocardiography in iron loaded beta thalassemia patients.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25293426 http://link.springer.com/10.1007/s00246-014-1035-y",
volume = 36,
year = 2015
}
Tom Treasure, John Pepper and Raad Mohiaddin.
Atenolol versus Losartan in Marfan's Syndrome..
The New England journal of medicine 372(10):978–9, March 2015.
URL, DOI BibTeX
@article{Treasure2015,
author = "Treasure, Tom and Pepper, John and Mohiaddin, Raad",
doi = "10.1056/NEJMc1500128#SA2",
issn = "1533-4406",
journal = "The New England journal of medicine",
month = "mar",
number = 10,
pages = "978--9",
pmid = 25738682,
title = "{Atenolol versus Losartan in Marfan's Syndrome.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25738682",
volume = 372,
year = 2015
}
Dudley J Pennell, John B Porter, Antonio Piga, Yong-Rong Lai, Amal El-Beshlawy, Mohsen Elalfy, Akif Yesilipek, Yurdanur Kilinç, Dany Habr, Khaled M Musallam, Junwu Shen, Yesim Aydinok and CORDELIA investigators.
Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine..
American journal of hematology 90(2):91–6, February 2015.
URL, DOI BibTeX
@article{Pennell2015a,
abstract = "Long-term controlled studies are needed to inform on the clinical benefit of chelation therapy for myocardial iron removal in transfusion-dependent beta thalassemia patients. In a 1-year nonrandomized extension to the CORDELIA study, data collected from patients with myocardial siderosis provided additional information on deferasirox or deferoxamine (DFO) efficacy and safety. Myocardial (m)T2* increased from baseline 11.6 to 15.9 ms in patients receiving deferasirox for 24 months (n = 74; geometric mean [Gmean ] ratio of month 24/baseline 1.38 [95{\%} confidence interval 1.28, 1.49]) and from 10.8 to 14.2 ms in those receiving DFO (n = 29; Gmean ratio 1.33 [1.13, 1.55]; P = 0.93 between groups). Improved mT2* with deferasirox was evident across all subgroups evaluated irrespective of baseline myocardial (mT2* {\textless} 10 vs. ≥ 10 ms) or liver (LIC {\textless}15 vs. ≥15 mg Fe/g dw) iron burden. Mean LVEF was stable and remained within normal limits with deferasirox or DFO. Liver iron concentration decreased from high baseline values of 30.6 ± 18.0 to 14.4 ± 16.6 mg Fe/g dw at month 24 in deferasirox patients and from 36.8 ± 15.6 to 11.0 ± 12.1 mg Fe/g dw in DFO patients. The long-term safety profile of deferasirox or DFO was consistent with previous reports; serious drug-related AEs were reported in 6.8{\%} of deferasirox and 6.9{\%} of DFO patients. Continued treatment of severely iron-overloaded beta thalassemia patients with deferasirox or DFO led to sustained improvements in myocardial iron irrespective of high or low baseline myocardial or liver iron burden, in parallel with substantial improvements in liver iron (Clinicaltrials.gov identifier: NCT00600938).",
author = "Pennell, Dudley J. and Porter, John B. and Piga, Antonio and Lai, Yong-Rong and El-Beshlawy, Amal and Elalfy, Mohsen and Yesilipek, Akif and Kilin{\c{c}}, Yurdanur and Habr, Dany and Musallam, Khaled M. and Shen, Junwu and Aydinok, Yesim and CORDELIA study investigators",
doi = "10.1002/ajh.23876",
issn = "1096-8652",
journal = "American journal of hematology",
keywords = ",Adolescent,Adult,Benzoates,Benzoates: adverse effects,Benzoates: therapeutic use,Blood Transfusion,Blood Transfusion: adverse effects,Chelation Therapy,Child,Deferoxamine,Deferoxamine: adverse effects,Deferoxamine: therapeutic use,Female,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: adverse effects,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: drug therapy,Iron Overload: etiology,Iron Overload: metabolism,Iron Overload: pathology,Iron: metabolism,Liver,Liver: metabolism,Liver: pathology,Male,Myocardium,Myocardium: metabolism,Myocardium: pathology,Prospective Studies,Treatment Outcome,Triazoles,Triazoles: adverse effects,Triazoles: therapeutic use,beta-Thalassemia,beta-Thalassemia: metabolism,beta-Thalassemia: pathology,beta-Thalassemia: therapy",
month = "feb",
number = 2,
pages = "91--6",
pmid = 25345697,
title = "{Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25345697 http://doi.wiley.com/10.1002/ajh.23876",
volume = 90,
year = 2015
}
Jennifer Keegan, Hitesh C Patel, Robin M Simpson, Raad H Mohiaddin and David N Firmin.
Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics.
Journal of Cardiovascular Magnetic Resonance 17(1):8, February 2015.
URL, DOI BibTeX
@article{Keegan2015b,
abstract = "BACKGROUND Qualitative and quantitative assessment of renal blood flow is valuable in the evaluation of patients with renal and renovascular diseases as well as in patients with heart failure. The temporal pattern of renal flow velocity through the cardiac cycle provides important information about renal haemodynamics. High temporal resolution interleaved spiral phase velocity mapping could potentially be used to study temporal patterns of flow and measure resistive and pulsatility indices which are measures of downstream resistance. METHODS A retrospectively gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Phase velocity maps were acquired in the proximal right and left arteries of 10 healthy subjects in each of two separate scanning sessions. Each acquisition was analysed by two independent observers who calculated the resistive index (RI), the pulsatility index (PI), the mean flow velocity and the renal artery blood flow (RABF). Inter-study and inter-observer reproducibility of each variable was determined as the mean +/- standard deviation of the differences between paired values. The effect of background phase errors on each parameter was investigated. RESULTS RI, PI, mean velocity and RABF per kidney were 0.71+/- 0.06, 1.47 +/- 0.29, 253.5 +/- 65.2 mm/s and 413 +/- 122 ml/min respectively. The inter-study reproducibilities were: RI -0.00 +/- 0.04 , PI -0.03 +/- 0.17, mean velocity -6.7 +/- 31.1 mm/s and RABF per kidney 17.9 +/- 44.8 ml/min. The effect of background phase errors was negligible ({\textless}2{\%} for each parameter). CONCLUSIONS High temporal resolution breath-hold spiral phase velocity mapping allows reproducible assessment of renal pulsatility indices and RABF.",
author = "Keegan, Jennifer and Patel, Hitesh C and Simpson, Robin M and Mohiaddin, Raad H and Firmin, David N",
doi = "10.1186/s12968-014-0105-x",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "feb",
number = 1,
pages = 8,
pmid = 25648103,
title = "{Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25648103 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4316806 http://jcmr-online.com/content/17/1/8",
volume = 17,
year = 2015
}
Jennifer Keegan, Peter D Gatehouse, Shouvik Haldar, Ricardo Wage, Sonya V Babu-Narayan and David N Firmin.
Dynamic inversion time for improved 3D late gadolinium enhancement imaging in patients with atrial fibrillation..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 73(2):646–54, February 2015.
URL, DOI BibTeX
@article{Keegan2015a,
abstract = "{PURPOSE: High resolution three-dimensional (3D) late gadolinium enhancement (LGE) imaging is performed with single R-wave gating to minimize lengthy acquisition durations. In patients with atrial fibrillation (AF), heart rate variability results in variable magnetization recovery between sequence repeats, and image quality is often poor. In this study, we implemented and tested a dynamic inversion time (dynamic-TI) scheme designed to reduce sequence sensitivity to heart rate variations. METHODS: An inversion-prepared 3D segmented gradient echo sequence was modified so that the TI varied automatically from beat-to-beat (dynamic-TI) based on the time since the last sequence repeat. 3D LGE acquisitions were performed in 17 patients prior to radio frequency ablation of persistent AF both with and without dynamic-TI. Qualitative image quality scores, blood signal-to-ghosting ratios (SGRs). and blood-myocardium contrast-to-ghosting ratios (CGRs) were compared. RESULTS: Image quality scores were higher with dynamic-TI than without dynamic-TI (2.2 ± 0.9 vs. 1.8 ± 1.1",
p = "",
author = "Keegan, Jennifer and Gatehouse, Peter D. and Haldar, Shouvik and Wage, Ricardo and Babu-Narayan, Sonya V. and Firmin, David N.",
doi = "10.1002/mrm.25190",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = ",3D,arrhythmia,late gadolinium enhancement imaging",
month = "feb",
number = 2,
pages = "646--54",
pmid = 24604664,
title = "{Dynamic inversion time for improved 3D late gadolinium enhancement imaging in patients with atrial fibrillation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24604664 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4562369 http://doi.wiley.com/10.1002/mrm.25190",
volume = 73,
year = 2015
}
Radwa Bedair, Sonya V Babu-Narayan, Konstantinos Dimopoulos, Sadia Quyam, Anne-Marie Doyle, Lorna Swan, Michael A Gatzoulis and Tom Wong.
Acceptance and psychological impact of implantable defibrillators amongst adults with congenital heart disease.
International Journal of Cardiology 181:218–224, February 2015.
URL, DOI BibTeX
@article{Bedair2015,
abstract = "{BACKGROUND The psychological impact of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (ACHD) has not been established. OBJECTIVE To compare device acceptance, quality of life, anxiety and depression between ACHD patients with ICDs (ICD-Congenital), with pacemakers (PPM-Congenital), with no devices (No Device-Congenital) and non-ACHD patients with ICDs (ICD-Non-Congenital). METHODS A total of 147 ACHD and 46 non-ACHD patients (age 45.0±14.7 years, 56.5{\%} males) completed the Florida Patient Acceptance Survey (FPAS), the 36-item Short Form Health Survey (SF-36) and Hospital Anxiety {\&} Depression Scale (HADS). RESULTS ICD-Congenital patients (n=59) showed lower device acceptance compared to PPM-Congenital patients (n=41)",
p = "",
author = "Bedair, Radwa and Babu-Narayan, Sonya V. and Dimopoulos, Konstantinos and Quyam, Sadia and Doyle, Anne-Marie and Swan, Lorna and Gatzoulis, Michael A. and Wong, Tom",
doi = "10.1016/j.ijcard.2014.12.028",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Adult congenital heart disease,Anxiety,Depression,Device acceptance,Implantable cardioverter defibrillator,Quality of life",
month = "feb",
pages = "218--224",
pmid = 25528316,
title = "{Acceptance and psychological impact of implantable defibrillators amongst adults with congenital heart disease}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25528316 http://linkinghub.elsevier.com/retrieve/pii/S0167527314024358",
volume = 181,
year = 2015
}
Christina Koutsoumpa, Robin Simpson, Jennifer Keegan, David Firmin and Guang-Zhong Yang.
Restoration of Phase-Contrast Cardiovascular MRI for the Construction of Cardiac Contractility Atlases.
Springer, Cham, 2015, pages 275–283.
URL, DOI BibTeX
@incollection{Koutsoumpa2015,
author = "Koutsoumpa, Christina and Simpson, Robin and Keegan, Jennifer and Firmin, David and Yang, Guang-Zhong",
doi = "10.1007/978-3-319-14678-2_29",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Koutsoumpa et al. - 2015 - Restoration of Phase-Contrast Cardiovascular MRI for the Construction of Cardiac Contractility Atlases.pdf:pdf",
pages = "275--283",
publisher = "Springer, Cham",
title = "{Restoration of Phase-Contrast Cardiovascular MRI for the Construction of Cardiac Contractility Atlases}",
url = "http://link.springer.com/10.1007/978-3-319-14678-2{\_}29",
year = 2015
}
O F Ali, C Schultz, A Jabbour, M Rubens, T Mittal, R Mohiaddin, S Davies, C Di Mario, R Van der Boon, A S Ahmad, M Amrani, N Moat, P P T De Jaegere and M Dalby.
Predictors of paravalvular aortic regurgitation following self-expanding Medtronic CoreValve implantation: The role of annulus size, degree of calcification, and balloon size during pre-implantation valvuloplasty and implant depth.
International Journal of Cardiology 179:539–545, January 2015.
URL, DOI BibTeX
@article{Ali2015,
abstract = "OBJECTIVES We sought to investigate the role of balloon size during pre-implantation valvuloplasty in predicting AR and optimal Medtronic CoreValve (MCS) implantation depth. BACKGROUND Paravalvular aortic regurgitation (AR) is common following MCS implantation. A number of anatomical and procedural variables have been proposed as determinants of AR including degree of valve calcification, valve undersizing and implantation depth. METHODS We conducted a multicenter retrospective analysis of 282 patients who had undergone MCS implantation with prior cardiac CT annular sizing between 2007 and 2011. Native valve minimum (Dmin), maximum (Dmax) and arithmetic mean (Dmean) annulus diameters as well as agatston calcium score were recorded. Nominal and achieved balloon size was also recorded. AR was assessed using contrast angiography at the end of each procedure. Implant depth was measured as the mean distance from the nadir of the non- and left coronary sinuses to the distal valve frame angiographically. RESULTS 29 mm and 26 mm MCS were implanted in 60{\%} and 39{\%} of patients respectively. The majority of patients (N=165) developed AR {\textless}2 following MCS implantation. AR ≥3 was observed in 16{\%} of the study population. High agatston calcium score and Dmean were found to be independent predictors of AR ≥3 in multivariate analysis (P{\textless}0.0001). Nominal balloon diameter and the number of balloon inflations did not influence AR. However a small achieved balloon diameter-to-Dmean ratio (≤0.85) showed modest correlation with AR ≥3 (P=0.04). This observation was made irrespective of the degree of valve calcification. A small MCS size-to-Dmean ratio is also associated with AR ≥3 (P=0.001). A mean implantation depth of ≥8+2mm was also associated with AR ≥3. Implantation depth of ≥12 mm was associated with small MCS diameter-to-Dmean ratio and increased 30-day mortality. CONCLUSION CT measured aortic annulus diameter and agatston calcium score remain important predictors of significant AR. Other procedural predictors include valve undersizing and low implantation depth. A small achieved balloon diameter-to-Dmean ratio might also predict AR ≥3. Our findings confirm that a small achieved balloon size during pre-implantation valvuloplasty predicts moderate-severe AR in addition to previously documented factors.",
author = "Ali, O.F. and Schultz, C. and Jabbour, A. and Rubens, M. and Mittal, T. and Mohiaddin, R. and Davies, S. and {Di Mario}, C. and {Van der Boon}, R. and Ahmad, A.S. and Amrani, M. and Moat, N. and {De Jaegere}, P.P.T. and Dalby, M.",
doi = "10.1016/j.ijcard.2014.10.117",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Aortic stenosis,Paravalvular aortic regurgitation,Transcatheter aortic valve intervention",
month = "jan",
pages = "539--545",
pmid = 25466563,
title = "{Predictors of paravalvular aortic regurgitation following self-expanding Medtronic CoreValve implantation: The role of annulus size, degree of calcification, and balloon size during pre-implantation valvuloplasty and implant depth}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25466563 http://linkinghub.elsevier.com/retrieve/pii/S0167527314020543",
volume = 179,
year = 2015
}
Pamela Moceri, Aleksander Kempny, Emmanouil Liodakis, Rafael Alonso Gonzales, Ioannis Germanakis, Gerhard-Paul Diller, Lorna Swan, Philip S Marino, Stephen J Wort, Sonya V Babu-Narayan, Emile Ferrari, Michael A Gatzoulis, Wei Li and Konstantinos Dimopoulos.
Physiological differences between various types of Eisenmenger syndrome and relation to outcome.
International Journal of Cardiology 179:455–460, January 2015.
URL, DOI BibTeX
@article{Moceri2015,
abstract = "BACKGROUND Eisenmenger syndrome (ES) is the most advanced form of pulmonary arterial hypertension (PAH) related to congenital heart disease. Several studies have suggested that the presence and location of the shunt defines the natural history of these patients by influencing right ventricular adaptation to PAH. We aimed to echocardiographically assess differences in cardiac physiology and outcome between various types of ES. METHODS AND RESULTS In this longitudinal cohort study, 191 patients with ES and non-complex congenital heart disease were recruited, 36 with pre-tricuspid and 155 with post-tricuspid shunts. Patients with pre-tricuspid shunts were older, had higher BNP concentrations and lower exercise tolerance compared to patients with post-tricuspid shunts. Right ventricular (RV) function was impaired in patients with atrial septal defects, with larger right ventricles, impaired systolic function and adaptation. The left ventricular eccentricity index was significantly higher in pre-tricuspid defects. Within post-tricuspid shunts, patients with atrio-ventricular septal defects had better right ventricular function compared to ventricular septal defects, while in those with a patent ductus arteriosus this was worse. There was a trend towards lower mortality in patients with post versus pre-tricuspid shunts, which was significant for patients above the age of 48 years. CONCLUSION The presence of a post-tricuspid shunt appears to carry physiological and possibly prognostic benefits in ES compared to patients with pre-tricuspid shunts. This should be borne in mind when management decisions and advanced therapies are considered.",
author = "Moceri, Pamela and Kempny, Aleksander and Liodakis, Emmanouil and {Alonso Gonzales}, Rafael and Germanakis, Ioannis and Diller, Gerhard-Paul and Swan, Lorna and Marino, Philip S. and Wort, Stephen J. and Babu-Narayan, Sonya V. and Ferrari, Emile and Gatzoulis, Michael A. and Li, Wei and Dimopoulos, Konstantinos",
doi = "10.1016/j.ijcard.2014.11.100",
issn = 01675273,
journal = "International Journal of Cardiology",
keywords = "Congenital heart disease,Echocardiography,Eisenmenger syndrome,Pulmonary arterial hypertension,Right ventricular function",
month = "jan",
pages = "455--460",
pmid = 25465305,
title = "{Physiological differences between various types of Eisenmenger syndrome and relation to outcome}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25465305 http://linkinghub.elsevier.com/retrieve/pii/S016752731402244X",
volume = 179,
year = 2015
}
Angharad M Roberts, James S Ware, Daniel S Herman, Sebastian Schafer, John Baksi, Alexander G Bick, Rachel J Buchan, Roddy Walsh, Shibu John, Samuel Wilkinson, Francesco Mazzarotto, Leanne E Felkin, Sungsam Gong, Jacqueline A L. MacArthur, Fiona Cunningham, Jason Flannick, Stacey B Gabriel, David M Altshuler, Peter S Macdonald, Matthias Heinig, Anne M Keogh, Christopher S Hayward, Nicholas R Banner, Dudley J Pennell, Declan P O'Regan, Tan Ru San, Antonio Marvao, Timothy J W. Dawes, Ankur Gulati, Emma J Birks, Magdi H Yacoub, Michael Radke, Michael Gotthardt, James G Wilson, Christopher J O'Donnell, Sanjay K Prasad, Paul J R. Barton, Diane Fatkin, Norbert Hubner, Jonathan G Seidman, Christine E Seidman and Stuart A Cook.
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Science Translational Medicine 7(270):270ra6–270ra6, January 2015.
URL, DOI BibTeX
@article{Roberts2015,
abstract = "The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abundant structural, sensory, and signaling filament in muscle) as a common cause of end-stage dilated cardiomyopathy (DCM) promises new prospects for improving heart failure management. However, realization of this opportunity has been hindered by the burden of TTN-truncating variants (TTNtv) in the general population and uncertainty about their consequences in health or disease. To elucidate the effects of TTNtv, we coupled TTN gene sequencing with cardiac phenotyping in 5267 individuals across the spectrum of cardiac physiology and integrated these data with RNA and protein analyses of human heart tissues. We report diversity of TTN isoform expression in the heart, define the relative inclusion of TTN exons in different isoforms (using the TTN transcript annotations available at http://cardiodb.org/titin), and demonstrate that these data, coupled with the position of the TTNtv, provide a robust strategy to discriminate pathogenic from benign TTNtv. We show that TTNtv is the most common genetic cause of DCM in ambulant patients in the community, identify clinically important manifestations of TTNtv-positive DCM, and define the penetrance and outcomes of TTNtv in the general population. By integrating genetic, transcriptome, and protein analyses, we provide evidence for a length-dependent mechanism of disease. These data inform diagnostic criteria and management strategies for TTNtv-positive DCM patients and for TTNtv that are identified as incidental findings.",
author = "Roberts, Angharad M. and Ware, James S. and Herman, Daniel S. and Schafer, Sebastian and Baksi, John and Bick, Alexander G. and Buchan, Rachel J. and Walsh, Roddy and John, Shibu and Wilkinson, Samuel and Mazzarotto, Francesco and Felkin, Leanne E. and Gong, Sungsam and {L. MacArthur}, Jacqueline A. and Cunningham, Fiona and Flannick, Jason and Gabriel, Stacey B. and Altshuler, David M. and Macdonald, Peter S. and Heinig, Matthias and Keogh, Anne M. and Hayward, Christopher S. and Banner, Nicholas R. and Pennell, Dudley J. and O'Regan, Declan P. and San, Tan Ru and de Marvao, Antonio and {W. Dawes}, Timothy J. and Gulati, Ankur and Birks, Emma J. and Yacoub, Magdi H. and Radke, Michael and Gotthardt, Michael and Wilson, James G. and O'Donnell, Christopher J. and Prasad, Sanjay K. and {R. Barton}, Paul J. and Fatkin, Diane and Hubner, Norbert and Seidman, Jonathan G. and Seidman, Christine E. and Cook, Stuart A.",
doi = "10.1126/scitranslmed.3010134",
issn = "1946-6234",
journal = "Science Translational Medicine",
month = "jan",
number = 270,
pages = "270ra6--270ra6",
pmid = 25589632,
title = "{Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25589632 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4560092 http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.3010134",
volume = 7,
year = 2015
}
Peter Kellman, Hui Xue, Bruce S Spottiswoode, Christopher M Sandino, Michael S Hansen, Amna Abdel-Gadir, Thomas A Treibel, Stefania Rosmini, Christine Mancini, W Bandettini, Laura-Ann McGill, Peter Gatehouse, James C Moon, Dudley J Pennell and Andrew E Arai.
Free-breathing T2* mapping using respiratory motion corrected averaging.
Journal of Cardiovascular Magnetic Resonance 17(1):3, January 2015.
URL, DOI BibTeX
@article{Kellman2015,
abstract = "BACKGROUND Pixel-wise T2* maps based on breath-held segmented image acquisition are prone to ghost artifacts in instances of poor breath-holding or cardiac arrhythmia. Single shot imaging is inherently immune to ghost type artifacts. We propose a free-breathing method based on respiratory motion corrected single shot imaging with averaging to improve the signal to noise ratio. METHODS Images were acquired using a multi-echo gradient recalled echo sequence and T2* maps were calculated at each pixel by exponential fitting. For 40 subjects (2 cohorts), two acquisition protocols were compared: (1) a breath-held, segmented acquisition, and (2) a free-breathing, single-shot multiple repetition respiratory motion corrected average. T2* measurements in the interventricular septum and liver were compared for the 2-methods in all studies with diagnostic image quality. RESULTS In cohort 1 (N = 28) with age 51.4 ± 17.6 (m ± SD) including 1 subject with severe myocardial iron overload, there were 8 non-diagnostic breath-held studies due to poor image quality resulting from ghost artifacts caused by respiratory motion or arrhythmias. In cohort 2 (N = 12) with age 30.9 ± 7.5 (m ± SD), including 7 subjects with severe myocardial iron overload and 4 subjects with mild iron overload, a single subject was unable to breath-hold. Free-breathing motion corrected T2* maps were of diagnostic quality in all 40 subjects. T2* measurements were in excellent agreement (In cohort {\#}1, T2*FB = 0.95 x T2*BH + 0.41, r2 = 0.93, N = 39 measurements, and in cohort {\#}2, T2*FB = 0.98 x T2*BH + 0.05, r2 {\textgreater} 0.99, N = 22 measurements). CONCLUSIONS A free-breathing approach to T2* mapping is demonstrated to produce consistently good quality maps in the presence of respiratory motion and arrhythmias.",
author = "Kellman, Peter and Xue, Hui and Spottiswoode, Bruce S and Sandino, Christopher M and Hansen, Michael S and Abdel-Gadir, Amna and Treibel, Thomas A and Rosmini, Stefania and Mancini, Christine and Bandettini, W and McGill, Laura-Ann and Gatehouse, Peter and Moon, James C and Pennell, Dudley J and Arai, Andrew E",
doi = "10.1186/s12968-014-0106-9",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
month = "jan",
number = 1,
pages = 3,
pmid = 25616857,
title = "{Free-breathing T2* mapping using respiratory motion corrected averaging}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25616857 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4305251 http://jcmr-online.com/content/17/1/3",
volume = 17,
year = 2015
}
Mohiaddin RH. Mahmoud M Othman N. Yunus AM.
Asymptomatic left atrial appendage aneurysm.
Notice: Undefined index: journal in /home/linweb21/r/rbh-cmr.org-1066018172/user/htdocs/joomla/plugins/content/bibtex/references.php on line 494
, pages 2–4, 2015.
BibTeX
@article{OthmanN.YunusAM2015,
author = "{Othman N. Yunus AM}, Mohiaddin RH. Mahmoud M.",
file = ":C$\backslash$:/Users/yk822/Downloads/ijcc-2-027.pdf:pdf",
pages = "2--4",
title = "{Asymptomatic left atrial appendage aneurysm}",
year = 2015
}
Tevfik F Ismail, Andrew Jabbour, Ankur Gulati, Amy Mallorie, Sadaf Raza, Thomas E Cowling, Bibek Das, Jahanzaib Khwaja, Francisco D Alpendurada, Ricardo Wage, Michael Roughton, William J McKenna, James C Moon, Amanda Varnava, Carl Shakespeare, Martin R Cowie, Stuart A Cook, Perry Elliott, Rory O'Hanlon, Dudley J Pennell and Sanjay K Prasad.
Role of late gadolinium enhancement cardiovascular magnetic resonance in the risk stratification of hypertrophic cardiomyopathy..
Heart (British Cardiac Society) 100(23):1851–8, December 2014.
URL, DOI BibTeX
@article{Ismail2014a,
abstract = "OBJECTIVE: Myocardial fibrosis identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM) is associated with adverse cardiovascular events, but its value as an independent risk factor for sudden cardiac death (SCD) is unknown. We investigated the role of LGE-CMR in the risk stratification of HCM. METHODS: We conducted a prospective cohort study in a tertiary referral centre. Consecutive patients with HCM (n=711, median age 56.3 years, IQR 46.7-66.6; 70.0{\%} male) underwent LGE-CMR and were followed for a median 3.5 years. The primary end point was SCD or aborted SCD. RESULTS: Overall, 471 patients (66.2{\%}) had myocardial fibrosis (median 5.9{\%} of left ventricular mass, IQR: 2.2-13.3). Twenty-two (3.1{\%}) reached the primary end point. The extent but not the presence of fibrosis was a significant univariable predictor of the primary end point (HR per 5{\%} LGE: 1.24, 95{\%} CI 1.06 to 1.45; p=0.007 and HR for LGE: 2.69, 95{\%} CI 0.91 to 7.97; p=0.073, respectively). However, on multivariable analysis, only LV-EF remained statistically significant (HR: 0.92, 95{\%} CI 0.89 to 0.95; p{\textless}0.001). For the secondary outcome of cardiovascular mortality/aborted SCD, the presence and the amount of fibrosis were significant predictors on univariable but not multivariable analysis after adjusting for LV-EF and non-sustained ventricular tachycardia. CONCLUSIONS: The amount of myocardial fibrosis was a strong univariable predictor of SCD risk. However, this effect was not maintained after adjusting for LV-EF. Further work is required to elucidate the interrelationship between fibrosis and traditional predictors of outcome in HCM.",
author = "Ismail, Tevfik F and Jabbour, Andrew and Gulati, Ankur and Mallorie, Amy and Raza, Sadaf and Cowling, Thomas E and Das, Bibek and Khwaja, Jahanzaib and Alpendurada, Francisco D and Wage, Ricardo and Roughton, Michael and McKenna, William J and Moon, James C and Varnava, Amanda and Shakespeare, Carl and Cowie, Martin R and Cook, Stuart A and Elliott, Perry and O'Hanlon, Rory and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1136/heartjnl-2013-305471",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = ",Aged,Cardiac,Cardiac: etiology,Cardiac: pathology,Cardiac: prevention {\&} control,Cardiomyopathy,Chi-Square Distribution,Contrast Media,Contrast Media: diagnostic use,Death,Disease-Free Survival,Female,Fibrosis,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Humans,Hypertrophic,Hypertrophic: complications,Hypertrophic: diagnosis,Hypertrophic: mortality,Hypertrophic: pathology,Hypertrophic: therapy,Kaplan-Meier Estimate,London,Magnetic Resonance Imaging,Male,Middle Aged,Multivariate Analysis,Myocardium,Myocardium: pathology,Organometallic Compounds,Organometallic Compounds: diagnostic use,Predictive Value of Tests,Proportional Hazards Models,Prospective Studies,Risk Assessment,Risk Factors,Sudden,Tertiary Care Centers,Time Factors",
month = "dec",
number = 23,
pages = "1851--8",
pmid = 24966307,
title = "{Role of late gadolinium enhancement cardiovascular magnetic resonance in the risk stratification of hypertrophic cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24966307 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2013-305471",
volume = 100,
year = 2014
}
Kristopher Knott, Naureen Starling, Shahnawaz Rasheed, John Foran, Catherine Cafferkey, Stuart Rosen, Andrew Nicholson, John Baksi and Alexander Lyon.
A case of Takotsubo syndrome following 5-fluorouracil chemotherapy..
International journal of cardiology 177(2):e65–7, December 2014.
URL, DOI BibTeX
@article{Knott2014,
author = "Knott, Kristopher and Starling, Naureen and Rasheed, Shahnawaz and Foran, John and Cafferkey, Catherine and Rosen, Stuart and Nicholson, Andrew and Baksi, John and Lyon, Alexander",
doi = "10.1016/j.ijcard.2014.09.154",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = ",Cardiomyopathy,Chemotoxicity,Takotsubo syndrome",
month = "dec",
number = 2,
pages = "e65--7",
pmid = 25449494,
title = "{A case of Takotsubo syndrome following 5-fluorouracil chemotherapy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25449494 http://linkinghub.elsevier.com/retrieve/pii/S0167527314018749",
volume = 177,
year = 2014
}
Anoop S V Shah, Calvin W L Chin, Vassilis Vassiliou, Joanna S Cowell, Mhairi Doris, T'ng Choong Kwok, Scott Semple, Vipin Zamvar, Audrey C White, Graham McKillop, Nicholas A Boon, Sanjay K Prasad, Nicholas L Mills, David E Newby and Marc R Dweck.
Left Ventricular Hypertrophy With Strain and Aortic StenosisCLINICAL PERSPECTIVE.
Circulation 130(18):1607–1616, October 2014.
URL, DOI BibTeX
@article{Shah2014a,
abstract = "BACKGROUND ECG left ventricular hypertrophy with strain is associated with an adverse prognosis in aortic stenosis. We investigated the mechanisms and outcomes associated with ECG strain. METHODS AND RESULTS One hundred and two patients (age, 70 years [range, 63-75 years]; male, 66{\%}; aortic valve area, 0.9 cm(2) [range, 0.7-1.2 cm(2)]) underwent ECG, echocardiography, and cardiovascular magnetic resonance. They made up the mechanism cohort. Myocardial fibrosis was determined with late gadolinium enhancement (replacement fibrosis) and T1 mapping (diffuse fibrosis). The relationship between ECG strain and cardiovascular magnetic resonance was then assessed in an external validation cohort (n=64). The outcome cohort was made up of 140 patients from the Scottish Aortic Stenosis and Lipid Lowering Trial Impact on Regression (SALTIRE) study and was followed up for 10.6 years (1254 patient-years). Compared with those without left ventricular hypertrophy (n=51) and left ventricular hypertrophy without ECG strain (n=30), patients with ECG strain (n=21) had more severe aortic stenosis, increased left ventricular mass index, more myocardial injury (high-sensitivity plasma cardiac troponin I concentration, 4.3 ng/L [interquartile range, 2.5-7.3 ng/L] versus 7.3 ng/L [interquartile range, 3.2-20.8 ng/L] versus 18.6 ng/L [interquartile range, 9.0-45.2 ng/L], respectively; P{\textless}0.001) and increased diffuse fibrosis (extracellular volume fraction, 27.4±2.2{\%} versus 27.2±2.9{\%} versus 30.9±1.9{\%}, respectively; P{\textless}0.001). All patients with ECG strain had midwall late gadolinium enhancement (positive and negative predictive values of 100{\%} and 86{\%}, respectively). Indeed, late gadolinium enhancement was independently associated with ECG strain (odds ratio, 1.73; 95{\%} confidence interval, 1.08-2.77; P=0.02), a finding confirmed in the validation cohort. In the outcome cohort, ECG strain was an independent predictor of aortic valve replacement or cardiovascular death (hazard ratio, 2.67; 95{\%} confidence interval, 1.35-5.27; P{\textless}0.01). CONCLUSION ECG strain is a specific marker of midwall myocardial fibrosis and predicts adverse clinical outcomes in aortic stenosis.",
author = "Shah, Anoop S.V. and Chin, Calvin W.L. and Vassiliou, Vassilis and Cowell, S. Joanna and Doris, Mhairi and Kwok, T'ng Choong and Semple, Scott and Zamvar, Vipin and White, Audrey C. and McKillop, Graham and Boon, Nicholas A. and Prasad, Sanjay K. and Mills, Nicholas L. and Newby, David E. and Dweck, Marc R.",
doi = "10.1161/CIRCULATIONAHA.114.011085",
issn = "0009-7322",
journal = "Circulation",
keywords = "aortic valve stenosis,fibrosis,hypertrophy, left ventricular,troponin I",
month = "oct",
number = 18,
pages = "1607--1616",
pmid = 25170097,
title = "{Left Ventricular Hypertrophy With Strain and Aortic StenosisCLINICAL PERSPECTIVE}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25170097 http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.114.011085",
volume = 130,
year = 2014
}
Anoop S V Shah, Calvin W L Chin, Vassilis Vassiliou, Joanna S Cowell, Mhairi Doris, T'ng Choong Kwok, Scott Semple, Vipin Zamvar, Audrey C White, Graham McKillop, Nicholas A Boon, Sanjay K Prasad, Nicholas L Mills, David E Newby and Marc R Dweck.
Left ventricular hypertrophy with strain and aortic stenosis..
Circulation 130(18):1607–16, October 2014.
URL, DOI BibTeX
@article{Shah2014,
abstract = "BACKGROUND: ECG left ventricular hypertrophy with strain is associated with an adverse prognosis in aortic stenosis. We investigated the mechanisms and outcomes associated with ECG strain. METHODS AND RESULTS: One hundred and two patients (age, 70 years [range, 63-75 years]; male, 66{\%}; aortic valve area, 0.9 cm(2) [range, 0.7-1.2 cm(2)]) underwent ECG, echocardiography, and cardiovascular magnetic resonance. They made up the mechanism cohort. Myocardial fibrosis was determined with late gadolinium enhancement (replacement fibrosis) and T1 mapping (diffuse fibrosis). The relationship between ECG strain and cardiovascular magnetic resonance was then assessed in an external validation cohort (n=64). The outcome cohort was made up of 140 patients from the Scottish Aortic Stenosis and Lipid Lowering Trial Impact on Regression (SALTIRE) study and was followed up for 10.6 years (1254 patient-years). Compared with those without left ventricular hypertrophy (n=51) and left ventricular hypertrophy without ECG strain (n=30), patients with ECG strain (n=21) had more severe aortic stenosis, increased left ventricular mass index, more myocardial injury (high-sensitivity plasma cardiac troponin I concentration, 4.3 ng/L [interquartile range, 2.5-7.3 ng/L] versus 7.3 ng/L [interquartile range, 3.2-20.8 ng/L] versus 18.6 ng/L [interquartile range, 9.0-45.2 ng/L], respectively; P{\textless}0.001) and increased diffuse fibrosis (extracellular volume fraction, 27.4±2.2{\%} versus 27.2±2.9{\%} versus 30.9±1.9{\%}, respectively; P{\textless}0.001). All patients with ECG strain had midwall late gadolinium enhancement (positive and negative predictive values of 100{\%} and 86{\%}, respectively). Indeed, late gadolinium enhancement was independently associated with ECG strain (odds ratio, 1.73; 95{\%} confidence interval, 1.08-2.77; P=0.02), a finding confirmed in the validation cohort. In the outcome cohort, ECG strain was an independent predictor of aortic valve replacement or cardiovascular death (hazard ratio, 2.67; 95{\%} confidence interval, 1.35-5.27; P{\textless}0.01). CONCLUSION: ECG strain is a specific marker of midwall myocardial fibrosis and predicts adverse clinical outcomes in aortic stenosis.",
author = "Shah, Anoop S V and Chin, Calvin W L and Vassiliou, Vassilis and Cowell, S Joanna and Doris, Mhairi and Kwok, T'ng Choong and Semple, Scott and Zamvar, Vipin and White, Audrey C and McKillop, Graham and Boon, Nicholas A and Prasad, Sanjay K and Mills, Nicholas L and Newby, David E and Dweck, Marc R",
doi = "10.1161/CIRCULATIONAHA.114.011085",
issn = "1524-4539",
journal = "Circulation",
keywords = "Aged,Aged, 80 and over,Aortic Valve Stenosis,Aortic Valve Stenosis: diagnosis,Aortic Valve Stenosis: mortality,Aortic Valve Stenosis: physiopathology,Echocardiography,Electrocardiography,Female,Fibrosis,Fibrosis: mortality,Fibrosis: physiopathology,Heart Function Tests,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Hypertrophy, Left Ventricular: mortality,Hypertrophy, Left Ventricular: physiopathology,Logistic Models,Magnetic Resonance Imaging,Male,Middle Aged,Multivariate Analysis,Outcome Assessment (Health Care),Predictive Value of Tests,Prognosis,Proportional Hazards Models,Randomized Controlled Trials as Topic,Stroke Volume,Troponin I,Troponin I: blood",
month = "oct",
number = 18,
pages = "1607--16",
pmid = 25170097,
title = "{Left ventricular hypertrophy with strain and aortic stenosis.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25170097",
volume = 130,
year = 2014
}
Huaibing Cheng, Minjie Lu, Cuihong Hou, Xuhua Chen, Jing Wang, Li Li, Junyi Wan, Gang Yin, Jianmin Chu, Sanjay K Prasad, Shu Zhang, Jielin Pu and Shihua Zhao.
Comparative study of CMR characteristics between arrhythmogenic right ventricular cardiomyopathy patients with/without syncope..
The international journal of cardiovascular imaging 30(7):1365–72, October 2014.
URL, DOI BibTeX
@article{Cheng2014,
abstract = "{To compare cardiovascular magnetic resonance (CMR) characteristics between arrhythmogenic right ventricular cardiomyopathy (ARVC) patients with syncope and without syncope and explore CMR parameters related with syncope. A consecutive series of 80 patients with ARVC were divided in two groups according to history of syncope prior to CMR examinations. The biventricular function and volumes were calculated and indexed by body surface area. Fatty infiltration and late-gadolinium enhancement (LGE) were self-quantitatively analyzed according to segmental model. Patients with syncope had statistically significant greater left ventricular end-diastolic volume index (LVEDVI) (79.6 ± 23.0 vs. 69.0 ± 17.9 mL/m(2)",
p = "",
author = "Cheng, Huaibing and Lu, Minjie and Hou, Cuihong and Chen, Xuhua and Wang, Jing and Li, Li and Wan, Junyi and Yin, Gang and Chu, Jianmin and Prasad, Sanjay K. and Zhang, Shu and Pu, Jielin and Zhao, Shihua",
doi = "10.1007/s10554-014-0481-1",
issn = "1875-8312",
journal = "The international journal of cardiovascular imaging",
month = "oct",
number = 7,
pages = "1365--72",
pmid = 25026910,
title = "{Comparative study of CMR characteristics between arrhythmogenic right ventricular cardiomyopathy patients with/without syncope.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25026910 http://link.springer.com/10.1007/s10554-014-0481-1",
volume = 30,
year = 2014
}
Robin Simpson, Jennifer Keegan, Peter Gatehouse, Michael Hansen and David Firmin.
Spiral tissue phase velocity mapping in a breath-hold with non-cartesian SENSE..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 72(3):659–68, September 2014.
URL, DOI BibTeX
@article{Simpson2014,
abstract = "PURPOSE: Tissue phase velocity mapping (TPVM) is capable of reproducibly measuring regional myocardial velocities. However acquisition durations of navigator gated techniques are long and unpredictable while current breath-hold techniques have low temporal resolution. This study presents a spiral TPVM technique which acquires high resolution data within a clinically acceptable breath-hold duration. METHODS: Ten healthy volunteers are scanned using a spiral sequence with temporal resolution of 24 ms and spatial resolution of 1.7 × 1.7 mm. Retrospective cardiac gating is used to acquire data over the entire cardiac cycle. The acquisition is accelerated by factors of 2 and 3 by use of non-Cartesian SENSE implemented on the Gadgetron GPU system resulting in breath-holds of 17 and 13 heartbeats, respectively. Systolic, early diastolic, and atrial systolic global and regional longitudinal, circumferential, and radial velocities are determined. RESULTS: Global and regional velocities agree well with those previously reported. The two acceleration factors show no significant differences for any quantitative parameter and the results also closely match previously acquired higher spatial resolution navigator-gated data in the same subjects. CONCLUSION: By using spiral trajectories and non-Cartesian SENSE high resolution, TPVM data can be acquired within a clinically acceptable breath-hold.",
author = "Simpson, Robin and Keegan, Jennifer and Gatehouse, Peter and Hansen, Michael and Firmin, David",
doi = "10.1002/mrm.24971",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = ",myocardial mechanics,spiral,tissue phase velocity mapping",
month = "sep",
number = 3,
pages = "659--68",
pmid = 24123135,
title = "{Spiral tissue phase velocity mapping in a breath-hold with non-cartesian SENSE.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24123135 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3979503 http://doi.wiley.com/10.1002/mrm.24971",
volume = 72,
year = 2014
}
Jennifer Keegan, Peter Drivas and David N Firmin.
Navigator artifact reduction in three-dimensional late gadolinium enhancement imaging of the atria..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 72(3):779–85, September 2014.
URL, DOI BibTeX
@article{Keegan2014a,
abstract = "PURPOSE: Navigator-gated three-dimensional (3D) late gadolinium enhancement (LGE) imaging demonstrates scarring following ablation of atrial fibrillation. An artifact originating from the slice-selective navigator-restore pulse is frequently present in the right pulmonary veins (PVs), obscuring the walls and making quantification of enhancement difficult. We describe a simple sequence modification to greatly reduce or remove this artifact. METHODS: A navigator-gated inversion-prepared gradient echo sequence was modified so that the slice-selective navigator-restore pulse was delayed in time from the nonselective preparation (NAV-restore-delayed). Both NAV-restore-delayed and conventional 3D LGE acquisitions were performed in 11 patients and the results compared. RESULTS: One patient was excluded due to severe respiratory motion artifact in both NAV-restore-delayed and conventional acquisitions. Moderate to severe artifact was present in 9 of the remaining 10 patients using the conventional sequence and was considerably reduced when using the NAV-restore-delayed sequence (ostial PV to blood pool ratio, 1.7 ± 0.5 versus 1.1 ± 0.2, respectively [P {\textless} 0.0001]; qualitative artifact scores, 2.8 ± 1.1 versus 1.2 ± 0.4, respectively [P {\textless} 0.001]). While navigator signal-to-noise ratio was reduced with the NAV-restore-delayed sequence, respiratory motion compensation was unaffected. CONCLUSIONS: Shifting the navigator-restore pulse significantly reduces or eliminates navigator artifact. This simple modification improves the quality of 3D LGE imaging and potentially aids late enhancement quantification in the atria.",
author = "Keegan, Jennifer and Drivas, Peter and Firmin, David N.",
doi = "10.1002/mrm.24967",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = ",artifact,late gadolinium enhancement imaging,navigator,pulmonary veins",
month = "sep",
number = 3,
pages = "779--85",
pmid = 24151231,
title = "{Navigator artifact reduction in three-dimensional late gadolinium enhancement imaging of the atria.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24151231 http://doi.wiley.com/10.1002/mrm.24967",
volume = 72,
year = 2014
}
Andrew D Scott, Pedro F A D C Ferreira, Sonia Nielles-Vallespin, Peter Gatehouse, Laura-Ann McGill, Philip Kilner, Dudley J Pennell and David N Firmin.
Optimal diffusion weighting for in vivo cardiac diffusion tensor imaging..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 74(2):420–430, August 2014.
URL, DOI BibTeX
@article{Scott2014,
abstract = "PURPOSE: To investigate the influence of the diffusion weighting on in vivo cardiac diffusion tensor imaging (cDTI) and obtain optimal parameters. METHODS: Ten subjects were scanned using stimulated echo acquisition mode echo planar imaging with six b-values, from 50 to 950 s{\textperiodcentered}mm(-2) , plus b = 15 s{\textperiodcentered}mm(-2) reference. The relationship between b-value and both signal loss and signal-to-noise ratio measures was investigated. Mean diffusivity, fractional anisotropy, and helical angle maps were calculated using all possible b-value pairs to investigate the effects of diffusion weighting on the main and reference data. RESULTS: Signal decay at low b-values was dominated by processes with high apparent diffusion coefficients, most likely microvascular perfusion. This effect could be avoided by diffusion weighting of the reference images. Parameter maps were improved with increased b-value until the diffusion-weighted signal approached the noise floor. For the protocol used in this study, b = 750 s{\textperiodcentered}mm(-2) combined with 150 s{\textperiodcentered}mm(-2) diffusion weighting of the reference images proved optimal. CONCLUSION: Mean diffusivity, fractional anisotropy, and helical angle from cDTI are influenced by the b-value of the main and reference data. Using optimal values improves parameter maps and avoids microvascular perfusion effects. This optimized protocol should provide greater sensitivity to pathological changes in parameter maps. Magn Reson Med, 2014. {\textcopyright} 2014 Wiley Periodicals, Inc.",
author = "Scott, Andrew D. and Ferreira, Pedro F. A. D. C. and Nielles-Vallespin, Sonia and Gatehouse, Peter and McGill, Laura-Ann and Kilner, Philip and Pennell, Dudley J. and Firmin, David N.",
doi = "10.1002/mrm.25418",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = ",DTI,b-value,cardiac diffusion,diffusion weighting,microvascular perfusion",
month = "aug",
number = 2,
pages = "420--430",
pmid = 25154715,
title = "{Optimal diffusion weighting for in vivo cardiac diffusion tensor imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25154715 http://doi.wiley.com/10.1002/mrm.25418",
volume = 74,
year = 2014
}
Dana K Dawson, David J McLernon, Vimal J Raj, Alicia M Maceira, Sanjay Prasad, Michael P Frenneaux, Dudley J Pennell and Philip J Kilner.
Cardiovascular magnetic resonance determinants of left ventricular noncompaction..
The American journal of cardiology 114(3):456–62, August 2014.
URL, DOI BibTeX
@article{Dawson2014,
abstract = "Insufficient precision remains in accurately identifying left ventricular noncompaction (LVNC) from the healthy normal morphologic spectrum. We aim to provide a better distinction between normal left ventricular trabeculations and LVNC. We used a previously well-defined cohort of 120 healthy volunteers for normal reference values of the trabecular/compacted ratio derived from a consistent selection of short-axis cardiovascular magnetic resonance images. We performed forward selection of logistic regression models, selecting the best model that was subsequently assessed for discrimination and calibration, validated, and converted into a clinical diagnostic chart to benchmark the boundaries of detection from a cohort of 30 patients considered to have LVNC. We showed that 3 combinations of a maximal end-diastolic trabecular/compacted ratio (≥1 [apex], {\textgreater}1.8 [midcavity]), ({\textgreater}2 [apex], ≥0.6 [midcavity]), or ({\textgreater}0.5 [base], {\textgreater}1.8 [midcavity]) separate the cohorts with the highest accuracy (C statistic [95{\%} confidence interval] of 0.9749 (0.9748 to 0.9751) for the diagnostic chart). Quantitative cardiovascular magnetic resonance also shows that patients considered to have LVNC have a significantly reduced ejection fraction compared with normal volunteers. At midcavity and apical level, it is difficult to identify papillary muscles that are replaced by a dense trabecular meshwork. In conclusion, we developed a new, refined, diagnostic tool for identifying LVNC, based on an a priori assessment of the trabecular architecture in healthy volunteers.",
author = "Dawson, Dana K. and McLernon, David J. and Raj, Vimal J. and Maceira, Alicia M. and Prasad, Sanjay and Frenneaux, Michael P. and Pennell, Dudley J. and Kilner, Philip J.",
doi = "10.1016/j.amjcard.2014.05.017",
issn = "1879-1913",
journal = "The American journal of cardiology",
keywords = ",80 and over,Adult,Aged,Cine,Cine: methods,Female,Healthy Volunteers,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Humans,Isolated Noncompaction of the Ventricular Myocardi,Magnetic Resonance Imaging,Male,Middle Aged,Reproducibility of Results,Young Adult",
month = "aug",
number = 3,
pages = "456--62",
pmid = 24934759,
title = "{Cardiovascular magnetic resonance determinants of left ventricular noncompaction.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24934759 http://linkinghub.elsevier.com/retrieve/pii/S000291491401128X",
volume = 114,
year = 2014
}
Steffen E Petersen, Ana G Almeida, Francisco Alpendurada, Redha Boubertakh, Chiara Bucciarelli-Ducci, Bernard Cosyns, Gerald F Greil, Theodoros D Karamitsos, Patrizio Lancellotti, Alexandros S Stefanidis, Oliver Tann, Mark Westwood, Sven Plein and Education Committee European Association Cardiovascular Imaging Association (EACVI).
Update of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam..
European heart journal cardiovascular Imaging 15(7):728–9, July 2014.
URL, DOI BibTeX
@article{Petersen2014,
abstract = "An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The syllabus lists key elements of knowledge in CMR. It represents a framework for the development of training curricula and provides expected knowledge-based learning outcomes to the CMR trainees, in particular those intending to demonstrate CMR knowledge in the European CMR exam, a core requirement in the CMR certification process.",
author = "Petersen, Steffen E. and Almeida, Ana G. and Alpendurada, Francisco and Boubertakh, Redha and Bucciarelli-Ducci, Chiara and Cosyns, Bernard and Greil, Gerald F. and Karamitsos, Theodoros D. and Lancellotti, Patrizio and Stefanidis, Alexandros S. and Tann, Oliver and Westwood, Mark and Plein, Sven and {Education Committee of European Association of Cardiovascular Imaging Association (EACVI)}",
doi = "10.1093/ehjci/jeu076",
issn = "2047-2412",
journal = "European heart journal cardiovascular Imaging",
keywords = ",Cardiology,Cardiology: education,Cardiovascular magnetic resonance,Certification,Certification: standards,Clinical Competence,Curriculum,Curriculum: standards,Education,Educational Measurement,Educational Measurement: standards,Europe,Exam,Humans,Magnetic Resonance Spectroscopy,Magnetic Resonance Spectroscopy: standards,Medical,Medical: standards,Societies,Syllabus",
month = "jul",
number = 7,
pages = "728--9",
pmid = 24855220,
title = "{Update of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24855220 https://academic.oup.com/ehjcimaging/article-lookup/doi/10.1093/ehjci/jeu076",
volume = 15,
year = 2014
}
Calvin WL L Chin, Vassilis Vassiliou, William SA A Jenkins, Sanjay K Prasad, David E Newby and Marc R Dweck.
Markers of left ventricular decompensation in aortic stenosis..
Expert review of cardiovascular therapy 12(7):901–12, July 2014.
URL, DOI BibTeX
@article{Chin2014,
abstract = "Calcified aortic stenosis is a condition that affects the valve and the myocardium. As the valve narrows, left ventricular hypertrophy occurs initially as an adaptive mechanism to maintain cardiac output. Ultimately, the ventricle decompensates and patients transition towards heart failure and adverse events. Current guidelines recommend aortic valve replacement in patients with severe aortic stenosis and evidence of decompensation based on either symptoms or an impaired ejection fraction {\textless}50{\%}. However, symptoms can be subjective and correlate only modestly with the severity of aortic stenosis whilst impaired ejection fraction is an advanced manifestation and often irreversible. In this review, the authors will discuss the pathophysiology of left ventricular hypertrophy and the transition to heart failure. Subsequently, the authors will examine novel biomarkers that may better identify the transition from hypertrophy to heart failure and therefore guide the optimal timing for aortic valve replacement.",
author = "Chin, Calvin WL L and Vassiliou, Vassilis and Jenkins, William SA A and Prasad, Sanjay K and Newby, David E and Dweck, Marc R",
doi = "10.1586/14779072.2014.923307",
issn = "1744-8344",
journal = "Expert review of cardiovascular therapy",
keywords = ",Aortic Valve Stenosis,Aortic Valve Stenosis: complications,Aortic Valve Stenosis: physiopathology,Biological Markers,Heart Failure,Heart Failure: complications,Heart Failure: physiopathology,Humans,Hypertrophy,Left Ventricular,Left Ventricular: complications,Left Ventricular: physiopathology,Severity of Illness Index,aortic stenosis,cardiac MRI,echocardiography,left ventricular decompensation,left ventricular hypertrophy,myocardial T1 mapping,myocardial fibrosis,myocyte death,tissue Doppler imaging",
month = "jul",
number = 7,
pages = "901--12",
pmid = 24866867,
title = "{Markers of left ventricular decompensation in aortic stenosis.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24866867 http://www.tandfonline.com/doi/full/10.1586/14779072.2014.923307",
volume = 12,
year = 2014
}
Yanqiu Feng, Taigang He, Meiyan Feng, John-Paul Carpenter, Andreas Greiser, Xuegang Xin, Wufan Chen, Dudley J Pennell, Guang-Zhong Yang and David N Firmin.
Improved pixel-by-pixel MRI R2* relaxometry by nonlocal means..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 72(1):260–8, July 2014.
URL, DOI BibTeX
@article{Feng2014,
abstract = "PURPOSE: To investigate the feasibility of improving MRI R2* mapping by filtering the images before curve-fitting. METHODS: Pixel-by-pixel curve-fitting for the quantification of MRI relaxometry remains a challenge for low signal-to-noise ratio images. By computing the weighted mean of spatially adjacent pixels, the low-pass Gaussian (LPG) filter can suppress the noise but at the expense of blurring. By assigning high weights to pixels with similar neighborhood patches, the nonlocal means (NLM) algorithm can reduce noise while retaining intrinsic signals, however, its potential has not been explored in pixel-by-pixel MRI relaxometry, and in this study, we aimed to investigate the impact of the LPG and the NLM filtering on decay signals and MRI R2* mapping. These two filtering methods were compared on both simulated and in vivo data. RESULTS: Both LPG and NLM algorithms produces R2* maps with decreased root-mean-square-errors. The LPG filter blurs edges of R2* maps while the NLM algorithm preserves details well. The NLM consistently yields R2* mapping with smaller errors than the LPG filtering in all cases. CONCLUSION: Pixel-by-pixel fitting can skew MRI relaxometry. The NLM outperforms the conventional LPG filter and has the potential to provide more accurate pixel-by-pixel MRI relaxometry for improved tissue characterization.",
author = "Feng, Yanqiu and He, Taigang and Feng, Meiyan and Carpenter, John-Paul and Greiser, Andreas and Xin, Xuegang and Chen, Wufan and Pennell, Dudley J. and Yang, Guang-Zhong and Firmin, David N.",
doi = "10.1002/mrm.24914",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = ",MRI relaxometry,R2* mapping,noise,nonlocal means,pixel-by-pixel",
month = "jul",
number = 1,
pages = "260--8",
pmid = 23963595,
title = "{Improved pixel-by-pixel MRI R2* relaxometry by nonlocal means.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23963595 http://doi.wiley.com/10.1002/mrm.24914",
volume = 72,
year = 2014
}
Tom Treasure, Johanna J M Takkenberg, Tal Golesworthy, Filip Rega, Mario Petrou, Ulrich Rosendahl, Raad Mohiaddin, Michael Rubens, Warren Thornton, Belinda Lees and John Pepper.
Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the publishe.
Heart (British Cardiac Society) 100(12):969–75, June 2014.
URL, DOI BibTeX
@article{Treasure2014,
abstract = "OBJECTIVE: Among people with Marfan syndrome who have a typical aortic root aneurysm, dissection is a characteristic cause of premature death. To pre-empt Type A dissection, composite root replacement with a mechanical valve became the standard of care in the 1980s and 1990s. This is being superseded by valve-sparing aortic root replacement to avoid lifelong anticoagulation. In 2004, a total root and valve-sparing procedure, personalised external aortic support, was introduced. We report here results among the first 30 recipients. METHODS: From cross-sectional digital images, the patient's own aorta is modelled by computer aided design and a replica is made in thermoplastic by rapid prototyping. On this, a personalised support of a macroporous polymer mesh is manufactured. The mesh is positioned around the aorta, closely applied from the aortoventricular junction to beyond the brachiocephalic artery. The operation is performed with a beating heart and usually without cardiopulmonary bypass. RESULTS: Between 2004 and 2011, 30 patients, median age 28 years (IQR 20-44) had this operation and have been prospectively followed for 1.4-8.8 years by February 2013. During a total of 133 patient-years there were no deaths or cerebrovascular, aortic or valve-related events. These early outcomes are better than published results for the more radical extirpative root replacement operations. CONCLUSIONS: The aortic valve, the root architecture, and the blood/endothelia interface are conserved. The perioperative burden is less and there has been freedom from aortic and valvular events. A prospective comparative study is planned.",
author = "Treasure, Tom and Takkenberg, Johanna J M and Golesworthy, Tal and Rega, Filip and Petrou, Mario and Rosendahl, Ulrich and Mohiaddin, Raad and Rubens, Michael and Thornton, Warren and Lees, Belinda and Pepper, John",
doi = "10.1136/heartjnl-2013-304913",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Treasure et al. - 2014 - Personalised external aortic root support (PEARS) in Marfan syndrome analysis of 1-9 year outcomes by intention.pdf:pdf",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = ",Adult,Aortic Aneurysm,Aortic Aneurysm: diagnosis,Aortic Aneurysm: etiology,Aortic Aneurysm: surgery,Aortic Valve,Aortic Valve: surgery,Belgium,Blood Vessel Prosthesis,Blood Vessel Prosthesis Implantation,Blood Vessel Prosthesis Implantation: adverse effe,Blood Vessel Prosthesis Implantation: instrumentat,Computer-Aided Design,Computer-Assisted,Computer-Assisted: adverse effects,Computer-Assisted: instrumentation,Female,Follow-Up Studies,Heart Valve Prosthesis Implantation,Humans,Individualized Medicine,Intention to Treat Analysis,London,Magnetic Resonance Angiography,Male,Marfan Syndrome,Marfan Syndrome: complications,Marfan Syndrome: diagnosis,Prospective Studies,Prosthesis Design,Surgery,Surgical Mesh,Time Factors,Treatment Outcome,Young Adult",
month = "jun",
number = 12,
pages = "969--75",
pmid = 24395977,
title = "{Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the publishe}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4033204{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/24395977 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4033204 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2013-304913",
volume = 100,
year = 2014
}
S S M S M Chen, K Dimopoulos, R Alonso-Gonzalez, E Liodakis, E Teijeira-Fernandez, M Alvarez-Barredo, A Kempny, G Diller, A Uebing, D Shore, L Swan, P J J Kilner, M A A Gatzoulis and R H H Mohiaddin.
Prevalence and prognostic implication of restenosis or dilatation at the aortic coarctation repair site assessed by cardiovascular MRI in adult patients late after coarctation repair..
International journal of cardiology 173(2):209–15, May 2014.
URL, DOI BibTeX
@article{Chen2014,
abstract = "BACKGROUND: Cardiovascular magnetic resonance (CMR) is ideal for assessing patients with repaired aortic coarctation (CoA). Little is known on the relation between long-term complications of CoA repair as assessed by CMR and clinical outcome. We examined the prevalence of restenosis and dilatation at the repair site and the long-term outcome in patients with repaired CoA. METHODS AND RESULTS: CMR imaging and clinical data for adult CoA patients (247 patients aged 33.0 ± 12.8 years, 60{\%} male), were analyzed. The diameter of the aorta at the repair site was measured on CMR and its ratio to the aortic diameter at the diaphragm (repair site-diaphragm ratio, RDR) was calculated. Restenosis (RDR≤70{\%}) was present in 31{\%} of patients (and significant in 9{\%} [RDR{\textless}50{\%}]), and dilatation (RDR{\textgreater}150{\%}) in 13.0{\%}. A discrete aneurysm at the repair site was observed in 9{\%}. Restenosis was more likely after resection and end-end anastomosis, whereas dilatation after patch repair. Systemic hypertension was present in 69{\%} of patients. Of the hypertensive patients, blood pressure (133 ± 20/73 ± 10 mm Hg) was well controlled in 93{\%} with antihypertensive therapy. Mortality rate over a median length of 5.9 years was low (0.69{\%} per year, 95{\%} CI: 0.33-1.26), but significantly higher than age-matched healthy controls (standardised mortality ratio 2.86, CI 1.43-5.72, p{\textless}0.001). CONCLUSION: Restenosis or dilatation at the CoA repair site as assessed by CMR is not uncommon. Medium term survival remains good, however, albeit lower than in the general population. Life-long follow-up and optimal blood pressure control are likely to secure a good longer term outlook in these patients.",
author = "Chen, S.S.M. S M and Dimopoulos, K. and Alonso-Gonzalez, R. and Liodakis, E. and Teijeira-Fernandez, E. and Alvarez-Barredo, M. and Kempny, A. and Diller, G. and Uebing, A. and Shore, D. and Swan, L. and Kilner, P.J. J and Gatzoulis, M.A. A and Mohiaddin, R.H. H",
doi = "10.1016/j.ijcard.2014.02.012",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = ",Adolescent,Adult,Adult congenital heart disease,Aged,Aortic Coarctation,Aortic Coarctation: diagnosis,Aortic Coarctation: mortality,Aortic Coarctation: surgery,Aortic Diseases,Aortic Diseases: epidemiology,Aortic Valve,Aortic coarctation,Cardiac Surgical Procedures,Cardiac Surgical Procedures: adverse effects,Cardiac Surgical Procedures: mortality,Cardiac magnetic resonance,Cine,Comorbidity,Congenital,Congenital: epidemiology,Coronary Aneurysm,Coronary Aneurysm: etiology,Coronary Aneurysm: mortality,Coronary Restenosis,Coronary Restenosis: diagnosis,Coronary Restenosis: etiology,Coronary Restenosis: mortality,Female,Heart Defects,Heart Valve Diseases,Heart Valve Diseases: epidemiology,Humans,Hypertension,Hypertension: epidemiology,Magnetic Resonance Imaging,Male,Middle Aged,Outcomes,Postoperative Complications,Postoperative Complications: etiology,Postoperative Complications: mortality,Prevalence,Prognosis,Young Adult",
month = "may",
number = 2,
pages = "209--15",
pmid = 24631116,
title = "{Prevalence and prognostic implication of restenosis or dilatation at the aortic coarctation repair site assessed by cardiovascular MRI in adult patients late after coarctation repair.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24631116 http://linkinghub.elsevier.com/retrieve/pii/S0167527314003659",
volume = 173,
year = 2014
}
Benoy N Shah, Sonya Babu-Narayan, Wei Li, Michael Rubens and Tom Wong.
Severe mitral annular calcification: insights from multimodality imaging..
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 41(2):245–7, April 2014.
URL, DOI BibTeX
@article{Shah2014b,
author = "Shah, Benoy N. and Babu-Narayan, Sonya and Li, Wei and Rubens, Michael and Wong, Tom",
doi = "10.14503/THIJ-12-3028",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Shah et al. - 2014 - Severe mitral annular calcification insights from multimodality imaging.pdf:pdf",
issn = "1526-6702",
journal = "Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital",
keywords = ",Aged,Calcinosis,Calcinosis: diagnosis,Cine,Cine: instrumentation,Cine: methods,Color,Color: methods,Doppler,Echocardiography,Female,Gadolinium,Gadolinium: diagnostic use,Heart Valve Diseases,Heart Valve Diseases: diagnosis,Humans,Magnetic Resonance Imaging,Mitral Valve,Mitral Valve: pathology,Severity of Illness Index",
month = "apr",
number = 2,
pages = "245--7",
pmid = 24808796,
title = "{Severe mitral annular calcification: insights from multimodality imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24808796 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4004498 http://thij.org/doi/10.14503/THIJ-12-3028 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4004498{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 41,
year = 2014
}
RA A Curry, E Gelson, L Swan, D Dob, SV V Babu-Narayan, MA A Gatzoulis, PJ J Steer and MR R Johnson.
Marfan syndrome and pregnancy: maternal and neonatal outcomes..
BJOG : an international journal of obstetrics and gynaecology 121(5):610–7, April 2014.
URL, DOI BibTeX
@article{Curry2014,
abstract = "{OBJECTIVE: To report outcomes in a recent series of pregnancies in women with Marfan syndrome (MFS). DESIGN: Retrospective case note review. SETTING: Tertiary referral unit (Chelsea and Westminster and Royal Brompton Hospitals). SAMPLE: Twenty-nine pregnancies in 21 women with MFS between 1995 and 2010. METHODS: Multidisciplinary review of case records. MAIN OUTCOME MEASURES: Maternal and neonatal mortality and morbidity of patients with MFS and healthy controls. RESULTS: There were no maternal deaths. Significant cardiac complications occurred in five pregnancies (17{\%}): one woman experienced a type-A aortic dissection; two women required cardiac surgery within 6 months of delivery; and a further two women developed impaired left ventricular function during the pregnancy. Women with MFS were also more likely to have obstetric complications (OR 3.29, 95{\%} CI 1.30-8.34), the most frequent of which was postpartum haemorrhage (OR 8.46, 95{\%} CI 2.52-28.38). There were no perinatal deaths, although babies born to mothers with MFS were delivered significantly earlier than those born to the control group (median 39 versus 40 weeks of gestation, Mann-Whitney U-test",
p = "",
author = "Curry, RA A and Gelson, E and Swan, L and Dob, D and Babu-Narayan, SV V and Gatzoulis, MA A and Steer, PJ J and Johnson, MR R",
doi = "10.1111/1471-0528.12515",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Curry et al. - 2014 - Marfan syndrome and pregnancy maternal and neonatal outcomes.pdf:pdf",
issn = "1471-0528",
journal = "BJOG : an international journal of obstetrics and gynaecology",
keywords = ",Adolescent,Adult,Aorta,Aorta: injuries,Aorta: surgery,Aorta: ultrasonography,Aortic Valve,Aortic Valve: surgery,Birth Weight,Cardiovascular,Cardiovascular: epidemiol,Case-Control Studies,Delivery,Echocardiography,Female,Heart Valve Prosthesis Implantation,Heart Valve Prosthesis Implantation: statistics {\&},Humans,Infant,Left,Left: epidemiology,Marfan Syndrome,Marfan Syndrome: epidemiology,Marfan syndrome,Newborn,Obstetric,Obstetric Labor Complications,Obstetric Labor Complications: epidemiology,Obstetric: statistics {\&} numerical data,Obstetrical Forceps,Obstetrical Forceps: utilization,Postpartum Hemorrhage,Postpartum Hemorrhage: epidemiology,Pregnancy,Pregnancy Complications,Premature Birth,Premature Birth: epidemiology,Retrospective Studies,Small for Gestational Age,Ventricular Dysfunction,Young Adult,pregnancy",
month = "apr",
number = 5,
pages = "610--7",
pmid = 24418012,
title = "{Marfan syndrome and pregnancy: maternal and neonatal outcomes.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24418012 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4162995 http://doi.wiley.com/10.1111/1471-0528.12515 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4162995{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 121,
year = 2014
}
Elisa Pietro, Maria Carmen De Angelis, Francesca Esposito, Gennaro Maresca, Alessia Agresta, Annunziata Cerrone, Ovidio De Filippo, Philip J Kilner, Gaetano Palma, Gennaro Galasso, Dario Leosco, Carlo Vosa, Bruno Trimarco and Antonio Rapacciuolo.
An imbalance between protective and detrimental molecular pathways is associated with right ventricular dysfunction in congenital heart diseases with outflow obstruction..
International journal of cardiology 172(3):e519–21, April 2014.
URL, DOI BibTeX
@article{DiPietro2014,
author = "di Pietro, Elisa and {De Angelis}, Maria Carmen and Esposito, Francesca and Maresca, Gennaro and Agresta, Alessia and Cerrone, Annunziata and {De Filippo}, Ovidio and Kilner, Philip J. and Palma, Gaetano and Galasso, Gennaro and Leosco, Dario and Vosa, Carlo and Trimarco, Bruno and Rapacciuolo, Antonio",
doi = "10.1016/j.ijcard.2014.01.077",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = ",Adrenergic,Cardiac,Cardiac: metabolism,Cardiac: pathology,Congenital,Congenital heart disease,Congenital: complications,Congenital: diagnosis,Congenital: surgery,Echocardiography,Follow-Up Studies,G-Protein-Coupled Receptor Kinase 2,G-Protein-Coupled Receptor Kinase 2: metabolism,Heart Atria,Heart Atria: metabolism,Heart Atria: pathology,Heart Atria: physiopathology,Heart Defects,Humans,Myocytes,Phosphorylation,Receptors,Right,Right ventricle failure,Right ventricle outflow obstruction,Right: etiology,Right: metabolism,Right: physiology,Right: physiopathology,Ventricular Dysfunction,Ventricular Function,Ventricular Outflow Obstruction,Ventricular Outflow Obstruction: etiology,Ventricular Outflow Obstruction: metabolism,Ventricular Outflow Obstruction: physiopathology,beta,beta: metabolism",
month = "apr",
number = 3,
pages = "e519--21",
pmid = 24534380,
title = "{An imbalance between protective and detrimental molecular pathways is associated with right ventricular dysfunction in congenital heart diseases with outflow obstruction.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24534380 http://linkinghub.elsevier.com/retrieve/pii/S0167527314002861",
volume = 172,
year = 2014
}
Daniel J Stuckey, Sara J McSweeney, May Zaw Thin, Josef Habib, Anthony N Price, Lorna R Fiedler, Willy Gsell, Sanjay K Prasad and Michael D Schneider.
T₁ mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy..
Circulation. Cardiovascular imaging 7(2):240–9, March 2014.
URL, DOI BibTeX
@article{Stuckey2014,
abstract = "BACKGROUND: Diffuse interstitial fibrosis is present in diverse cardiomyopathies and associated with poor prognosis. We investigated whether magnetic resonance imaging-based T1 mapping could quantify the induction and pharmacological suppression of diffuse cardiac fibrosis in murine pressure-overload hypertrophy. METHODS AND RESULTS: Mice were subjected to transverse aortic constriction or sham surgery. The angiotensin receptor blocker losartan was given to half the animals. Cine-magnetic resonance imaging performed at 7 and 28 days showed hypertrophy and remodeling and systolic and diastolic dysfunction in transverse aortic constriction groups as expected. Late gadolinium-enhanced magnetic resonance imaging revealed focal signal enhancement at the inferior right ventricular insertion point of transverse aortic constriction mice concordant with the foci of fibrosis in histology. The extracellular volume fraction, calculated from pre- and postcontrast T1 measurements, was elevated by transverse aortic constriction and showed direct linear correlation with picrosirius red collagen volume fraction, thus confirming the suitability of extracellular volume fraction as an in vivo measure of diffuse fibrosis. Treatment with losartan reduced left ventricular dysfunction and prevented increased extracellular volume fraction, indicating that T1 mapping is sensitive to pharmacological prevention of fibrosis. CONCLUSIONS: Magnetic resonance imaging can detect diffuse and focal cardiac fibrosis in a clinically relevant animal model of pressure overload and is sensitive to pharmacological reduction of fibrosis by angiotensin receptor blockade. Thus, T1 mapping can be used to assess antifibrotic therapeutic strategies.",
author = "Stuckey, Daniel J and McSweeney, Sara J and Thin, May Zaw and Habib, Josef and Price, Anthony N and Fiedler, Lorna R and Gsell, Willy and Prasad, Sanjay K and Schneider, Michael D",
doi = "10.1161/CIRCIMAGING.113.000993",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Angiotensin II Type 1 Receptor Blockers,Angiotensin II Type 1 Receptor Blockers: administr,Animals,Contrast Media,Contrast Media: diagnostic use,Disease Models, Animal,Dose-Response Relationship, Drug,Fibrosis,Fibrosis: diagnosis,Fibrosis: prevention {\&} control,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Heart Ventricles,Heart Ventricles: drug effects,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Hypertrophy, Left Ventricular: drug therapy,Hypertrophy, Left Ventricular: physiopathology,Losartan,Losartan: administration {\&} dosage,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Mice,Mice, Inbred C57BL,Myocardium,Myocardium: pathology,Treatment Outcome,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: diagnosis,Ventricular Pressure,Ventricular Pressure: drug effects,Ventricular Pressure: physiology,Ventricular Remodeling,Ventricular Remodeling: drug effects",
month = "mar",
number = 2,
pages = "240--9",
pmid = 24425501,
title = "{T₁ mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24425501",
volume = 7,
year = 2014
}
Joanna Petryka, John A Baksi, Sanjay K Prasad, Dudley J Pennell and Philip J Kilner.
Prevalence of inferobasal myocardial crypts among patients referred for cardiovascular magnetic resonance..
Circulation. Cardiovascular imaging 7(2):259–64, March 2014.
URL, DOI BibTeX
@article{Petryka2014,
abstract = "BACKGROUND: Crypts or clefts in the left ventricular inferobasal myocardium have been detected by cardiovascular magnetic resonance (CMR), but the extent to which they represent prephenotypic markers of hypertrophic cardiomyopathy (HCM) or incidental structural variants remains controversial. METHODS AND RESULTS: We examined retrospectively the routine vertical long-axis cines in 686 consecutive patients (48±20 years, 55{\%} men) referred for CMR. Crypts were identified in 46 (6.7{\%}), 17 being among patients (8.7{\%} of 196) with otherwise normal CMR findings and without a known family history of HCM. Higher percentages were found in patients with HCM (16{\%}), myocarditis (15{\%}), and hypertension (14{\%}) but without reaching statistical significance (P=0.12). Only 1 (5{\%}) of 20 phenotype-negative HCM family members had a visible crypt. Relative to those without, patients with crypts had lower indexed left ventricular end-systolic volumes (P=0.042) and higher indexed left and right ventricular stroke volumes (P=0.007 and P=0.015) and ejection fractions (P=0.003 and P=0.021). Crypts tended to narrow in systole, varying slightly in size, shape- and number, without obvious group-related features. CONCLUSIONS: Single or paired inferobasal myocardial crypts were an occasional and by no means rare finding among patients referred for CMR without a pretest suspicion of HCM. This, together with similar previous findings in a cohort of healthy volunteers, supports their being regarded, in such individuals, as incidental variants of local myocardial structure, unlikely to require further investigation. However, a larger registry-type study may be justified to investigate the clinical implications of multiple crypts, especially if associated with HCM family history.",
author = "Petryka, Joanna and Baksi, A. John and Prasad, Sanjay K. and Pennell, Dudley J. and Kilner, Philip J.",
doi = "10.1161/CIRCIMAGING.113.001241",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = ",Adolescent,Adult,Cardiomyopathy,Cine,Cine: methods,Diagnosis,Differential,Female,Heart Ventricles,Heart Ventricles: pathology,Humans,Hypertrophic,Hypertrophic: diagnosis,Hypertrophic: physiopathology,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,ROC Curve,Referral and Consultation,Reproducibility of Results,Retrospective Studies,Stroke Volume,Young Adult,cardiomyopathy,cleft,crypt,diverticulum,hypertrophic,magnetic resonance imaging",
month = "mar",
number = 2,
pages = "259--64",
pmid = 24508667,
title = "{Prevalence of inferobasal myocardial crypts among patients referred for cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24508667 http://circimaging.ahajournals.org/cgi/doi/10.1161/CIRCIMAGING.113.001241",
volume = 7,
year = 2014
}
Amal El Beshlawy, Mona El Tagui, Mona Hamdy, Mona El Ghamrawy, Khaled Abdel Azim, Doria Salem, Fadwa Said, Ahmed Samir, Timothy St Pierre, Dudley J Pennell, Timothy St Pierre and Dudley J Pennell.
Low prevalence of cardiac siderosis in heavily iron loaded Egyptian thalassemia major patients..
Annals of hematology 93(3):375–9, March 2014.
URL, DOI BibTeX
@article{ElBeshlawy2014,
abstract = "Myocardial siderosis in thalassemia major remains the leading cause of death in developing countries. Once heart failure develops, the outlook is usually poor with precipitous deterioration and death. Cardiovascular magnetic resonance (CMR) can measure cardiac iron deposition directly using the magnetic relaxation time T2*. This allows earlier diagnosis and treatment and helps to reduce mortality from this cardiac affection. This study aims to determine the prevalence of cardiac siderosis in Egyptian patients who are heavily iron loaded and its relation to liver iron concentration, serum ferritin, and left ventricular ejection fraction. Eighty-nine $\beta$-thalassemia patients receiving chelation therapy (mean age of 20.8 ± 6.4 years) were recruited in this study. Tissue iron levels were determined by CMR with cardiac T2* and liver R2*. The mean ± standard deviation (range) of cardiac T2* was 28.5 ± 11.7 ms (4.3 to 53.8 ms), the left ventricular ejection fraction (LVEF) was 67.7 ± 4.7 {\%} (55 to 78 {\%}), and the liver iron concentration (LIC) was 26.1 ± 13.4 mg Fe/g dry weight (dw) (1.5 to 56 mg Fe/g dw). The mean serum ferritin was 4,510 ± 2,847 ng/ml (533 to 22,360 ng/ml), and in 83.2 {\%}, the serum ferritin was {\textgreater}2,500 ng/ml. The prevalence of myocardial siderosis (T2* of {\textless}20 ms) was 24.7 {\%} (mean age 20.9 ± 7.5 years), with mean T2* of 12.7 ± 4.4 ms, mean LVEF of 68.6 ±5.8 {\%}, mean LIC of 30.9 ± 13 mg Fe/g dw, and median serum ferritin of 4,996 ng/ml. There was no correlation between T2* and age, LVEF, LIC, and serum ferritin (P = 0.65, P = 0.085, P = 0.99, and P = 0.63, respectively). Severe cardiac siderosis (T2* of {\textless}10 ms) was present in 7.9 {\%}, with a mean age of 18.4 ± 4.4 years. Although these patients had a mean T2* of 7.8 ± 1.7 ms, the LVEF was 65.1 ± 6.2 {\%}, and only one patient had heart failure (T2* of 4.3 ms and LVEF of 55 {\%}). LIC and serum ferritin results were 29.8 ± 17.0 mg/g and 7,200 ± 6,950 ng/ml, respectively. In this group of severe cardiac siderosis, T2* was also not correlated to age (P = 0.5), LVEF (P = 0.14), LIC (P = 0.97), or serum ferritin (P = 0.82). There was a low prevalence of myocardial siderosis in the Egyptian thalassemia patients in spite of very high serum ferritin and high LIC. T2* is the best test that can identify at-risk patients who can be managed with optimization of their chelation therapy. The possibility of a genetic component for the resistance to cardiac iron loading in our population should be considered.",
author = "{El Beshlawy}, Amal and {El Tagui}, Mona and Hamdy, Mona and {El Ghamrawy}, Mona and Azim, Khaled Abdel and Salem, Doria and Said, Fadwa and Samir, Ahmed and Pierre, Timothy St and Pennell, Dudley J and {St Pierre}, Timothy and Pennell, Dudley J",
doi = "10.1007/s00277-013-1876-0",
issn = "1432-0584",
journal = "Annals of hematology",
keywords = ",Adolescent,Adult,Blood Transfusion,Blood Transfusion: adverse effects,Cardiomyopathies,Cardiomyopathies: epidemiology,Cardiomyopathies: etiology,Cardiomyopathies: prevention {\&} control,Chelation Therapy,Child,Cohort Studies,Egypt,Egypt: epidemiology,Ferritins,Ferritins: blood,Heart Failure,Heart Failure: epidemiology,Heart Failure: etiology,Heart Ventricles,Heart Ventricles: chemistry,Heart Ventricles: physiopathology,Hemosiderosis,Hemosiderosis: epidemiology,Hemosiderosis: etiology,Hemosiderosis: prevention {\&} control,Hospitals,Humans,Iron,Iron: analysis,Liver,Liver: chemistry,Magnetic Resonance Imaging,Pediatric,Prevalence,Stroke Volume,Young Adult,beta-Thalassemia,beta-Thalassemia: blood,beta-Thalassemia: physiopathology,beta-Thalassemia: therapy",
month = "mar",
number = 3,
pages = "375--9",
pmid = 23949317,
title = "{Low prevalence of cardiac siderosis in heavily iron loaded Egyptian thalassemia major patients.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23949317 http://link.springer.com/10.1007/s00277-013-1876-0",
volume = 93,
year = 2014
}
Jennifer Keegan, Permi Jhooti, Sonya V Babu-Narayan, Peter Drivas, Sabine Ernst and David N Firmin.
Improved respiratory efficiency of 3D late gadolinium enhancement imaging using the continuously adaptive windowing strategy (CLAWS)..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 71(3):1064–74, March 2014.
URL, DOI BibTeX
@article{Keegan2014,
abstract = "PURPOSE: Acquisition durations of navigator-gated high-resolution three-dimensional late gadolinium enhancement studies may typically be up to 10 min, depending on the respiratory efficiency and heart rate. Implementation of the continuously adaptive windowing strategy (CLAWS) could increase respiratory efficiency, but the resulting non-smooth k-space acquisition order during gadolinium wash-out could result in increased artifact. METHODS: Navigator-gated three-dimensional late gadolinium enhancement acquisitions were performed in 18 patients using tracking end-expiratory accept/reject (EE-ARA) and CLAWS algorithms in random order. RESULTS: Retrospective analysis of the stored navigator data shows that CLAWS scan times are very close to (within 1{\%}) or equal to the fastest achievable scan times while EE-ARA significantly extends the acquisition duration (P {\textless} 0.0001). EE-ARA acquisitions are 26{\%} longer than CLAWS acquisitions (378 ± 104 s compared to 301 ± 85 s, P = 0.002). Image quality scores for CLAWS and EE-ARA acquisitions are not significantly different (4.1 ± 0.6 compared to 4.3 ± 0.6, P = ns). Numerical phantom simulations show that the non-uniform k-space ordering introduced by CLAWS results in slight, but not statistically significant, reductions in both blood signal-to-noise ratio (10{\%}) and blood-myocardium contrast-to-noise ratio (12{\%}). CONCLUSIONS: CLAWS results in markedly reduced acquisition durations compared to EE-ARA without significant detriment to the image quality. Magn Reson Med 71:1064-1074, 2014. {\textcopyright} 2013 Wiley Periodicals, Inc.",
author = "Keegan, Jennifer and Jhooti, Permi and Babu-Narayan, Sonya V and Drivas, Peter and Ernst, Sabine and Firmin, David N.",
doi = "10.1002/mrm.24758",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
month = "mar",
number = 3,
pages = "1064--74",
pmid = 23605998,
title = "{Improved respiratory efficiency of 3D late gadolinium enhancement imaging using the continuously adaptive windowing strategy (CLAWS).}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23605998 http://doi.wiley.com/10.1002/mrm.24758",
volume = 71,
year = 2014
}
Dudley J Pennell, John B Porter, Antonio Piga, Yongrong Lai, Amal El-Beshlawy, Khawla M Belhoul, Mohsen Elalfy, Akif Yesilipek, Yurdanur Kilinç, Tomasz Lawniczek, Dany Habr, Marianne Weisskopf, Yiyun Zhang, Yesim Aydinok, Y Kilinc, Tomasz Lawniczek, Dany Habr, Marianne Weisskopf, Yiyun Zhang, Yesim Aydinok and CORDELIA investigators.
A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in $\beta$-thalassemia major (CORDELIA)..
Blood 123(10):1447–54, March 2014.
URL, DOI BibTeX
@article{Pennell2014,
abstract = "Randomized comparison data on the efficacy and safety of deferasirox for myocardial iron removal in transfusion dependent patients are lacking. CORDELIA was a prospective, randomized comparison of deferasirox (target dose 40 mg/kg per day) vs subcutaneous deferoxamine (50-60 mg/kg per day for 5-7 days/week) for myocardial iron removal in 197 $\beta$-thalassemia major patients with myocardial siderosis (T2* 6-20 milliseconds) and no signs of cardiac dysfunction (mean age, 19.8 years). Primary objective was to demonstrate noninferiority of deferasirox for myocardial iron removal, assessed by changes in myocardial T2* after 1 year using a per-protocol analysis. Geometric mean (Gmean) myocardial T2* improved with deferasirox from 11.2 milliseconds at baseline to 12.6 milliseconds at 1 year (Gmeans ratio, 1.12) and with deferoxamine (11.6 milliseconds to 12.3 milliseconds; Gmeans ratio, 1.07). The between-arm Gmeans ratio was 1.056 (95{\%} confidence interval [CI], 0.998, 1.133). The lower 95{\%} CI boundary was greater than the prespecified margin of 0.9, establishing noninferiority of deferasirox vs deferoxamine (P = .057 for superiority of deferasirox). Left ventricular ejection fraction remained stable in both arms. Frequency of drug-related adverse events was comparable between deferasirox (35.4{\%}) and deferoxamine (30.8{\%}). CORDELIA demonstrated the noninferiority of deferasirox compared with deferoxamine for myocardial iron removal. This trial is registered at www.clinicaltrials.gov as {\#}NCT00600938.",
author = "Pennell, Dudley J. and Porter, John B. and Piga, Antonio and Lai, Yongrong and El-Beshlawy, Amal and Belhoul, Khawla M. and Elalfy, Mohsen and Yesilipek, Akif and Kilin{\c{c}}, Yurdanur and Lawniczek, Tomasz and Habr, Dany and Weisskopf, Marianne and Zhang, Yiyun and Aydinok, Yesim and Kilinc, Y. and Lawniczek, Tomasz and Habr, Dany and Weisskopf, Marianne and Zhang, Yiyun and Aydinok, Yesim and CORDELIA study investigators",
doi = "10.1182/blood-2013-04-497842",
issn = "1528-0020",
journal = "Blood",
keywords = ",Adolescent,Adult,Benzoates,Benzoates: administration {\&} dosage,Benzoates: adverse effects,Benzoates: therapeutic use,Child,Deferoxamine,Deferoxamine: administration {\&} dosage,Deferoxamine: adverse effects,Deferoxamine: therapeutic use,Female,Ferritins,Ferritins: blood,Heart,Heart: physiopathology,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: administration {\&} dosage,Iron Chelating Agents: adverse effects,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: drug therapy,Iron Overload: etiology,Iron: administration {\&} dosage,Iron: metabolism,Male,Medication Adherence,Myocardium,Myocardium: metabolism,Myocardium: pathology,Treatment Outcome,Triazoles,Triazoles: administration {\&} dosage,Triazoles: adverse effects,Triazoles: therapeutic use,Troponin T,Troponin T: metabolism,Young Adult,beta-Thalassemia,beta-Thalassemia: complications",
month = "mar",
number = 10,
pages = "1447--54",
pmid = 24385534,
title = "{A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in $\beta$-thalassemia major (CORDELIA).}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24385534 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3945858 http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-04-497842 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3945858{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 123,
year = 2014
}
Patrick J Goleski, Florence H Sheehan, Sylvia S M M Chen, Philip J Kilner and Michael A Gatzoulis.
The shape and function of the left ventricle in Ebstein's anomaly..
International journal of cardiology 171(3):404–12, February 2014.
URL, DOI BibTeX
@article{Goleski2014,
abstract = "{BACKGROUND: Left ventricular (LV) failure is common in Ebstein's anomaly, though remains poorly understood. We investigated whether shape deformity impacts LV function. METHODS: Three-dimensional models of the right ventricle (RV) and LV from 29 adult Ebstein's patients and nine normal subjects were generated from cardiac magnetic resonance image tracings. LV end diastolic (ED) shape, systolic function, septal motion and ventricular interaction were analyzed. RESULTS: LV ED volume index was normal in Ebstein's (75 ± 19 vs. 78 ± 11 ml/m(2) in normals",
p = "",
author = "Goleski, Patrick J. and Sheehan, Florence H. and Chen, Sylvia S.M. M and Kilner, Philip J. and Gatzoulis, Michael A.",
doi = "10.1016/j.ijcard.2013.12.037",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = ",Adult,Ebstein Anomaly,Ebstein Anomaly: diagnosis,Ebstein Anomaly: pathology,Ebstein Anomaly: physiopathology,Ebstein's anomaly,Female,Heart Ventricles,Heart Ventricles: anatomy {\&} histology,Heart Ventricles: pathology,Humans,Left,Left ventricle,Left: physiology,Magnetic resonance imaging,Male,Middle Aged,Ventricular Function,Young Adult",
month = "feb",
number = 3,
pages = "404--12",
pmid = 24411210,
title = "{The shape and function of the left ventricle in Ebstein's anomaly.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24411210 http://linkinghub.elsevier.com/retrieve/pii/S016752731302247X",
volume = 171,
year = 2014
}
Arun John Baksi and Dudley John Pennell.
T2* imaging of the heart: methods, applications, and outcomes..
Topics in magnetic resonance imaging : TMRI 23(1):13–20, February 2014.
URL, DOI BibTeX
@article{Baksi2014a,
abstract = "This review describes and discusses the rationale, technique, applications, and impact of cardiovascular magnetic resonance (CMR) T2* imaging, principally in the assessment of iron loading within the heart, and highlights how this robust imaging strategy has transformed disease outcome.Until recently, no simple noninvasive measurement was available to reliably indicate severe cardiac iron loading before the development of overt cardiac dysfunction or heart failure. Consequently, the majority of patients with transfusion-dependent anemias, such as $\beta$-thalassemia major, died prematurely of cardiovascular complications of severe iron overload.The magnetic properties of particulate iron disrupt magnetic field homogeneity in the CMR environment and consequently influence the CMR parameter T2*, which describes signal decay relating to both field inhomogeneity and loss of spin coherence. There is a direct relationship between T2* and myocardial iron concentration, enabling this to be used to identify and quantify myocardial iron load. Single breath-hold gradient-echo sequences in which a single midventricular short-axis myocardial slice is acquired at multiple echo times enables a myocardial T2* value to be measured from the rate of exponential decay. The application of T2* CMR to assessing cardiac iron loading is rapid, reproducible, extensively validated, and now widely performed. Data have highlighted the profound predictive power of this imaging technique and moreover its ability to inform management strategies such that, over a relatively short duration, outcome has been dramatically improved, and the disease course in $\beta$-thalassemia major transformed.",
author = "Baksi, Arun John and Pennell, Dudley John",
doi = "10.1097/RMR.0000000000000011",
issn = "1536-1004",
journal = "Topics in magnetic resonance imaging : TMRI",
keywords = "Algorithms,Biological Markers,Biological Markers: metabolism,Heart Failure,Heart Failure: diagnosis,Heart Failure: etiology,Heart Failure: metabolism,Humans,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Iron,Iron Overload,Iron Overload: complications,Iron Overload: diagnosis,Iron Overload: metabolism,Iron: metabolism,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Magnetic Resonance Spectroscopy,Magnetic Resonance Spectroscopy: methods",
month = "feb",
number = 1,
pages = "13--20",
pmid = 24509620,
title = "{T2* imaging of the heart: methods, applications, and outcomes.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24509620",
volume = 23,
year = 2014
}
Anthony J Barron, Alun D Hughes, Andrew Sharp, Arun J Baksi, Praveen Surendran, Richard J Jabbour, Alice Stanton, Neil Poulter, Des Fitzgerald, Peter Sever, Eoin O'Brien, Simon Thom, Jamil Mayet and ASCOT Investigators.
Long-term antihypertensive treatment fails to improve E/e' despite regression of left ventricular mass: an Anglo-Scandinavian cardiac outcomes trial substudy..
Hypertension 63(2):252–8, February 2014.
URL, DOI BibTeX
@article{Barron2014,
abstract = "Antihypertensive treatment can improve tissue Doppler indices of left ventricular diastolic function in the short term, but little is known about the longer-term effect of different antihypertensive treatments on progression of left ventricular diastolic function and left ventricular hypertrophy. We hypothesized that long-term treatment of hypertension will lead to improvements in left ventricular hypertrophy and diastolic function. We collected detailed cardiovascular phenotypic data on 1006 participants from a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial. Patients randomized to either an amlodipine±perindopril-based or an atenolol±bendroflumethiazide-based regimen underwent conventional and tissue Doppler echocardiography at time of control of blood pressure after randomization (≈1.5 years; phase 1) and after a further 2 years of antihypertensive treatment (phase 2). There were no prerandomization data. Five hundred thirty-six patients had complete data collection at both phases. Left ventricular mass index regressed from phase 1 to 2 with no significant difference between treatment groups (amlodipine: 119.5-116.8; atenolol: 122.9-117.5; P{\textless}0.001 for both). Conversely, tissue Doppler diastolic indices did not change in the amlodipine±perindopril-based regimen (E/e', 7.5-7.6 cm/s; P=not significant), but deteriorated in the atenolol±bendroflumethiazide-based regimen (E/e', 8.0-8.5 cm/s; P{\textless}0.01). Despite regression of left ventricular hypertrophy, there was no associated improvement in diastolic function. In fact, long-term treatment with atenolol±bendroflumethiazide resulted in a progressive deterioration in E/e'. This may be a factor contributing to the previously described worse clinical outcome in patients treated with atenolol±bendroflumethiazide compared with amlodipine±perindopril.",
author = "Barron, Anthony J. and Hughes, Alun D. and Sharp, Andrew and Baksi, Arun J. and Surendran, Praveen and Jabbour, Richard J. and Stanton, Alice and Poulter, Neil and Fitzgerald, Des and Sever, Peter and O'Brien, Eoin and Thom, Simon and Mayet, Jamil and {ASCOT Investigators}",
doi = "10.1161/HYPERTENSIONAHA.113.01360",
issn = "1524-4563",
journal = "Hypertension",
keywords = ",Adult,Aged,Amlodipine,Amlodipine: administration {\&} dosage,Antihypertensive Agents,Antihypertensive Agents: administration {\&} dosage,Atenolol,Atenolol: administration {\&} dosage,Bendroflumethiazide,Bendroflumethiazide: administration {\&} dosage,Combination,Doppler,Drug Therapy,Echocardiography,European Continental Ancestry Group,Female,Humans,Hypertrophy,Left,Left Ventricular,Left Ventricular: prevention {\&} contro,Left Ventricular: ultrasonography,Left: drug effects,Male,Middle Aged,Perindopril,Perindopril: administration {\&} dosage,Time,Treatment Failure,Ventricular Function,calcium-channel blockers,echocardiography,hypertension,hypertrophy,left ventricular",
month = "feb",
number = 2,
pages = "252--8",
pmid = 24218432,
title = "{Long-term antihypertensive treatment fails to improve E/e' despite regression of left ventricular mass: an Anglo-Scandinavian cardiac outcomes trial substudy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24218432 http://hyper.ahajournals.org/cgi/doi/10.1161/HYPERTENSIONAHA.113.01360",
volume = 63,
year = 2014
}
Anne Marie Valente, Kimberlee Gauvreau, Gabriele Egidy Assenza, Sonya V Babu-Narayan, Jenna Schreier, Michael A Gatzoulis, Maarten Groenink, Ryo Inuzuka, Philip J Kilner, Zeliha Koyak, Michael J Landzberg, Barbara Mulder, Andrew J Powell, Rachel Wald and Tal Geva.
Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort..
Heart (British Cardiac Society) 100(3):247–53, February 2014.
URL, DOI BibTeX
@article{Valente2014,
abstract = "OBJECTIVE: Patients with repaired tetralogy of Fallot (TOF) experience increased rates of mortality and morbidity in adulthood. This study was designed to identify risk factors for death and ventricular tachycardia (VT) in a large contemporary cohort of patients with repaired TOF. METHODS: Subjects with repaired TOF from four large congenital heart centres in the USA, Canada and Europe were enrolled. Clinical, ECG, exercise, cardiac magnetic resonance (CMR) and outcome data were analysed. RESULTS: Of the 873 patients (median age 24.4 years), 32 (3.7{\%}) reached the primary outcome (28 deaths, 4 sustained VT; median age at outcome 38 years; median time from CMR to outcome 1.9 years). Cox proportional-hazards regression identified RV mass-to-volume ratio ≥ 0.3 g/mL (HR, 5.04; 95{\%} CI 2.3 to 11.0; p{\textless}0.001), LV EF z score{\textless}-2.0 (HR, 3.34; 95{\%} CI 1.59 to 7.01; p=0.001), and history of atrial tachyarrhythmia (HR, 3.65; 95{\%} CI 1.75 to 7.62; p=0.001) as outcome predictors. RV dysfunction was predictive of the outcome similar to LV dysfunction. In subgroup analysis of 315 subjects with echocardiographic assessment of RV systolic pressure, higher pressure (HR 1.39; 95{\%} CI 1.19 to 1.62; p{\textless}0.001) was associated with death and sustained VT independent of RV hypertrophy and LV dysfunction. CONCLUSIONS: RV hypertrophy, ventricular dysfunction and atrial tachyarrhythmias are predictive of death and sustained VT in adults with repaired TOF. These findings may inform risk stratification and the design of future therapeutic trials.",
author = "Valente, Anne Marie and Gauvreau, Kimberlee and Assenza, Gabriele Egidy and Babu-Narayan, Sonya V and Schreier, Jenna and Gatzoulis, Michael A and Groenink, Maarten and Inuzuka, Ryo and Kilner, Philip J and Koyak, Zeliha and Landzberg, Michael J and Mulder, Barbara and Powell, Andrew J and Wald, Rachel and Geva, Tal",
doi = "10.1136/heartjnl-2013-304958",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Valente et al. - 2014 - Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fa.pdf:pdf",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = ",Adolescent,Adult,Aged,Canada,Child,Cohort Studies,Congenital Heart Disease,Electrocardiography,Europe,Exercise Test,Humans,Infant,Magnetic Resonance Imaging,Middle Aged,Predictive Value of Tests,Preschool,Prognosis,Registries,Risk Factors,Tachycardia,Tetralogy of Fallot,Tetralogy of Fallot: complications,Tetralogy of Fallot: mortality,Tetralogy of Fallot: surgery,United States,Ventricular,Ventricular: diagnosis,Ventricular: epidemiology,Young Adult",
month = "feb",
number = 3,
pages = "247--53",
pmid = 24179163,
title = "{Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24179163 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3913216 http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2013-304958 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3913216{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 100,
year = 2014
}
Tina Z Khan, Alison Pottle, Dudley J Pennell and Mahmoud S Barbir.
The expanding role of lipoprotein apheresis in the treatment of raised lipoprotein(a) in ischaemic heart disease and refractory angina..
Global cardiology science & practice 2014(1):3–12, January 2014.
URL, DOI BibTeX
@article{Khan2014,
abstract = "It is increasingly recognised that lipoprotein(a) [Lp(a)], an inherited, genetically-determined form of LDL-cholesterol, is an independent cardiovascular risk factor and predictor of adverse cardiovascular outcomes. Lp(a) is felt to increase cardiovascular risk via its pro-thrombotic effect and by enhancing intimal lipoprotein deposition. Lipoprotein apheresis is currently the most effective treatment for raised Lp(a). There is a growing body of evidence suggesting that aggressively lowering raised Lp(a) may improve cardiovascular and clinical outcomes, although much more research is required in this field. Angina which is refractory to conventional medical therapy and revascularisation, is extremely challenging to manage. Treatment options for such patients remain very limited. We describe the case of a patient with refractory angina and raised lipoprotein(a) in whom aggressive reduction of Lp(a) with lipoprotein apheresis successfully ameliorated the progression of coronary stenosis and provided effective and durable relief of angina symptoms. In our centre, we are currently conducting a prospective, randomised controlled cross-over study of patients with refractory angina and raised Lp(a), randomised to undergoing lipoprotein apheresis or 'sham' apheresis with assessment of myocardial perfusion, carotid atherosclerosis, endothelial vascular function, thrombogenesis, oxidised phospholipids and their antibodies, exercise capacity, angina symptoms and quality of life at the beginning and end of treatment.",
author = "Khan, Tina Z and Pottle, Alison and Pennell, Dudley J and Barbir, Mahmoud S",
doi = "10.5339/gcsp.2014.3",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Khan et al. - 2014 - The expanding role of lipoprotein apheresis in the treatment of raised lipoprotein(a) in ischaemic heart disease an.pdf:pdf",
issn = "2305-7823",
journal = "Global cardiology science {\&} practice",
keywords = ",Ischaemic heart disease,Lipoprotein Apheresis,Lipoprotein(a),Refractory angina",
month = "jan",
number = 1,
pages = "3--12",
pmid = 25054114,
title = "{The expanding role of lipoprotein apheresis in the treatment of raised lipoprotein(a) in ischaemic heart disease and refractory angina.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4104372{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/25054114 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4104372 http://www.qscience.com/doi/abs/10.5339/gcsp.2014.3",
volume = 2014,
year = 2014
}
David P Ripley, Ansuman Saha, Albert Teis, Akhlaque Uddin, Petra Bijsterveld, Ananth Kidambi, Adam K McDiarmid, Mohan Sivananthan, Sven Plein, Dudley J Pennell and John P Greenwood.
The distribution and prognosis of anomalous coronary arteries identified by cardiovascular magnetic resonance: 15 year experience from two tertiary centres..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):34, January 2014.
URL, DOI BibTeX
@article{Ripley2014,
abstract = "BACKGROUND: Aberrant coronary arteries represent a diverse group of congenital disorders. Post-mortem studies reveal a high risk of exercise-related sudden cardiac death in those with an anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS) with an inter-arterial course. There is little documentation of lifetime history and long-term follow-up of patients with coronary artery anomalies. METHODS: Patients with anomalous coronary arteries undergoing cardiovascular magnetic resonance over a 15-year period were identified and classified by anatomy and course. Medical records were reviewed for major adverse cardiovascular events (MACE). Revascularisation or myocardial infarction counted only if occurring in the distribution of the anomalous artery. RESULTS: Consecutive patients with coronary artery anomalies were retrospectively identified (n = 172). Median follow-up time was 4.3 years (IQR 2.5-7.8, maximum 15.6). 116 patients had ACAOS of which 64 (55{\%}) had an inter-arterial course (IAC) and 52 (45{\%}) did not. During follow up 110 ACAOS patients were alive, 5 died and 1 lost to follow-up.ACAOS patients experienced 58 MACE events (5 cardiovascular deaths, 5 PCI, 24 CABG and 24 had myocardial infarction). 47 MACE events occurred in ACAOS with IAC and 11 in those without (p {\textless} 0.0001), the statistical difference driven by surgical revascularisation and myocardial infarction. CONCLUSIONS: In life, patients with an anomalous coronary artery originating from the opposite sinus of Valsalva taking an IAC have higher rates of both myocardial infarction and surgical revascularisation during long-term follow up, compared to those without IAC.",
author = "Ripley, David P and Saha, Ansuman and Teis, Albert and Uddin, Akhlaque and Bijsterveld, Petra and Kidambi, Ananth and McDiarmid, Adam K and Sivananthan, Mohan and Plein, Sven and Pennell, Dudley J and Greenwood, John P",
doi = "10.1186/1532-429X-16-34",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ripley et al. - 2014 - The distribution and prognosis of anomalous coronary arteries identified by cardiovascular magnetic resonance 15.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",80 and over,Adolescent,Adult,Aged,Child,Coronary Artery Bypass,Coronary Vessel Anomalies,Coronary Vessel Anomalies: complications,Coronary Vessel Anomalies: diagnosis,Coronary Vessel Anomalies: mortality,Coronary Vessel Anomalies: pathology,Coronary Vessel Anomalies: therapy,Coronary Vessels,Coronary Vessels: pathology,England,Humans,Infant,Kaplan-Meier Estimate,Magnetic Resonance Imaging,Middle Aged,Myocardial Infarction,Myocardial Infarction: etiology,Myocardial Infarction: mortality,Myocardial Infarction: therapy,Percutaneous Coronary Intervention,Predictive Value of Tests,Preschool,Prognosis,Retrospective Studies,Risk Assessment,Risk Factors,Sinus of Valsalva,Sinus of Valsalva: abnormalities,Tertiary Care Centers,Time Factors,Young Adult",
month = "jan",
number = 1,
pages = 34,
pmid = 24886614,
title = "{The distribution and prognosis of anomalous coronary arteries identified by cardiovascular magnetic resonance: 15 year experience from two tertiary centres.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24886614 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4038832 http://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-16-34 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4038832{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 16,
year = 2014
}
Matthias G Friedrich, Chiara Bucciarelli-Ducci, James A White, Sven Plein, James C Moon, Ana G Almeida, Christopher M Kramer, Stefan Neubauer, Dudley J Pennell, Steffen E Petersen, Raymond Y Kwong, Victor A Ferrari, Jeanette Schulz-Menger, Hajime Sakuma, Erik B Schelbert, Éric Larose, Ingo Eitel, Iacopo Carbone, Andrew J Taylor, Alistair Young, Albert Roos and Eike Nagel.
Simplifying cardiovascular magnetic resonance pulse sequence terminology..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):3960, January 2014.
URL, DOI BibTeX
@article{Friedrich2014,
abstract = "We propose a set of simplified terms to describe applied Cardiovascular Magnetic Resonance (CMR) pulse sequence techniques in clinical reports, scientific articles and societal guidelines or recommendations. Rather than using various technical details in clinical reports, the description of the technical approach should be based on the purpose of the pulse sequence. In scientific papers or other technical work, this should be followed by a more detailed description of the pulse sequence and settings. The use of a unified set of widely understood terms would facilitate the communication between referring physicians and CMR readers by increasing the clarity of CMR reports and thus improve overall patient care. Applied in research articles, its use would facilitate non-expert readers' understanding of the methodology used and its clinical meaning.",
author = "Friedrich, Matthias G and Bucciarelli-Ducci, Chiara and White, James A and Plein, Sven and Moon, James C and Almeida, Ana G and Kramer, Christopher M and Neubauer, Stefan and Pennell, Dudley J and Petersen, Steffen E and Kwong, Raymond Y and Ferrari, Victor A and Schulz-Menger, Jeanette and Sakuma, Hajime and Schelbert, Erik B and Larose, {\'{E}}ric and Eitel, Ingo and Carbone, Iacopo and Taylor, Andrew J and Young, Alistair and de Roos, Albert and Nagel, Eike",
doi = "10.1186/s12968-014-0103-z",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Friedrich et al. - 2014 - Simplifying cardiovascular magnetic resonance pulse sequence terminology.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
month = "jan",
number = 1,
pages = 3960,
pmid = 25551695,
title = "{Simplifying cardiovascular magnetic resonance pulse sequence terminology.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25551695 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4280685 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-014-0103-z http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4280685{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 16,
year = 2014
}
Dudley John Pennell, Arun John Baksi, Philip John Kilner, Raad Hashem Mohiaddin, Sanjay Kumar Prasad, Francisco Alpendurada, Sonya Vidya Babu-Narayan, Stefan Neubauer and David Nigel Firmin.
Review of Journal of Cardiovascular Magnetic Resonance 2013..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):100, January 2014.
URL, DOI BibTeX
@article{Pennell2014a,
abstract = "There were 109 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2013, which is a 21{\%} increase on the 90 articles published in 2012. The quality of the submissions continues to increase. The editors are delighted to report that the 2012 JCMR Impact Factor (which is published in June 2013) has risen to 5.11, up from 4.44 for 2011 (as published in June 2012), a 15{\%} increase and taking us through the 5 threshold for the first time. The 2012 impact factor means that the JCMR papers that were published in 2010 and 2011 were cited on average 5.11 times in 2012. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is {\textless}25{\%} and has been falling because the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR for publication.",
author = "Pennell, Dudley John and Baksi, Arun John and Kilner, Philip John and Mohiaddin, Raad Hashem and Prasad, Sanjay Kumar and Alpendurada, Francisco and Babu-Narayan, Sonya Vidya and Neubauer, Stefan and Firmin, David Nigel",
doi = "10.1186/s12968-014-0100-2",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2014 - Review of Journal of Cardiovascular Magnetic Resonance 2013.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Animals,Bibliometrics,Biomedical Research,Biomedical Research: statistics {\&} numerical data,Cardiology,Cardiology: statistics {\&} numerical data,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: pathology,Cardiovascular Diseases: physiopathology,Editorial Policies,Humans,Journal Impact Factor,Magnetic Resonance Imaging,Magnetic Resonance Imaging: statistics {\&} numerical,Periodicals as Topic,Periodicals as Topic: statistics {\&} numerical data,Predictive Value of Tests,Prognosis",
month = "jan",
number = 1,
pages = 100,
pmid = 25475898,
title = "{Review of Journal of Cardiovascular Magnetic Resonance 2013.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4256918{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/25475898 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4256918 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-014-0100-2",
volume = 16,
year = 2014
}
John A Baksi and Dudley J Pennell.
Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major..
Frontiers in pharmacology 5:217, January 2014.
URL, DOI BibTeX
@article{Baksi2014,
abstract = "In conditions requiring repeated blood transfusion or where iron metabolism is abnormal, heart failure may result from accumulation of iron in the heart (cardiac siderosis). Death due to heart failure from cardiac iron overload has accounted for considerable early mortality in $\beta$-thalassemia major. The ability to detect iron loading in the heart by cardiovascular magnetic resonance using T2* sequences has created an opportunity to intervene in the natural history of such conditions. However, effective and well tolerated therapy is required to remove iron from the heart. There are currently three approved commercially available iron chelators: deferoxamine, deferiprone and deferasirox. We review the high quality randomized controlled trials in this area for iron chelation therapy in the management of cardiac siderosis.",
author = "Baksi, A. John and Pennell, Dudley J.",
doi = "10.3389/fphar.2014.00217",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Baksi, Pennell - 2014 - Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major.pdf:pdf",
issn = "1663-9812",
journal = "Frontiers in pharmacology",
keywords = ",T2* imaging,cardiac siderosis,chelation trials,iron,thalassaemia",
month = "jan",
pages = 217,
pmid = 25295007,
title = "{Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4172003{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/25295007 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4172003 http://journal.frontiersin.org/article/10.3389/fphar.2014.00217/abstract",
volume = 5,
year = 2014
}
Craig S Broberg, Sanjay K Prasad, Chad Carr, Sonya V Babu-Narayan, Konstantinos Dimopoulos and Michael A Gatzoulis.
Myocardial fibrosis in Eisenmenger syndrome: a descriptive cohort study exploring associations of late gadolinium enhancement with clinical status and survival..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):32, January 2014.
URL, DOI BibTeX
@article{Broberg2014,
abstract = "BACKGROUND: A relationship between myocardial fibrosis and ventricular dysfunction has been demonstrated using late gadolinium enhancement (LGE) in the pressure-loaded right ventricle from congenital heart defects. In patients with Eisenmenger syndrome (ES), the presence of LGE has not been investigated. The aims of this study were to detect any myocardial fibrosis in ES and describe major clinical variables associated with the finding. METHODS: From 45 subjects screened, 30 subjects (age 43 ± 13 years, 20 female) underwent prospective cardiovascular magnetic resonance with LGE to quantify biventricular volume and function as well as maximal and submaximal exercise during a single visit. Standard cine acquisitions were obtained for ventricular volume and function. Further imaging was performed after administration of 0.1 mmol/kg gadolinium contrast. Regions of LGE were evaluated qualitatively and quantitatively by manual contouring of identified areas, with total area expressed as a percentage of mass. Patients were followed prospectively (mean follow up 7.4 ± 0.4 years) and any deaths recorded. Patients with LGE findings were compared to those without. RESULTS: LGE was present in 22/30 (73{\%}) patients, specifically in RV myocardium (70{\%}), RV trabeculae (60{\%}), LV myocardium (33{\%}) or LV papillary muscles (30{\%}), though in small amounts (mean 1.4{\%} of total ventricular mass, range 0.16 - 6.0{\%}). Those with any LGE were not different in age, history of arrhythmia, desaturation, nor hemoglobin, nor ventricular size, mass, or function. Exercise capacity was low, but also not different between those with and without LGE. Similarly no significant associations were found with amount of fibrosis. There were five deaths among patients with LGE, versus two in patients without, but no difference in survival (log rank =0.03, P = 0.85). CONCLUSIONS: Myocardial fibrosis by LGE is common in ES, though not extensive. The presence and quantity of LGE did not correlate with ventricular size, function, degree of cyanosis, exercise capacity, or survival in this pilot study. More data are clearly required before recommendations for routine use of LGE in these patients can be made.",
author = "Broberg, Craig S and Prasad, Sanjay K and Carr, Chad and Babu-Narayan, Sonya V and Dimopoulos, Konstantinos and Gatzoulis, Michael A",
doi = "10.1186/1532-429X-16-32",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Broberg et al. - 2014 - Myocardial fibrosis in Eisenmenger syndrome a descriptive cohort study exploring associations of late gadolinium.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Adult,Cine,Contrast Media,Contrast Media: diagnostic use,Eisenmenger Complex,Eisenmenger Complex: complications,Eisenmenger Complex: diagnosis,Eisenmenger Complex: mortality,Eisenmenger Complex: pathology,Eisenmenger Complex: physiopathology,Exercise Test,Exercise Tolerance,Female,Fibrosis,Humans,Kaplan-Meier Estimate,Left,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,Pilot Projects,Predictive Value of Tests,Prognosis,Prospective Studies,Right,Risk Factors,Time Factors,Ventricular Function",
month = "jan",
number = 1,
pages = 32,
pmid = 24886403,
title = "{Myocardial fibrosis in Eisenmenger syndrome: a descriptive cohort study exploring associations of late gadolinium enhancement with clinical status and survival.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4051886{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/24886403 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4051886 http://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-16-32",
volume = 16,
year = 2014
}
Michael J House, Adam J Fleming, Martin D Jonge, David Paterson, Daryl L Howard, John-Paul Carpenter, Dudley J Pennell and Tim G St Pierre.
Mapping iron in human heart tissue with synchrotron x-ray fluorescence microscopy and cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):80, January 2014.
URL, DOI BibTeX
@article{House2014,
abstract = "BACKGROUND: MRI assessment of cardiac iron is particularly important for assessing transfusion-dependent anaemia patients. However, comparing the iron distribution from histology or bulk samples to MRI is not ideal. Non-destructive, high-resolution imaging of post-mortem samples offers the ability to examine iron distributions across large samples at resolutions closer to those used in MRI. The aim of this ex vivo case study was to compare synchrotron X-ray fluorescence microscopy (XFM) elemental iron maps with magnetic resonance transverse relaxation rate maps of cardiac tissue samples from an iron-loaded patient. METHODS: Two 5 mm thick slices of formalin fixed cardiac tissue from a Diamond Blackfan anaemia patient were imaged in a 1.5 T MR scanner. R2 and R2* transverse relaxation rate maps were generated for both slices using RF pulse recalled spin echo and gradient echo acquisition sequences. The tissue samples were then imaged at the Australian Synchrotron on the X-ray Fluorescence Microscopy beamline using a focussed incident X-ray beam of 18.74 keV and the Maia 384 detector. The event data were analyzed to produce elemental iron maps (uncalibrated) at 25 to 60 microns image resolution. RESULTS: The R2 and R2* maps and profiles for both samples showed very similar macro-scale spatial patterns compared to the XFM iron distribution. Iron appeared to preferentially load into the lateral epicardium wall and there was a strong gradient of decreasing iron, R2 and R2* from the epicardium to the endocardium in the lateral wall of the left ventricle and to a lesser extent in the septum. On co-registered images XFM iron was more strongly correlated to R2* (r = 0.86) than R2 (r = 0.79). There was a strong linear relationship between R2* and R2 (r = 0.87). CONCLUSIONS: The close qualitative and quantitative agreement between the synchrotron XFM iron maps and MR relaxometry maps indicates that iron is a significant determinant of R2 and R2* in these ex vivo samples. The R2 and R2* maps of human heart tissue give information on the spatial distribution of tissue iron deposits.",
author = "House, Michael J and Fleming, Adam J and de Jonge, Martin D and Paterson, David and Howard, Daryl L and Carpenter, John-Paul and Pennell, Dudley J and {St Pierre}, Tim G",
doi = "10.1186/s12968-014-0080-2",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/House et al. - 2014 - Mapping iron in human heart tissue with synchrotron x-ray fluorescence microscopy and cardiovascular magnetic reso.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
month = "jan",
number = 1,
pages = 80,
pmid = 25270330,
title = "{Mapping iron in human heart tissue with synchrotron x-ray fluorescence microscopy and cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/25270330 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4177424 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-014-0080-2 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4177424{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 16,
year = 2014
}
Alicia M Maceira, Carmen Ripoll, Juan Cosin-Sales, Begoña Igual, Mirella Gavilan, Jose Salazar, Vicente Belloch and Dudley J Pennell.
Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):26, January 2014.
URL, DOI BibTeX
@article{Maceira2014,
abstract = "BACKGROUND: Cocaine is an addictive, sympathomimetic drug with potentially lethal effects. The prevalence and features of cocaine cardiotoxicity are not well known. We aimed to assess these effects using a comprehensive cardiovascular magnetic resonance (CMR) protocol in a large group of asymptomatic cocaine users. METHODS: Consecutive (n = 94, 81 males, 36.6 ±7 years), non-selected, cocaine abusers were recruited and had a medical history, examination, ECG, blood test and CMR. The CMR study included measurement of left and right ventricular (LV, RV) dimensions and ejection fraction (EF), sequences for detection of myocardial oedema and late gadolinium enhancement (LGE). Images were compared to a cohort of healthy controls. RESULTS: Years of regular cocaine use were 13.9 ± 9. When compared to the age-matched healthy cohort, the cocaine abusers had increased LV end-systolic volume, LV mass index and RV end-systolic volume, with decreased LVEF and RVEF. No subject had myocardial oedema, but 30{\%} had myocardial LGE indicating myocardial damage. CONCLUSIONS: CMR detected cardiovascular disease in 71{\%} of this cohort of consecutive asymptomatic cocaine abusers and mean duration of abuse was related to probability of LV systolic dysfunction.",
author = "Maceira, Alicia M and Ripoll, Carmen and Cosin-Sales, Juan and Igual, Bego{\~{n}}a and Gavilan, Mirella and Salazar, Jose and Belloch, Vicente and Pennell, Dudley J",
doi = "10.1186/1532-429X-16-26",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Maceira et al. - 2014 - Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Adult,Asymptomatic Diseases,Cardiac,Cardiac: diagnosis,Cardiac: etiology,Cardiac: pathology,Case-Control Studies,Cine,Cocaine-Related Disorders,Cocaine-Related Disorders: complications,Contrast Media,Contrast Media: diagnostic use,Edema,Electrocardiography,Female,Fibrosis,Humans,Left,Left: diagnosis,Left: etiology,Left: pathology,Left: physiopathology,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,Predictive Value of Tests,Prospective Studies,Right,Right: diagnosis,Right: etiology,Right: pathology,Right: physiopathology,Risk Factors,Stroke Volume,Time Factors,Ventricular Dysfunction,Ventricular Function,Young Adult",
month = "jan",
number = 1,
pages = 26,
pmid = 24758161,
title = "{Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24758161 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4026110 http://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-16-26 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4026110{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 16,
year = 2014
}
Elizabeth M Tunnicliffe, Andrew D Scott, Pedro Ferreira, Rina Ariga, Laura-Ann McGill, Sonia Nielles-Vallespin, Stefan Neubauer, Dudley J Pennell, Matthew D Robson and David N Firmin.
Intercentre reproducibility of cardiac apparent diffusion coefficient and fractional anisotropy in healthy volunteers..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):31, January 2014.
URL, DOI BibTeX
@article{Tunnicliffe2014,
abstract = "BACKGROUND: Diffusion tensor cardiac magnetic resonance (DT-CMR) enables probing of the microarchitecture of the myocardium, but the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) reported in healthy volunteers have been inconsistent. The aim of this study was to validate a stimulated-echo diffusion sequence using phantoms, and to assess the intercentre reproducibility of in-vivo diffusion measures using the sequence. METHODS AND RESULTS: A stimulated-echo, cardiac-gated DT-CMR sequence with a reduced-field-of-view, single-shot EPI readout was used at two centres with 3 T MRI scanners. Four alkane phantoms with known diffusivities were scanned at a single centre using a stimulated echo sequence and a spin-echo Stejskal-Tanner diffusion sequence. The median (maximum, minimum) difference between the DT-CMR sequence and Stejskal-Tanner sequence was 0.01 (0.04, 0.0006) × 10(-3) mm2/s (2{\%}), and between the DT-CMR sequence and literature diffusivities was 0.02 (0.05, 0.006) × 10(-3) mm2/s (4{\%}).The same ten healthy volunteers were scanned using the DT-CMR sequence at the two centres less than seven days apart. Average ADC and FA were calculated in a single mid-ventricular, short axis slice. Intercentre differences were tested for statistical significance at the p {\textless} 0.05 level using paired t-tests. The mean ADC ± standard deviation for all subjects averaged over both centres was 1.10 ± 0.06 × 10(-3) mm2/s in systole and 1.20 ± 0.09 × 10-3 mm2/s in diastole; FA was 0.41 ± 0.04 in systole and 0.54 ± 0.03 in diastole. With similarly-drawn regions-of-interest, systolic ADC (difference 0.05 × 10(-3) mm2/s), systolic FA (difference 0.003) and diastolic FA (difference 0.01) were not statistically significantly different between centres (p {\textgreater} 0.05), and only the diastolic ADC showed a statistically significant, but numerically small, difference of 0.07 × 10(-3) mm2/s (p = 0.047). The intercentre, intrasubject coefficients of variance were: systolic ADC 7{\%}, FA 6{\%}; diastolic ADC 7{\%}, FA 3{\%}. CONCLUSIONS: This is the first study to demonstrate the accuracy of a stimulated-echo DT-CMR sequence in phantoms, and demonstrates the feasibility of obtaining reproducible ADC and FA in healthy volunteers at separate centres with well-matched sequences and processing.",
author = "Tunnicliffe, Elizabeth M and Scott, Andrew D and Ferreira, Pedro and Ariga, Rina and McGill, Laura-Ann and Nielles-Vallespin, Sonia and Neubauer, Stefan and Pennell, Dudley J and Robson, Matthew D and Firmin, David N",
doi = "10.1186/1532-429X-16-31",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Tunnicliffe et al. - 2014 - Intercentre reproducibility of cardiac apparent diffusion coefficient and fractional anisotropy in healthy v.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Adult,Anisotropy,Computer-Assisted,Diffusion Magnetic Resonance Imaging,Diffusion Magnetic Resonance Imaging: instrumentat,England,Feasibility Studies,Female,Healthy Volunteers,Heart,Heart: anatomy {\&} histology,Humans,Image Interpretation,Imaging,Male,Middle Aged,Observer Variation,Phantoms,Predictive Value of Tests,Reproducibility of Results,Young Adult",
month = "jan",
number = 1,
pages = 31,
pmid = 24886285,
title = "{Intercentre reproducibility of cardiac apparent diffusion coefficient and fractional anisotropy in healthy volunteers.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4028111{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/24886285 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4028111 http://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-16-31",
volume = 16,
year = 2014
}
Pedro F Ferreira, Philip J Kilner, Laura-Ann McGill, Sonia Nielles-Vallespin, Andrew D Scott, Siew Y Ho, Karen P McCarthy, Margarita M Haba, Tevfik F Ismail, Peter D Gatehouse, Ranil Silva, Alexander R Lyon, Sanjay K Prasad, David N Firmin and Dudley J Pennell.
In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):87, January 2014.
URL, DOI BibTeX
@article{Ferreira2014,
abstract = "{BACKGROUND: Cardiac diffusion tensor imaging (cDTI) measures the magnitudes and directions of intramyocardial water diffusion. Assuming the cross-myocyte components to be constrained by the laminar microstructures of myocardium, we hypothesized that cDTI at two cardiac phases might identify any abnormalities of laminar orientation and mobility in hypertrophic cardiomyopathy (HCM). METHODS: We performed cDTI in vivo at 3 Tesla at end-systole and late diastole in 11 healthy controls and 11 patients with HCM, as well as late gadolinium enhancement (LGE) for detection of regional fibrosis. RESULTS: Voxel-wise analysis of diffusion tensors relative to left ventricular coordinates showed expected transmural changes of myocardial helix-angle, with no significant differences between phases or between HCM and control groups. In controls, the angle of the second eigenvector of diffusion (E2A) relative to the local wall tangent plane was larger in systole than diastole, in accord with previously reported changes of laminar orientation. HCM hearts showed higher than normal global E2A in systole (63.9° vs 56.4° controls",
p = "",
author = "Ferreira, Pedro F and Kilner, Philip J and McGill, Laura-Ann and Nielles-Vallespin, Sonia and Scott, Andrew D and Ho, Siew Y and McCarthy, Karen P and Haba, Margarita M and Ismail, Tevfik F and Gatehouse, Peter D and de Silva, Ranil and Lyon, Alexander R and Prasad, Sanjay K and Firmin, David N and Pennell, Dudley J",
doi = "10.1186/s12968-014-0087-8",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ferreira et al. - 2014 - In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial lamina.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Aged,Cardiomyopathy,Case-Control Studies,Cine,Computer-Assisted,Diffusion Magnetic Resonance Imaging,Diffusion Tensor Imaging,Female,Fibrosis,Humans,Hypertrophic,Hypertrophic: diagnosis,Hypertrophic: pathology,Hypertrophic: physiopathology,Image Interpretation,Left,Magnetic Resonance Imaging,Male,Middle Aged,Myocardial Contraction,Myocardium,Myocardium: pathology,Predictive Value of Tests,Ventricular Function",
month = "jan",
number = 1,
pages = 87,
pmid = 25388867,
title = "{In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4229618{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/25388867 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4229618 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-014-0087-8",
volume = 16,
year = 2014
}
Tevfik F Ismail, Li-Yueh Hsu, Anders M Greve, Carla Gonçalves, Andrew Jabbour, Ankur Gulati, Benjamin Hewins, Niraj Mistry, Ricardo Wage, Michael Roughton, Pedro F Ferreira, Peter Gatehouse, David Firmin, Rory O'Hanlon, Dudley J Pennell, Sanjay K Prasad, Andrew E Arai, Rory O'Hanlon, Dudley J Pennell, Sanjay K Prasad and Andrew E Arai.
Coronary microvascular ischemia in hypertrophic cardiomyopathy - a pixel-wise quantitative cardiovascular magnetic resonance perfusion study..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):49, January 2014.
URL, DOI BibTeX
@article{Ismail2014,
abstract = "{BACKGROUND: Microvascular dysfunction in HCM has been associated with adverse clinical outcomes. Advances in quantitative cardiovascular magnetic resonance (CMR) perfusion imaging now allow myocardial blood flow to be quantified at the pixel level. We applied these techniques to investigate the spectrum of microvascular dysfunction in hypertrophic cardiomyopathy (HCM) and to explore its relationship with fibrosis and wall thickness. METHODS: CMR perfusion imaging was undertaken during adenosine-induced hyperemia and again at rest in 35 patients together with late gadolinium enhancement (LGE) imaging. Myocardial blood flow (MBF) was quantified on a pixel-by-pixel basis from CMR perfusion images using a Fermi-constrained deconvolution algorithm. Regions-of-interest (ROI) in hypoperfused and hyperemic myocardium were identified from the MBF pixel maps. The myocardium was also divided into 16 AHA segments. RESULTS: Resting MBF was significantly higher in the endocardium than in the epicardium (mean ± SD: 1.25 ± 0.35 ml/g/min versus 1.20 ± 0.35 ml/g/min, P{\textless}0.001), a pattern that reversed with stress (2.00 ± 0.76 ml/g/min versus 2.36 ± 0.83 ml/g/min, P{\textless}0.001). ROI analysis revealed 11 (31{\%}) patients with stress MBF lower than resting values (1.05 ± 0.39 ml/g/min versus 1.22 ± 0.36 ml/g/min",
p = "",
author = "Ismail, Tevfik F and Hsu, Li-Yueh and Greve, Anders M and Gon{\c{c}}alves, Carla and Jabbour, Andrew and Gulati, Ankur and Hewins, Benjamin and Mistry, Niraj and Wage, Ricardo and Roughton, Michael and Ferreira, Pedro F and Gatehouse, Peter and Firmin, David and O'Hanlon, Rory and Pennell, Dudley J and Prasad, Sanjay K and Arai, Andrew E and O'Hanlon, Rory and Pennell, Dudley J and Prasad, Sanjay K and Arai, Andrew E",
doi = "10.1186/s12968-014-0049-1",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ismail et al. - 2014 - Coronary microvascular ischemia in hypertrophic cardiomyopathy - a pixel-wise quantitative cardiovascular magneti.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Adult,Aged,Algorithms,Cardiomyopathy,Computer-Assisted,Contrast Media,Contrast Media: diagnostic use,Coronary Circulation,Coronary Vessels,Coronary Vessels: physiopathology,Female,Fibrosis,Humans,Hyperemia,Hyperemia: physiopathology,Hypertrophic,Hypertrophic: diagnosis,Hypertrophic: pathology,Hypertrophic: physiopathology,Image Interpretation,Magnetic Resonance Imaging,Male,Microcirculation,Microvessels,Microvessels: physiopathology,Middle Aged,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Myocardial Ischemia: pathology,Myocardial Ischemia: physiopathology,Myocardial Perfusion Imaging,Myocardial Perfusion Imaging: methods,Myocardium,Myocardium: pathology,Organometallic Compounds,Organometallic Compounds: diagnostic use,Predictive Value of Tests,Severity of Illness Index,Time Factors,Vasodilator Agents,Vasodilator Agents: diagnostic use",
month = "jan",
number = 1,
pages = 49,
pmid = 25160568,
title = "{Coronary microvascular ischemia in hypertrophic cardiomyopathy - a pixel-wise quantitative cardiovascular magnetic resonance perfusion study.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4145339{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/25160568 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4145339 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-014-0049-1",
volume = 16,
year = 2014
}
Sonya V Babu-Narayan, Gerhard-Paul Diller, Radu R Gheta, Anthony J Bastin, Theodoros Karonis, Wei Li, Dudley J Pennell, Hideki Uemura, Babulal Sethia, Michael A Gatzoulis and Darryl F Shore.
Clinical outcomes of surgical pulmonary valve replacement after repair of tetralogy of Fallot and potential prognostic value of preoperative cardiopulmonary exercise testing..
Circulation 129(1):18–27, January 2014.
URL, DOI BibTeX
@article{Babu-Narayan2014,
abstract = "BACKGROUND: Indications for surgical pulmonary valve replacement (PVR) after repair of tetralogy of Fallot have recently been broadened to include asymptomatic patients. METHODS AND RESULTS: The outcomes of PVR in adults after repair of tetralogy of Fallot at a single tertiary center were retrospectively studied. Preoperative cardiopulmonary exercise testing was included. Mortality was the primary outcome measure. In total, 221 PVRs were performed in 220 patients (130 male patients; median age, 32 years; range, 16-64 years). Homografts were used in 117 patients, xenografts in 103 patients, and a mechanical valve in 1 patient. Early (30-day) mortality was 2{\%}. Overall survival was 97{\%} at 1 year, 96{\%} at 3 years, and 92{\%} at 10 years. Survival after PVR in the later era (2005-2010; n=156) was significantly better compared with survival in the earlier era (1993-2004; n=65; 99{\%} versus 94{\%} at 1 year and 98{\%} versus 92{\%} at 3 years, respectively; P=0.019). Earlier era patients were more symptomatic preoperatively (P=0.036) with a lower preoperative peak oxygen consumption (peak Vo₂; P{\textless}0.001). Freedom from redo surgical or transcatheter PVR was 98{\%} at 5 years and 96{\%} at 10 years for the whole cohort. Peak Vo₂, E/CO2 slope (ratio of minute ventilation to carbon dioxide production), and heart rate reserve during cardiopulmonary exercise testing predicted risk of early mortality when analyzed with logistic regression analysis; peak Vo₂ emerged as the strongest predictor on multivariable analysis (odds ratio, 0.65 per 1 mL{\textperiodcentered}kg⁻¹{\textperiodcentered}min⁻¹; P=0.041). CONCLUSIONS: PVR after repair of tetralogy of Fallot has a low and improving mortality, with a low need for reintervention. Preoperative cardiopulmonary exercise testing predicts surgical outcome and should therefore be included in the routine assessment of these patients.",
author = "Babu-Narayan, Sonya V. and Diller, Gerhard-Paul and Gheta, Radu R. and Bastin, Anthony J. and Karonis, Theodoros and Li, Wei and Pennell, Dudley J. and Uemura, Hideki and Sethia, Babulal and Gatzoulis, Michael A. and Shore, Darryl F.",
doi = "10.1161/CIRCULATIONAHA.113.001485",
issn = "1524-4539",
journal = "Circulation",
keywords = ",Adolescent,Adult,Asymptomatic Diseases,Exercise Test,Female,Heart Valve Prosthesis Implantation,Heart Valve Prosthesis Implantation: mortality,Humans,Male,Middle Aged,Predictive Value of Tests,Preoperative Care,Prognosis,Pulmonary Valve Insufficiency,Pulmonary Valve Insufficiency: diagnosis,Pulmonary Valve Insufficiency: mortality,Pulmonary Valve Insufficiency: surgery,Reoperation,Reoperation: mortality,Retrospective Studies,Tetralogy of Fallot,Tetralogy of Fallot: mortality,Tetralogy of Fallot: surgery,Treatment Outcome,Young Adult,congenital,exercise test,heart defects,surgery,survival,tetralogy of Fallot",
month = "jan",
number = 1,
pages = "18--27",
pmid = 24146254,
title = "{Clinical outcomes of surgical pulmonary valve replacement after repair of tetralogy of Fallot and potential prognostic value of preoperative cardiopulmonary exercise testing.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24146254 http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAHA.113.001485",
volume = 129,
year = 2014
}
John-Paul Carpenter, Taigang He, Paul Kirk, Michael Roughton, Lisa J Anderson, Sofia V Noronha, John A Baksi, Mary N Sheppard, John B Porter, Malcolm J Walker, John C Wood, Gianluca Forni, Gualtiero Catani, Gildo Matta, Suthat Fucharoen, Adam Fleming, Mike House, Greg Black, David N Firmin, Timothy G St. Pierre, Dudley J Pennell, Timothy G St Pierre and Dudley J Pennell.
Calibration of myocardial T2 and T1 against iron concentration..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):62, January 2014.
URL, DOI BibTeX
@article{Carpenter2014,
abstract = "BACKGROUND: The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use. However, there is very limited data assessing the relaxation parameters T1 and T2 for measurement of human myocardial iron. METHODS: Twelve hearts were examined from transfusion-dependent patients: 11 with end-stage heart failure, either following death (n=7) or cardiac transplantation (n=4), and 1 heart from a patient who died from a stroke with no cardiac iron loading. Ex-vivo R1 and R2 measurements (R1=1/T1 and R2=1/T2) at 1.5 Tesla were compared with myocardial iron concentration measured using inductively coupled plasma atomic emission spectroscopy. RESULTS: From a single myocardial slice in formalin which was repeatedly examined, a modest decrease in T2 was observed with time, from mean (± SD) 23.7 ± 0.93 ms at baseline (13 days after death and formalin fixation) to 18.5 ± 1.41 ms at day 566 (p{\textless}0.001). Raw T2 values were therefore adjusted to correct for this fall over time. Myocardial R2 was correlated with iron concentration [Fe] (R2 0.566, p{\textless}0.001), but the correlation was stronger between LnR2 and Ln[Fe] (R2 0.790, p{\textless}0.001). The relation was [Fe] = 5081•(T2)-2.22 between T2 (ms) and myocardial iron (mg/g dry weight). Analysis of T1 proved challenging with a dichotomous distribution of T1, with very short T1 (mean 72.3 ± 25.8 ms) that was independent of iron concentration in all hearts stored in formalin for greater than 12 months. In the remaining hearts stored for {\textless}10 weeks prior to scanning, LnR1 and iron concentration were correlated but with marked scatter (R2 0.517, p{\textless}0.001). A linear relationship was present between T1 and T2 in the hearts stored for a short period (R2 0.657, p{\textless}0.001). CONCLUSION: Myocardial T2 correlates well with myocardial iron concentration, which raises the possibility that T2 may provide additive information to T2* for patients with myocardial siderosis. However, ex-vivo T1 measurements are less reliable due to the severe chemical effects of formalin on T1 shortening, and therefore T1 calibration may only be practical from in-vivo human studies.",
author = "Carpenter, John-Paul and He, Taigang and Kirk, Paul and Roughton, Michael and Anderson, Lisa J and de Noronha, Sofia V and Baksi, A John and Sheppard, Mary N and Porter, John B and Walker, J Malcolm and Wood, John C and Forni, Gianluca and Catani, Gualtiero and Matta, Gildo and Fucharoen, Suthat and Fleming, Adam and House, Mike and Black, Greg and Firmin, David N and {St. Pierre}, Timothy G and Pennell, Dudley J and {St Pierre}, Timothy G and Pennell, Dudley J",
doi = "10.1186/s12968-014-0062-4",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Carpenter et al. - 2014 - Calibration of myocardial T2 and T1 against iron concentration.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Adolescent,Adult,Atomic,Biological Markers,Biological Markers: metabolism,Calibration,Child,Europe,Female,Fixatives,Formaldehyde,Heart Failure,Heart Failure: diagnosis,Heart Failure: metabolism,Heart Failure: mortality,Heart Failure: pathology,Heart Failure: physiopathology,Heart Failure: surgery,Heart Transplantation,Hemosiderosis,Hemosiderosis: diagnosis,Hemosiderosis: metabolism,Hemosiderosis: mortality,Hemosiderosis: pathology,Hemosiderosis: physiopathology,Hemosiderosis: surgery,Humans,Iron,Iron: metabolism,Left,Linear Models,Magnetic Resonance Imaging,Magnetic Resonance Imaging: standards,Male,Middle Aged,Myocardial Contraction,Myocardium,Myocardium: metabolism,Myocardium: pathology,Predictive Value of Tests,Prognosis,Spectrophotometry,Thailand,Time Factors,Tissue Fixation,Tissue Fixation: methods,Ventricular Function,Young Adult",
month = "jan",
number = 1,
pages = 62,
pmid = 25158620,
title = "{Calibration of myocardial T2 and T1 against iron concentration.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4145261{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/25158620 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4145261 http://jcmr-online.biomedcentral.com/articles/10.1186/s12968-014-0062-4",
volume = 16,
year = 2014
}
Maciej W Garbowski, John-Paul Carpenter, Gillian Smith, Michael Roughton, Mohammed H Alam, Taigang He, Dudley J Pennell and John B Porter.
Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16(1):40, January 2014.
URL, DOI BibTeX
@article{Garbowski2014,
abstract = "BACKGROUND: There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload. Since the first demonstration of an inverse relationship between biopsy LIC and liver magnetic resonance (MR) using a proof-of-concept T2* sequence, MR technology has advanced dramatically with a shorter minimum echo-time, closer inter-echo spacing and constant repetition time. These important advances allow more accurate calculation of liver T2* especially in patients with high LIC. METHODS: Here, we used an optimised liver T2* sequence calibrated against 50 liver biopsy samples on 25 patients with transfusional haemosiderosis using ordinary least squares linear regression, and assessed the method reproducibility in 96 scans over an LIC range up to 42 mg/g dry weight (dw) using Bland-Altman plots. Using mixed model linear regression we compared the new T2*-LIC with R2-LIC (Ferriscan) on 92 scans in 54 patients with transfusional haemosiderosis and examined method agreement using Bland-Altman approach. RESULTS: Strong linear correlation between ln(T2*) and ln(LIC) led to the calibration equation LIC = 31.94(T2*)-1.014. This yielded LIC values approximately 2.2 times higher than the proof-of-concept T2* method. Comparing this new T2*-LIC with the R2-LIC (Ferriscan) technique in 92 scans, we observed a close relationship between the two methods for values up to 10 mg/g dw, however the method agreement was poor. CONCLUSIONS: New calibration of T2* against liver biopsy estimates LIC in a reproducible way, correcting the proof-of-concept calibration by 2.2 times. Due to poor agreement, both methods should be used separately to diagnose or rule out liver iron overload in patients with increased ferritin.",
author = "Garbowski, Maciej W and Carpenter, John-Paul and Smith, Gillian and Roughton, Michael and Alam, Mohammed H and He, Taigang and Pennell, Dudley J and Porter, John B",
doi = "10.1186/1532-429X-16-40",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Garbowski et al. - 2014 - Biopsy-based calibration of T2 magnetic resonance for estimation of liver iron concentration and comparison wi.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Algorithms,Benzoates,Benzoates: therapeutic use,Biological Markers,Biological Markers: analysis,Biopsy,Blood Transfusion,Blood Transfusion: adverse effects,Calibration,Computer-Assisted,Hemosiderosis,Hemosiderosis: diagnosis,Hemosiderosis: drug therapy,Hemosiderosis: etiology,Hemosiderosis: metabolism,Hemosiderosis: pathology,Humans,Image Interpretation,Iron,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron: analysis,Least-Squares Analysis,Linear Models,Liver,Liver: chemistry,Liver: drug effects,Liver: pathology,Magnetic Resonance Imaging,Magnetic Resonance Imaging: standards,Observer Variation,Predictive Value of Tests,Reproducibility of Results,Retrospective Studies,Triazoles,Triazoles: therapeutic use",
month = "jan",
number = 1,
pages = 40,
pmid = 24915987,
title = "{Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4064805{\&}tool=pmcentrez{\&}rendertype=abstract http://www.ncbi.nlm.nih.gov/pubmed/24915987 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4064805 http://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-16-40",
volume = 16,
year = 2014
}
Yanqiu Feng, Taigang He, Peter D Gatehouse, Xinzhong Li, Mohammed Harith Alam, Dudley J Pennell, Wufan Chen and David N Firmin.
Improved MRI R2 * relaxometry of iron-loaded liver with noise correction..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 70(6):1765–74, December 2013.
URL, DOI BibTeX
@article{Feng2013,
abstract = {Accurate and reproducible MRI R2 * relaxometry for tissue iron quantification is important in managing transfusion-dependent patients. MRI data are often acquired using array coils and reconstructed by the root-sum-square algorithm, and as such, measured signals follow the noncentral chi distribution. In this study, two noise-corrected models were proposed for the liver R2 * quantification: fitting the signal to the first moment and fitting the squared signal to the second moment in the presence of the noncentral chi noise. These two models were compared with the widely implemented offset and truncation models on both simulation and in vivo data. The results demonstrated that the "slow decay component" of the liver R2 * was mainly caused by the noise. The offset model considerably overestimated R2 * values by incorrectly adding a constant to account for the slow decay component. The truncation model generally produced accurate R2 * measurements by only fitting the initial data well above the noise level to remove the major source of errors, but underestimated very high R2 * values due to the sequence limit of obtaining very short echo time images. Both the first and second-moment noise-corrected models constantly produced accurate and precise R2 * measurements by correctly addressing the noise problem.},
author = "Feng, Yanqiu and He, Taigang and Gatehouse, Peter D and Li, Xinzhong and {Harith Alam}, Mohammed and Pennell, Dudley J and Chen, Wufan and Firmin, David N",
doi = "10.1002/mrm.24607",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = "Adult,Algorithms,Artifacts,Female,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Iron Overload,Iron Overload: complications,Iron Overload: pathology,Liver,Liver: pathology,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Reproducibility of Results,Sensitivity and Specificity,Signal-To-Noise Ratio,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: pathology",
month = "dec",
number = 6,
pages = "1765--74",
pmid = 23359410,
title = "{Improved MRI R2 * relaxometry of iron-loaded liver with noise correction.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23359410",
volume = 70,
year = 2013
}
John A Baksi and Dudley J Pennell.
T1 mapping in heart failure: from technique to prognosis, toward altering outcome..
Circulation. Cardiovascular imaging 6(6):861–3, November 2013.
URL, DOI BibTeX
@article{Baksi2013,
author = "Baksi, A John and Pennell, Dudley J",
doi = "10.1161/CIRCIMAGING.113.001178",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Female,Heart Failure,Heart Failure: physiopathology,Humans,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Stroke Volume,Ventricular Function, Left,Ventricular Function, Left: physiology",
month = "nov",
number = 6,
pages = "861--3",
pmid = 24254477,
title = "{T1 mapping in heart failure: from technique to prognosis, toward altering outcome.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24254477",
volume = 6,
year = 2013
}
Miguel Silva Vieira, Francisco Alpendurada, Sonya Babu-Narayan and Philip Kilner.
Criss-cross heart: twisted anatomy by cardiovascular magnetic resonance..
Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 32(11):947–9, November 2013.
URL, DOI BibTeX
@article{SilvaVieira2013,
author = "{Silva Vieira}, Miguel and Alpendurada, Francisco and Babu-Narayan, Sonya and Kilner, Philip",
doi = "10.1016/j.repc.2013.05.003",
issn = "2174-2030",
journal = "Revista portuguesa de cardiologia : org{\~{a}}o oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology",
month = "nov",
number = 11,
pages = "947--9",
pmid = 24246720,
title = "{Criss-cross heart: twisted anatomy by cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24246720",
volume = 32,
year = 2013
}
Sylvia S M Chen and Philip J Kilner.
Unilateral pulmonary artery branch stenosis: diastolic prolongation of forward flow appears to maintain flow to the affected lung if the pulmonary valve is competent..
International journal of cardiology 168(4):3698–703, October 2013.
URL, DOI BibTeX
@article{Chen2013,
abstract = "{BACKGROUND: We sought to improve understanding of the diastolic prolongation of forward flow seen through a unilateral branch pulmonary artery (PA) stenosis. METHODS AND RESULTS: Of patients studied by cardiovascular magnetic resonance (CMR) for congenital heart disease, we reviewed right and left PA flow to find 10 cases with a diastolic prolongation of flow in a stenosed branch PA. They were aged 20 years (median",
range = "",
p = "",
author = "Chen, Sylvia S M and Kilner, Philip J",
doi = "10.1016/j.ijcard.2013.06.019",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adolescent,Adult,Blood Flow Velocity,Blood Flow Velocity: physiology,Cross-Sectional Studies,Diastole,Diastole: physiology,Female,Humans,Lung,Lung: blood supply,Male,Pulmonary Artery,Pulmonary Artery: pathology,Pulmonary Artery: physiopathology,Pulmonary Circulation,Pulmonary Circulation: physiology,Pulmonary Valve Stenosis,Pulmonary Valve Stenosis: diagnosis,Pulmonary Valve Stenosis: physiopathology,Retrospective Studies,Time Factors,Young Adult",
month = "oct",
number = 4,
pages = "3698--703",
pmid = 23849966,
title = "{Unilateral pulmonary artery branch stenosis: diastolic prolongation of forward flow appears to maintain flow to the affected lung if the pulmonary valve is competent.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23849966",
volume = 168,
year = 2013
}
K Guha, T A Treibel, I Roussin, S K Prasad, A M Duncan, C Brookes, T A McDonagh and R Sharma.
Treatment of left ventricular non-compaction with cardiac resynchronization therapy..
QJM : monthly journal of the Association of Physicians 106(6):hcr201–, October 2013.
URL, DOI BibTeX
@article{Guha2011,
author = "Guha, K and Treibel, T A and Roussin, I and Prasad, S K and Duncan, A M and Brookes, C and McDonagh, T A and Sharma, R",
doi = "10.1093/qjmed/hcr201",
issn = "1460-2393",
journal = "QJM : monthly journal of the Association of Physicians",
keywords = ",Cardiac Resynchronization Therapy,Cardiac Resynchronization Therapy: methods,Congenital,Congenital: complications,Congenital: diagnosis,Congenital: therapy,Electrocardiography,Female,Heart Defects,Heart Failure,Heart Failure: etiology,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Middle Aged",
month = "oct",
number = 6,
pages = "hcr201--",
pmid = 22021572,
title = "{Treatment of left ventricular non-compaction with cardiac resynchronization therapy.}",
url = "http://qjmed.oxfordjournals.org/content/early/2011/10/22/qjmed.hcr201.extract http://www.ncbi.nlm.nih.gov/pubmed/22021572",
volume = 106,
year = 2013
}
Ankur Gulati, Tevfik F Ismail, Andrew Jabbour, Francisco Alpendurada, Kaushik Guha, Nizar A Ismail, Sadaf Raza, Jahanzaib Khwaja, Tristan D H Brown, Kishen Morarji, Emmanouil Liodakis, Michael Roughton, Ricardo Wage, Tapesh C Pakrashi, Rakesh Sharma, John-Paul Carpenter, Stuart A Cook, Martin R Cowie, Ravi G Assomull, Dudley J Pennell and Sanjay K Prasad.
The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy..
Circulation 128(15):1623–33, October 2013.
URL, DOI BibTeX
@article{Gulati2013b,
abstract = "BACKGROUND: Cardiovascular magnetic resonance is the gold-standard technique for the assessment of ventricular function. Although left ventricular volumes and ejection fraction are strong predictors of outcome in dilated cardiomyopathy (DCM), there are limited data regarding the prognostic significance of right ventricular (RV) systolic dysfunction (RVSD). We investigated whether cardiovascular magnetic resonance assessment of RV function has prognostic value in DCM. METHODS AND RESULTS: We prospectively studied 250 consecutive DCM patients with the use of cardiovascular magnetic resonance. RVSD, defined by RV ejection fraction≤45{\%}, was present in 86 (34{\%}) patients. During a median follow-up period of 6.8 years, there were 52 deaths, and 7 patients underwent cardiac transplantation. The primary end point of all-cause mortality or cardiac transplantation was reached by 42 of 86 patients with RVSD and 17 of 164 patients without RVSD (49{\%} versus 10{\%}; hazard ratio, 5.90; 95{\%} confidence interval [CI], 3.35-10.37; P{\textless}0.001). On multivariable analysis, RVSD remained a significant independent predictor of the primary end point (hazard ratio, 3.90; 95{\%} CI, 2.16-7.04; P{\textless}0.001), as well as secondary outcomes of cardiovascular mortality or cardiac transplantation (hazard ratio, 3.35; 95{\%} CI, 1.76-6.39; P{\textless}0.001), and heart failure death, heart failure hospitalization, or cardiac transplantation (hazard ratio, 2.70; 95{\%} CI, 1.32-5.51; P=0.006). Assessment of RVSD improved risk stratification for all-cause mortality or cardiac transplantation (net reclassification improvement, 0.31; 95{\%} CI 0.10-0.53; P=0.001). CONCLUSIONS: RVSD is a powerful, independent predictor of transplant-free survival and adverse heart failure outcomes in DCM. Cardiovascular magnetic resonance assessment of RV function is important in the evaluation and risk stratification of DCM patients.",
author = "Gulati, Ankur and Ismail, Tevfik F and Jabbour, Andrew and Alpendurada, Francisco and Guha, Kaushik and Ismail, Nizar A and Raza, Sadaf and Khwaja, Jahanzaib and Brown, Tristan D H and Morarji, Kishen and Liodakis, Emmanouil and Roughton, Michael and Wage, Ricardo and Pakrashi, Tapesh C and Sharma, Rakesh and Carpenter, John-Paul and Cook, Stuart A and Cowie, Martin R and Assomull, Ravi G and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1161/CIRCULATIONAHA.113.002518",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adult,Aged,Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: mortality,Cardiomyopathy, Dilated: pathology,Cardiomyopathy, Dilated: physiopathology,Female,Follow-Up Studies,Humans,Kaplan-Meier Estimate,Magnetic Resonance Imaging,Male,Middle Aged,Predictive Value of Tests,Prevalence,Prognosis,Prospective Studies,Risk Factors,Stroke Volume,Stroke Volume: physiology,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: mortality,Ventricular Dysfunction, Right: pathology,Ventricular Dysfunction, Right: physiopathology,Ventricular Function, Right,Ventricular Function, Right: physiology",
month = "oct",
number = 15,
pages = "1623--33",
pmid = 23965488,
title = "{The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23965488",
volume = 128,
year = 2013
}
Beatrice Bonello, Aleksander Kempny, Anselm Uebing, Wei Li, Philip J Kilner, Gerhard-Paul Diller, Dudley J Pennell, Darryl F Shore, Sabine Ernst, Michael A Gatzoulis and Sonya V Babu-Narayan.
Right atrial area and right ventricular outflow tract akinetic length predict sustained tachyarrhythmia in repaired tetralogy of Fallot..
International journal of cardiology 168(4):3280–6, October 2013.
URL, DOI BibTeX
@article{Bonello2013,
abstract = "AIMS: Repaired tetralogy of Fallot (rtoF) patients are at risk of atrial or ventricular tachyarrhythmia and sudden cardiac death. Risk stratification for arrhythmia remains difficult. We investigated whether cardiac anatomy and function predict arrhythmia. METHODS: One-hundred-and-fifty-four adults with rtoF, median age 30.8 (21.9-40.2) years, were studied with a standardised protocol including cardiovascular magnetic resonance (CMR) and prospectively followed up over median 5.6 (4.6-7.0) years for the pre-specified endpoints of new-onset atrial or ventricular tachyarrhythmia (sustained ventricular tachycardia/ventricular fibrillation). RESULTS: Atrial tachyarrhythmia (n=11) was predicted by maximal right atrial area indexed to body surface area (RAAi) on four-chamber cine-CMR (Hazard ratio 1.17, 95{\%} Confidence Interval 1.07-1.28 per cm(2)/m(2); p=0.0005, survival receiver operating curve; ROC analysis, area under curve; AUC 0.74 [0.66-0.81]; cut-off value 16 cm(2)/m(2)). Atrial arrhythmia-free survival was reduced in patients with RAAi ≥16 cm(2)/m(2) (logrank p=0.0001). Right ventricular (RV) restrictive physiology on echocardiography (n=38) related to higher RAAi (p=0.02) and had similar RV dilatation compared with remaining patients. Ventricular arrhythmia (n=9) was predicted by CMR RV outflow tract (RVOT) akinetic area length (Hazard ratio 1.05, 95{\%} Confidence Interval 1.01-1.09 per mm; p=0.003, survival ROC analysis, AUC 0.77 [0.83-0.61]; cut-off value 30 mm) and decreased RV ejection fraction (Hazard ratio 0.93, 95{\%} Confidence Interval 0.87-0.99 per {\%}; p=0.03). Ventricular arrhythmia-free survival was reduced in patients with RVOT akinetic region length {\textgreater}30 mm (logrank p=0.02). CONCLUSION: RAAi predicts atrial arrhythmia and RVOT akinetic region length predicts ventricular arrhythmia in late follow-up of rtoF. These are simple, feasible measurements for inclusion in serial surveillance and risk stratification of rtoF patients.",
author = "Bonello, Beatrice and Kempny, Aleksander and Uebing, Anselm and Li, Wei and Kilner, Philip J and Diller, Gerhard-Paul and Pennell, Dudley J and Shore, Darryl F and Ernst, Sabine and Gatzoulis, Michael A and Babu-Narayan, Sonya V",
doi = "10.1016/j.ijcard.2013.04.048",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adult,Female,Follow-Up Studies,Heart Atria,Heart Atria: pathology,Humans,Male,Middle Aged,Predictive Value of Tests,Prospective Studies,Tachycardia, Ventricular,Tachycardia, Ventricular: diagnosis,Tachycardia, Ventricular: physiopathology,Tetralogy of Fallot,Tetralogy of Fallot: physiopathology,Tetralogy of Fallot: surgery,Ventricular Function, Right,Ventricular Function, Right: physiology,Young Adult",
month = "oct",
number = 4,
pages = "3280--6",
pmid = 23643427,
title = "{Right atrial area and right ventricular outflow tract akinetic length predict sustained tachyarrhythmia in repaired tetralogy of Fallot.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3819622{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 168,
year = 2013
}
Monica Deac, Francisco Alpendurada, Fariba Fanaie, Raj Vimal, John-Paul Carpenter, Adelle Dawson, Chris Miller, Isabelle Roussin, Elisa Pietro, Tevfik F Ismail, Michael Roughton, Joyce Wong, Dana Dawson, Janice A Till, Mary N Sheppard, Raad H Mohiaddin, Philip J Kilner, Dudley J Pennell and Sanjay K Prasad.
Prognostic value of cardiovascular magnetic resonance in patients with suspected arrhythmogenic right ventricular cardiomyopathy..
International journal of cardiology 168(4):3514–21, October 2013.
URL, DOI BibTeX
@article{Deac2013,
abstract = "BACKGROUND: Early recognition and accurate risk stratification are important in the management of arrhythmogenic right ventricular cardiomyopathy (ARVC). Identification of predictors of outcome by cardiovascular magnetic resonance (CMR) in patients undergoing evaluation for ARVC is limited. We investigated the predictive value of morphological abnormalities detected by CMR for major clinical events in patients with suspected ARVC. METHODS: We performed a longitudinal study on 369 consecutive patients with at least one criterion for ARVC. Abnormal CMR was defined by the presence of one of the following: increased right ventricular (RV) volumes, reduced RV ejection fraction, RV regional wall motion abnormalities, myocardial fatty infiltration, and myocardial fibrosis. The end-point was a composite of cardiac death, sustained ventricular tachycardia, ventricular fibrillation, and appropriate ICD discharge. RESULTS: Twenty patients met the composite end-point over a mean follow-up of 4.3±1.5 years. An abnormal CMR was an independent predictor of outcomes (p{\textless}0.001). The presence of multiple abnormalities heralded a particular high risk of events (HR 23.0, 95{\%} CI 5.7-93.2, p{\textless}0.001 for 2 abnormalities; HR 35.8, 95{\%} CI 9.7-132.6, p{\textless}0.001 for 3 or more abnormalities). The positive predictive value of an abnormal CMR study was 21.0{\%} for an adverse event, whilst the negative predictive value of a normal CMR study was 98.8{\%} over the follow-up period. CONCLUSIONS: CMR provides important prognostic information in patients under evaluation for ARVC. A normal study portends a good prognosis. Conversely, the presence of multiple abnormalities identifies a high risk group of patients who may benefit from ICD implantation.",
author = "Deac, Monica and Alpendurada, Francisco and Fanaie, Fariba and Vimal, Raj and Carpenter, John-Paul and Dawson, Adelle and Miller, Chris and Roussin, Isabelle and di Pietro, Elisa and Ismail, Tevfik F and Roughton, Michael and Wong, Joyce and Dawson, Dana and Till, Janice A and Sheppard, Mary N and Mohiaddin, Raad H and Kilner, Philip J and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1016/j.ijcard.2013.04.208",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adult,Arrhythmogenic Right Ventricular Dysplasia,Arrhythmogenic Right Ventricular Dysplasia: diagno,Arrhythmogenic Right Ventricular Dysplasia: physio,Cohort Studies,Female,Follow-Up Studies,Humans,Longitudinal Studies,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Middle Aged,Prognosis,Retrospective Studies",
month = "oct",
number = 4,
pages = "3514--21",
pmid = 23701935,
title = "{Prognostic value of cardiovascular magnetic resonance in patients with suspected arrhythmogenic right ventricular cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23701935",
volume = 168,
year = 2013
}
Marc R Dweck, Phong Teck Lee, Sparsh Prasher, Anoop S Shah, Steve E Humphries, Dudley J Pennell, Hugh Montgomery and John Payne.
Response to Letter about article, "Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study"..
Circulation. Cardiovascular imaging 6(5):e29, September 2013.
URL, DOI BibTeX
@article{Dweck2013,
author = "Dweck, Marc R and Lee, Phong Teck and Prasher, Sparsh and Shah, Anoop S and Humphries, Steve E and Pennell, Dudley J and Montgomery, Hugh and Payne, John",
doi = "10.1161/CIRCIMAGING.113.000773",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Cardiomegaly, Exercise-Induced,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Exercise,Heart Ventricles,Heart Ventricles: pathology,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Male,Military Personnel",
month = "sep",
number = 5,
pages = "e29",
pmid = 24046384,
title = {{Response to Letter about article, "Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study".}},
url = "http://www.ncbi.nlm.nih.gov/pubmed/24046384",
volume = 6,
year = 2013
}
John-Paul Carpenter, Michael Roughton and Dudley J Pennell.
International survey of T2* cardiovascular magnetic resonance in $\beta$-thalassemia major..
Haematologica 98(9):1368–74, September 2013.
URL, DOI BibTeX
@article{Carpenter2013,
abstract = "Accumulation of myocardial iron is the cause of heart failure and early death in most transfused thalassemia major patients. T2* cardiovascular magnetic resonance provides calibrated, reproducible measurements of myocardial iron. However, there are few data regarding myocardial iron loading and its relation to outcome across the world. A survey is reported of 3,095 patients in 27 worldwide centers using T2* cardiovascular magnetic resonance. Data on baseline T2* and numbers of patients with symptoms of heart failure at first scan (defined as symptoms and signs of heart failure with objective evidence of left ventricular dysfunction) were requested together with more detailed information about patients who subsequently developed heart failure or died. At first scan, 20.6{\%} had severe myocardial iron (T2*≤ 10 ms), 22.8{\%} had moderate myocardial iron (T2* 10-20 ms) and 56.6{\%} of patients had no iron loading (T2*{\textgreater}20 ms). There was significant geographical variation in myocardial iron loading (24.8-52.6{\%}; P{\textless}0.001). At first scan, 85 (2.9{\%}) of 2,915 patients were reported to have heart failure (81.2{\%} had T2* {\textless}10 ms; 98.8{\%} had T2* {\textless}20 ms). During follow up, 108 (3.8{\%}) of 2,830 patients developed new heart failure. Of these, T2* at first scan had been less than 10 ms in 96.3{\%} and less than 20 ms in 100{\%}. There were 35 (1.1{\%}) cardiac deaths. Of these patients, myocardial T2* at first scan had been less than 10 ms in 85.7{\%} and less than 20 ms in 97.1{\%}. Therefore, in this worldwide cohort of thalassemia major patients, over 43{\%} had moderate/severe myocardial iron loading with significant geographical differences, and myocardial T2* values less than 10 ms were strongly associated with heart failure and death.",
author = "Carpenter, John-Paul and Roughton, Michael and Pennell, Dudley J",
doi = "10.3324/haematol.2013.083634",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Carpenter, Roughton, Pennell - 2013 - International survey of T2 cardiovascular magnetic resonance in $\beta$-thalassemia major.pdf:pdf",
issn = "1592-8721",
journal = "Haematologica",
keywords = "Cohort Studies,Data Collection,Data Collection: methods,Heart Failure,Heart Failure: diagnosis,Heart Failure: epidemiology,Humans,Internationality,Iron Overload,Iron Overload: diagnosis,Iron Overload: epidemiology,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,beta-Thalassemia,beta-Thalassemia: diagnosis,beta-Thalassemia: epidemiology",
month = "sep",
number = 9,
pages = "1368--74",
pmid = 23812939,
title = "{International survey of T2* cardiovascular magnetic resonance in $\beta$-thalassemia major.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3762092{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 98,
year = 2013
}
Sonia Nielles-Vallespin, Choukri Mekkaoui, Peter Gatehouse, Timothy G Reese, Jennifer Keegan, Pedro F Ferreira, Steve Collins, Peter Speier, Thorsten Feiweier, Ranil Silva, Marcel P Jackowski, Dudley J Pennell, David E Sosnovik and David Firmin.
In vivo diffusion tensor MRI of the human heart: Reproducibility of breath-hold and navigator-based approaches..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 70(2):454–65, September 2013.
URL, DOI BibTeX
@article{Nielles-Vallespin2012,
abstract = "{The aim of this study was to implement a quantitative in vivo cardiac diffusion tensor imaging (DTI) technique that was robust, reproducible, and feasible to perform in patients with cardiovascular disease. A stimulated-echo single-shot echo-planar imaging (EPI) sequence with zonal excitation and parallel imaging was implemented, together with a novel modification of the prospective navigator (NAV) technique combined with a biofeedback mechanism. Ten volunteers were scanned on two different days, each time with both multiple breath-hold (MBH) and NAV multislice protocols. Fractional anisotropy (FA), mean diffusivity (MD), and helix angle (HA) fiber maps were created. Comparison of initial and repeat scans showed good reproducibility for both MBH and NAV techniques for FA (P {\textgreater} 0.22), MD (P {\textgreater} 0.15), and HA (P {\textgreater} 0.28). Comparison of MBH and NAV FA (FA(MBHday1) = 0.60 ± 0.04, FA(NAVday1) = 0.60 ± 0.03",
p = "",
author = "Nielles-Vallespin, Sonia and Mekkaoui, Choukri and Gatehouse, Peter and Reese, Timothy G and Keegan, Jennifer and Ferreira, Pedro F and Collins, Steve and Speier, Peter and Feiweier, Thorsten and de Silva, Ranil and Jackowski, Marcel P and Pennell, Dudley J and Sosnovik, David E and Firmin, David",
doi = "10.1002/mrm.24488",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Nielles-Vallespin et al. - 2013 - In vivo diffusion tensor MRI of the human heart reproducibility of breath-hold and navigator-based app.pdf:pdf",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = ",Biofeedback,Breath Holding,Cardiac-Gated Imaging Techniques,Cardiac-Gated Imaging Techniques: methods,Computer-Assisted,Computer-Assisted: methods,Diffusion Tensor Imaging,Diffusion Tensor Imaging: methods,Feasibility Studies,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation,Left,Left: pathology,Psychology,Psychology: methods,Reproducibility of Results,Sensitivity and Specificity,Ventricular Dysfunction",
month = "sep",
number = 2,
pages = "454--65",
pmid = 23001828,
title = "{In vivo diffusion tensor MRI of the human heart: Reproducibility of breath-hold and navigator-based approaches.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23001828 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3864770{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 70,
year = 2013
}
Yanqiu Feng, Taigang He, John-Paul Carpenter, Andrew Jabbour, Mohammed Harith Alam, Peter D Gatehouse, Andreas Greiser, Daniel Messroghli, David N Firmin and Dudley J Pennell.
In vivo comparison of myocardial T1 with T2 and T2* in thalassaemia major..
Journal of magnetic resonance imaging : JMRI 38(3):588–93, September 2013.
URL, DOI BibTeX
@article{Feng2013a,
abstract = "PURPOSE: To compare myocardial T1 against T2 and T2* in patients with thalassemia major (TM) for myocardial iron characterization. MATERIALS AND METHODS: A total of 106 TM patients (29 ± 10 years; 58 males) were studied on a 1.5 Tesla scanner using dedicated T1, T2*, and T2 relaxometry sequences. A single mid-ventricular short axis slice was acquired within a breath-hold. RESULTS: In patients with myocardial iron overload (T2* {\textless} 20 ms; n = 52), there were linear correlations between T2 and T2* (r = 0.82; P = 0.0), and between T1 and T2* (r = 0.83; P = 0.0). In patients with no myocardial iron (n = 54), T2* values were scattered with no significant correlation against T2 or T1. For all patients (n = 106) there was a strong linear correlation (r = 0.93; P = 0.0) between myocardial T1 and T2. CONCLUSION: In patients with iron overload, myocardial T2 and T1 are correlated with T2*. In patients with low or normal myocardial iron concentration, other factors become dominant in affecting T2* values as shown by scattered T2* data. Myocardial T1 correlates linearly with T2 measurements in all patients suggesting that these two relaxation parameters avoid extrinsic magnetic field inhomogeneity effects and may potentially provide improved myocardial tissue characterization.",
author = "Feng, Yanqiu and He, Taigang and Carpenter, John-Paul and Jabbour, Andrew and Alam, Mohammed Harith and Gatehouse, Peter D and Greiser, Andreas and Messroghli, Daniel and Firmin, David N and Pennell, Dudley J",
doi = "10.1002/jmri.24010",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Cardiomyopathies,Cardiomyopathies: complications,Cardiomyopathies: pathology,Female,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Iron Overload,Iron Overload: complications,Iron Overload: pathology,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Reproducibility of Results,Sensitivity and Specificity,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: pathology",
month = "sep",
number = 3,
pages = "588--93",
pmid = 23371802,
title = "{In vivo comparison of myocardial T1 with T2 and T2* in thalassaemia major.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23371802",
volume = 38,
year = 2013
}
Masliza Mahmod, Rick Wage, Francisco Alpendurada and Dudley J Pennell.
Cardiovascular magnetic resonance of acute myocardial infarction following traumatic coronary artery dissection..
Journal of cardiovascular medicine (Hagerstown, Md.) 14(9):669–72, September 2013.
URL, DOI BibTeX
@article{Mahmod2013,
abstract = "Traumatic coronary artery dissection is a very rare cause of myocardial infarction. Occurrence of this condition late in the posttraumatic period is extremely uncommon. We present a case of a young patient with acute myocardial infarction 4 weeks after blunt chest trauma. Coronary angiography showed left anterior descending artery dissection as well as thrombus formation, and multiple small infarctions were shown by cardiovascular magnetic resonance.",
author = "Mahmod, Masliza and Wage, Rick and Alpendurada, Francisco and Pennell, Dudley J",
doi = "10.2459/JCM.0b013e32833dae93",
issn = "1558-2035",
journal = "Journal of cardiovascular medicine (Hagerstown, Md.)",
keywords = "Adult,Angioplasty, Balloon, Coronary,Coronary Angiography,Coronary Thrombosis,Coronary Thrombosis: radiography,Coronary Thrombosis: therapy,Coronary Vessels,Coronary Vessels: injuries,Drug-Eluting Stents,Electrocardiography,Hockey,Hockey: injuries,Humans,Magnetic Resonance Imaging, Cine,Male,Myocardial Infarction,Myocardial Infarction: diagnosis,Myocardial Infarction: etiology,Platelet Aggregation Inhibitors,Platelet Aggregation Inhibitors: therapeutic use,Platelet Glycoprotein GPIIb-IIIa Complex,Platelet Glycoprotein GPIIb-IIIa Complex: antagoni,Thoracic Injuries,Thoracic Injuries: complications,Troponin,Troponin: blood,Wounds, Nonpenetrating,Wounds, Nonpenetrating: complications",
month = "sep",
number = 9,
pages = "669--72",
pmid = 20686414,
title = "{Cardiovascular magnetic resonance of acute myocardial infarction following traumatic coronary artery dissection.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20686414",
volume = 14,
year = 2013
}
Yumi Shiina, Philip J Kilner, Anselm Uebing and Hideki Uemura.
Tricuspid valve implantation after Bjork procedure to establish biventricular physiology..
The Annals of thoracic surgery 96(1):309–11, July 2013.
URL, DOI BibTeX
@article{Shiina2013,
abstract = "A 29-year-old male, who had undergone a Bjork procedure for tricuspid atresia with a ventricular septal defect, had redo surgery for relief of stenosis and systolic regurgitation of the right atrioventricular pathway. After revision using a valved bioprosthesis, effective biventricular physiology was established and the patient's functional status improved.",
author = "Shiina, Yumi and Kilner, Philip J and Uebing, Anselm and Uemura, Hideki",
doi = "10.1016/j.athoracsur.2012.11.032",
issn = "1552-6259",
journal = "The Annals of thoracic surgery",
keywords = "Abnormalities, Multiple,Adult,Bioprosthesis,Cardiac Catheterization,Cardiac Surgical Procedures,Cardiac Surgical Procedures: methods,Echocardiography,Heart Septal Defects, Ventricular,Heart Septal Defects, Ventricular: diagnosis,Heart Septal Defects, Ventricular: physiopathology,Heart Septal Defects, Ventricular: surgery,Heart Valve Prosthesis Implantation,Heart Valve Prosthesis Implantation: methods,Humans,Magnetic Resonance Imaging, Cine,Male,Stroke Volume,Stroke Volume: physiology,Tricuspid Atresia,Tricuspid Atresia: diagnosis,Tricuspid Atresia: physiopathology,Tricuspid Atresia: surgery,Ventricular Function, Left,Ventricular Function, Right",
month = "jul",
number = 1,
pages = "309--11",
pmid = 23816084,
title = "{Tricuspid valve implantation after Bjork procedure to establish biventricular physiology.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23816084",
volume = 96,
year = 2013
}
Dudley J Pennell, James E Udelson, Andrew E Arai, Biykem Bozkurt, Alan R Cohen, Renzo Galanello, Timothy M Hoffman, Michael S Kiernan, Stamatios Lerakis, Antonio Piga, John B Porter, John Malcolm Walker and John Wood.
Cardiovascular function and treatment in $\beta$-thalassemia major: a consensus statement from the American Heart Association..
Circulation 128(3):281–308, July 2013.
URL, DOI BibTeX
@article{Pennell2013,
abstract = "This aim of this statement is to report an expert consensus on the diagnosis and treatment of cardiac dysfunction in $\beta$-thalassemia major (TM). This consensus statement does not cover other hemoglobinopathies, including thalassemia intermedia and sickle cell anemia, in which a different spectrum of cardiovascular complications is typical. There are considerable uncertainties in this field, with a few randomized controlled trials relating to treatment of chronic myocardial siderosis but none relating to treatment of acute heart failure. The principles of diagnosis and treatment of cardiac iron loading in TM are directly relevant to other iron-overload conditions, including in particular Diamond-Blackfan anemia, sideroblastic anemia, and hereditary hemochromatosis. Heart failure is the most common cause of death in TM and primarily results from cardiac iron accumulation. The diagnosis of ventricular dysfunction in TM patients differs from that in nonanemic patients because of the cardiovascular adaptation to chronic anemia in non-cardiac-loaded TM patients, which includes resting tachycardia, low blood pressure, enlarged end-diastolic volume, high ejection fraction, and high cardiac output. Chronic anemia also leads to background symptomatology such as dyspnea, which can mask the clinical diagnosis of cardiac dysfunction. Central to early identification of cardiac iron overload in TM is the estimation of cardiac iron by cardiac T2* magnetic resonance. Cardiac T2* {\textless}10 ms is the most important predictor of development of heart failure. Serum ferritin and liver iron concentration are not adequate surrogates for cardiac iron measurement. Assessment of cardiac function by noninvasive techniques can also be valuable clinically, but serial measurements to establish trends are usually required because interpretation of single absolute values is complicated by the abnormal cardiovascular hemodynamics in TM and measurement imprecision. Acute decompensated heart failure is a medical emergency and requires urgent consultation with a center with expertise in its management. The first principle of management of acute heart failure is control of cardiac toxicity related to free iron by urgent commencement of a continuous, uninterrupted infusion of high-dose intravenous deferoxamine, augmented by oral deferiprone. Considerable care is required to not exacerbate cardiovascular problems from overuse of diuretics or inotropes because of the unusual loading conditions in TM. The current knowledge on the efficacy of removal of cardiac iron by the 3 commercially available iron chelators is summarized for cardiac iron overload without overt cardiac dysfunction. Evidence from well-conducted randomized controlled trials shows superior efficacy of deferiprone versus deferoxamine, the superiority of combined deferiprone with deferoxamine versus deferoxamine alone, and the equivalence of deferasirox versus deferoxamine.",
author = "Pennell, Dudley J and Udelson, James E and Arai, Andrew E and Bozkurt, Biykem and Cohen, Alan R and Galanello, Renzo and Hoffman, Timothy M and Kiernan, Michael S and Lerakis, Stamatios and Piga, Antonio and Porter, John B and Walker, John Malcolm and Wood, John",
doi = "10.1161/CIR.0b013e31829b2be6",
issn = "1524-4539",
journal = "Circulation",
keywords = "American Heart Association,Consensus,Heart Failure,Heart Failure: etiology,Heart Failure: physiopathology,Heart Failure: therapy,Humans,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: complications,Iron Overload: drug therapy,United States,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: drug therapy",
month = "jul",
number = 3,
pages = "281--308",
pmid = 23775258,
title = "{Cardiovascular function and treatment in $\beta$-thalassemia major: a consensus statement from the American Heart Association.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23775258",
volume = 128,
year = 2013
}
Irina Suman-Horduna, Sonya V Babu-Narayan, Akiko Ueda, Lilian Mantziari, Marko Gujic, Procolo Marchese, Konstantinos Dimopoulos, Michael A Gatzoulis, Michael L Rigby, Siew Yen Ho and Sabine Ernst.
Magnetic navigation in adults with atrial isomerism (heterotaxy syndrome) and supraventricular arrhythmias..
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 15(6):877–85, June 2013.
URL, DOI BibTeX
@article{Suman-Horduna2013a,
abstract = "AIMS: We analysed the type and mechanism of supraventricular arrhythmias encountered in a series of symptomatic adults with atrial isomerism undergoing catheter ablation procedures. METHODS AND RESULTS: The study population included consecutive adults with atrial isomerism who had previously undergone surgical repair or palliation of the associated anomalies. Patients underwent electrophysiological study for symptomatic arrhythmia in our institution between 2010 and 2012 using magnetic navigation in conjunction with CARTO RMT and three-dimensional (3D) image integration. Eight patients (five females) with a median age of 33 years [interquartile range (IQR) 24-39] were studied. Access to the cardiac chambers of interest was obtained retrogradely via the aorta using remotely navigated magnetic catheters in six patients. Radiofrequency ablation successfully targeted twin atrioventricular (AV) nodal reentrant tachycardia in two patients, atrial fibrillation (AF) in three, focal atrial tachycardia (AT) mainly originating in the left-sided atrium in four patients, and macro-reentrant AT dependent on a right-sided inferior isthmus in three patients. The median fluoroscopy time was 3.0 min (IQR 2-11). After a median follow-up of 10 months (IQR 6-21), five of the ablated patients are free from arrhythmia; two patients experienced episodes of self-terminated AF and AT, respectively, within one month post-ablation; the remaining patient had only non-sustained AT during the electrophysiological study and was managed medically. CONCLUSION: Various supraventricular tachycardia mechanisms are possible in adults with heterotaxy syndrome, all potentially amenable to radiofrequency ablation. The use of remote magnetic navigation along with 3D mapping facilitated the procedures and resulted in a short radiation time.",
author = "Suman-Horduna, Irina and Babu-Narayan, Sonya V and Ueda, Akiko and Mantziari, Lilian and Gujic, Marko and Marchese, Procolo and Dimopoulos, Konstantinos and Gatzoulis, Michael A and Rigby, Michael L and Ho, Siew Yen and Ernst, Sabine",
doi = "10.1093/europace/eus384",
issn = "1532-2092",
journal = "Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology",
keywords = "Adult,Body Surface Potential Mapping,Body Surface Potential Mapping: methods,Female,Heterotaxy Syndrome,Heterotaxy Syndrome: diagnosis,Heterotaxy Syndrome: surgery,Humans,Magnetics,Magnetics: methods,Male,Surgery, Computer-Assisted,Surgery, Computer-Assisted: methods,Tachycardia, Supraventricular,Tachycardia, Supraventricular: diagnosis,Tachycardia, Supraventricular: surgery,Treatment Outcome,Young Adult",
month = "jun",
number = 6,
pages = "877--85",
pmid = 23355132,
title = "{Magnetic navigation in adults with atrial isomerism (heterotaxy syndrome) and supraventricular arrhythmias.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23355132",
volume = 15,
year = 2013
}
James H Hull, Andrew Menzies-Gow, Andrew G Nicholson, Raad H Mohiaddin and Toby M Maher.
Exercise-induced haemoptysis: a thoroughbred cause?.
Thorax 68(6):599–600, June 2013.
URL, DOI BibTeX
@article{Hull2013,
abstract = "The authors report a novel case of exercise-induced haemoptysis with an unexpected underlying pathology. The report discusses the case and provides a pragmatic overview of the diagnosis and management of the pulmonary vein stenosis.",
author = "Hull, James H and Menzies-Gow, Andrew and Nicholson, Andrew G and Mohiaddin, Raad H and Maher, Toby M",
doi = "10.1136/thoraxjnl-2012-202209",
issn = "1468-3296",
journal = "Thorax",
keywords = "Adult,Biopsy,Bronchoscopy,Diagnosis, Differential,Exercise Test,Exercise Test: adverse effects,Hemoptysis,Hemoptysis: etiology,Hemoptysis: pathology,Hemoptysis: radiography,Humans,Lung,Lung: pathology,Lung: radiography,Male,Tomography, X-Ray Computed",
month = "jun",
number = 6,
pages = "599--600",
pmid = 23404840,
title = "{Exercise-induced haemoptysis: a thoroughbred cause?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23404840",
volume = 68,
year = 2013
}
Akiko Ueda, Irina Suman-Horduna, Lilian Mantziari, Marko Gujic, Procolo Marchese, Siew Yen Ho, Sonya V Babu-Narayan and Sabine Ernst.
Contemporary outcomes of supraventricular tachycardia ablation in congenital heart disease: a single-center experience in 116 patients..
Circulation. Arrhythmia and electrophysiology 6(3):606–13, June 2013.
URL, DOI BibTeX
@article{Ueda2013,
abstract = "BACKGROUND: Remote magnetic navigation-guided ablation with 3-dimensional (3D)-image integration could provide maximum benefit in patients with complex anatomy. We reviewed supraventricular tachycardia (SVT) ablation in adult patients with congenital heart disease to assess the contribution of these technologies. METHODS AND RESULTS: One hundred fifty-four SVT ablation procedures (228 SVTs) using a 3D-electroanatomic mapping system in 116 adult patients with congenital heart disease (mean age, 41; 76 male) were classified into 3 groups: Group A, manual mapping/ablation (n=60 procedures); Group B, remote magnetic navigation-guided mapping/ablation with normal femoral vein access (49); and Group C, remote magnetic navigation-guided mapping/ablation with difficult access (45). Group A included simple anomalies with less SVTs. Group B comprised predominantly Fontan patients with more SVTs. Group C included more complex defects, such as intra-atrial baffle or interrupted inferior venous access, in which retrograde aortic and superior venous accesses were used exclusively with more frequent use of image integration (97.8{\%}; P{\textless}0.001). Acute success was 91.5{\%}, 83.7{\%}, and 82.2{\%}, respectively (P=0.370). In group C, fluoroscopy time was the shortest (median, 4.2 min; P{\textless}0.001) despite the longer procedure duration (median, 253 min; P{\textless}0.001). SVTs free rates were 80.4{\%}, 82.4{\%}, and 75.8{\%}, respectively (P=0.787) during a mean 20-months follow-up period. CONCLUSIONS: The combination of remote magnetic navigation, 3D-image integration, and electroanatomic mapping system facilitated safe and feasible ablation with very low fluoroscopy exposure even in patients with complex anomalies.",
author = "Ueda, Akiko and Suman-Horduna, Irina and Mantziari, Lilian and Gujic, Marko and Marchese, Procolo and Ho, Siew Yen and Babu-Narayan, Sonya V and Ernst, Sabine",
doi = "10.1161/CIRCEP.113.000415",
issn = "1941-3084",
journal = "Circulation. Arrhythmia and electrophysiology",
keywords = "Adult,Analysis of Variance,Body Surface Potential Mapping,Cardiac Catheterization,Cardiac Catheterization: methods,Catheter Ablation,Cohort Studies,Electrocardiography, Ambulatory,Electrocardiography, Ambulatory: methods,Female,Heart Defects, Congenital,Heart Defects, Congenital: complications,Heart Defects, Congenital: diagnosis,Heart Defects, Congenital: surgery,Humans,Imaging, Three-Dimensional,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Postoperative Care,Prognosis,Prospective Studies,Risk Assessment,Severity of Illness Index,Statistics, Nonparametric,Tachycardia, Supraventricular,Tachycardia, Supraventricular: complications,Tachycardia, Supraventricular: diagnosis,Tachycardia, Supraventricular: surgery,Treatment Outcome",
month = "jun",
number = 3,
pages = "606--13",
pmid = 23685536,
title = "{Contemporary outcomes of supraventricular tachycardia ablation in congenital heart disease: a single-center experience in 116 patients.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23685536",
volume = 6,
year = 2013
}
Ankur Gulati, Tevfik F Ismail, Andrew Jabbour, Nizar A Ismail, Kishen Morarji, Aamir Ali, Sadaf Raza, Jahanzaib Khwaja, Tristan D H Brown, Emmanouil Liodakis, Arun J Baksi, Rameen Shakur, Kaushik Guha, Michael Roughton, Ricardo Wage, Stuart A Cook, Francisco Alpendurada, Ravi G Assomull, Raad H Mohiaddin, Martin R Cowie, Dudley J Pennell and Sanjay K Prasad.
Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy..
European journal of heart failure 15(6):660–70, June 2013.
URL, DOI BibTeX
@article{Gulati2013a,
abstract = "AIMS: Echocardiographic studies have shown that left atrial volume (LAV) predicts adverse outcome in small heart failure (HF) cohorts of mixed aetiology. However, the prognostic value of LAV in non-ischaemic dilated cardiomyopathy (DCM) is unknown. Cardiovascular magnetic resonance (CMR) allows accurate and reproducible measurement of LAV. We sought to determine the long-term prognostic significance of LAV assessed by CMR in DCM. METHODS AND RESULTS: We measured LAV indexed to body surface area (LAVi) in 483 consecutive DCM patients referred for CMR. Patients were prospectively followed up for a primary endpoint of all-cause mortality or cardiac transplantation. During a median follow-up of 5.3 years, 75 patients died and 9 underwent cardiac transplantation. After adjustment for established risk factors, LAVi was an independent predictor of the primary endpoint [hazard ratio (HR) per 10 mL/m(2) 1.08; 95{\%} confidence interval (CI) 1.01-1.15; P = 0.022]. LAVi was also independently associated with the secondary composite endpoints of cardiovascular mortality or cardiac transplantation (HR per 10 mL/m(2) 1.11; 95{\%} CI 1.04-1.19; P = 0.003), and HF death, HF hospitalization, or cardiac transplantation (HR per 10 mL/m(2) 1.11; 95{\%} CI 1.04-1.18; P = 0.001). The optimal LAVi cut-off value for predicting the primary endpoint was 72 mL/m(2). Patients with LAVi {\textgreater}72 mL/m(2) had a three-fold elevated risk of death or transplantation (HR 3.00; 95{\%} CI 1.92-4.70; P {\textless} 0.001). LAVi provided incremental prognostic value for the prediction of transplant-free survival (net reclassification improvement 0.17; 95{\%} CI 0.05-0.29; P = 0.002). CONCLUSIONS: LAVi is a powerful independent predictor of transplant-free survival and HF outcomes in DCM. Assessment of LAV improves risk stratification in DCM and should be incorporated into routine CMR examination.",
author = "Gulati, Ankur and Ismail, Tevfik F and Jabbour, Andrew and Ismail, Nizar A and Morarji, Kishen and Ali, Aamir and Raza, Sadaf and Khwaja, Jahanzaib and Brown, Tristan D H and Liodakis, Emmanouil and Baksi, Arun J and Shakur, Rameen and Guha, Kaushik and Roughton, Michael and Wage, Ricardo and Cook, Stuart A and Alpendurada, Francisco and Assomull, Ravi G and Mohiaddin, Raad H and Cowie, Martin R and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1093/eurjhf/hft019",
issn = "1879-0844",
journal = "European journal of heart failure",
keywords = "Adult,Aged,Cardiac Volume,Cardiac Volume: physiology,Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: mortality,Cardiomyopathy, Dilated: physiopathology,Cardiomyopathy, Dilated: surgery,Cohort Studies,Female,Follow-Up Studies,Heart Atria,Heart Atria: physiopathology,Heart Transplantation,Humans,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Observer Variation,Prognosis,Prospective Studies,Risk Factors",
month = "jun",
number = 6,
pages = "660--70",
pmid = 23475781,
title = "{Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23475781",
volume = 15,
year = 2013
}
Irina Suman-Horduna, Navtej Chahal, Andrew G Nicholson, Francisco Alpendurada and Tushar V Salukhe.
Cardiac infiltration from melanoma causing atrio-ventricular block..
European heart journal cardiovascular Imaging 14(6):606, June 2013.
URL, DOI BibTeX
@article{Suman-Horduna2013,
author = "Suman-Horduna, Irina and Chahal, Navtej and Nicholson, Andrew G and Alpendurada, Francisco and Salukhe, Tushar V",
doi = "10.1093/ehjci/jes311",
issn = "2047-2412",
journal = "European heart journal cardiovascular Imaging",
keywords = "Adult,Atrioventricular Block,Atrioventricular Block: diagnosis,Dyspnea,Dyspnea: diagnosis,Dyspnea: etiology,Echocardiography,Echocardiography: methods,Electrocardiography,Electrocardiography: methods,Follow-Up Studies,Heart Neoplasms,Heart Neoplasms: diagnosis,Heart Neoplasms: secondary,Heart Neoplasms: therapy,Humans,Male,Melanoma,Melanoma: diagnosis,Melanoma: secondary,Melanoma: surgery,Palliative Care,Palliative Care: methods,Pericardial Effusion,Pericardial Effusion: pathology,Pericardial Effusion: therapy,Pericardial Effusion: ultrasonography,Skin Neoplasms,Skin Neoplasms: pathology,Skin Neoplasms: surgery,Syncope,Syncope: diagnosis,Syncope: etiology",
month = "jun",
number = 6,
pages = 606,
pmid = 23302392,
title = "{Cardiac infiltration from melanoma causing atrio-ventricular block.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23302392",
volume = 14,
year = 2013
}
Lilian Mantziari, Sonya V Babu-Narayan, Irina Suman-Horduna, Michael L Rigby and Sabine Ernst.
Atrial arrhythmia after Fontan surgery leads to giant thrombus: opening Pandora's box..
International journal of cardiology 166(1):e23–4, June 2013.
URL, DOI BibTeX
@article{Mantziari2013a,
author = "Mantziari, Lilian and Babu-Narayan, Sonya V and Suman-Horduna, Irina and Rigby, Michael L and Ernst, Sabine",
doi = "10.1016/j.ijcard.2013.01.178",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adult,Atrial Fibrillation,Atrial Fibrillation: diagnosis,Atrial Fibrillation: etiology,Fontan Procedure,Fontan Procedure: adverse effects,Heart Diseases,Heart Diseases: diagnosis,Heart Diseases: etiology,Humans,Male,Thrombosis,Thrombosis: diagnosis,Thrombosis: etiology",
month = "jun",
number = 1,
pages = "e23--4",
pmid = 23465557,
title = "{Atrial arrhythmia after Fontan surgery leads to giant thrombus: opening Pandora's box.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23465557",
volume = 166,
year = 2013
}
Ying Wang, Steve Downie, Nigel Wood, David Firmin and Xiao Yun Xu.
Finite element analysis of the deformation of deep veins in the lower limb under external compression..
Medical engineering & physics 35(4):515–23, April 2013.
URL, DOI BibTeX
@article{Wang2013,
abstract = "Compression devices applied to the lower limb can help improve venous flow by deforming the muscles and veins. In this study, a two-dimensional finite element model using displacement boundary conditions was employed to simulate the deformations of deep veins in the calf under external compression. Magnetic resonance (MR) scans were performed on four healthy volunteers with and without compression stockings. The displacement boundary condition was extracted from the corresponding deformed (with stocking) and undeformed (without stocking) MR images by using a non-rigid image registration procedure. In the finite element model, soft tissues of the calf were simplified as a homogenous material with hyperelastic properties. The effective bulk modulus of the material was evaluated at a chosen transverse section for each subject, which was also applied to three other locations at 2mm, 6mm and 10mm below the original section. Comparison between the simulation and measurement showed good agreement in area reduction of deep veins (discrepancy=8.7±6.4{\%}), especially for sections close to the chosen location where the effective bulk modulus was evaluated. Beyond a certain distance, the discrepancies increased and became quite variable. The reason for this is that the architecture and stiffness of the calf tissues vary along the leg. The results also showed considerable variation in effective bulk modulus among the four subjects examined.",
author = "Wang, Ying and Downie, Steve and Wood, Nigel and Firmin, David and Xu, Xiao Yun",
doi = "10.1016/j.medengphy.2012.06.019",
issn = "1873-4030",
journal = "Medical engineering {\&} physics",
keywords = "Adult,Biomechanical Phenomena,Finite Element Analysis,Humans,Lower Extremity,Lower Extremity: blood supply,Magnetic Resonance Imaging,Male,Mechanical Processes,Veins,Veins: physiology,Young Adult",
month = "apr",
number = 4,
pages = "515--23",
pmid = 22819344,
title = "{Finite element analysis of the deformation of deep veins in the lower limb under external compression.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22819344",
volume = 35,
year = 2013
}
Dana K Dawson, Karin Hawlisch, Gordon Prescott, Isabelle Roussin, Elisa Di Pietro, Monica Deac, Joyce Wong, Michael P Frenneaux, Dudley J Pennell and Sanjay K Prasad.
Prognostic role of CMR in patients presenting with ventricular arrhythmias..
JACC. Cardiovascular imaging 6(3):335–44, March 2013.
URL, DOI BibTeX
@article{Dawson2013,
abstract = "{OBJECTIVES: The goal of this study was to explore whether fibrosis detected by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) is an independent predictor of hard cardiovascular events in patients presenting with ventricular arrhythmia. BACKGROUND: In patients at risk of sudden cardiac death, risk stratification for device therapy remains challenging. METHODS: A total of 373 consecutive patients with sustained ventricular tachycardia (VT) (n = 204) or nonsustained ventricular tachycardia (NSVT) (n = 169) underwent LGE-CMR. The group was prospectively followed up for a median of 2.6 years (range 11 months to 11 years). The predetermined endpoint was a composite of cardiac death/arrest, new episode of sustained VT, or appropriate implantable cardioverter-defibrillator discharge. RESULTS: Mean left ventricular (LV) ejection fraction (EF) was 60 ± 13{\%}. The presence of fibrosis was a strong and independent predictor of the primary outcome for the whole group (hazard ratio [HR]: 3.3, 95{\%} confidence interval [CI]: 1.8 to 5.8, p {\textless} 0.001). In the sustained VT subset, both LV fibrosis and severely impaired systolic function (LVEF {\textless}35{\%}) were significant independent predictors in the multivariate model (HR: 3.0, 95{\%} CI: 1.4 to 6.2",
p = "",
author = "Dawson, Dana K and Hawlisch, Karin and Prescott, Gordon and Roussin, Isabelle and {Di Pietro}, Elisa and Deac, Monica and Wong, Joyce and Frenneaux, Michael P and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1016/j.jcmg.2012.09.012",
issn = "1876-7591",
journal = "JACC. Cardiovascular imaging",
keywords = "Adult,Aged,Chi-Square Distribution,Contrast Media,Contrast Media: diagnostic use,Death, Sudden, Cardiac,Death, Sudden, Cardiac: etiology,Defibrillators, Implantable,Disease-Free Survival,Electric Countershock,Electric Countershock: instrumentation,Female,Fibrosis,Humans,Kaplan-Meier Estimate,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Multivariate Analysis,Myocardium,Myocardium: pathology,Organometallic Compounds,Organometallic Compounds: diagnostic use,Predictive Value of Tests,Prognosis,Proportional Hazards Models,Prospective Studies,Risk Assessment,Risk Factors,Stroke Volume,Systole,Tachycardia, Ventricular,Tachycardia, Ventricular: complications,Tachycardia, Ventricular: diagnosis,Tachycardia, Ventricular: mortality,Tachycardia, Ventricular: pathology,Tachycardia, Ventricular: physiopathology,Tachycardia, Ventricular: therapy,Time Factors,Ventricular Function, Left",
month = "mar",
number = 3,
pages = "335--44",
pmid = 23433931,
title = "{Prognostic role of CMR in patients presenting with ventricular arrhythmias.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23433931",
volume = 6,
year = 2013
}
Robin M Simpson, Jennifer Keegan and David N Firmin.
MR assessment of regional myocardial mechanics..
Journal of magnetic resonance imaging : JMRI 37(3):576–99, March 2013.
URL, DOI BibTeX
@article{Simpson2013a,
abstract = "Regional myocardial function can be measured by several MR techniques including tissue tagging, phase velocity mapping, and more recently, displacement encoding with stimulated echoes (DENSE) and strain encoding (SENC). Each of these techniques was developed separately and has undergone significant change since its original implementation. As a result, in the current literature, the common features and the differences between the techniques and what they measure are often unclear and confusing. This review article delivers an extensively referenced introductory text which clarifies the current methodology from the starting point of the Bloch equations. By doing this in a consistent way for each method, the similarities and differences between them are highlighted. In addition, their capabilities and limitations are discussed, together with their relative advantages and disadvantages. While the focus is on sequence design and development, the principal parameters measured by each technique are also summarized, together with brief results, with the reader being directed to the extensive literature on data processing and clinical applications for more detail.",
author = "Simpson, Robin M and Keegan, Jennifer and Firmin, David N",
doi = "10.1002/jmri.23756",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Algorithms,Fourier Analysis,Humans,Image Processing, Computer-Assisted,Image Processing, Computer-Assisted: methods,Imaging, Three-Dimensional,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Movement,Myocardial Contraction,Myocardium,Myocardium: pathology,Reproducibility of Results",
month = "mar",
number = 3,
pages = "576--99",
pmid = 22826177,
title = "{MR assessment of regional myocardial mechanics.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22826177",
volume = 37,
year = 2013
}
Phong T Lee, Marc R Dweck, Sparsh Prasher, Anoop Shah, Steve E Humphries, Dudley J Pennell, Hugh E Montgomery and John R Payne.
Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study..
Circulation. Cardiovascular imaging 6(2):262–7, March 2013.
URL, DOI BibTeX
@article{Lee2013,
abstract = "BACKGROUND: To use cardiovascular magnetic resonance to investigate left ventricular wall thickness and the presence of asymmetrical hypertrophy in young army recruits before and after a period of intense exercise training. METHODS AND RESULTS: Using cardiovascular magnetic resonance, the left ventricular wall thickness was measured in all 17 segments and a normal range was calculated for each. The prevalence of asymmetrical wall thickening was assessed before and after training and defined by a ventricular wall thickness ≥13.0 mm that was {\textgreater}1.5× the thickness of the opposing myocardial segment. Five hundred forty-one men (mean age, 20±2 years) were recruited, 309 underwent repeat scanning. Considerable variation in wall thickness was observed across the ventricle with progressive thickening on moving from the apex to base (P{\textless}0.001) and in the basal and midcavity septum compared with the lateral wall (11.0±1.4 versus 10.1±1.3 mm; P{\textless}0.001). Twenty-three percent had a maximal wall thickness ≥13.0 mm, whereas the prevalence of asymmetrical wall thickening increased from 2.2{\%} to 10{\%} after the exercise-training program. In those who developed asymmetry, the wall thickness/diastolic volume ration remained normal (0.09±0.02 mm⋅m(2)⋅mL(-1)), indicative of a remodeling response to exercise. CONCLUSIONS: In a cohort of healthy young white men, we have demonstrated that wall thickness frequently measures ≥13.0 mm and that asymmetrical wall thickening is common and can develop as part of the physiological response to exercise. A diagnosis of hypertrophic cardiomyopathy in young athletic men should, therefore, not be made purely on the basis of regional wall thickening.",
author = "Lee, Phong T and Dweck, Marc R and Prasher, Sparsh and Shah, Anoop and Humphries, Steve E and Pennell, Dudley J and Montgomery, Hugh E and Payne, John R",
doi = "10.1161/CIRCIMAGING.112.979294",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Adolescent,Age Factors,Analysis of Variance,Cardiomegaly, Exercise-Induced,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Cardiomyopathy, Hypertrophic: ethnology,Cardiomyopathy, Hypertrophic: pathology,Cardiomyopathy, Hypertrophic: physiopathology,Diagnosis, Differential,European Continental Ancestry Group,Exercise,Great Britain,Great Britain: epidemiology,Heart Ventricles,Heart Ventricles: pathology,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Hypertrophy, Left Ventricular: ethnology,Hypertrophy, Left Ventricular: pathology,Hypertrophy, Left Ventricular: physiopathology,Magnetic Resonance Imaging,Male,Military Personnel,Observer Variation,Predictive Value of Tests,Prospective Studies,Reproducibility of Results,Young Adult",
month = "mar",
number = 2,
pages = "262--7",
pmid = 23307776,
title = "{Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23307776",
volume = 6,
year = 2013
}
Ankur Gulati, Andrew Jabbour, Tevfik F Ismail, Kaushik Guha, Jahanzaib Khwaja, Sadaf Raza, Kishen Morarji, Tristan D H Brown, Nizar A Ismail, Marc R Dweck, Elisa Di Pietro, Michael Roughton, Ricardo Wage, Yousef Daryani, Rory O'Hanlon, Mary N Sheppard, Francisco Alpendurada, Alexander R Lyon, Stuart A Cook, Martin R Cowie, Ravi G Assomull, Dudley J Pennell and Sanjay K Prasad.
Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy..
JAMA 309(9):896–908, March 2013.
URL, DOI BibTeX
@article{Gulati2013,
abstract = "{IMPORTANCE: Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF). Superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions. OBJECTIVE: To determine whether myocardial fibrosis (detected by late gadolinium enhancement cardiovascular magnetic resonance [LGE-CMR] imaging) is an independent and incremental predictor of mortality and sudden cardiac death (SCD) in dilated cardiomyopathy. DESIGN, SETTING, AND PATIENTS: Prospective, longitudinal study of 472 patients with dilated cardiomyopathy referred to a UK center for CMR imaging between November 2000 and December 2008 after presence and extent of midwall replacement fibrosis were determined. Patients were followed up through December 2011. MAIN OUTCOME MEASURES: Primary end point was all-cause mortality. Secondary end points included cardiovascular mortality or cardiac transplantation; an arrhythmic composite of SCD or aborted SCD (appropriate ICD shock, nonfatal ventricular fibrillation, or sustained ventricular tachycardia); and a composite of HF death, HF hospitalization, or cardiac transplantation. RESULTS: Among the 142 patients with midwall fibrosis, there were 38 deaths (26.8{\%}) vs 35 deaths (10.6{\%}) among the 330 patients without fibrosis (hazard ratio [HR], 2.96 [95{\%} CI, 1.87-4.69]; absolute risk difference, 16.2{\%} [95{\%} CI, 8.2{\%}-24.2{\%}]; P {\textless} .001) during a median follow-up of 5.3 years (2557 patient-years of follow-up). The arrhythmic composite was reached by 42 patients with fibrosis (29.6{\%}) and 23 patients without fibrosis (7.0{\%}) (HR, 5.24 [95{\%} CI, 3.15-8.72]; absolute risk difference, 22.6{\%} [95{\%} CI, 14.6{\%}-30.6{\%}]; P {\textless} .001). After adjustment for LVEF and other conventional prognostic factors, both the presence of fibrosis (HR, 2.43 [95{\%} CI, 1.50-3.92]; P {\textless} .001) and the extent (HR, 1.11 [95{\%} CI, 1.06-1.16]; P {\textless} .001) were independently and incrementally associated with all-cause mortality. Fibrosis was also independently associated with cardiovascular mortality or cardiac transplantation (by fibrosis presence: HR, 3.22 [95{\%} CI, 1.95-5.31], P {\textless} .001; and by fibrosis extent: HR, 1.15 [95{\%} CI, 1.10-1.20], P {\textless} .001), SCD or aborted SCD (by fibrosis presence: HR, 4.61 [95{\%} CI, 2.75-7.74], P {\textless} .001; and by fibrosis extent: HR, 1.10 [95{\%} CI, 1.05-1.16], P {\textless} .001), and the HF composite (by fibrosis presence: HR, 1.62 [95{\%} CI, 1.00-2.61]",
p = "",
author = "Gulati, Ankur and Jabbour, Andrew and Ismail, Tevfik F and Guha, Kaushik and Khwaja, Jahanzaib and Raza, Sadaf and Morarji, Kishen and Brown, Tristan D H and Ismail, Nizar A and Dweck, Marc R and {Di Pietro}, Elisa and Roughton, Michael and Wage, Ricardo and Daryani, Yousef and O'Hanlon, Rory and Sheppard, Mary N and Alpendurada, Francisco and Lyon, Alexander R and Cook, Stuart A and Cowie, Martin R and Assomull, Ravi G and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1001/jama.2013.1363",
issn = "1538-3598",
journal = "JAMA",
keywords = "Adult,Aged,Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: mortality,Cardiomyopathy, Dilated: pathology,Cause of Death,Death, Sudden, Cardiac,Death, Sudden, Cardiac: epidemiology,Defibrillators, Implantable,Female,Fibrosis,Gadolinium,Gadolinium: diagnostic use,Great Britain,Great Britain: epidemiology,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,Patient Selection,Predictive Value of Tests,Prognosis,Prospective Studies,Risk Assessment,Stroke Volume,Ventricular Function, Left",
month = "mar",
number = 9,
pages = "896--908",
pmid = 23462786,
title = "{Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23462786",
volume = 309,
year = 2013
}
Yuen Chi Ho, Sylvia S M Chen and Raad H Mohiaddin.
Late stenosis after repair of anomalous pulmonary venous drainage and the value of cardiovascular magnetic resonance for assessment of this important complication..
Pediatric cardiology 34(2):480–2, February 2013.
URL, DOI BibTeX
@article{Ho2013,
author = "Ho, Yuen Chi and Chen, Sylvia S M and Mohiaddin, Raad H",
doi = "10.1007/s00246-012-0518-y",
issn = "1432-1971",
journal = "Pediatric cardiology",
keywords = "Adult,Aged,Constriction, Pathologic,Constriction, Pathologic: diagnosis,Constriction, Pathologic: etiology,Diagnosis, Differential,Female,Follow-Up Studies,Humans,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Postoperative Complications,Postoperative Complications: diagnosis,Pulmonary Veins,Pulmonary Veins: pathology,Pulmonary Veno-Occlusive Disease,Pulmonary Veno-Occlusive Disease: diagnosis,Pulmonary Veno-Occlusive Disease: surgery,Time Factors",
month = "feb",
number = 2,
pages = "480--2",
pmid = 23076498,
title = "{Late stenosis after repair of anomalous pulmonary venous drainage and the value of cardiovascular magnetic resonance for assessment of this important complication.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23076498",
volume = 34,
year = 2013
}
Taigang He, Jun Zhang, John-Paul Carpenter, Yanqiu Feng, Gillian C Smith, Dudley J Pennell and David N Firmin.
Automated truncation method for myocardial T2* measurement in thalassemia..
Journal of magnetic resonance imaging : JMRI 37(2):479–83, February 2013.
URL, DOI BibTeX
@article{He2013,
abstract = "To propose an automated truncation method for myocardial T2* measurement and evaluate this method on a large population of patients with iron loading in the heart and scanned at multiple magnetic resonance imaging (MRI) centers.",
author = "He, Taigang and Zhang, Jun and Carpenter, John-Paul and Feng, Yanqiu and Smith, Gillian C and Pennell, Dudley J and Firmin, David N",
doi = "10.1002/jmri.23780",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
month = "feb",
number = 2,
pages = "479--83",
pmid = 22927335,
title = "{Automated truncation method for myocardial T2* measurement in thalassemia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22927335",
volume = 37,
year = 2013
}
Sabine Ernst, Michala Pedersen, Anselm Uebing, Irina Suman-Horduna, Lilian Mantziari, Wei Li and Sonya V Babu-Narayan.
Successful ablation of two right atrial tachycardias on either side of the lateral tunnel patch in a patient with double inlet left ventricle and total cavopulmonary connection: Two sites and two mechanisms..
Global cardiology science & practice 2013(2):198–202, January 2013.
URL, DOI BibTeX
@article{Ernst2013,
author = "Ernst, Sabine and Pedersen, Michala and Uebing, Anselm and Suman-Horduna, Irina and Mantziari, Lilian and Li, Wei and Babu-Narayan, Sonya V",
doi = "10.5339/gcsp.2013.26",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ernst et al. - 2013 - Successful ablation of two right atrial tachycardias on either side of the lateral tunnel patch in a patient with.pdf:pdf",
issn = "2305-7823",
journal = "Global cardiology science {\&} practice",
month = "jan",
number = 2,
pages = "198--202",
pmid = 24689020,
title = "{Successful ablation of two right atrial tachycardias on either side of the lateral tunnel patch in a patient with double inlet left ventricle and total cavopulmonary connection: Two sites and two mechanisms.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3963736{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 2013,
year = 2013
}
Jeanette Schulz-Menger, David A Bluemke, Jens Bremerich, Scott D Flamm, Mark A Fogel, Matthias G Friedrich, Raymond J Kim, Florian Knobelsdorff-Brenkenhoff, Christopher M Kramer, Dudley J Pennell, Sven Plein and Eike Nagel.
Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:35, January 2013.
URL, DOI BibTeX
@article{Schulz-Menger2013,
abstract = "With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters, however, agreement on specific standards for the interpretation and post-processing of CMR studies is required to ensure consistent quality and reproducibility of CMR reports. This document addresses this need by providing consensus recommendations developed by the Task Force for Post Processing of the Society for Cardiovascular MR (SCMR). The aim of the task force is to recommend requirements and standards for image interpretation and post processing enabling qualitative and quantitative evaluation of CMR images. Furthermore, pitfalls of CMR image analysis are discussed where appropriate.",
author = "Schulz-Menger, Jeanette and Bluemke, David A and Bremerich, Jens and Flamm, Scott D and Fogel, Mark A and Friedrich, Matthias G and Kim, Raymond J and von Knobelsdorff-Brenkenhoff, Florian and Kramer, Christopher M and Pennell, Dudley J and Plein, Sven and Nagel, Eike",
doi = "10.1186/1532-429X-15-35",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Schulz-Menger et al. - 2013 - Standardized image interpretation and post processing in cardiovascular magnetic resonance Society for Car.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Humans,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: standards,Magnetic Resonance Imaging,Magnetic Resonance Imaging: standards,Reproducibility of Results",
month = "jan",
pages = 35,
pmid = 23634753,
title = "{Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3695769{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Dudley J Pennell, John A Baksi, John Paul Carpenter, David N Firmin, Philip J Kilner, Raad H Mohiaddin and Sanjay K Prasad.
Review of Journal of Cardiovascular Magnetic Resonance 2012..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:76, January 2013.
URL, DOI BibTeX
@article{Pennell2013a,
abstract = "There were 90 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2012, which is an 8{\%} increase in the number of articles since 2011. The quality of the submissions continues to increase. The editors are delighted to report that the 2011 JCMR Impact Factor (which is published in June 2012) has risen to 4.44, up from 3.72 for 2010 (as published in June 2011), a 20{\%} increase. The 2011 impact factor means that the JCMR papers that were published in 2009 and 2010 were cited on average 4.44 times in 2011. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is approximately 25{\%}, and has been falling as the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR for publication.",
author = "Pennell, Dudley J and Baksi, A John and Carpenter, John Paul and Firmin, David N and Kilner, Philip J and Mohiaddin, Raad H and Prasad, Sanjay K",
doi = "10.1186/1532-429X-15-76",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2013 - Review of Journal of Cardiovascular Magnetic Resonance 2012.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Animals,Bibliometrics,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: physiopathology,Cardiovascular Diseases: therapy,Editorial Policies,Humans,Journal Impact Factor,Magnetic Resonance Imaging,Periodicals as Topic,Predictive Value of Tests,Prognosis",
month = "jan",
pages = 76,
pmid = 24006874,
title = "{Review of Journal of Cardiovascular Magnetic Resonance 2012.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3847143{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Alicia M Maceira, Juan Cosín-Sales, Michael Roughton, Sanjay K Prasad and Dudley J Pennell.
Reference right atrial dimensions and volume estimation by steady state free precession cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:29, January 2013.
URL, DOI BibTeX
@article{Maceira2013,
abstract = "BACKGROUND: Cardiovascular magnetic resonance (CMR) steady state free precession (SSFP) cine sequences with high temporal resolution and improved post-processing can accurately measure RA dimensions. We used this technique to define ranges for normal RA volumes and dimensions normalized, when necessary, to the influence of gender, body surface area (BSA) and age, and also to define the best 2D images-derived predictors of RA enlargement. METHODS: For definition of normal ranges of RA volume we studied 120 healthy subjects (60 men, 60 women; 20 subjects per age decile from 20 to 80 years), after careful exclusion of cardiovascular abnormality. We also studied 120 patients (60 men, 60 women; age range 20 to 80 years) with a clinical indication for CMR in order to define the best 1D and 2D predictors of RA enlargement. Data were generated from SSFP cine CMR, with 3-dimensional modeling, including tracking of the atrioventricular ring motion and time-volume curves analysis. RESULTS: In the group of healthy individuals, age influenced RA 2-chamber area and transverse diameter. Gender influenced most absolute RA dimensions and volume. Interestingly, right atrial volumes did not change with age and gender when indexed to body surface area. New CMR normal ranges for RA dimensions were modeled and displayed for clinical use with normalization for BSA and gender and display of parameter variation with age. Finally, the best 2D images-derived independent predictors of RA enlargement were indexed area and indexed longitudinal diameter in the 2-chamber view. CONCLUSION: Reference RA dimensions and predictors of RA enlargement are provided using state-of-the-art CMR techniques.",
author = "Maceira, Alicia M and Cos{\'{i}}n-Sales, Juan and Roughton, Michael and Prasad, Sanjay K and Pennell, Dudley J",
doi = "10.1186/1532-429X-15-29",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Maceira et al. - 2013 - Reference right atrial dimensions and volume estimation by steady state free precession cardiovascular magnetic.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Age Factors,Aged,Aged, 80 and over,Body Surface Area,Case-Control Studies,Chi-Square Distribution,Female,Heart Atria,Heart Atria: pathology,Heart Diseases,Heart Diseases: diagnosis,Heart Diseases: pathology,Humans,Linear Models,Logistic Models,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: standards,Male,Middle Aged,Multivariate Analysis,Myocardium,Myocardium: pathology,Observer Variation,Odds Ratio,Predictive Value of Tests,Reference Values,Reproducibility of Results,Sex Factors,Young Adult",
month = "jan",
pages = 29,
pmid = 23566426,
title = "{Reference right atrial dimensions and volume estimation by steady state free precession cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3627628{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Anne Marie Valente, Kimberlee Gauvreau, Gabriele Egidy Assenza, Sonya V Babu-Narayan, Sarah P Evans, Michael Gatzoulis, Maarten Groenink, Ryo Inuzuka, Philip J Kilner, Zeliha Koyak, Michael J Landzberg, Barbara Mulder, Andrew J Powell, Rachel Wald and Tal Geva.
Rationale and design of an International Multicenter Registry of patients with repaired tetralogy of Fallot to define risk factors for late adverse outcomes: the INDICATOR cohort..
Pediatric cardiology 34(1):95–104, January 2013.
URL, DOI BibTeX
@article{Valente2013,
abstract = "Although early survival after tetralogy of Fallot (TOF) repair in the modern era is excellent, studies on late outcomes have shown increasing rates of mortality and morbidity. Despite multiple publications on factors associated with late complications, risk factors for major outcomes (death and sustained ventricular tachycardia [VT]) remain poorly defined. Consequently, the International Multicenter TOF Registry (INDICATOR) was established. This article describes the development, structure, and goals of this registry and characterizes the initial cohort derived from four large congenital heart centers in the United States, Canada, and Europe. A data coordinating center with a core cardiac magnetic resonance (CMR) laboratory and statistical core was established. Subjects with repaired TOF who had CMR imaging performed between 1997 and 2010 and ≥ 1 year follow-up were included. Clinical end points were death and sustained VT. Demographic, electrophysiologic, exercise, and outcome data were collected. A total of 873 subjects fulfilled inclusion criteria (median age at repair 2.9 years and at CMR imaging 22.8 years). Of these, 9 {\%} had QRS duration {\textgreater}180 ms on electrocardiogram (ECG). On CMR imaging, 38 {\%} had severe right-ventricular (RV) dilatation (≥ 160 mL/m(2)), and 6 {\%} had severe RV dysfunction (ejection fraction {\textless} 35 {\%}). Of the 551 subjects with exercise testing available, 28 {\%} had severely decreased exercise capacity with {\textless}50 {\%} predicted peak oxygen consumption. The INDICATOR cohort allows robust statistical analysis to evaluate major clinical outcomes in patients with repaired TOF. Continued follow-up and further expansion of the registry may provide new insights into innovative therapeutic strategies to improve late outcomes.",
author = "Valente, Anne Marie and Gauvreau, Kimberlee and Assenza, Gabriele Egidy and Babu-Narayan, Sonya V and Evans, Sarah P and Gatzoulis, Michael and Groenink, Maarten and Inuzuka, Ryo and Kilner, Philip J and Koyak, Zeliha and Landzberg, Michael J and Mulder, Barbara and Powell, Andrew J and Wald, Rachel and Geva, Tal",
doi = "10.1007/s00246-012-0394-5",
issn = "1432-1971",
journal = "Pediatric cardiology",
keywords = "Adolescent,Adult,Canada,Child,Child, Preschool,Cohort Studies,Electrocardiography,Europe,Exercise Test,Female,Humans,Infant,Infant, Newborn,Magnetic Resonance Imaging,Male,Middle Aged,Prognosis,Registries,Registries: statistics {\&} numerical data,Research Design,Risk Factors,Tetralogy of Fallot,Tetralogy of Fallot: complications,Tetralogy of Fallot: mortality,Tetralogy of Fallot: surgery,Treatment Outcome,United States,Young Adult",
month = "jan",
number = 1,
pages = "95--104",
pmid = 22669402,
title = "{Rationale and design of an International Multicenter Registry of patients with repaired tetralogy of Fallot to define risk factors for late adverse outcomes: the INDICATOR cohort.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22669402",
volume = 34,
year = 2013
}
John-Paul Carpenter, Agata E Grasso, John B Porter, Farrukh Shah, James Dooley and Dudley J Pennell.
On myocardial siderosis and left ventricular dysfunction in hemochromatosis..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:24, January 2013.
URL, DOI BibTeX
@article{Carpenter2013a,
abstract = "{BACKGROUND: Chronically increased intestinal iron uptake in genetic hemochromatosis (HC) may cause organ failure. Whilst iron loading from blood transfusions may cause dilated cardiomyopathy in conditions such as thalassemia, the in-vivo prevalence of myocardial siderosis in HC is unclear, and its relation to left ventricular (LV) dysfunction is controversial. Most previous data on myocardial siderosis in HC has come from post-mortem studies. METHODS: Cardiovascular magnetic resonance (CMR) was performed at first presentation of 41 HC patients (58.9 ± 14.1 years) to measure myocardial iron and left ventricular (LV) ejection fraction (EF). RESULTS: In 31 patients (genetically confirmed HFE-HC), the HFE genotype was C282Y/C282Y (n = 30) and C282Y/H63D (n = 1). Patients with other genotypes (n = 10) were labeled genetically unconfirmed HC. Of the genetically confirmed HFE-HC patients, 6 (19{\%}) had myocardial siderosis (T2* {\textless}20 ms). Of these, 5 (83{\%}) had heart failure and reduced LVEF which was correlated to the severity of siderosis (R2 0.57",
p = "",
author = "Carpenter, John-Paul and Grasso, Agata E and Porter, John B and Shah, Farrukh and Dooley, James and Pennell, Dudley J",
doi = "10.1186/1532-429X-15-24",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Carpenter et al. - 2013 - On myocardial siderosis and left ventricular dysfunction in hemochromatosis.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Aged,Biological Markers,Biological Markers: blood,Cardiomyopathies,Cardiomyopathies: blood,Cardiomyopathies: diagnosis,Cardiomyopathies: etiology,Cardiomyopathies: pathology,Cardiomyopathies: physiopathology,Cardiomyopathies: therapy,Ferritins,Ferritins: blood,Genetic Predisposition to Disease,Heart Failure,Heart Failure: blood,Heart Failure: etiology,Heart Failure: physiopathology,Hemochromatosis,Hemochromatosis: blood,Hemochromatosis: complications,Hemochromatosis: diagnosis,Hemochromatosis: genetics,Hemochromatosis: therapy,Hemosiderosis,Hemosiderosis: blood,Hemosiderosis: diagnosis,Hemosiderosis: etiology,Hemosiderosis: pathology,Hemosiderosis: physiopathology,Hemosiderosis: therapy,Histocompatibility Antigens Class I,Histocompatibility Antigens Class I: genetics,Humans,Linear Models,Magnetic Resonance Imaging,Membrane Proteins,Membrane Proteins: genetics,Middle Aged,Myocardium,Myocardium: metabolism,Myocardium: pathology,Phenotype,Phlebotomy,Prospective Studies,Stroke Volume,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: blood,Ventricular Dysfunction, Left: diagnosis,Ventricular Dysfunction, Left: etiology,Ventricular Dysfunction, Left: pathology,Ventricular Dysfunction, Left: physiopathology,Ventricular Dysfunction, Left: therapy,Ventricular Function, Left",
month = "jan",
pages = 24,
pmid = 23509881,
title = "{On myocardial siderosis and left ventricular dysfunction in hemochromatosis.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3621377{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Robin Simpson, Jennifer Keegan and David Firmin.
Efficient and reproducible high resolution spiral myocardial phase velocity mapping of the entire cardiac cycle..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:34, January 2013.
URL, DOI BibTeX
@article{Simpson2013,
abstract = "BACKGROUND: Three-directional phase velocity mapping (PVM) is capable of measuring longitudinal, radial and circumferential regional myocardial velocities. Current techniques use Cartesian k-space coverage and navigator-gated high spatial and high temporal resolution acquisitions are long. In addition, prospective ECG-gating means that analysis of the full cardiac cycle is not possible. The aim of this study is to develop a high temporal and high spatial resolution PVM technique using efficient spiral k-space coverage and retrospective ECG-gating. Detailed analysis of regional motion over the entire cardiac cycle, including atrial systole for the first time using MR, is presented in 10 healthy volunteers together with a comprehensive assessment of reproducibility. METHODS: A navigator-gated high temporal (21 ms) and spatial (1.4 × 1.4 mm) resolution spiral PVM sequence was developed, acquiring three-directional velocities in 53 heartbeats (100{\%} respiratory-gating efficiency). Basal, mid and apical short-axis slices were acquired in 10 healthy volunteers on two occasions. Regional and transmural early systolic, early diastolic and atrial systolic peak longitudinal, radial and circumferential velocities were measured, together with the times to those peaks (TTPs). Reproducibilities were determined as mean ± SD of the signed differences between measurements made from acquisitions performed on the two days. RESULTS: All slices were acquired in all volunteers on both occasions with good image quality. The high temporal resolution allowed consistent detection of fine features of motion, while the high spatial resolution allowed the detection of statistically significant regional and transmural differences in motion. Colour plots showing the regional variations in velocity over the entire cardiac cycle enable rapid interpretation of the regional motion within any given slice. The reproducibility of peak velocities was high with the reproducibility of early systolic, early diastolic and atrial systolic peak radial velocities in the mid slice (for example) being -0.01 ± 0.36, 0.20 ± 0.56 and 0.14 ± 0.42 cm/s respectively. Reproducibility of the corresponding TTP values, when normalised to a fixed systolic and diastolic length, was also high (-13.8 ± 27.4, 1.3 ± 21.3 and 3.0 ± 10.9 ms for early systolic, early diastolic and atrial systolic respectively). CONCLUSIONS: Retrospectively gated spiral PVM is an efficient and reproducible method of acquiring 3-directional, high resolution velocity data throughout the entire cardiac cycle, including atrial systole.",
author = "Simpson, Robin and Keegan, Jennifer and Firmin, David",
doi = "10.1186/1532-429X-15-34",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Simpson, Keegan, Firmin - 2013 - Efficient and reproducible high resolution spiral myocardial phase velocity mapping of the entire cardi.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Algorithms,Cardiac-Gated Imaging Techniques,Diastole,Electrocardiography,Healthy Volunteers,Heart Rate,Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging, Cine,Myocardial Contraction,Observer Variation,Predictive Value of Tests,Reference Values,Reproducibility of Results,Systole,Time Factors",
month = "jan",
pages = 34,
pmid = 23587250,
title = "{Efficient and reproducible high resolution spiral myocardial phase velocity mapping of the entire cardiac cycle.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3651364{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Helen Dormand and Raad H Mohiaddin.
Cardiovascular magnetic resonance in Marfan syndrome..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:33, January 2013.
URL, DOI BibTeX
@article{Dormand2013,
abstract = "This review provides an overview of Marfan syndrome with an emphasis on cardiovascular complications and cardiovascular imaging. Both pre- and post-operative imaging is addressed with an explanation of surgical management. All relevant imaging modalities are discussed with a particular focus on cardiovascular MR.",
author = "Dormand, Helen and Mohiaddin, Raad H",
doi = "10.1186/1532-429X-15-33",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dormand, Mohiaddin - 2013 - Cardiovascular magnetic resonance in Marfan syndrome.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: etiology,Cardiovascular Diseases: therapy,Contrast Media,Contrast Media: diagnostic use,Diagnosis, Differential,Echocardiography,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Marfan Syndrome,Marfan Syndrome: complications,Marfan Syndrome: diagnosis,Marfan Syndrome: genetics,Marfan Syndrome: therapy,Practice Guidelines as Topic,Prognosis,Tomography, X-Ray Computed",
month = "jan",
pages = 33,
pmid = 23587220,
title = "{Cardiovascular magnetic resonance in Marfan syndrome.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3651373{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Pedro F Ferreira, Peter D Gatehouse, Raad H Mohiaddin and David N Firmin.
Cardiovascular magnetic resonance artefacts..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15:41, January 2013.
URL, DOI BibTeX
@article{Ferreira2013a,
abstract = "The multitude of applications offered by CMR make it an increasing popular modality to study the heart and the surrounding vessels. Nevertheless the anatomical complexity of the chest, together with cardiac and respiratory motion, and the fast flowing blood, present many challenges which can possibly translate into imaging artefacts. The literature is wide in terms of papers describing specific MR artefacts in great technical detail. In this review we attempt to summarise, in a language accessible to a clinical readership, some of the most common artefacts found in CMR applications. It begins with an introduction of the most common pulse sequences, and imaging techniques, followed by a brief section on typical cardiovascular applications. This leads to the main section on common CMR artefacts with examples, a short description of the mechanisms behind them, and possible solutions.",
author = "Ferreira, Pedro F and Gatehouse, Peter D and Mohiaddin, Raad H and Firmin, David N",
doi = "10.1186/1532-429X-15-41",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ferreira et al. - 2013 - Cardiovascular magnetic resonance artefacts.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Artifacts,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods",
month = "jan",
pages = 41,
pmid = 23697969,
title = "{Cardiovascular magnetic resonance artefacts.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3674921{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 15,
year = 2013
}
Kyriacos I Eleftheriou, Jaikirty S Rawal, Lawrence E James, John R Payne, Mike Loosemore, Dudley J Pennell, Michael World, Fotios Drenos, Fares S Haddad, Steve E Humphries, Julie Sanders and Hugh E Montgomery.
Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity..
Bone 52(1):17–26, January 2013.
URL, DOI BibTeX
@article{Eleftheriou2013,
abstract = "BACKGROUND: The development of osteoporosis is influenced by peak bone mass attained in youth - the influence of lifestyle factors upon which is poorly described, especially amongst males. We sought to address this issue in a large scale study. METHODS: Hip bone mineral density (dual X-ray absorptiometry, DXA), bone microarchitecture (calcaneal quantitative ultrasound, QUS) and femoral geometry (magnetic resonance imaging, MRI) were characterised in 723 healthy male military recruits (mean ± S.E. age 19.92 ± 0.09 years [range 16-18 years], height 177.67 ± 0.24 cm, weight 73.17 ± 0.37 kg) on entry to UK Army training. Association was sought with prior physical activity, smoking status and alcohol intake. RESULTS: DXA measures were made in 651, MRI measures in 650, and QUS measures in 572 recruits. Increasing levels of weight-bearing physical activity enhanced periostial bone apposition, increases in both total hip and femoral neck bone mineral density (BMD; p ≤ 0.0001 in both cases), and cortical [p{\textless}0.0001] and periostial bone volumes [p=0.016]. Smoking habit was associated with preserved bone geometry, but worse BMD [p=0.0001] and QUS characteristics [p ≤ 0.0005]. Moderate alcohol consumption was associated with greater BMD [p ≤ 0.015]. CONCLUSIONS: Whilst exercise (and perhaps moderate alcohol intake) is beneficial to bone morphometry, smoking is detrimental to bone mineral density in young males notable for the likely short duration of smoking to influence skeletal properties. However, differences in socio-economic status, lifestyle and related environmental factors may to some extent confound our results.",
author = "Eleftheriou, Kyriacos I and Rawal, Jaikirty S and James, Lawrence E and Payne, John R and Loosemore, Mike and Pennell, Dudley J and World, Michael and Drenos, Fotios and Haddad, Fares S and Humphries, Steve E and Sanders, Julie and Montgomery, Hugh E",
doi = "10.1016/j.bone.2012.09.003",
issn = "1873-2763",
journal = "Bone",
keywords = "Absorptiometry, Photon,Adolescent,Alcohol Drinking,Bone Density,Bone and Bones,Bone and Bones: anatomy {\&} histology,Cohort Studies,European Continental Ancestry Group,Humans,Magnetic Resonance Imaging,Male,Motor Activity,Phenotype,Smoking",
month = "jan",
number = 1,
pages = "17--26",
pmid = 22985892,
title = "{Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22985892",
volume = 52,
year = 2013
}
Lilian Mantziari, Irina Suman-Horduna, Sonya V Babu-Narayan and Sabine Ernst.
Advanced ablation strategies for management of post-surgical atrial arrhythmias..
Global cardiology science & practice 2013(2):140–8, January 2013.
URL, DOI BibTeX
@article{Mantziari2013,
abstract = "Post-surgical arrhythmias include a wide range of arrhythmias occurring late after cardiac surgery and represent a complex substrate for catheter ablation either because of extended scar and remodeling or because of limited access to the area of interest. Novel image integration and ablation tools have made the catheter ablation in this population both feasible and successful. We review a structured approach to catheter ablation of post-surgical atrial arrhythmias in various patient cohorts including the most common congenital heart defects.",
author = "Mantziari, Lilian and Suman-Horduna, Irina and Babu-Narayan, Sonya V and Ernst, Sabine",
doi = "10.5339/gcsp.2013.20",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Mantziari et al. - 2013 - Advanced ablation strategies for management of post-surgical atrial arrhythmias.pdf:pdf",
issn = "2305-7823",
journal = "Global cardiology science {\&} practice",
month = "jan",
number = 2,
pages = "140--8",
pmid = 24689014,
title = "{Advanced ablation strategies for management of post-surgical atrial arrhythmias.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3963742{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 2013,
year = 2013
}
António Miguel Ferreira, Ana G Almeida, Luís Oliveira, Nuno Bettencourt, Hugo Marques, Pedro Matos, João Abecasis, João Abreu, Francisco Alpendurada, Ana Botelho, Paula Campos, Susana Castela, Damião Cunha, Paulo Donato, Maria João Ferreira, Luís Rocha Lopes, Teresa Pinho, Isabel Sá, Carla Saraiva, Nuno Jalles Tavares and Raquel Themudo.
[Consensus document on coding of cardiac magnetic resonance examinations in Portugal]..
Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 32(1):1–5, January 2013.
URL, DOI BibTeX
@article{Ferreira2013,
abstract = "One of the obstacles to more frequent and appropriate use of cardiac magnetic resonance (CMR) in Portugal has been the lack of specific codes that accurately describe these examinations as they are currently performed. In this consensus document, recommendations are made for updating and standardizing CMR codes in Portugal. Guidance on which techniques and codes should be used in the most common clinical scenarios is also provided.",
author = "Ferreira, Ant{\'{o}}nio Miguel and Almeida, Ana G and Oliveira, Lu{\'{i}}s and Bettencourt, Nuno and Marques, Hugo and Matos, Pedro and Abecasis, Jo{\~{a}}o and Abreu, Jo{\~{a}}o and Alpendurada, Francisco and Botelho, Ana and Campos, Paula and Castela, Susana and Cunha, Dami{\~{a}}o and Donato, Paulo and Ferreira, Maria Jo{\~{a}}o and {Rocha Lopes}, Lu{\'{i}}s and Pinho, Teresa and S{\'{a}}, Isabel and Saraiva, Carla and {Jalles Tavares}, Nuno and Themudo, Raquel",
doi = "10.1016/j.repc.2012.08.003",
issn = "0870-2551",
journal = "Revista portuguesa de cardiologia : org{\~{a}}o oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology",
keywords = "Cardiac Imaging Techniques,Clinical Coding,Heart Diseases,Heart Diseases: diagnosis,Humans,Magnetic Resonance Imaging,Portugal",
month = "jan",
number = 1,
pages = "1--5",
pmid = 23199823,
title = "{[Consensus document on coding of cardiac magnetic resonance examinations in Portugal].}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23199823",
volume = 32,
year = 2013
}
Sanjeev Bhattacharyya, Cathy West, Philip J Kilner, Roxy Senior and Wei Li.
Three-dimensional echocardiographic evaluation of quadricuspid systemic atrioventricular valve..
European heart journal cardiovascular Imaging 13(12):1055, December 2012.
URL, DOI BibTeX
@article{Bhattacharyya2012,
author = "Bhattacharyya, Sanjeev and West, Cathy and Kilner, Philip J and Senior, Roxy and Li, Wei",
doi = "10.1093/ehjci/jes162",
issn = "2047-2412",
journal = "European heart journal cardiovascular Imaging",
language = "en",
month = "dec",
number = 12,
pages = 1055,
pmid = 22864817,
publisher = "Oxford University Press",
title = "{Three-dimensional echocardiographic evaluation of quadricuspid systemic atrioventricular valve.}",
url = "http://ehjcimaging.oxfordjournals.org/content/early/2012/08/03/ehjci.jes162.full",
volume = 13,
year = 2012
}
Miguel Silva Vieira, Peter Drivas and Raad H Mohiaddin.
Becker's muscular dystrophy cardiomyopathy: insights from imaging modalities..
Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 31(12):833–4, December 2012.
URL, DOI BibTeX
@article{SilvaVieira2012,
author = "{Silva Vieira}, Miguel and Drivas, Peter and Mohiaddin, Raad H",
doi = "10.1016/j.repc.2012.05.011",
issn = "0870-2551",
journal = "Revista portuguesa de cardiologia : org{\~{a}}o oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology",
keywords = "Adolescent,Cardiomyopathies,Cardiomyopathies: diagnosis,Diagnostic Imaging,Humans,Male,Muscular Dystrophy, Duchenne,Muscular Dystrophy, Duchenne: diagnosis",
month = "dec",
number = 12,
pages = "833--4",
pmid = 23182293,
title = "{Becker's muscular dystrophy cardiomyopathy: insights from imaging modalities.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23182293",
volume = 31,
year = 2012
}
M G Wilson, S Sharma, F Carré, P Charron, P Richard, R O'Hanlon, S K Prasad, H Heidbuchel, J Brugada, O Salah, M Sheppard, K P George, G Whyte, B Hamilton and H Chalabi.
Significance of deep T-wave inversions in asymptomatic athletes with normal cardiovascular examinations: practical solutions for managing the diagnostic conundrum..
British journal of sports medicine 46 Suppl 1:i51–8, November 2012.
URL, DOI BibTeX
@article{Wilson2012,
abstract = "Preparticipation screening programmes for underlying cardiac pathologies are now commonplace for many international sporting organisations. However, providing medical clearance for an asymptomatic athlete without a family history of sudden cardiac death (SCD) is especially challenging when the athlete demonstrates particularly abnormal repolarisation patterns, highly suggestive of an inherited cardiomyopathy or channelopathy. Deep T-wave inversions of ≥ 2 contiguous anterior or lateral leads (but not aVR, and III) are of major concern for sports cardiologists who advise referring team physicians, as these ECG alterations are a recognised manifestation of hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC). Subsequently, inverted T-waves may represent the first and only sign of an inherited heart muscle disease, in the absence of any other features and before structural changes in the heart can be detected. However, to date, there remains little evidence that deep T-wave inversions are always pathognomonic of either a cardiomyopathy or an ion channel disorder in an asymptomatic athlete following long-term follow-up. This paper aims to provide a systematic review of the prevalence of T-wave inversion in athletes and examine T-wave inversion and its relationship to structural heart disease, notably HCM and ARVC with a view to identify young athletes at risk of SCD during sport. Finally, the review proposes clinical management pathways (including genetic testing) for asymptomatic athletes demonstrating significant T-wave inversion with structurally normal hearts.",
author = "Wilson, M G and Sharma, S and Carr{\'{e}}, F and Charron, P and Richard, P and O'Hanlon, R and Prasad, S K and Heidbuchel, H and Brugada, J and Salah, O and Sheppard, M and George, K P and Whyte, G and Hamilton, B and Chalabi, H",
doi = "10.1136/bjsports-2011-090838",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Wilson et al. - 2012 - Significance of deep T-wave inversions in asymptomatic athletes with normal cardiovascular examinations practical.pdf:pdf",
issn = "1473-0480",
journal = "British journal of sports medicine",
keywords = "Arrhythmogenic Right Ventricular Dysplasia,Arrhythmogenic Right Ventricular Dysplasia: diagno,Arrhythmogenic Right Ventricular Dysplasia: therap,Athletes,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Cardiomyopathy, Hypertrophic: therapy,Critical Pathways,Death, Sudden, Cardiac,Death, Sudden, Cardiac: prevention {\&} control,Early Diagnosis,Electrocardiography,Genetic Testing,Genetic Testing: methods,Humans,Physical Examination,Physical Examination: methods,Prognosis,Risk Assessment,Risk Assessment: methods,Sports,Sports: physiology",
month = "nov",
pages = "i51--8",
pmid = 23097480,
title = "{Significance of deep T-wave inversions in asymptomatic athletes with normal cardiovascular examinations: practical solutions for managing the diagnostic conundrum.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3603779{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = "46 Suppl 1",
year = 2012
}
Deirdre F Waterhouse, Tevfik F Ismail, Sanjay K Prasad, Mathew G Wilson and Rory O'Hanlon.
Imaging focal and interstitial fibrosis with cardiovascular magnetic resonance in athletes with left ventricular hypertrophy: implications for sporting participation..
British journal of sports medicine 46 Suppl 1(Suppl_1):i69–77, November 2012.
URL, DOI BibTeX
@article{Waterhouse2012,
abstract = "Long-term high-intensity physical activity is associated with morphological changes, termed as the 'athlete's heart'. The differentiation of physiological cardiac adaptive changes in response to high-level exercise from pathological changes consistent with an inherited cardiomyopathy is imperative. Cardiovascular magnetic resonance (CMR) imaging allows definition of abnormal processes occurring at the tissue level, including, importantly, myocardial fibrosis. It is therefore vital in accurately making this differentiation. In this review, we will review the role of CMR imaging of fibrosis, and detail CMR characterisation of myocardial fibrosis in various cardiomyopathies, and the implications of fibrosis. Additionally, we will outline advances in imaging fibrosis, in particular T1 mapping. Finally we will address the role of CMR in pre-participation screening.",
author = "Waterhouse, Deirdre F and Ismail, Tevfik F and Prasad, Sanjay K and Wilson, Mathew G and O'Hanlon, Rory",
doi = "10.1136/bjsports-2012-091482",
issn = "1473-0480",
journal = "British journal of sports medicine",
keywords = "Arrhythmias, Cardiac,Arrhythmias, Cardiac: diagnosis,Athletes,Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: diagnosis,Death, Sudden, Cardiac,Death, Sudden, Cardiac: prevention {\&} control,Echocardiography,Fibrosis,Fibrosis: diagnosis,Fibrosis: etiology,Forecasting,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Magnetic Resonance Angiography: trends,Myocarditis,Myocarditis: diagnosis,Myocardium,Myocardium: pathology,Sports,Sports: physiology",
month = "nov",
number = "Suppl{\_}1",
pages = "i69--77",
pmid = 23097483,
title = "{Imaging focal and interstitial fibrosis with cardiovascular magnetic resonance in athletes with left ventricular hypertrophy: implications for sporting participation.}",
url = "http://bjsm.bmj.com/content/46/Suppl{\_}1/i69.abstract",
volume = "46 Suppl 1",
year = 2012
}
John K M Chan, Prakash P Punjabi, Marcus Flather, Riccardo Wage, Karen Symmonds, Isabelle Roussin, Shelley Rahman-Haley, Dudley J Pennell, Philip J Kilner, Gilles D Dreyfus and John R Pepper.
Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial..
Circulation 126(21):2502–10, November 2012.
URL, DOI BibTeX
@article{Chan2012,
abstract = "The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG alone.",
author = "Chan, K M John and Punjabi, Prakash P and Flather, Marcus and Wage, Riccardo and Symmonds, Karen and Roussin, Isabelle and Rahman-Haley, Shelley and Pennell, Dudley J and Kilner, Philip J and Dreyfus, Gilles D and Pepper, John R",
doi = "10.1161/CIRCULATIONAHA.112.143818",
issn = "1524-4539",
journal = "Circulation",
keywords = "Aged,Aged, 80 and over,Coronary Artery Bypass,Coronary Artery Bypass: methods,Female,Follow-Up Studies,Humans,Male,Middle Aged,Mitral Valve Annuloplasty,Mitral Valve Annuloplasty: methods,Mitral Valve Insufficiency,Mitral Valve Insufficiency: epidemiology,Mitral Valve Insufficiency: physiopathology,Mitral Valve Insufficiency: surgery,Myocardial Ischemia,Myocardial Ischemia: epidemiology,Myocardial Ischemia: physiopathology,Myocardial Ischemia: surgery,Single-Blind Method,Treatment Outcome",
month = "nov",
number = 21,
pages = "2502--10",
pmid = 23136163,
title = "{Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23136163",
volume = 126,
year = 2012
}
I T Pierce, P D Gatehouse, E Kalodiki, C Lattimer, G Geroulakos, X Y Xu and D N Firmin.
Magnetic resonance venous velocity mapping during intermittent pneumatic compression of the calf and foot..
Phlebology / Venous Forum of the Royal Society of Medicine 27(7):352–9, October 2012.
URL, DOI BibTeX
@article{Pierce2012,
abstract = "Assessment and optimization of intermittent pneumatic compression (IPC) devices for prophylaxis of deep vein thrombosis has previously used duplex ultrasound. The aim was to investigate novel magnetic resonance (MR) venous velocity mapping (VM) for IPC research and development.",
author = "Pierce, I T and Gatehouse, P D and Kalodiki, E and Lattimer, C and Geroulakos, G and Xu, X Y and Firmin, D N",
doi = "10.1258/phleb.2011.011053",
issn = "1758-1125",
journal = "Phlebology / Venous Forum of the Royal Society of Medicine",
month = "oct",
number = 7,
pages = "352--9",
pmid = 22156366,
title = "{Magnetic resonance venous velocity mapping during intermittent pneumatic compression of the calf and foot.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22156366",
volume = 27,
year = 2012
}
Francisco Leyva, Robin J Taylor, Paul W X Foley, Fraz Umar, Lawrence J Mulligan, Kiran Patel, Berthold Stegemann, Tarek Haddad, Russell E A Smith and Sanjay K Prasad.
Left ventricular midwall fibrosis as a predictor of mortality and morbidity after cardiac resynchronization therapy in patients with nonischemic cardiomyopathy..
Journal of the American College of Cardiology 60(17):1659–67, October 2012.
URL, DOI BibTeX
@article{Leyva2012,
abstract = "The aim of this study was to determine whether left ventricular (LV) midwall fibrosis, detected by midwall hyperenhancement (MWHE) on late gadolinium enhancement cardiovascular magnetic resonance (CMR) imaging, predicts mortality and morbidity in patients with dilated cardiomyopathy (DCM) undergoing cardiac resynchronization therapy (CRT).",
author = "Leyva, Francisco and Taylor, Robin J and Foley, Paul W X and Umar, Fraz and Mulligan, Lawrence J and Patel, Kiran and Stegemann, Berthold and Haddad, Tarek and Smith, Russell E A and Prasad, Sanjay K",
doi = "10.1016/j.jacc.2012.05.054",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Aged,Cardiac Resynchronization Therapy,Cardiomyopathies,Cardiomyopathies: mortality,Cardiomyopathies: physiopathology,Cardiomyopathies: therapy,Female,Fibrosis,Fibrosis: mortality,Follow-Up Studies,Great Britain,Great Britain: epidemiology,Heart Ventricles,Heart Ventricles: pathology,Humans,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Morbidity,Morbidity: trends,Prognosis,Retrospective Studies,Survival Rate,Survival Rate: trends,Time Factors,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: diagnosis,Ventricular Dysfunction, Left: epidemiology",
month = "oct",
number = 17,
pages = "1659--67",
pmid = 23021326,
title = "{Left ventricular midwall fibrosis as a predictor of mortality and morbidity after cardiac resynchronization therapy in patients with nonischemic cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/23021326",
volume = 60,
year = 2012
}
Vimal Raj, Francisco Alpendurada, Timothy Christmas, Neil E Moat and Raad H Mohiaddin.
Cardiovascular magnetic resonance imaging in assessment of intracaval and intracardiac extension of renal cell carcinoma..
The Journal of thoracic and cardiovascular surgery 144(4):845–51, October 2012.
URL, DOI BibTeX
@article{Raj2012,
abstract = "About 1 in 5 patients with renal cell carcinoma have intravascular tumoral extension at presentation. Level of tumoral extension within inferior vena cava determines surgical approach, with higher extension requiring cardiopulmonary bypass. Tumoral invasion of inferior vena caval wall is associated with poor prognosis. We evaluated accuracy of magnetic resonance imaging (MRI) in assessing level of intravascular extension of renal cell carcinoma and predicting vessel wall invasion.",
author = "Raj, Vimal and Alpendurada, Francisco and Christmas, Timothy and Moat, Neil E and Mohiaddin, Raad H",
doi = "10.1016/j.jtcvs.2011.11.035",
issn = "1097-685X",
journal = "The Journal of thoracic and cardiovascular surgery",
keywords = "Adult,Aged,Aged, 80 and over,Carcinoma, Renal Cell,Carcinoma, Renal Cell: diagnosis,Carcinoma, Renal Cell: pathology,Carcinoma, Renal Cell: surgery,England,Female,Humans,Incidental Findings,Kidney Neoplasms,Kidney Neoplasms: diagnosis,Kidney Neoplasms: pathology,Kidney Neoplasms: surgery,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,Neoplasm Invasiveness,Neoplasm Staging,Predictive Value of Tests,Prognosis,Retrospective Studies,Sensitivity and Specificity,Vena Cava, Inferior,Vena Cava, Inferior: pathology,Vena Cava, Inferior: surgery,Young Adult",
month = "oct",
number = 4,
pages = "845--51",
pmid = 22177095,
title = "{Cardiovascular magnetic resonance imaging in assessment of intracaval and intracardiac extension of renal cell carcinoma.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22177095",
volume = 144,
year = 2012
}
Masliza Mahmod, Francisco Alpendurada, Peter Drivas, Rick Wage, Hannah Barnes and Raad H Mohiaddin.
Demonstration of a rare variant of partial anomalous pulmonary venous drainage and quantification of shunt by cardiac magnetic resonance..
Journal of cardiovascular medicine (Hagerstown, Md.) 13(9):603–6, September 2012.
URL, DOI BibTeX
@article{Mahmod2012,
author = "Mahmod, Masliza and Alpendurada, Francisco and Drivas, Peter and Wage, Rick and Barnes, Hannah and Mohiaddin, Raad H",
doi = "10.2459/JCM.0b013e32833a08c8",
issn = "1558-2035",
journal = "Journal of cardiovascular medicine (Hagerstown, Md.)",
keywords = "Humans,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Middle Aged,Pulmonary Circulation,Pulmonary Veins,Pulmonary Veins: abnormalities,Pulmonary Veins: physiopathology,Regional Blood Flow,Vascular Malformations,Vascular Malformations: diagnosis,Vascular Malformations: physiopathology",
month = "sep",
number = 9,
pages = "603--6",
pmid = 22859256,
title = "{Demonstration of a rare variant of partial anomalous pulmonary venous drainage and quantification of shunt by cardiac magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22859256",
volume = 13,
year = 2012
}
Jason M Tarkin, Nearchos Hadjiloizou, Henry Oluwasefunmi Savage, Sanjay K Prasad, Mary N Sheppard, Neil E Moat and Sam Kaddoura.
Severe cardiac failure due to rapidly progressive rheumatoid arthritis-associated valvulopathy..
Cardiovascular journal of Africa 23(7):e1–3, August 2012.
URL, DOI BibTeX
@article{Tarkin2012,
abstract = "Cardiac failure due to rapidly progressive valve disease is a rare complication of rheumatoid arthritis (RA) that can be challenging to manage. A patient with severe heart failure secondary to RA who, after failing to respond to medical therapy, underwent high-risk valve surgery and did remarkably well, with dramatic symptomatic improvement and essentially normalised left ventricular size and function as seen on follow-up echocardiography.",
author = "Tarkin, Jason M and Hadjiloizou, Nearchos and Savage, Henry Oluwasefunmi and Prasad, Sanjay K and Sheppard, Mary N and Moat, Neil E and Kaddoura, Sam",
doi = "10.5830/CVJA-2012-012",
issn = "1680-0745",
journal = "Cardiovascular journal of Africa",
keywords = "Arthritis, Rheumatoid,Arthritis, Rheumatoid: complications,Disease Progression,Echocardiography,Follow-Up Studies,Heart Failure,Heart Failure: etiology,Heart Failure: physiopathology,Heart Failure: ultrasonography,Humans,Male,Middle Aged,Mitral Valve Insufficiency,Mitral Valve Insufficiency: complications,Mitral Valve Insufficiency: physiopathology,Mitral Valve Insufficiency: ultrasonography,Severity of Illness Index,Ventricular Function, Left",
month = "aug",
number = 7,
pages = "e1--3",
pmid = 22915056,
title = "{Severe cardiac failure due to rapidly progressive rheumatoid arthritis-associated valvulopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22915056",
volume = 23,
year = 2012
}
Cesare Quarto, Marc R Dweck, Timothy Murigu, Sanjiv Joshi, Giovanni Melina, Emiliano Angeloni, Sanjay K Prasad and John R Pepper.
Late gadolinium enhancement as a potential marker of increased perioperative risk in aortic valve replacement..
Interactive cardiovascular and thoracic surgery 15(1):45–50, July 2012.
URL, DOI BibTeX
@article{Quarto2012,
abstract = "OBJECTIVES Risk assessment of patients with aortic stenosis (AS) undergoing aortic valve replacement (AVR) is challenging. We set out to determine the impact of myocardial late gadolinium enhancement (LGE), as detected by cardiovascular magnetic resonance (CMR), on postoperative outcomes following AVR. METHODS A prospective observational study was conducted on patients undergoing CMR using the LGE technique within 1 year of subsequent AVR. Patients were categorized into absent, mid-wall or infarct patterns of LGE by independent observers blinded to all clinical data, and data were collected with regard to 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE) and postoperative complications. RESULTS A total of 63 patients were studied. Twenty-five patients had no LGE; 20 had mid-wall LGE and 18 had an infarct pattern. The incidence of MACCE, cerebrovascular accident (CVA) and heart block were significantly higher in the mid-wall group compared with the other two groups (MACCE: 25 vs. 0 vs. 5{\%",
p = "",
author = "Quarto, Cesare and Dweck, Marc R and Murigu, Timothy and Joshi, Sanjiv and Melina, Giovanni and Angeloni, Emiliano and Prasad, Sanjay K and Pepper, John R",
doi = "10.1093/icvts/ivs098",
issn = "1569-9285",
journal = "Interactive cardiovascular and thoracic surgery",
keywords = "Aged,Aged, 80 and over,Analysis of Variance,Aortic Valve Stenosis,Aortic Valve Stenosis: complications,Aortic Valve Stenosis: diagnosis,Aortic Valve Stenosis: mortality,Aortic Valve Stenosis: pathology,Aortic Valve Stenosis: surgery,Cerebrovascular Disorders,Cerebrovascular Disorders: etiology,Chi-Square Distribution,Contrast Media,Contrast Media: diagnostic use,Female,Fibrosis,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Heart Block,Heart Block: etiology,Heart Valve Prosthesis Implantation,Heart Valve Prosthesis Implantation: adverse effec,Heart Valve Prosthesis Implantation: mortality,Humans,London,Magnetic Resonance Imaging,Male,Middle Aged,Myocardial Infarction,Myocardial Infarction: complications,Myocardial Infarction: diagnosis,Myocardial Infarction: mortality,Myocardial Infarction: pathology,Myocardium,Myocardium: pathology,Predictive Value of Tests,Prospective Studies,Risk Assessment,Risk Factors,Treatment Outcome",
month = "jul",
number = 1,
pages = "45--50",
pmid = 22514254,
title = "{Late gadolinium enhancement as a potential marker of increased perioperative risk in aortic valve replacement.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22514254",
volume = 15,
year = 2012
}
Sebastian B S Krittian, Pablo Lamata, Christian Michler, David A Nordsletten, Jelena Bock, Chris P Bradley, Alex Pitcher, Philip J Kilner, Michael Markl and Nic P Smith.
A finite-element approach to the direct computation of relative cardiovascular pressure from time-resolved MR velocity data..
Medical image analysis 16(5):1029–37, July 2012.
URL, DOI BibTeX
@article{Krittian2012,
abstract = "The evaluation of cardiovascular velocities, their changes through the cardiac cycle and the consequent pressure gradients has the capacity to improve understanding of subject-specific blood flow in relation to adjacent soft tissue movements. Magnetic resonance time-resolved 3D phase contrast velocity acquisitions (4D flow) represent an emerging technology capable of measuring the cyclic changes of large scale, multi-directional, subject-specific blood flow. A subsequent evaluation of pressure differences in enclosed vascular compartments is a further step which is currently not directly available from such data. The focus of this work is to address this deficiency through the development of a novel simulation workflow for the direct computation of relative cardiovascular pressure fields. Input information is provided by enhanced 4D flow data and derived MR domain masking. The underlying methodology shows numerical advantages in terms of robustness, global domain composition, the isolation of local fluid compartments and a treatment of boundary conditions. This approach is demonstrated across a range of validation examples which are compared with analytic solutions. Four subject-specific test cases are subsequently run, showing good agreement with previously published calculations of intra-vascular pressure differences. The computational engine presented in this work contributes to non-invasive access to relative pressure fields, incorporates the effects of both blood flow acceleration and viscous dissipation, and enables enhanced evaluation of cardiovascular blood flow.",
author = "Krittian, Sebastian B S and Lamata, Pablo and Michler, Christian and Nordsletten, David A and Bock, Jelena and Bradley, Chris P and Pitcher, Alex and Kilner, Philip J and Markl, Michael and Smith, Nic P",
doi = "10.1016/j.media.2012.04.003",
issn = "1361-8423",
journal = "Medical image analysis",
keywords = "Blood Pressure,Blood Pressure Determination,Blood Pressure Determination: methods,Computer Simulation,Finite Element Analysis,Heart,Heart: anatomy {\&} histology,Heart: physiology,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Models, Cardiovascular,Myocardial Perfusion Imaging,Myocardial Perfusion Imaging: methods,Reproducibility of Results,Sensitivity and Specificity",
month = "jul",
number = 5,
pages = "1029--37",
pmid = 22626833,
title = "{A finite-element approach to the direct computation of relative cardiovascular pressure from time-resolved MR velocity data.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3387378{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 16,
year = 2012
}
Mitral valve prolapse.
June 2012.
URL BibTeX
@misc{,
month = "jun",
publisher = "A.D.A.M.",
title = "{Mitral valve prolapse}",
url = "http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001232/",
year = 2012
}
Ryo Torii, Ismail El-Hamamsy, Mohamed Donya, Sonya V Babu-Narayan, Michael Ibrahim, Philip J Kilner, Raad H Mohiaddin, Xiao Yun Xu and Magdi H Yacoub.
Integrated morphologic and functional assessment of the aortic root after different tissue valve root replacement procedures..
The Journal of thoracic and cardiovascular surgery 143(6):1422–8, June 2012.
URL, DOI BibTeX
@article{Torii2012,
abstract = "This study was undertaken to explore aspects of the hemodynamic function of different biologic tissue aortic valve root replacements. We set out to image and display the spatiotemporal distributions of axially directed blood velocity through the aortic root.",
author = "Torii, Ryo and El-Hamamsy, Ismail and Donya, Mohamed and Babu-Narayan, Sonya V and Ibrahim, Michael and Kilner, Philip J and Mohiaddin, Raad H and Xu, Xiao Yun and Yacoub, Magdi H",
doi = "10.1016/j.jtcvs.2011.12.034",
issn = "1097-685X",
journal = "The Journal of thoracic and cardiovascular surgery",
keywords = "Adult,Aged,Aged, 80 and over,Analysis of Variance,Aortic Valve,Aortic Valve Insufficiency,Aortic Valve Insufficiency: pathology,Aortic Valve Insufficiency: physiopathology,Aortic Valve Insufficiency: surgery,Aortic Valve Stenosis,Aortic Valve Stenosis: pathology,Aortic Valve Stenosis: physiopathology,Aortic Valve Stenosis: surgery,Aortic Valve: pathology,Aortic Valve: physiopathology,Aortic Valve: surgery,Bioprosthesis,Blood Flow Velocity,Female,Heart Valve Prosthesis,Heart Valve Prosthesis Implantation,Heart Valve Prosthesis Implantation: instrumentati,Heart Valve Prosthesis Implantation: methods,Hemodynamics,Humans,Image Processing, Computer-Assisted,London,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Predictive Value of Tests,Prosthesis Design,Time Factors,Transplantation, Autologous,Transplantation, Homologous,Treatment Outcome",
month = "jun",
number = 6,
pages = "1422--8",
pmid = 22361248,
title = "{Integrated morphologic and functional assessment of the aortic root after different tissue valve root replacement procedures.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22361248",
volume = 143,
year = 2012
}
Mathew G Wilson, François Carré, Othman Salah, Sanjay Sharma, Sanjay K Prasad, Gregory P Whyte, Bruce Hamilton and Hakim Chalabi.
Significance of deep T-wave inversions in an asymptomatic athlete with a family history of sudden death: addendum–full sporting disqualification..
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 22(3):284–7, May 2012.
URL, DOI BibTeX
@article{Wilson2012a,
author = "Wilson, Mathew G and Carr{\'{e}}, Fran{\c{c}}ois and Salah, Othman and Sharma, Sanjay and Prasad, Sanjay K and Whyte, Gregory P and Hamilton, Bruce and Chalabi, Hakim",
doi = "10.1097/JSM.0b013e31824c851a",
issn = "1536-3724",
journal = "Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine",
keywords = "Athletes,Atrial Fibrillation,Atrial Fibrillation: diagnosis,Blood Pressure,Blood Pressure: physiology,Death, Sudden,Death, Sudden: prevention {\&} control,Electrocardiography,Exercise Test,Heart Rate,Humans,Male,Myocarditis,Myocarditis: diagnosis,Oxygen Consumption,Oxygen Consumption: physiology,Soccer,Soccer: physiology,Tachycardia, Supraventricular,Tachycardia, Supraventricular: diagnosis,Unconsciousness,Unconsciousness: diagnosis",
month = "may",
number = 3,
pages = "284--7",
pmid = 22450592,
title = "{Significance of deep T-wave inversions in an asymptomatic athlete with a family history of sudden death: addendum--full sporting disqualification.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22450592",
volume = 22,
year = 2012
}
Christopher M Lee, Florence H Sheehan, Beatriz Bouzas, Sylvia S M Chen, Michael A Gatzoulis and Philip J Kilner.
The shape and function of the right ventricle in Ebstein's anomaly..
International journal of cardiology, March 2012.
URL, DOI BibTeX
@article{Lee2012,
abstract = "{BACKGROUND: Ebstein's anomaly involves both the right ventricle (RV) and tricuspid valve. METHODS: The functional RV and tricuspid orifice were traced from magnetic resonance images in 29 adult Ebstein patients and 9 normal subjects and reconstructed for visualization and measurement of regional RV size, function, and shape at 20 cross sections, and inlet and outflow tract ejection fractions (EFs). RESULTS: The RV in Ebstein's had RV dilation (end diastolic volume index 179±69 vs. 84±22ml/m(2) in normals, p{\textless}0.001) and global dysfunction (EF 45±8 vs. 55±5{\%} in normals, p{\textless}0.001). Longitudinal contraction was preserved (26±13 vs. 26±4mm in normals) and correlated more weakly with EF than short axis fractional shortening (r=0.44 vs. r=0.71, p{\textless}0.05 for both). The apical region in Ebstein's RV was enlarged, rounded and contributed more than normal to the global stroke volume. However this contribution correlated inversely with global EF. In contrast slices in the basal region had normal cross sectional area and their function correlated directly with global EF. Inlet EF was depressed (46±8{\%} vs. 55±6 in normals",
p = "",
author = "Lee, Christopher M and Sheehan, Florence H and Bouzas, Beatriz and Chen, Sylvia S M and Gatzoulis, Michael A and Kilner, Philip J",
doi = "10.1016/j.ijcard.2012.03.062",
issn = "1874-1754",
journal = "International journal of cardiology",
month = "mar",
pmid = 22465348,
title = "{The shape and function of the right ventricle in Ebstein's anomaly.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22465348",
year = 2012
}
Tevfik F Ismail, Sanjay K Prasad and Dudley J Pennell.
Prognostic importance of late gadolinium enhancement cardiovascular magnetic resonance in cardiomyopathy..
Heart (British Cardiac Society) 98(6):438–42, March 2012.
URL, DOI BibTeX
@article{Ismail2012,
abstract = "Cardiovascular magnetic resonance has revolutionised the diagnosis of cardiomyopathy, particularly through the use of late gadolinium enhancement imaging which provides the unique opportunity to assess myocardial fibrosis in vivo. More recently, the prognostic capability of cardiovascular magnetic resonance to predict outcomes has been assessed. Traditional risk markers do not at present adequately predict outcomes in either dilated cardiomyopathy or hypertrophic cardiomyopathy, which are the two most common causes of primary heart muscle disease. Many of these existing markers reflect underlying disease severity. Given the important role fibrosis is thought to play in the pathogenesis and sequelae of these cardiomyopathies, the presence and amount of fibrosis has been proposed as a potential novel risk factor for adverse events. This paper reviews the evidence for late gadolinium enhancement as a prognostic marker in dilated and hypertrophic cardiomyopathy and highlights the challenges ahead.",
author = "Ismail, Tevfik F and Prasad, Sanjay K and Pennell, Dudley J",
doi = "10.1136/heartjnl-2011-300814",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = "Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: diagnosis,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Contrast Media,Gadolinium,Gadolinium: diagnostic use,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Prognosis",
month = "mar",
number = 6,
pages = "438--42",
pmid = 22128204,
title = "{Prognostic importance of late gadolinium enhancement cardiovascular magnetic resonance in cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22128204",
volume = 98,
year = 2012
}
Partho P Sengupta, Gianni Pedrizzetti, Philip J Kilner, Arash Kheradvar, Tino Ebbers, Giovanni Tonti, Alan G Fraser and Jagat Narula.
Emerging trends in CV flow visualization..
JACC. Cardiovascular imaging 5(3):305–16, March 2012.
URL, DOI BibTeX
@article{Sengupta2012,
abstract = "Blood flow patterns are closely linked to the morphology and function of the cardiovascular system. These patterns reflect the exceptional adaptability of the cardiovascular system to maintain normal blood circulation under a wide range of workloads. Accurate retrieval and display of flow-related information remains a challenge because of the processes involved in mapping the flow velocity fields within specific chambers of the heart. We review the potentials and pitfalls of current approaches for blood flow visualization, with an emphasis on acquisition, display, and analysis of multidirectional flow. This document is divided into 3 sections. First, we provide a descriptive outline of the relevant concepts in cardiac fluid mechanics, including the emergence of rotation in flow and the variables that delineate vortical structures. Second, we elaborate on the main methods developed to image and visualize multidirectional cardiovascular flow, which are mainly based on cardiac magnetic resonance, ultrasound Doppler, and contrast particle imaging velocimetry, with recommendations for developing dedicated imaging protocols. Finally, we discuss the potential clinical applications and technical challenges with suggestions for further investigations.",
author = "Sengupta, Partho P and Pedrizzetti, Gianni and Kilner, Philip J and Kheradvar, Arash and Ebbers, Tino and Tonti, Giovanni and Fraser, Alan G and Narula, Jagat",
doi = "10.1016/j.jcmg.2012.01.003",
issn = "1876-7591",
journal = "JACC. Cardiovascular imaging",
keywords = "Biomechanics,Blood Flow Velocity,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: physiopathology,Cardiovascular System,Cardiovascular System: physiopathology,Echocardiography, Doppler, Color,Echocardiography, Doppler, Color: trends,Hemorheology,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: trends,Perfusion Imaging,Perfusion Imaging: trends,Predictive Value of Tests,Prognosis,Regional Blood Flow,Rheology,Rheology: trends",
month = "mar",
number = 3,
pages = "305--16",
pmid = 22421178,
title = "{Emerging trends in CV flow visualization.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22421178",
volume = 5,
year = 2012
}
Daniel S Herman, Lien Lam, Matthew R G Taylor, Libin Wang, Polakit Teekakirikul, Danos Christodoulou, Lauren Conner, Steven R DePalma, Barbara McDonough, Elizabeth Sparks, Debbie Lin Teodorescu, Allison L Cirino, Nicholas R Banner, Dudley J Pennell, Sharon Graw, Marco Merlo, Andrea Di Lenarda, Gianfranco Sinagra, Martijn J Bos, Michael J Ackerman, Richard N Mitchell, Charles E Murry, Neal K Lakdawala, Carolyn Y Ho, Paul J R Barton, Stuart A Cook, Luisa Mestroni, J G Seidman and Christine E Seidman.
Truncations of titin causing dilated cardiomyopathy..
The New England journal of medicine 366(7):619–28, February 2012.
URL, DOI BibTeX
@article{Herman2012,
abstract = "Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently analyzed for cardiomyopathy mutations because of its enormous size.",
author = "Herman, Daniel S and Lam, Lien and Taylor, Matthew R G and Wang, Libin and Teekakirikul, Polakit and Christodoulou, Danos and Conner, Lauren and DePalma, Steven R and McDonough, Barbara and Sparks, Elizabeth and Teodorescu, Debbie Lin and Cirino, Allison L and Banner, Nicholas R and Pennell, Dudley J and Graw, Sharon and Merlo, Marco and {Di Lenarda}, Andrea and Sinagra, Gianfranco and Bos, J Martijn and Ackerman, Michael J and Mitchell, Richard N and Murry, Charles E and Lakdawala, Neal K and Ho, Carolyn Y and Barton, Paul J R and Cook, Stuart A and Mestroni, Luisa and Seidman, J G and Seidman, Christine E",
doi = "10.1056/NEJMoa1110186",
issn = "1533-4406",
journal = "The New England journal of medicine",
keywords = "Adult,Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: genetics,Cardiomyopathy, Dilated: pathology,Female,Genotyping Techniques,Humans,Male,Middle Aged,Muscle Proteins,Muscle Proteins: genetics,Mutation,Myocardium,Myocardium: pathology,Protein Kinases,Protein Kinases: genetics,Sequence Analysis, DNA,Sequence Analysis, DNA: methods,Sequence Deletion",
month = "feb",
number = 7,
pages = "619--28",
pmid = 22335739,
title = "{Truncations of titin causing dilated cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22335739",
volume = 366,
year = 2012
}
Kyriacos I Eleftheriou, Jaikirty S Rawal, Anthony Kehoe, Laurence E James, John R Payne, James R Skipworth, Zudin A Puthucheary, Fotios Drenos, Dudley J Pennell, Mike Loosemore, Michael World, Steve E Humphries, Fares S Haddad and Hugh E Montgomery.
The Lichfield bone study: the skeletal response to exercise in healthy young men..
Journal of applied physiology (Bethesda, Md. : 1985) 112(4):615–26, February 2012.
URL, DOI BibTeX
@article{Eleftheriou2012,
abstract = "{The skeletal response to short-term exercise training remains poorly described. We thus studied the lower limb skeletal response of 723 Caucasian male army recruits to a 12-wk training regime. Femoral bone volume was assessed using magnetic resonance imaging, bone ultrastructure by quantitative ultrasound (QUS), and bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) of the hip. Left hip BMD increased with training (mean ± SD: 0.85 ± 3.24, 2.93 ± 4.85, and 1.89 ± 2.85{\%} for femoral neck, Ward's area, and total hip, respectively; all P {\textless} 0.001). Left calcaneal broadband ultrasound attenuation rose 3.57 ± 0.5{\%} (P {\textless} 0.001), and left and right femoral cortical volume by 1.09 ± 4.05 and 0.71 ± 4.05{\%}, respectively (P = 0.0001 and 0.003), largely through the rise in periosteal volume (0.78 ± 3.14 and 0.59 ± 2.58{\%} for right and left, respectively, P {\textless} 0.001) with endosteal volumes unchanged. Before training, DXA and QUS measures were independent of limb dominance. However, the dominant femur had higher periosteal (25,991.49 vs. 2,5572 mm(3), P {\textless} 0.001), endosteal (6,063.33 vs. 5,983.12 mm(3)",
p = "",
author = "Eleftheriou, Kyriacos I and Rawal, Jaikirty S and Kehoe, Anthony and James, Laurence E and Payne, John R and Skipworth, James R and Puthucheary, Zudin A and Drenos, Fotios and Pennell, Dudley J and Loosemore, Mike and World, Michael and Humphries, Steve E and Haddad, Fares S and Montgomery, Hugh E",
doi = "10.1152/japplphysiol.00788.2011",
issn = "1522-1601",
journal = "Journal of applied physiology (Bethesda, Md. : 1985)",
keywords = "Absorptiometry, Photon,Adolescent,Aging,Aging: physiology,Bone Density,Bone and Bones,Bone and Bones: anatomy {\&} histology,Bone and Bones: physiology,Bone and Bones: ultrasonography,Calcification, Physiologic,Exercise,Exercise: physiology,Functional Laterality,Humans,Magnetic Resonance Imaging,Male,Prospective Studies,Young Adult",
month = "feb",
number = 4,
pages = "615--26",
pmid = 22114178,
title = "{The Lichfield bone study: the skeletal response to exercise in healthy young men.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3289434{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 112,
year = 2012
}
Sabine Ernst, Sonya V Babu-Narayan, Jennifer Keegan, Irina Horduna, Jonathan Lyne, Janice Till, Philip J Kilner, Dudley Pennell, Michael L Rigby and Michael A Gatzoulis.
Remote-controlled magnetic navigation and ablation with 3D image integration as an alternative approach in patients with intra-atrial baffle anatomy..
Circulation. Arrhythmia and electrophysiology 5(1):131–9, February 2012.
URL, DOI BibTeX
@article{Ernst2012,
abstract = "Improvement in outcome of infants born with congenital heart defects has been accompanied by an increasing frequency of late arrhythmias. Ablation is difficult because of multiple tachycardias in the presence of complex anatomy with limited accessibility. We report on remote-controlled ablation using magnetic navigation in conjunction with 3D image integration in patients with previous intra-atrial baffle procedures.",
author = "Ernst, Sabine and Babu-Narayan, Sonya V and Keegan, Jennifer and Horduna, Irina and Lyne, Jonathan and Till, Janice and Kilner, Philip J and Pennell, Dudley and Rigby, Michael L and Gatzoulis, Michael A",
doi = "10.1161/CIRCEP.111.962993",
issn = "1941-3084",
journal = "Circulation. Arrhythmia and electrophysiology",
keywords = "Adult,Catheter Ablation,Catheter Ablation: methods,Female,Follow-Up Studies,Heart Atria,Heart Atria: innervation,Heart Atria: pathology,Heart Atria: radiography,Heart Conduction System,Heart Conduction System: pathology,Heart Conduction System: radiography,Heart Conduction System: surgery,Humans,Imaging, Three-Dimensional,Imaging, Three-Dimensional: methods,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Reproducibility of Results,Retrospective Studies,Robotics,Robotics: methods,Tachycardia, Supraventricular,Tachycardia, Supraventricular: diagnosis,Tachycardia, Supraventricular: surgery,Tomography, X-Ray Computed,Treatment Outcome",
month = "feb",
number = 1,
pages = "131--9",
pmid = 22062797,
title = "{Remote-controlled magnetic navigation and ablation with 3D image integration as an alternative approach in patients with intra-atrial baffle anatomy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22062797",
volume = 5,
year = 2012
}
Sonya V Babu-Narayan, Anselm Uebing, Periklis A Davlouros, Michael Kemp, Simon Davidson, Konstantinos Dimopoulos, Stephanie Bayne, Dudley J Pennell, Derek G Gibson, Marcus Flather, Philip J Kilner, Wei Li and Michael A Gatzoulis.
Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)..
International journal of cardiology 154(3):299–305, February 2012.
URL, DOI BibTeX
@article{Babu-Narayan2012,
abstract = "Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.",
author = "Babu-Narayan, Sonya V and Uebing, Anselm and Davlouros, Periklis A and Kemp, Michael and Davidson, Simon and Dimopoulos, Konstantinos and Bayne, Stephanie and Pennell, Dudley J and Gibson, Derek G and Flather, Marcus and Kilner, Philip J and Li, Wei and Gatzoulis, Michael A",
doi = "10.1016/j.ijcard.2010.09.057",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Angiotensin-Converting Enzyme Inhibitors,Angiotensin-Converting Enzyme Inhibitors: therapeu,Double-Blind Method,Feasibility Studies,Humans,Prospective Studies,Pulmonary Valve Insufficiency,Pulmonary Valve Insufficiency: complications,Pulmonary Valve Insufficiency: physiopathology,Ramipril,Ramipril: therapeutic use,Tetralogy of Fallot,Tetralogy of Fallot: complications,Tetralogy of Fallot: physiopathology,Tetralogy of Fallot: surgery,Time Factors,Ventricular Function,Ventricular Function: drug effects",
month = "feb",
number = 3,
pages = "299--305",
pmid = 20970202,
title = "{Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot).}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20970202",
volume = 154,
year = 2012
}
Dudley J Pennell, John Paul Carpenter, David N Firmin, Philip J Kilner, Raad H Mohiaddin and Sanjay K Prasad.
Review of Journal of Cardiovascular Magnetic Resonance 2011..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14:78, January 2012.
URL, DOI BibTeX
@article{Pennell2012,
abstract = "There were 83 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2011, which is an 11{\%} increase in the number of articles since 2010. The quality of the submissions continues to increase. The editors had been delighted with the 2010 JCMR Impact Factor of 4.33, although this fell modestly to 3.72 for 2011. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, we remain very pleased with the progress of the journal's impact over the last 5 years. Our acceptance rate is approximately 25{\%}, and has been falling as the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors feel it is useful to summarize the papers for the readership into broad areas of interest or theme, which we feel would be useful, so that areas of interest from the previous year can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR for publication.",
author = "Pennell, Dudley J and Carpenter, John Paul and Firmin, David N and Kilner, Philip J and Mohiaddin, Raad H and Prasad, Sanjay K",
doi = "10.1186/1532-429X-14-78",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2012 - Review of Journal of Cardiovascular Magnetic Resonance 2011.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Animals,Bibliometrics,Biomedical Research,Biomedical Research: statistics {\&} numerical data,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Editorial Policies,Humans,Information Dissemination,Journal Impact Factor,Magnetic Resonance Imaging,Magnetic Resonance Imaging: statistics {\&} numerical,Periodicals as Topic,Periodicals as Topic: statistics {\&} numerical data,Predictive Value of Tests,Prognosis",
month = "jan",
pages = 78,
pmid = 23158097,
title = "{Review of Journal of Cardiovascular Magnetic Resonance 2011.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3519784{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 14,
year = 2012
}
Laura-Ann McGill, Tevfik F Ismail, Sonia Nielles-Vallespin, Pedro Ferreira, Andrew D Scott, Michael Roughton, Philip J Kilner, Yen S Ho, Karen P McCarthy, Peter D Gatehouse, Ranil Silva, Peter Speier, Thorsten Feiweier, Choukkri Mekkaoui, David E Sosnovik, Sanjay K Prasad, David N Firmin and Dudley J Pennell.
Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14(1):86, January 2012.
URL, DOI BibTeX
@article{McGill2012,
abstract = "{BACKGROUND: Myocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) which has been studied post-mortem, but its in-vivo prevalence and extent is unknown. Cardiac Diffusion Tensor Imaging (cDTI) provides information on mean intravoxel myocyte orientation and potentially myocardial disarray. Recent technical advances have improved in-vivo cDTI, and the aim of this study was to assess the interstudy reproducibility of quantitative in-vivo cDTI in patients with HCM. METHODS AND RESULTS: A stimulated-echo single-shot-EPI sequence with zonal excitation and parallel imaging was implemented. Ten patients with HCM were each scanned on 2 different days. For each scan 3 short axis mid-ventricular slices were acquired with cDTI at end systole. Fractional anisotropy (FA), mean diffusivity (MD), and helix angle (HA) maps were created using a cDTI post-processing platform developed in-house. The mean ± SD global FA was 0.613 ± 0.044, MD was 0.750 ± 0.154 × 10-3 mm2/s and HA was epicardium -34.3 ± 7.6°, mesocardium 3.5 ± 6.9° and endocardium 38.9 ± 8.1°. Comparison of initial and repeat studies showed global interstudy reproducibility for FA (SD = ± 0.045, Coefficient of Variation (CoV) = 7.2{\%}), MD (SD = ± 0.135 × 10-3 mm2/s",
cov = "",
author = "McGill, Laura-Ann and Ismail, Tevfik F and Nielles-Vallespin, Sonia and Ferreira, Pedro and Scott, Andrew D and Roughton, Michael and Kilner, Philip J and Ho, S Yen and McCarthy, Karen P and Gatehouse, Peter D and de Silva, Ranil and Speier, Peter and Feiweier, Thorsten and Mekkaoui, Choukkri and Sosnovik, David E and Prasad, Sanjay K and Firmin, David N and Pennell, Dudley J",
doi = "10.1186/1532-429X-14-86",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/McGill et al. - 2012 - Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = ",Aged,Cardiomyopathy,Contrast Media,Contrast Media: diagnostic use,Diffusion Tensor Imaging,Female,Fibrosis,Humans,Hypertrophic,Hypertrophic: diagnosis,Hypertrophic: pathology,Hypertrophic: physiopathology,Left,Male,Middle Aged,Myocardium,Myocardium: pathology,Observer Variation,Predictive Value of Tests,Prospective Studies,Reproducibility of Results,Stroke Volume,Ventricular Function",
month = "jan",
number = 1,
pages = 86,
pmid = 23259835,
title = "{Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3551746{\&}tool=pmcentrez{\&}rendertype=abstract http://jcmr-online.com/content/14/1/86",
volume = 14,
year = 2012
}
Pedro F Ferreira, Peter D Gatehouse and David N Firmin.
Myocardial first-pass perfusion imaging with hybrid-EPI: frequency-offsets and potential artefacts..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14:44, January 2012.
URL, DOI BibTeX
@article{Ferreira2012,
abstract = "First-pass myocardial perfusion is often imaged with a tailored hybrid centric interleaved echo-planar-imaging sequence, providing rapid image acquisition with good contrast enhancement. The centric interleaved phase-encode order minimises the effective time-of-echo but it is sensitive to frequency-offsets. This short article aims to show possible artefacts that might originate with this sequence, in the context of first-pass perfusion imaging, when frequency-offsets are present. Non-uniform magnitude modulation effects were also analysed.",
author = "Ferreira, Pedro F and Gatehouse, Peter D and Firmin, David N",
doi = "10.1186/1532-429X-14-44",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ferreira, Gatehouse, Firmin - 2012 - Myocardial first-pass perfusion imaging with hybrid-EPI frequency-offsets and potential artefacts.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Artifacts,Echo-Planar Imaging,Echo-Planar Imaging: instrumentation,Heart,Heart: anatomy {\&} histology,Humans,Image Enhancement,Image Enhancement: methods,Myocardial Perfusion Imaging,Myocardial Perfusion Imaging: instrumentation,Myocardium,Myocardium: metabolism,Phantoms, Imaging,Reproducibility of Results",
month = "jan",
pages = 44,
pmid = 22731814,
title = "{Myocardial first-pass perfusion imaging with hybrid-EPI: frequency-offsets and potential artefacts.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3457847{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 14,
year = 2012
}
Marc R Dweck, Sanjiv Joshi, Timothy Murigu, Ankur Gulati, Francisco Alpendurada, Andrew Jabbour, Alicia Maceira, Isabelle Roussin, David B Northridge, Philip J Kilner, Stuart A Cook, Nicholas A Boon, John Pepper, Raad H Mohiaddin, David E Newby, Dudley J Pennell and Sanjay K Prasad.
Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14:50, January 2012.
URL, DOI BibTeX
@article{Dweck2012,
abstract = "Cardiovascular magnetic resonance (CMR) is the gold standard non-invasive method for determining left ventricular (LV) mass and volume but has not been used previously to characterise the LV remodeling response in aortic stenosis. We sought to investigate the degree and patterns of hypertrophy in aortic stenosis using CMR.",
author = "Dweck, Marc R and Joshi, Sanjiv and Murigu, Timothy and Gulati, Ankur and Alpendurada, Francisco and Jabbour, Andrew and Maceira, Alicia and Roussin, Isabelle and Northridge, David B and Kilner, Philip J and Cook, Stuart A and Boon, Nicholas A and Pepper, John and Mohiaddin, Raad H and Newby, David E and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1186/1532-429X-14-50",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dweck et al. - 2012 - Left ventricular remodeling and hypertrophy in patients with aortic stenosis insights from cardiovascular magnetic.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Aged,Aortic Valve Stenosis,Aortic Valve Stenosis: complications,Aortic Valve Stenosis: diagnosis,Aortic Valve Stenosis: physiopathology,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: complications,Cardiomyopathy, Hypertrophic: diagnosis,Cardiomyopathy, Hypertrophic: physiopathology,Diagnosis, Differential,Female,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Hypertrophy, Left Ventricular: etiology,Hypertrophy, Left Ventricular: physiopathology,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Middle Aged,Ventricular Function, Left,Ventricular Remodeling",
month = "jan",
pages = 50,
pmid = 22839417,
title = "{Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3457907{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 14,
year = 2012
}
Francisco Alpendurada, Gill C Smith, John-Paul Carpenter, Sunil V Nair, Mark A Tanner, Winston Banya, Carlo Dessi, Renzo Galanello, John Malcolm Walker and Dudley J Pennell.
Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14:8, January 2012.
URL, DOI BibTeX
@article{Alpendurada2012,
abstract = "Combination therapy with deferoxamine and oral deferiprone is superior to deferoxamine alone in removing cardiac iron and improving left ventricular ejection fraction (LVEF). The right ventricle (RV) is also affected by the toxic effects of iron and may cause additional cardiovascular perturbation. We assessed the effects of combination therapy on the RV in thalassaemia major (TM) using cardiovascular magnetic resonance (CMR).",
author = "Alpendurada, Francisco and Smith, Gill C and Carpenter, John-Paul and Nair, Sunil V and Tanner, Mark A and Banya, Winston and Dessi, Carlo and Galanello, Renzo and Walker, John Malcolm and Pennell, Dudley J",
doi = "10.1186/1532-429X-14-8",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Alpendurada et al. - 2012 - Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Analysis of Variance,Chi-Square Distribution,Deferoxamine,Deferoxamine: therapeutic use,Drug Therapy, Combination,Echocardiography, Doppler,Female,Hemosiderosis,Hemosiderosis: diagnosis,Hemosiderosis: drug therapy,Hemosiderosis: etiology,Hemosiderosis: physiopathology,Humans,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Magnetic Resonance Imaging,Male,Pyridones,Pyridones: therapeutic use,Randomized Controlled Trials as Topic,Recovery of Function,Retrospective Studies,Severity of Illness Index,Siderophores,Siderophores: therapeutic use,Stroke Volume,Stroke Volume: drug effects,Therapeutics,Time Factors,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: diagnosis,Ventricular Dysfunction, Right: drug therapy,Ventricular Dysfunction, Right: etiology,Ventricular Dysfunction, Right: physiopathology,Ventricular Function, Right,Ventricular Function, Right: drug effects,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: diagnosis,beta-Thalassemia: drug therapy,beta-Thalassemia: physiopathology",
month = "jan",
pages = 8,
pmid = 22277065,
title = "{Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3278357{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 14,
year = 2012
}
Chirine Parsai, Rory O'Hanlon, Sanjay K Prasad and Raad H Mohiaddin.
Diagnostic and prognostic value of cardiovascular magnetic resonance in non-ischaemic cardiomyopathies..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14(1):54, January 2012.
URL, DOI BibTeX
@article{Parsai2012,
abstract = "Cardiovascular Magnetic Resonance (CMR) is recognised as a valuable clinical tool which in a single scan setting can assess ventricular volumes and function, myocardial fibrosis, iron loading, flow quantification, tissue characterisation and myocardial perfusion imaging. The advent of CMR using extrinsic and intrinsic contrast-enhanced protocols for tissue characterisation have dramatically changed the non-invasive work-up of patients with suspected or known cardiomyopathy. Although the technique initially focused on the in vivo identification of myocardial necrosis through the late gadolinium enhancement (LGE) technique, recent work highlighted the ability of CMR to provide more detailed in vivo tissue characterisation to help establish a differential diagnosis of the underlying aetiology, to exclude an ischaemic substrate and to provide important prognostic markers. The potential application of CMR in the clinical approach of a patient with suspected non-ischaemic cardiomyopathy is discussed in this review.",
author = "Parsai, Chirine and O'Hanlon, Rory and Prasad, Sanjay K and Mohiaddin, Raad H",
doi = "10.1186/1532-429X-14-54",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Parsai et al. - 2012 - Diagnostic and prognostic value of cardiovascular magnetic resonance in non-ischaemic cardiomyopathies.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Cardiomyopathies,Cardiomyopathies: diagnosis,Diagnosis, Differential,Humans,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Myocardium,Myocardium: pathology,Prognosis",
month = "jan",
number = 1,
pages = 54,
pmid = 22857649,
title = "{Diagnostic and prognostic value of cardiovascular magnetic resonance in non-ischaemic cardiomyopathies.}",
url = "http://www.jcmr-online.com/content/14/1/54",
volume = 14,
year = 2012
}
Alicia M Maceira and Raad H Mohiaddin.
Cardiovascular magnetic resonance in systemic hypertension..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14:28, January 2012.
URL, DOI BibTeX
@article{Maceira2012,
abstract = "Systemic hypertension is a highly prevalent potentially modifiable cardiovascular risk factor. Imaging plays an important role in the diagnosis of underlying causes for hypertension, in assessing cardiovascular complications of hypertension, and in understanding the pathophysiology of the disease process. Cardiovascular magnetic resonance (CMR) provides accurate and reproducible measures of ventricular volumes, mass, function and haemodynamics as well as uniquely allowing tissue characterization of diffuse and focal fibrosis. In addition, CMR is well suited for exclusion of common secondary causes for hypertension. We review the current and emerging clinical and research applications of CMR in hypertension.",
author = "Maceira, Alicia M and Mohiaddin, Raad H",
doi = "10.1186/1532-429X-14-28",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Maceira, Mohiaddin - 2012 - Cardiovascular magnetic resonance in systemic hypertension.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: epidemiology,Cardiovascular Diseases: pathology,Cardiovascular Diseases: physiopathology,Fibrosis,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Hemodynamics,Humans,Hypertension,Hypertension: diagnosis,Hypertension: epidemiology,Hypertension: pathology,Hypertension: physiopathology,Magnetic Resonance Imaging,Myocardium,Myocardium: pathology,Predictive Value of Tests,Prognosis,Risk Assessment,Risk Factors,Ventricular Function",
month = "jan",
pages = 28,
pmid = 22559053,
title = "{Cardiovascular magnetic resonance in systemic hypertension.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3372443{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 14,
year = 2012
}
William M Bradlow, Simon J R Gibbs and Raad H Mohiaddin.
Cardiovascular magnetic resonance in pulmonary hypertension..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14(1):6, January 2012.
URL, DOI BibTeX
@article{Bradlow2012,
abstract = "Pulmonary hypertension represents a group of conditions characterized by higher than normal pulmonary artery pressures. Despite improved treatments, outcomes in many instances remain poor. In recent years, there has been growing interest in the use of cardiovascular magnetic resonance (CMR) in patients with pulmonary hypertension. This technique offers certain advantages over other imaging modalities since it is well suited to the assessment of the right ventricle and the proximal pulmonary arteries. Reflecting the relatively sparse evidence supporting its use, CMR is not routinely recommended for patients with pulmonary hypertension. However, it is particularly useful in patient with pulmonary arterial hypertension associated with congenital heart disease. Furthermore, it has proven informative in a number of ways; illustrating how right ventricular remodeling is favorably reversed by drug therapies and providing explicit confirmation of the importance of the right ventricle to clinical outcome. This review will discuss these aspects and practical considerations before speculating on future applications.",
author = "Bradlow, William M and Gibbs, J Simon R and Mohiaddin, Raad H",
doi = "10.1186/1532-429X-14-6",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Bradlow, Gibbs, Mohiaddin - 2012 - Cardiovascular magnetic resonance in pulmonary hypertension.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Blood Pressure,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: diagnosis,Hypertension, Pulmonary: etiology,Hypertension, Pulmonary: physiopathology,Magnetic Resonance Imaging,Predictive Value of Tests,Prognosis,Pulmonary Artery,Pulmonary Artery: physiopathology,Ventricular Function, Right,Ventricular Remodeling",
month = "jan",
number = 1,
pages = 6,
pmid = 22257586,
title = "{Cardiovascular magnetic resonance in pulmonary hypertension.}",
url = "http://www.jcmr-online.com/content/14/1/6",
volume = 14,
year = 2012
}
Peter D Gatehouse, Marijn P Rolf, Karin Markenroth Bloch, Martin J Graves, Philip J Kilner, David N Firmin and Mark B M Hofman.
A multi-center inter-manufacturer study of the temporal stability of phase-contrast velocity mapping background offset errors..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 14(1):72, January 2012.
URL, DOI BibTeX
@article{Gatehouse2012,
abstract = "Phase-contrast velocity images often contain a background or baseline offset error, which adds an unknown offset to the measured velocities. For accurate flow measurements, this offset must be shown negligible or corrected. Some correction techniques depend on replicating the clinical flow acquisition using a uniform stationary phantom, in order to measure the baseline offset at the region of interest and subtract it from the clinical study. Such techniques assume that the background offset is stable over the time of a patient scan, or even longer if the phantom scans are acquired later, or derived from pre-stored background correction images. There is no published evidence regarding temporal stability of the background offset.",
author = "Gatehouse, Peter D and Rolf, Marijn P and Bloch, Karin Markenroth and Graves, Martin J and Kilner, Philip J and Firmin, David N and Hofman, Mark B M",
doi = "10.1186/1532-429X-14-72",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Gatehouse et al. - 2012 - A multi-center inter-manufacturer study of the temporal stability of phase-contrast velocity mapping backgroun.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Equipment Design,Europe,Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: instrumentation,Phantoms, Imaging,Predictive Value of Tests,Reproducibility of Results,Time Factors,Whole Body Imaging,Whole Body Imaging: instrumentation",
month = "jan",
number = 1,
pages = 72,
pmid = 23083397,
title = "{A multi-center inter-manufacturer study of the temporal stability of phase-contrast velocity mapping background offset errors.}",
url = "http://www.jcmr-online.com/content/14/1/72",
volume = 14,
year = 2012
}
P J Kilner.
Imaging congenital heart disease in adults..
The British journal of radiology 84 Spec No:S258–68, December 2011.
URL, DOI BibTeX
@article{Kilner2011a,
abstract = "Transthoracic echocardiography is the first-line modality for cardiovascular imaging in adults with congenital heart disease (ACHD). The windows of access that are possible with transthoracic echocardiography are, however, rarely adequate for all regions of interest. The choice of further imaging depends on the clinical questions that remain to be addressed. The strengths of MRI include comprehensive access and coverage, providing imaging of all parts of the right ventricle, the pulmonary arteries, pulmonary veins and aorta. Cine images and velocity maps are acquired in specifically aligned planes, with stacks of cines or dynamic contrast angiography providing more comprehensive coverage. Tissues can be characterised if necessary, and MRI provides relatively accurate measurements of biventricular function and volume flow. These parameters are important in the assessment and follow-up of adults after repairs for tetralogy of Fallot or transposition of the great arteries and after Fontan operations. The superior spatial resolution and rapid acquisition of CT are invaluable in selected situations, including the visualisation of anomalous coronary or aortopulmonary collateral arteries, the assessment of luminal patency after stenting and imaging in patients with pacemakers. Ionising radiation is, however, a concern in younger patients who may need repeated investigation. Adults with relatively complex conditions should ideally be imaged in a specialist ACHD centre, where dedicated echocardiographic and cardiovascular MRI services are a necessary facility. General radiologists should be aware of the nature and pathophysiology of congenital heart disease, and should be alert for previously undiagnosed cases presenting in adulthood, including cases of atrial septal defect, aortic coarctation, patent ductus arteriosus, double-chambered right ventricle and congenitally corrected transposition.",
author = "Kilner, P J",
doi = "10.1259/bjr/74240815",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Kilner - 2011 - Imaging congenital heart disease in adults.pdf:pdf",
issn = "1748-880X",
journal = "The British journal of radiology",
keywords = "Adult,Aortic Coarctation,Aortic Coarctation: diagnosis,Coronary Angiography,Coronary Vessels,Coronary Vessels: ultrasonography,Ebstein Anomaly,Ebstein Anomaly: diagnosis,Echocardiography,Echocardiography: methods,Heart Defects, Congenital,Heart Defects, Congenital: diagnosis,Heart Valve Diseases,Heart Valve Diseases: diagnosis,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: diagnosis,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Marfan Syndrome,Marfan Syndrome: diagnosis,Pulmonary Subvalvular Stenosis,Pulmonary Subvalvular Stenosis: diagnosis,Tetralogy of Fallot,Tetralogy of Fallot: radiography,Tetralogy of Fallot: surgery,Tomography, X-Ray Computed,Tomography, X-Ray Computed: methods,Transposition of Great Vessels,Transposition of Great Vessels: surgery,Tricuspid Valve Insufficiency,Tricuspid Valve Insufficiency: diagnosis",
month = "dec",
pages = "S258--68",
pmid = 22723533,
title = "{Imaging congenital heart disease in adults.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3473918{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = "84 Spec No",
year = 2011
}
G Quarta, D M Sado and J C Moon.
Cardiomyopathies: focus on cardiovascular magnetic resonance..
The British journal of radiology 84 Spec No:S296–305, December 2011.
URL, DOI BibTeX
@article{Quarta2011a,
abstract = "Cardiomyopathies (CMPs) are a group of often inherited diseases characterised by abnormalities and associated dysfunction of heart muscle. In the past decade, cardiovascular magnetic resonance (CMR) has emerged as a powerful tool in their assessment, providing data that are complementary to other aspects of clinical evaluation. Key advantages of CMR are three-dimensional visualisation of the heart and its relationship to thoracic structures; gold-standard quantification of cardiac volumes and function, which can safely be repeated over time (no ionising radiation is involved); and tissue characterisation to detect focal scar and fatty infiltration. This paper reviews the role of CMR in the clinical assessment of patients with CMPs.",
author = "Quarta, G and Sado, D M and Moon, J C",
doi = "10.1259/bjr/67212179",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Quarta, Sado, Moon - 2011 - Cardiomyopathies focus on cardiovascular magnetic resonance.pdf:pdf",
issn = "1748-880X",
journal = "The British journal of radiology",
keywords = "Arrhythmogenic Right Ventricular Dysplasia,Arrhythmogenic Right Ventricular Dysplasia: diagno,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathy, Dilated,Cardiomyopathy, Dilated: diagnosis,Cardiomyopathy, Restrictive,Cardiomyopathy, Restrictive: diagnosis,Contrast Media,Contrast Media: diagnostic use,Coronary Vessels,Coronary Vessels: physiopathology,Humans,Ischemia,Ischemia: diagnosis,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Takotsubo Cardiomyopathy,Takotsubo Cardiomyopathy: diagnosis,Ventricular Function, Left,Ventricular Function, Left: physiology",
month = "dec",
pages = "S296--305",
pmid = 22723536,
title = "{Cardiomyopathies: focus on cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3473912{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = "84 Spec No",
year = 2011
}
Igor Klem, Dipan J Shah, Richard D White, Dudley J Pennell, Albert C Rossum, Matthias Regenfus, Udo Sechtem, Paulo R Schvartzman, Peter Hunold, Pierre Croisille, Michele Parker, Robert M Judd and Raymond J Kim.
Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection fraction and myocardial damage: an international, multicenter study..
Circulation. Cardiovascular imaging 4(6):610–9, November 2011.
URL, DOI BibTeX
@article{Klem2011,
abstract = "Cardiac magnetic resonance (CMR) is considered the reference standard for assessment of left ventricular ejection fraction (LVEF) and myocardial damage. However, few studies have evaluated the relationship between CMR findings and patient outcome, and of these, most are small and none multicenter. We performed an international, multicenter study to assess the prognostic importance of routine CMR in patients with known or suspected heart disease.",
author = "Klem, Igor and Shah, Dipan J and White, Richard D and Pennell, Dudley J and van Rossum, Albert C and Regenfus, Matthias and Sechtem, Udo and Schvartzman, Paulo R and Hunold, Peter and Croisille, Pierre and Parker, Michele and Judd, Robert M and Kim, Raymond J",
doi = "10.1161/CIRCIMAGING.111.964965",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Adult,Age Factors,Aged,Chi-Square Distribution,Cohort Studies,Coronary Artery Disease,Coronary Artery Disease: diagnosis,Coronary Artery Disease: mortality,Diagnostic Tests, Routine,Female,Humans,International Cooperation,Kaplan-Meier Estimate,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Middle Aged,Multivariate Analysis,Myocardial Infarction,Myocardial Infarction: diagnosis,Myocardial Infarction: mortality,Myocardium,Myocardium: pathology,Predictive Value of Tests,Prognosis,Proportional Hazards Models,Risk Assessment,Severity of Illness Index,Sex Factors,Stroke Volume,Stroke Volume: physiology,Survival Analysis",
month = "nov",
number = 6,
pages = "610--9",
pmid = 21911738,
title = "{Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection fraction and myocardial damage: an international, multicenter study.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21911738",
volume = 4,
year = 2011
}
Andrew Jabbour, Tevfik F Ismail, Neil Moat, Ankur Gulati, Isabelle Roussin, Francisco Alpendurada, Bradley Park, Francois Okoroafor, Anita Asgar, Sarah Barker, Simon Davies, Sanjay K Prasad, Michael Rubens and Raad H Mohiaddin.
Multimodality imaging in transcatheter aortic valve implantation and post-procedural aortic regurgitation: comparison among cardiovascular magnetic resonance, cardiac computed tomography, and echocardiography..
Journal of the American College of Cardiology 58(21):2165–73, November 2011.
URL, DOI BibTeX
@article{Jabbour2011,
abstract = "The purpose of this study was to determine imaging predictors of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the agreement and reproducibility of cardiovascular magnetic resonance (CMR), cardiac computed tomography (CCT), and transthoracic echocardiography (TTE) in aortic root assessment.",
author = "Jabbour, Andrew and Ismail, Tevfik F and Moat, Neil and Gulati, Ankur and Roussin, Isabelle and Alpendurada, Francisco and Park, Bradley and Okoroafor, Francois and Asgar, Anita and Barker, Sarah and Davies, Simon and Prasad, Sanjay K and Rubens, Michael and Mohiaddin, Raad H",
doi = "10.1016/j.jacc.2011.09.010",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Aged,Aortic Valve Insufficiency,Aortic Valve Insufficiency: diagnosis,Aortic Valve Insufficiency: surgery,Cardiac Catheterization,Cardiac Catheterization: methods,Echocardiography,Echocardiography: methods,Female,Follow-Up Studies,Heart Valve Prosthesis,Humans,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Male,Postoperative Period,ROC Curve,Reproducibility of Results,Tomography, X-Ray Computed,Tomography, X-Ray Computed: methods,Treatment Outcome",
month = "nov",
number = 21,
pages = "2165--73",
pmid = 22078422,
title = "{Multimodality imaging in transcatheter aortic valve implantation and post-procedural aortic regurgitation: comparison among cardiovascular magnetic resonance, cardiac computed tomography, and echocardiography.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22078422",
volume = 58,
year = 2011
}
Ravi G Assomull, Ankur Gulati, Cheuk F Chan, Nizar Ismail, Tristan D H Brown, Sadaf Raza, Kaushik Guha, Nicholas Bunce and Raad H Mohiaddin.
Acute chest pain of cardiovascular aetiology: a diagnostic dilemma..
QJM : monthly journal of the Association of Physicians, November 2011.
URL, DOI BibTeX
@article{Assomull2011a,
author = "Assomull, Ravi G and Gulati, Ankur and Chan, Cheuk F and Ismail, Nizar and Brown, Tristan D H and Raza, Sadaf and Guha, Kaushik and Bunce, Nicholas and Mohiaddin, Raad H",
doi = "10.1093/qjmed/hcr219",
issn = "1460-2393",
journal = "QJM : monthly journal of the Association of Physicians",
month = "nov",
pmid = 22075009,
title = "{Acute chest pain of cardiovascular aetiology: a diagnostic dilemma.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/22075009",
year = 2011
}
Andrew D Scott, Jennifer Keegan, Raad H Mohiaddin and David N Firmin.
Noninvasive detection of coronary artery wall thickening with age in healthy subjects using high resolution MRI with beat-to-beat respiratory motion correction..
Journal of magnetic resonance imaging : JMRI 34(4):824–30, October 2011.
URL, DOI BibTeX
@article{Scott2011,
abstract = "To demonstrate coronary artery wall thickening with age in a small healthy cohort using a highly efficient, reliable, and reproducible high-resolution MR technique.",
author = "Scott, Andrew D and Keegan, Jennifer and Mohiaddin, Raad H and Firmin, David N",
doi = "10.1002/jmri.22704",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Aging,Aging: physiology,Cohort Studies,Coronary Angiography,Coronary Angiography: methods,Coronary Stenosis,Coronary Stenosis: physiopathology,Coronary Stenosis: radiography,Coronary Vessels,Coronary Vessels: pathology,Female,Humans,Imaging, Three-Dimensional,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Motion,Reference Values,Regression Analysis,Respiration",
month = "oct",
number = 4,
pages = "824--30",
pmid = 21800396,
title = "{Noninvasive detection of coronary artery wall thickening with age in healthy subjects using high resolution MRI with beat-to-beat respiratory motion correction.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21800396",
volume = 34,
year = 2011
}
Ravi G Assomull, Carl Shakespeare, Paul R Kalra, Guy Lloyd, Ankur Gulati, Julian Strange, William M Bradlow, Jonathan Lyne, Jennifer Keegan, Philip Poole-Wilson, Martin R Cowie, Dudley J Pennell and Sanjay K Prasad.
Role of cardiovascular magnetic resonance as a gatekeeper to invasive coronary angiography in patients presenting with heart failure of unknown etiology..
Circulation 124(12):1351–60, September 2011.
URL, DOI BibTeX
@article{Assomull2011,
abstract = "In patients presenting with new-onset heart failure of uncertain etiology, the role of coronary angiography (CA) is unclear. Although conventionally performed to differentiate underlying coronary artery disease from dilated cardiomyopathy, CA is associated with a risk of complications and may not detect an ischemic cause resulting from arterial recanalization or an embolic episode. In this study, we assessed the diagnostic accuracy of a cardiovascular magnetic resonance (CMR) protocol incorporating late gadolinium enhancement (LGE) and magnetic resonance CA as a noninvasive gatekeeper to CA in determining the etiology of heart failure in this subset of patients.",
author = "Assomull, Ravi G and Shakespeare, Carl and Kalra, Paul R and Lloyd, Guy and Gulati, Ankur and Strange, Julian and Bradlow, William M and Lyne, Jonathan and Keegan, Jennifer and Poole-Wilson, Philip and Cowie, Martin R and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1161/CIRCULATIONAHA.110.011346",
issn = "1524-4539",
journal = "Circulation",
keywords = "Aged,Cardiac Imaging Techniques,Cardiac Imaging Techniques: economics,Cardiac Imaging Techniques: standards,Cardiac Imaging Techniques: statistics {\&} numerical,Coronary Angiography,Coronary Angiography: economics,Decision Trees,Female,Follow-Up Studies,Gadolinium,Gadolinium: diagnostic use,Great Britain,Health Care Costs,Heart Failure,Heart Failure: diagnosis,Heart Failure: economics,Heart Failure: etiology,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: economics,Magnetic Resonance Imaging: standards,Magnetic Resonance Imaging: statistics {\&} numerical,Male,Middle Aged,Observer Variation,Referral and Consultation,Referral and Consultation: economics,Referral and Consultation: standards,Referral and Consultation: statistics {\&} numerical,Reproducibility of Results,Sensitivity and Specificity",
month = "sep",
number = 12,
pages = "1351--60",
pmid = 21900085,
title = "{Role of cardiovascular magnetic resonance as a gatekeeper to invasive coronary angiography in patients presenting with heart failure of unknown etiology.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21900085",
volume = 124,
year = 2011
}
Iain T Pierce, Peter D Gatehouse, Yun X Xu and David N Firmin.
MR phase-contrast velocity mapping methods for measuring venous blood velocity in the deep veins of the calf..
Journal of magnetic resonance imaging : JMRI 34(3):634–44, September 2011.
URL, DOI BibTeX
@article{Pierce2011,
abstract = "To evaluate the feasibility of using un-gated, real-time MRI for venous blood velocity mapping in the calf, comparing an interleaved spiral k-space sequence (ISP) against a standard segmented gradient echo sequence (GRE).",
author = "Pierce, Iain T and Gatehouse, Peter D and Xu, X Yun and Firmin, David N",
doi = "10.1002/jmri.22655",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Aged,Algorithms,Blood Flow Velocity,Feasibility Studies,Female,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Leg,Leg: blood supply,Leg: physiology,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Middle Aged,Reproducibility of Results,Sensitivity and Specificity",
month = "sep",
number = 3,
pages = "634--44",
pmid = 21761470,
title = "{MR phase-contrast velocity mapping methods for measuring venous blood velocity in the deep veins of the calf.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21761470",
volume = 34,
year = 2011
}
Marc R Dweck, Sanjiv Joshi, Timothy Murigu, Francisco Alpendurada, Andrew Jabbour, Giovanni Melina, Winston Banya, Ankur Gulati, Isabelle Roussin, Sadaf Raza, Nishant A Prasad, Rick Wage, Cesare Quarto, Emiliano Angeloni, Simone Refice, Mary Sheppard, Stuart A Cook, Philip J Kilner, Dudley J Pennell, David E Newby, Raad H Mohiaddin, John Pepper and Sanjay K Prasad.
Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis..
Journal of the American College of Cardiology 58(12):1271–9, September 2011.
URL, DOI BibTeX
@article{Dweck2011,
abstract = "The goal of this study was to assess the prognostic significance of midwall and infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis.",
author = "Dweck, Marc R and Joshi, Sanjiv and Murigu, Timothy and Alpendurada, Francisco and Jabbour, Andrew and Melina, Giovanni and Banya, Winston and Gulati, Ankur and Roussin, Isabelle and Raza, Sadaf and Prasad, Nishant A and Wage, Rick and Quarto, Cesare and Angeloni, Emiliano and Refice, Simone and Sheppard, Mary and Cook, Stuart A and Kilner, Philip J and Pennell, Dudley J and Newby, David E and Mohiaddin, Raad H and Pepper, John and Prasad, Sanjay K",
doi = "10.1016/j.jacc.2011.03.064",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Aged,Aged, 80 and over,Aortic Valve Stenosis,Aortic Valve Stenosis: complications,Aortic Valve Stenosis: mortality,Female,Fibrosis,Gadolinium,Gadolinium: diagnostic use,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: radionuclide imaging,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: etiology,Hypertrophy, Left Ventricular: pathology,Hypertrophy, Left Ventricular: radionuclide imagin,Kaplan-Meier Estimate,Magnetic Resonance Imaging,Male,Middle Aged,Prognosis,Prospective Studies,Radiopharmaceuticals,Radiopharmaceuticals: diagnostic use,Registries,Risk Assessment",
month = "sep",
number = 12,
pages = "1271--9",
pmid = 21903062,
title = "{Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21903062",
volume = 58,
year = 2011
}
Philip J Kilner.
Non invasive assessment of pulmonary hypertension severity and disease progression..
Heart (British Cardiac Society) 97(15):1196–7, August 2011.
URL, DOI BibTeX
@article{Kilner2011,
author = "Kilner, Philip J",
doi = "10.1136/hrt.2011.222471",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = "Angiography,Angiography: methods,Female,Fractals,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: diagnosis,Male,Pulmonary Artery,Pulmonary Artery: physiopathology,Vascular Resistance,Vascular Resistance: physiology",
month = "aug",
number = 15,
pages = "1196--7",
pmid = 21478386,
title = "{Non invasive assessment of pulmonary hypertension severity and disease progression.}",
url = "http://heart.bmj.com/content/97/15/1196.extract",
volume = 97,
year = 2011
}
M Wein, A Wolf-Puetz, R Niehues, T Klein, P J Kilner and R M Klein.
Multiple left ventricular inferoseptal clefts. Multimodality imaging appearance and differential diagnosis..
Herz 36(5):438–43, August 2011.
URL, DOI BibTeX
@article{Wein2011,
abstract = "Left ventricular inferoseptal clefts are a localized variant of myocardial structure, easily overlooked but potentially raising concern when identified through imaging.",
author = "Wein, M and Wolf-Puetz, A and Niehues, R and Klein, T and Kilner, P J and Klein, R M",
doi = "10.1007/s00059-011-3424-9",
issn = "1615-6692",
journal = "Herz",
keywords = "Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Cardiomyopathy, Hypertrophic: genetics,Chest Pain,Chest Pain: etiology,Diagnosis, Differential,Diagnostic Imaging,Heart Defects, Congenital,Heart Defects, Congenital: diagnosis,Heart Defects, Congenital: genetics,Heart Ventricles,Heart Ventricles: abnormalities,Heterozygote Detection,Humans,Image Processing, Computer-Assisted,Male,Middle Aged",
month = "aug",
number = 5,
pages = "438--43",
pmid = 21344270,
title = "{Multiple left ventricular inferoseptal clefts. Multimodality imaging appearance and differential diagnosis.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21344270",
volume = 36,
year = 2011
}
M Wilson, R O'Hanlon, S Prasad, D Oxborough, R Godfrey, F Alpendurada, G Smith, J Wong, S Basavarajaiah, S Sharma, A Nevill, David Gaze, K George and G Whyte.
Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance and echocardiography after an acute bout of prolonged endurance exercise..
British journal of sports medicine 45(10):780–4, August 2011.
URL, DOI BibTeX
@article{Wilson2011,
abstract = "Seventeen male participants (mean (SD) (range): age 33.5 (6.5) years (46-26 years), body mass 80 (9.2) kg (100-63 kg), height 1.81 (0.06) m (1.93- 1.70 m)) ran a marathon to investigate the relationship between systolic function (using cardiac magnetic resonance (CMR)) and diastolic function (using echocardiography) against biomarkers of cardiac damage.",
author = "Wilson, M and O'Hanlon, R and Prasad, S and Oxborough, D and Godfrey, R and Alpendurada, F and Smith, G and Wong, J and Basavarajaiah, S and Sharma, S and Nevill, A and Gaze, David and George, K and Whyte, G",
doi = "10.1136/bjsm.2009.064089",
issn = "1473-0480",
journal = "British journal of sports medicine",
keywords = "Adult,Biological Markers,Biological Markers: metabolism,Body Mass Index,Diastole,Diastole: physiology,Echocardiography, Doppler,Humans,Magnetic Resonance Angiography,Male,Middle Aged,Natriuretic Peptide, Brain,Natriuretic Peptide, Brain: metabolism,Peptide Fragments,Peptide Fragments: metabolism,Physical Endurance,Physical Endurance: physiology,Running,Running: physiology,Stroke Volume,Stroke Volume: physiology,Systole,Systole: physiology,Troponin I,Troponin I: metabolism,Troponin T,Troponin T: metabolism,Ventricular Function, Left,Ventricular Function, Left: physiology",
month = "aug",
number = 10,
pages = "780--4",
pmid = 19854761,
title = "{Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance and echocardiography after an acute bout of prolonged endurance exercise.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19854761",
volume = 45,
year = 2011
}
Alan M Batterham, Keith P George, Karen M Birch, Dudley J Pennell and Saul G Myerson.
Growth of left ventricular mass with military basic training in army recruits..
Medicine and science in sports and exercise 43(7):1295–300, July 2011.
URL, DOI BibTeX
@article{Batterham2011,
abstract = "Exercise-induced left ventricular hypertrophy is well documented, but whether this occurs merely in line with concomitant increases in lean body mass is unclear.",
author = "Batterham, Alan M and George, Keith P and Birch, Karen M and Pennell, Dudley J and Myerson, Saul G",
doi = "10.1249/MSS.0b013e3182093300",
issn = "1530-0315",
journal = "Medicine and science in sports and exercise",
keywords = "Adolescent,Adult,Body Composition,Body Composition: physiology,Cohort Studies,Exercise,Heart Ventricles,Heart Ventricles: anatomy {\&} histology,Heart Ventricles: chemistry,Heart Ventricles: growth {\&} development,Humans,Male,Military Personnel,Organ Size,Young Adult",
month = "jul",
number = 7,
pages = "1295--300",
pmid = 21200347,
title = "{Growth of left ventricular mass with military basic training in army recruits.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21200347",
volume = 43,
year = 2011
}
Isabelle Roussin, Mary N Sheppard, Michael Rubens, Sam Kaddoura, John Pepper and Raad H Mohiaddin.
Cardiovascular complications of cutis laxa syndrome: successful diagnosis and surgical management..
Circulation 124(1):100–2, July 2011.
URL, DOI BibTeX
@article{Roussin2011,
author = "Roussin, Isabelle and Sheppard, Mary N and Rubens, Michael and Kaddoura, Sam and Pepper, John and Mohiaddin, Raad H",
doi = "10.1161/CIRCULATIONAHA.111.025056",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adult,Aneurysm,Aneurysm: diagnosis,Aneurysm: etiology,Aneurysm: surgery,Aortic Valve,Aortic Valve Insufficiency,Aortic Valve Insufficiency: diagnosis,Aortic Valve Insufficiency: etiology,Aortic Valve Insufficiency: surgery,Aortic Valve: radiography,Aortic Valve: surgery,Cardiovascular Surgical Procedures,Cardiovascular Surgical Procedures: methods,Coronary Angiography,Coronary Sinus,Coronary Vessels,Coronary Vessels: surgery,Cutis Laxa,Cutis Laxa: complications,Humans,Male,Syndrome,Tomography, X-Ray Computed,Treatment Outcome",
month = "jul",
number = 1,
pages = "100--2",
pmid = 21730323,
title = "{Cardiovascular complications of cutis laxa syndrome: successful diagnosis and surgical management.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21730323",
volume = 124,
year = 2011
}
Sylvia S M Chen, Marinela Chaparro-Muñoz, Hideki Uemura, Michael A Gatzoulis, Mary N Sheppard and Philip J Kilner.
A multilobulated intracardiac mass in Ebstein's malformation..
European heart journal 32(14):1819, July 2011.
URL, DOI BibTeX
@article{Chen2011,
author = "Chen, Sylvia S M and Chaparro-Mu{\~{n}}oz, Marinela and Uemura, Hideki and Gatzoulis, Michael A and Sheppard, Mary N and Kilner, Philip J",
doi = "10.1093/eurheartj/ehr030",
issn = "1522-9645",
journal = "European heart journal",
keywords = "Calcinosis,Calcinosis: etiology,Calcinosis: pathology,Diagnosis, Differential,Dyspnea,Dyspnea: etiology,Ebstein Anomaly,Ebstein Anomaly: complications,Ebstein Anomaly: pathology,Echocardiography,Heart Neoplasms,Heart Neoplasms: pathology,Humans,Male,Middle Aged,Myxoma,Myxoma: pathology,Thrombosis,Thrombosis: pathology,Tricuspid Valve Insufficiency,Tricuspid Valve Insufficiency: etiology,Tricuspid Valve Insufficiency: pathology",
month = "jul",
number = 14,
pages = 1819,
pmid = 21385789,
title = "{A multilobulated intracardiac mass in Ebstein's malformation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21385789",
volume = 32,
year = 2011
}
Sonya V Babu-Narayan, Raad H Mohiaddin, Timothy M Cannell, Isabelle Vonder Muhll, Konstantinos Dimopoulos and Michael J Mullen.
Cardiovascular changes after transcatheter endovascular stenting of adult aortic coarctation..
International journal of cardiology 149(2):157–63, June 2011.
URL, DOI BibTeX
@article{Babu-Narayan2011,
abstract = "Longer term data on efficacy and clinical endpoints relating to transcatheter endovascular stenting in adults with aortic coarctation remains limited. We hypothesised that stenting would have effects on blood pressure, presence and extent of collaterals, left ventricular (LV) mass and vascular function.",
author = "Babu-Narayan, Sonya V and Mohiaddin, Raad H and Cannell, Timothy M and Muhll, Isabelle Vonder and Dimopoulos, Konstantinos and Mullen, Michael J",
doi = "10.1016/j.ijcard.2009.12.025",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adult,Aorta,Aorta: physiology,Aortic Coarctation,Aortic Coarctation: physiopathology,Aortic Coarctation: therapy,Blood Pressure,Blood Pressure: physiology,Cardiac Catheterization,Cardiac Catheterization: methods,Coronary Circulation,Coronary Circulation: physiology,Endovascular Procedures,Endovascular Procedures: methods,Female,Follow-Up Studies,Humans,Male,Prospective Studies,Stents",
month = "jun",
number = 2,
pages = "157--63",
pmid = 20116869,
title = "{Cardiovascular changes after transcatheter endovascular stenting of adult aortic coarctation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20116869",
volume = 149,
year = 2011
}
N Qureshi, F Amin, D Chatterjee, S Prasad, M Al-Obaidi and C Missouris.
MR imaging of endomyocardial fibrosis (EMF)..
International journal of cardiology 149(1):e36–7, May 2011.
URL, DOI BibTeX
@article{Qureshi2011,
abstract = "We present a case of endomyocardial fibrosis and discuss the use of cardiac magnetic resonance imaging (CMR) as a tool in aiding the diagnosis.",
author = "Qureshi, N and Amin, F and Chatterjee, D and Prasad, S and Al-Obaidi, M and Missouris, C",
doi = "10.1016/j.ijcard.2009.03.091",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Aged, 80 and over,Cardiac Imaging Techniques,Cardiac Imaging Techniques: methods,Endomyocardial Fibrosis,Endomyocardial Fibrosis: pathology,Eosinophilia,Eosinophilia: pathology,Female,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Myocardium,Myocardium: pathology",
month = "may",
number = 1,
pages = "e36--7",
pmid = 19410309,
title = "{MR imaging of endomyocardial fibrosis (EMF).}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19410309",
volume = 149,
year = 2011
}
Ankur Gulati, Radu Gheta, Cheuk F Chan, Nizar A Ismail, Mary N Sheppard, Philip J Kilner and Alan G Magee.
Longitudinal follow-up of a right atrial appendage aneurysm by cardiac magnetic resonance imaging..
Circulation 123(20):2289–91, May 2011.
URL, DOI BibTeX
@article{Gulati2011a,
author = "Gulati, Ankur and Gheta, Radu and Chan, Cheuk F and Ismail, Nizar A and Sheppard, Mary N and Kilner, Philip J and Magee, Alan G",
doi = "10.1161/CIRCULATIONAHA.110.010363",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adolescent,Atrial Appendage,Atrial Appendage: pathology,Atrial Appendage: radiography,Atrial Appendage: ultrasonography,Biopsy,Echocardiography,Follow-Up Studies,Heart Aneurysm,Heart Aneurysm: pathology,Heart Aneurysm: radiography,Heart Aneurysm: ultrasonography,Humans,Magnetic Resonance Imaging,Male,Radiography, Thoracic",
month = "may",
number = 20,
pages = "2289--91",
pmid = 21606408,
title = "{Longitudinal follow-up of a right atrial appendage aneurysm by cardiac magnetic resonance imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21606408",
volume = 123,
year = 2011
}
Andrew D Scott, Jennifer Keegan and David N Firmin.
{Beat-to-beat respiratory motion correction with near 100% efficiency: a quantitative assessment using high-resolution coronary artery imaging.}.
Magnetic resonance imaging 29(4):568–78, May 2011.
URL, DOI BibTeX
@article{Scott2011b,
abstract = "{This study quantitatively assesses the effectiveness of retrospective beat-to-beat respiratory motion correction (B2B-RMC) at near 100{\%} efficiency using high-resolution coronary artery imaging. Three-dimensional (3D) spiral images were obtained in a coronary respiratory motion phantom with B2B-RMC and navigator gating. In vivo, targeted 3D coronary imaging was performed in 10 healthy subjects using B2B-RMC spiral and navigator gated balanced steady-state free-precession (nav-bSSFP) techniques. Vessel diameter and sharpness in proximal and mid arteries were used as a measure of respiratory motion compensation effectiveness and compared between techniques. Phantom acquisitions with B2B-RMC were sharper than those acquired with navigator gating (B2B-RMC vs. navigator gating: 1.01±0.02 mm(-1) vs. 0.86±0.08 mm(-1), P{\textless}.05). In vivo B2B-RMC respiratory efficiency was significantly and substantially higher (99.7{\%}±0.5{\%}) than nav-bSSFP (44.0{\%}±8.9{\%}, P{\textless}.0001). Proximal and mid vessel sharpnesses were similar (B2B-RMC vs. nav-bSSFP, proximal: 1.00±0.14 mm(-1) vs. 1.08±0.11 mm(-1), mid: 1.01±0.11 mm(-1) vs. 1.05±0.12 mm(-1); both P=not significant [ns]). Mid vessel diameters were not significantly different (2.85±0.39 mm vs. 2.80±0.35 mm",
p = "",
author = "Scott, Andrew D and Keegan, Jennifer and Firmin, David N",
doi = "10.1016/j.mri.2010.11.004",
issn = "1873-5894",
journal = "Magnetic resonance imaging",
keywords = "Adult,Algorithms,Coronary Vessels,Coronary Vessels: pathology,Diagnostic Imaging,Diagnostic Imaging: methods,Female,Heart,Heart: anatomy {\&} histology,Humans,Imaging, Three-Dimensional,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Middle Aged,Motion,Phantoms, Imaging,Reproducibility of Results,Respiration",
month = "may",
number = 4,
pages = "568--78",
pmid = 21292418,
title = "{Beat-to-beat respiratory motion correction with near 100{\%} efficiency: a quantitative assessment using high-resolution coronary artery imaging.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3082051{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 29,
year = 2011
}
Sven Plein, Jeanette Schulz-Menger, Ana Almeida, Heiko Mahrholdt, Frank Rademakers, Dudley Pennell, Eike Nagel, Juerg Schwitter and Massimo Lombardi.
Training and accreditation in cardiovascular magnetic resonance in Europe: a position statement of the working group on cardiovascular magnetic resonance of the European Society of Cardiology..
European heart journal 32(7):793–8, April 2011.
URL, DOI BibTeX
@article{Plein2011,
author = "Plein, Sven and Schulz-Menger, Jeanette and Almeida, Ana and Mahrholdt, Heiko and Rademakers, Frank and Pennell, Dudley and Nagel, Eike and Schwitter, Juerg and Lombardi, Massimo",
doi = "10.1093/eurheartj/ehq474",
issn = "1522-9645",
journal = "European heart journal",
keywords = "Accreditation,Cardiology,Cardiology: education,Certification,Clinical Competence,Clinical Competence: standards,Curriculum,Europe,Magnetic Resonance Angiography,Practice Guidelines as Topic,Quality Assurance, Health Care,Societies, Medical",
month = "apr",
number = 7,
pages = "793--8",
pmid = 21289043,
title = "{Training and accreditation in cardiovascular magnetic resonance in Europe: a position statement of the working group on cardiovascular magnetic resonance of the European Society of Cardiology.}",
url = "http://eurheartj.oxfordjournals.org/content/32/7/793.extract",
volume = 32,
year = 2011
}
John-Paul Carpenter, Taigang He, Paul Kirk, Michael Roughton, Lisa J Anderson, Sofia V Noronha, Mary N Sheppard, John B Porter, Malcolm J Walker, John C Wood, Renzo Galanello, Gianluca Forni, Gualtiero Catani, Gildo Matta, Suthat Fucharoen, Adam Fleming, Michael J House, Greg Black, David N Firmin, Timothy G St Pierre and Dudley J Pennell.
On T2* magnetic resonance and cardiac iron..
Circulation 123(14):1519–28, April 2011.
URL, DOI BibTeX
@article{Carpenter2011a,
abstract = "Measurement of myocardial iron is key to the clinical management of patients at risk of siderotic cardiomyopathy. The cardiovascular magnetic resonance relaxation parameter R2* (assessed clinically via its reciprocal, T2*) measured in the ventricular septum is used to assess cardiac iron, but iron calibration and distribution data in humans are limited.",
author = "Carpenter, John-Paul and He, Taigang and Kirk, Paul and Roughton, Michael and Anderson, Lisa J and de Noronha, Sofia V and Sheppard, Mary N and Porter, John B and Walker, J Malcolm and Wood, John C and Galanello, Renzo and Forni, Gianluca and Catani, Gualtiero and Matta, Gildo and Fucharoen, Suthat and Fleming, Adam and House, Michael J and Black, Greg and Firmin, David N and {St Pierre}, Timothy G and Pennell, Dudley J",
doi = "10.1161/CIRCULATIONAHA.110.007641",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Carpenter et al. - 2011 - On T2 magnetic resonance and cardiac iron.pdf:pdf",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adolescent,Adult,Cadaver,Child,Female,Heart Atria,Heart Atria: metabolism,Heart Atria: pathology,Heart Valves,Heart Valves: metabolism,Heart Valves: pathology,Heart Ventricles,Heart Ventricles: metabolism,Heart Ventricles: pathology,Humans,Iron,Iron Overload,Iron Overload: metabolism,Iron: metabolism,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Myocardium,Myocardium: metabolism,Myocardium: pathology,Ventricular Septum,Ventricular Septum: metabolism,Ventricular Septum: pathology,Young Adult",
month = "apr",
number = 14,
pages = "1519--28",
pmid = 21444881,
title = "{On T2* magnetic resonance and cardiac iron.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3435874{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 123,
year = 2011
}
Michael Markl, Julia Geiger, Philip J Kilner, Daniela Föll, Brigitte Stiller, Friedhelm Beyersdorf, Raoul Arnold and Alex Frydrychowicz.
Time-resolved three-dimensional magnetic resonance velocity mapping of cardiovascular flow paths in volunteers and patients with Fontan circulation..
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 39(2):206–12, March 2011.
URL, DOI BibTeX
@article{Markl2011,
abstract = "To apply flow-sensitive magnetic resonance imaging for the evaluation of whole-heart flow characteristics in healthy volunteers and patients with Fontan circulation.",
author = {Markl, Michael and Geiger, Julia and Kilner, Philip J and F{\"{o}}ll, Daniela and Stiller, Brigitte and Beyersdorf, Friedhelm and Arnold, Raoul and Frydrychowicz, Alex},
doi = "10.1016/j.ejcts.2010.05.026",
issn = "1873-734X",
journal = "European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery",
keywords = "Adolescent,Adult,Aorta,Aorta: physiopathology,Blood Flow Velocity,Blood Flow Velocity: physiology,Child,Coronary Circulation,Coronary Circulation: physiology,Feasibility Studies,Female,Fontan Procedure,Fontan Procedure: methods,Heart Defects, Congenital,Heart Defects, Congenital: physiopathology,Heart Defects, Congenital: surgery,Humans,Imaging, Three-Dimensional,Imaging, Three-Dimensional: methods,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Pulmonary Artery,Pulmonary Artery: physiopathology,Pulsatile Flow,Pulsatile Flow: physiology,Vena Cava, Inferior,Vena Cava, Inferior: physiopathology,Vena Cava, Superior,Vena Cava, Superior: physiopathology",
month = "mar",
number = 2,
pages = "206--12",
pmid = 20598560,
title = "{Time-resolved three-dimensional magnetic resonance velocity mapping of cardiovascular flow paths in volunteers and patients with Fontan circulation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20598560",
volume = 39,
year = 2011
}
John G F Cleland, Melanie Calvert, Nick Freemantle, Yvonne Arrow, Stephen G Ball, Robert S Bonser, Sudipta Chattopadhyay, Michael S Norell, Dudley J Pennell and Roxy Senior.
The Heart Failure Revascularisation Trial (HEART)..
European journal of heart failure 13(2):227–33, March 2011.
URL, DOI BibTeX
@article{Cleland2011,
abstract = "Revascularization is frequently advocated to improve ventricular function and prognosis for patients with heart failure due to coronary artery disease, especially when there is evidence of extensive myocardial viability.",
author = "Cleland, John G F and Calvert, Melanie and Freemantle, Nick and Arrow, Yvonne and Ball, Stephen G and Bonser, Robert S and Chattopadhyay, Sudipta and Norell, Michael S and Pennell, Dudley J and Senior, Roxy",
doi = "10.1093/eurjhf/hfq230",
issn = "1879-0844",
journal = "European journal of heart failure",
keywords = "Aged,Angina Pectoris,Angina Pectoris: radiography,Angina Pectoris: surgery,Angioplasty,Angioplasty: methods,Angioplasty: mortality,Coronary Angiography,Coronary Angiography: methods,Coronary Artery Bypass,Coronary Artery Bypass: methods,Coronary Artery Bypass: mortality,Coronary Artery Disease,Coronary Artery Disease: mortality,Coronary Artery Disease: radiography,Coronary Artery Disease: therapy,Female,Follow-Up Studies,Heart Failure,Heart Failure: diagnosis,Heart Failure: mortality,Heart Failure: therapy,Humans,Kaplan-Meier Estimate,Male,Middle Aged,Myocardial Revascularization,Myocardial Revascularization: adverse effects,Myocardial Revascularization: methods,Patient Selection,Risk Assessment,Survival Rate,Treatment Outcome",
month = "mar",
number = 2,
pages = "227--33",
pmid = 21156659,
title = "{The Heart Failure Revascularisation Trial (HEART).}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21156659",
volume = 13,
year = 2011
}
Dana K Dawson, Alicia M Maceira, Vimal J Raj, Catriona Graham, Dudley J Pennell and Philip J Kilner.
Regional thicknesses and thickening of compacted and trabeculated myocardial layers of the normal left ventricle studied by cardiovascular magnetic resonance..
Circulation. Cardiovascular imaging 4(2):139–46, March 2011.
URL, DOI BibTeX
@article{Dawson2011,
abstract = "We used cardiovascular magnetic resonance (CMR) to study normal left ventricular (LV) trabeculation as a basis for differentiation from pathological noncompaction.",
author = "Dawson, Dana K and Maceira, Alicia M and Raj, Vimal J and Graham, Catriona and Pennell, Dudley J and Kilner, Philip J",
doi = "10.1161/CIRCIMAGING.110.960229",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dawson et al. - 2011 - Regional thicknesses and thickening of compacted and trabeculated myocardial layers of the normal left ventricle.pdf:pdf",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Adult,Age Distribution,Age Factors,Aged,Aged, 80 and over,Analysis of Variance,Female,Heart Ventricles,Heart Ventricles: anatomy {\&} histology,Humans,Image Interpretation, Computer-Assisted,Isolated Noncompaction of the Ventricular Myocardi,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Observer Variation,Predictive Value of Tests,Reference Values,Reproducibility of Results,Sex Distribution,Sex Factors,Young Adult",
month = "mar",
number = 2,
pages = "139--46",
pmid = 21193690,
title = "{Regional thicknesses and thickening of compacted and trabeculated myocardial layers of the normal left ventricle studied by cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3245853{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 4,
year = 2011
}
J P Carpenter, Susanna Price, Michael B Rubens, Mary N Sheppard, Neil E Moat, Andrew Morgan, Sanjay K Prasad and Raad H Mohiaddin.
Aortic papillary fibroelastoma as an unusual cause of angina: insights from multimodality imaging..
Circulation. Cardiovascular imaging 4(2):191–3, March 2011.
URL, DOI BibTeX
@article{Carpenter2011,
author = "Carpenter, J P and Price, Susanna and Rubens, Michael B and Sheppard, Mary N and Moat, Neil E and Morgan, Andrew and Prasad, Sanjay K and Mohiaddin, Raad H",
doi = "10.1161/CIRCIMAGING.110.962332",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Angina Pectoris,Angina Pectoris: etiology,Aorta,Aorta: pathology,Aorta: surgery,Aorta: ultrasonography,Aortography,Aortography: methods,Contrast Media,Contrast Media: diagnostic use,Coronary Angiography,Echocardiography, Three-Dimensional,Echocardiography, Transesophageal,Female,Fibroma,Fibroma: complications,Fibroma: diagnosis,Fibroma: surgery,Humans,Magnetic Resonance Imaging,Middle Aged,Predictive Value of Tests,Tomography, X-Ray Computed,Vascular Neoplasms,Vascular Neoplasms: complications,Vascular Neoplasms: diagnosis,Vascular Neoplasms: surgery,Vascular Surgical Procedures",
month = "mar",
number = 2,
pages = "191--3",
pmid = 21406665,
title = "{Aortic papillary fibroelastoma as an unusual cause of angina: insights from multimodality imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21406665",
volume = 4,
year = 2011
}
Craig S Broberg, Ananda R Jayaweera, Gerhard P Diller, Sanjay K Prasad, Swee Lay Thein, Bridget E Bax, John Burman and Michael A Gatzoulis.
Seeking optimal relation between oxygen saturation and hemoglobin concentration in adults with cyanosis from congenital heart disease..
The American journal of cardiology 107(4):595–9, February 2011.
URL, DOI BibTeX
@article{Broberg2011,
abstract = "{In patients with cyanosis from congenital heart disease, erythropoiesis is governed by many factors that can alter the expected relation between the oxygen saturation (O(2sat)) and hemoglobin concentration. We sought to define the relation between the O(2sat) and hemoglobin in such patients and to predict an ideal hemoglobin concentration for a given O(2sat). Adults with congenital heart defects and cyanosis were studied prospectively using blood tests and exercise testing. Nonoptimal hemoglobin was defined as any evidence of inadequate erythropoiesis (i.e., iron, folate, or vitamin B(12) deficiency, increased erythropoietin, reticulocytosis, or a right-shifted oxygen-hemoglobin curve). For patients without these factors, a linear regression equation of hemoglobin versus O(2sat) was used to predict the optimal hemoglobin for all patients. Of the 65 patients studied, 21 met all the prestudy criteria for an optimal hemoglobin. For all patients, no correlation was found between O(2sat) and hemoglobin (r = -0.22). However, a strong linear correlation was found for those meeting the criteria for optimal hemoglobin (r = -0.865, p {\textless}0.001). The optimal hemoglobin regression equation was as follows: predicted hemoglobin = 57.5 - (0.444 × O(2sat)). A negative correlation was found between the hemoglobin difference (predicted minus measured) and exercise duration on cardiopulmonary exercise testing (r = -0.396",
p = "",
author = "Broberg, Craig S and Jayaweera, Ananda R and Diller, Gerhard P and Prasad, Sanjay K and Thein, Swee Lay and Bax, Bridget E and Burman, John and Gatzoulis, Michael A",
doi = "10.1016/j.amjcard.2010.10.019",
issn = "1879-1913",
journal = "The American journal of cardiology",
keywords = "Adult,Algorithms,Cyanosis,Cyanosis: blood,Cyanosis: congenital,Exercise Test,Female,Heart Defects, Congenital,Heart Defects, Congenital: blood,Heart Defects, Congenital: physiopathology,Hemoglobins,Hemoglobins: metabolism,Humans,Male,Middle Aged,Oxygen,Oxygen Consumption,Oxygen: blood,Predictive Value of Tests,Prospective Studies,Reference Values,Sensitivity and Specificity",
month = "feb",
number = 4,
pages = "595--9",
pmid = 21295176,
title = "{Seeking optimal relation between oxygen saturation and hemoglobin concentration in adults with cyanosis from congenital heart disease.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21295176",
volume = 107,
year = 2011
}
Dana K Dawson, Periklis A Davlouros and Philip J Kilner.
A saw-tooth rather than noncompacted variant of left ventricular structure..
Journal of the American College of Cardiology 57(8):999, February 2011.
URL, DOI BibTeX
@article{Dawson2011a,
author = "Dawson, Dana K and Davlouros, Periklis A and Kilner, Philip J",
doi = "10.1016/j.jacc.2010.09.061",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
month = "feb",
number = 8,
pages = 999,
pmid = 21329851,
title = "{A saw-tooth rather than noncompacted variant of left ventricular structure.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21329851",
volume = 57,
year = 2011
}
Gillian C Smith, John Paul Carpenter, Taigang He, Mohammed H Alam, David N Firmin and Dudley J Pennell.
Value of black blood T2* cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:21, January 2011.
URL, DOI BibTeX
@article{Smith2011,
abstract = "To assess whether black blood T2* cardiovascular magnetic resonance is superior to conventional white blood imaging of cardiac iron in patients with thalassaemia major (TM).",
author = "Smith, Gillian C and Carpenter, John Paul and He, Taigang and Alam, Mohammed H and Firmin, David N and Pennell, Dudley J",
doi = "10.1186/1532-429X-13-21",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Smith et al. - 2011 - Value of black blood T2 cardiovascular magnetic resonance.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adolescent,Adult,Artifacts,Blood Transfusion,Blood Transfusion: adverse effects,Child,Female,Heart Diseases,Heart Diseases: blood,Heart Diseases: diagnosis,Heart Diseases: etiology,Hemosiderosis,Hemosiderosis: blood,Hemosiderosis: diagnosis,Hemosiderosis: etiology,Humans,Image Interpretation, Computer-Assisted,Iron,Iron: metabolism,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Myocardium,Myocardium: metabolism,Observer Variation,Predictive Value of Tests,Reproducibility of Results,Young Adult,beta-Thalassemia,beta-Thalassemia: blood,beta-Thalassemia: therapy",
month = "jan",
pages = 21,
pmid = 21401929,
title = "{Value of black blood T2* cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3062187{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Philip J Kilner.
The role of cardiovascular magnetic resonance in adults with congenital heart disease..
Progress in cardiovascular diseases 54(3):295–304, 2011.
URL, DOI BibTeX
@article{Kilner,
abstract = "The comprehensive coverage and versatility of cardiovascular magnetic resonance (CMR), providing functional as well as anatomical information, make it an important facility in a center specializing in the care of adults with congenital heart disease. Imaging specialists using CMR to investigate acquired heart disease should also be able to recognize and evaluate previously unsuspected congenital malformations. Conditions that may present or be picked up during imaging in adulthood include atrial septal defect, anomalously connected pulmonary veins, double-chambered right ventricle, congenitally corrected transposition of the great arteries, aortic coarctation, and patent arterial duct. To realize its full potential and to avoid pitfalls, CMR of adults with congenital heart disease requires specific training and experience. Appropriate pathophysiological understanding is needed to evaluate cardiovascular function after surgery for tetralogy of Fallot, after transposition of the great arteries, and after Fontan operations. For these and other more complex cases, CMR should ideally be undertaken by specialists committed to long-term collaboration with the clinicians and surgeons managing the patients in a tertiary referral center.",
author = "Kilner, Philip J",
doi = "10.1016/j.pcad.2011.07.006",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Kilner - 2011 - The role of cardiovascular magnetic resonance in adults with congenital heart disease.pdf:pdf",
issn = "1532-8643",
journal = "Progress in cardiovascular diseases",
keywords = "Adult,Age Factors,Congenital,Congenital: diagnosis,Congenital: physiopathology,Congenital: therapy,Heart Defects,Humans,Magnetic Resonance Imaging,Predictive Value of Tests,Prognosis,Severity of Illness Index",
number = 3,
pages = "295--304",
pmid = 22014496,
title = "{The role of cardiovascular magnetic resonance in adults with congenital heart disease.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3245850{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 54,
year = 2011
}
Giovanni Quarta, Agata Grasso, Ferdinando Pasquale, Andrew S Flett, Dan Sado, Elena B, Cono Ariti, Sanjay K Prasad, Perry M Elliott and James C Moon.
The evolution and clinical importance of scar in hypertrophic cardiomyopathy - a 7 year CMR follow-up study.
Journal of Cardiovascular Magnetic Resonance 13(Suppl 1):P296, 2011.
URL, DOI BibTeX
@article{Quarta2011,
author = "Quarta, Giovanni and Grasso, Agata and Pasquale, Ferdinando and Flett, Andrew S and Sado, Dan and B, Elena and Ariti, Cono and Prasad, Sanjay K and Elliott, Perry M and Moon, James C",
doi = "10.1186/1532-429X-13-S1-P296",
issn = "1532-429X",
journal = "Journal of Cardiovascular Magnetic Resonance",
language = "en",
number = "Suppl 1",
pages = "P296",
publisher = "BioMed Central",
title = "{The evolution and clinical importance of scar in hypertrophic cardiomyopathy - a 7 year CMR follow-up study}",
url = "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106512/",
volume = 13,
year = 2011
}
Marijn P Rolf, Mark B M Hofman, Peter D Gatehouse, Karin Markenroth-Bloch, Martijn W Heymans, Tino Ebbers, Martin J Graves, John J Totman, Beat Werner, Albert C Rossum, Philip J Kilner and Rob M Heethaar.
Sequence optimization to reduce velocity offsets in cardiovascular magnetic resonance volume flow quantification–a multi-vendor study..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:18, January 2011.
URL, DOI BibTeX
@article{Rolf2011,
abstract = "Eddy current induced velocity offsets are of concern for accuracy in cardiovascular magnetic resonance (CMR) volume flow quantification. However, currently known theoretical aspects of eddy current behavior have not led to effective guidelines for the optimization of flow quantification sequences. This study is aimed at identifying correlations between protocol parameters and the resulting velocity error in clinical CMR flow measurements in a multi-vendor study.",
author = "Rolf, Marijn P and Hofman, Mark B M and Gatehouse, Peter D and Markenroth-Bloch, Karin and Heymans, Martijn W and Ebbers, Tino and Graves, Martin J and Totman, John J and Werner, Beat and van Rossum, Albert C and Kilner, Philip J and Heethaar, Rob M",
doi = "10.1186/1532-429X-13-18",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Rolf et al. - 2011 - Sequence optimization to reduce velocity offsets in cardiovascular magnetic resonance volume flow quantification--a.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Aorta,Aorta: physiology,Blood Flow Velocity,Equipment Design,Europe,Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging,Magnetic Resonance Imaging: instrumentation,Magnetic Resonance Imaging: standards,Materials Testing,Models, Cardiovascular,Phantoms, Imaging,Pulmonary Circulation,Regional Blood Flow,Reproducibility of Results",
month = "jan",
pages = 18,
pmid = 21388521,
title = "{Sequence optimization to reduce velocity offsets in cardiovascular magnetic resonance volume flow quantification--a multi-vendor study.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3065419{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Francisco Alpendurada, Kaushik Guha, Rakesh Sharma, Tevfik F Ismail, Amy Clifford, Winston Banya, Raad H Mohiaddin, Dudley J Pennell, Martin R Cowie, Theresa McDonagh and Sanjay K Prasad.
Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13(1):68, January 2011.
URL, DOI BibTeX
@article{Alpendurada2011,
abstract = "Cardiac resynchronization therapy (CRT) is an established treatment in advanced heart failure (HF). However, an important subset does not derive a significant benefit. Despite an established predictive role in HF, the significance of right ventricular (RV) dysfunction in predicting clinical benefit from CRT remains unclear. We investigated the role of RV function, assessed by cardiovascular magnetic resonance (CMR), in predicting response to and major adverse clinical events in HF patients undergoing CRT.",
author = "Alpendurada, Francisco and Guha, Kaushik and Sharma, Rakesh and Ismail, Tevfik F and Clifford, Amy and Banya, Winston and Mohiaddin, Raad H and Pennell, Dudley J and Cowie, Martin R and McDonagh, Theresa and Prasad, Sanjay K",
doi = "10.1186/1532-429X-13-68",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Alpendurada et al. - 2011 - Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchr.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Aged,Aged, 80 and over,Cardiac Resynchronization Therapy,Cardiac Resynchronization Therapy: adverse effects,Cardiac Resynchronization Therapy: mortality,Female,Heart Failure,Heart Failure: complications,Heart Failure: diagnosis,Heart Failure: mortality,Heart Failure: physiopathology,Heart Failure: therapy,Humans,Kaplan-Meier Estimate,Logistic Models,London,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Odds Ratio,Patient Selection,Predictive Value of Tests,Proportional Hazards Models,Retrospective Studies,Risk Assessment,Risk Factors,Time Factors,Treatment Outcome,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: complications,Ventricular Dysfunction, Right: diagnosis,Ventricular Dysfunction, Right: mortality,Ventricular Dysfunction, Right: physiopathology,Ventricular Dysfunction, Right: therapy,Ventricular Function, Left,Ventricular Function, Right",
month = "jan",
number = 1,
pages = 68,
pmid = 22040270,
title = "{Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy.}",
url = "http://www.jcmr-online.com/content/13/1/68",
volume = 13,
year = 2011
}
Dudley J Pennell, David N Firmin, Philip J Kilner, Warren J Manning, Raad H Mohiaddin and Sanjay K Prasad.
Review of journal of cardiovascular magnetic resonance 2010..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:48, January 2011.
URL, DOI BibTeX
@article{Pennell2011c,
abstract = "There were 75 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2010, which is a 34{\%} increase in the number of articles since 2009. The quality of the submissions continues to increase, and the editors were delighted with the recent announcement of the JCMR Impact Factor of 4.33 which showed a 90{\%} increase since last year. Our acceptance rate is approximately 30{\%}, but has been falling as the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. Last year for the first time, the Editors summarized the papers for the readership into broad areas of interest or theme, which we felt would be useful to practitioners of cardiovascular magnetic resonance (CMR) so that you could review areas of interest from the previous year in a single article in relation to each other and other recent JCMR articles 1. This experiment proved very popular with a very high rate of downloading, and therefore we intend to continue this review annually. The papers are presented in themes and comparison is drawn with previously published JCMR papers to identify the continuity of thought and publication in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR for publication.",
author = "Pennell, Dudley J and Firmin, David N and Kilner, Philip J and Manning, Warren J and Mohiaddin, Raad H and Prasad, Sanjay K",
doi = "10.1186/1532-429X-13-48",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2011 - Review of journal of cardiovascular magnetic resonance 2010.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Animals,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: physiopathology,Editorial Policies,Humans,Journal Impact Factor,Magnetic Resonance Imaging,Periodicals as Topic,Predictive Value of Tests,Prognosis,Severity of Illness Index",
month = "jan",
pages = 48,
pmid = 21914185,
title = "{Review of journal of cardiovascular magnetic resonance 2010.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3182946{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
D J Pennell, J P Carpenter, M Roughton and Zi Cabantchik.
On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:45, January 2011.
URL, DOI BibTeX
@article{Pennell2011d,
abstract = "Trials of iron chelator regimens have increased the treatment options for cardiac siderosis in beta-thalassemia major (TM) patients. Treatment effects with improved left ventricular (LV) ejection fraction (EF) have been observed in patients without overt heart failure, but it is unclear whether these changes are clinically meaningful.",
author = "Pennell, D J and Carpenter, J P and Roughton, M and Cabantchik, Zi",
doi = "10.1186/1532-429X-13-45",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2011 - On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failur.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adolescent,Adult,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathies: drug therapy,Cardiomyopathies: etiology,Cardiomyopathies: physiopathology,Female,Great Britain,Heart Failure,Heart Failure: etiology,Heart Failure: physiopathology,Heart Failure: prevention {\&} control,Humans,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Magnetic Resonance Imaging,Male,Recovery of Function,Retrospective Studies,Risk Assessment,Risk Factors,Stroke Volume,Stroke Volume: drug effects,Time Factors,Treatment Outcome,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: diagnosis,Ventricular Dysfunction, Left: drug therapy,Ventricular Dysfunction, Left: etiology,Ventricular Dysfunction, Left: physiopathology,Ventricular Function, Left,Ventricular Function, Left: drug effects,Young Adult,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: drug therapy,beta-Thalassemia: physiopathology",
month = "jan",
pages = 45,
pmid = 21910880,
title = "{On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3180261{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Ankur Gulati, Cheuk Chan, Alison Duncan, Sadaf Raza, Philip J Kilner and John Pepper.
Multimodality cardiac imaging in the evaluation of mitral annular caseous calcification..
Circulation 123(1):e1–2, January 2011.
URL, DOI BibTeX
@article{Gulati2011,
author = "Gulati, Ankur and Chan, Cheuk and Duncan, Alison and Raza, Sadaf and Kilner, Philip J and Pepper, John",
doi = "10.1161/CIRCULATIONAHA.110.954313",
issn = "1524-4539",
journal = "Circulation",
keywords = "Aged,Calcinosis,Calcinosis: diagnosis,Echocardiography,Heart Valve Diseases,Heart Valve Diseases: diagnosis,Humans,Magnetic Resonance Imaging,Male,Mitral Valve,Mitral Valve: pathology,Tomography, X-Ray Computed",
month = "jan",
number = 1,
pages = "e1--2",
pmid = 21200011,
title = "{Multimodality cardiac imaging in the evaluation of mitral annular caseous calcification.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21200011",
volume = 123,
year = 2011
}
Paul Kirk, John Paul Carpenter, Mark A Tanner and Dudley J Pennell.
Low prevalence of fibrosis in thalassemia major assessed by late gadolinium enhancement cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13(1):8, January 2011.
URL, DOI BibTeX
@article{Kirk2011,
abstract = "Heart failure remains a major cause of mortality in thalassaemia major. The possible role of cardiac fibrosis in thalassemia major in the genesis of heart failure is not clear. It is also unclear whether cardiac fibrosis might arise as a result of heart failure.",
author = "Kirk, Paul and Carpenter, John Paul and Tanner, Mark A and Pennell, Dudley J",
doi = "10.1186/1532-429X-13-8",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Kirk et al. - 2011 - Low prevalence of fibrosis in thalassemia major assessed by late gadolinium enhancement cardiovascular magnetic res.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adolescent,Adult,Contrast Media,Contrast Media: diagnostic use,England,Female,Fibrosis,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Heart Failure,Heart Failure: etiology,Heart Failure: metabolism,Heart Failure: pathology,Heart Failure: physiopathology,Humans,Iron,Iron: metabolism,Magnetic Resonance Imaging,Male,Myocardium,Myocardium: metabolism,Myocardium: pathology,Predictive Value of Tests,Prevalence,Stroke Volume,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: etiology,Ventricular Dysfunction, Left: pathology,Ventricular Function, Left,Young Adult,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: metabolism,beta-Thalassemia: pathology,beta-Thalassemia: physiopathology",
month = "jan",
number = 1,
pages = 8,
pmid = 21241474,
title = "{Low prevalence of fibrosis in thalassemia major assessed by late gadolinium enhancement cardiovascular magnetic resonance.}",
url = "http://www.jcmr-online.com/content/13/1/8",
volume = 13,
year = 2011
}
Mathew G Wilson, Navin Chandra, Michael Papadakis, Rory O'Hanlon, Sanjay K Prasad and Sanjay Sharma.
Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities?.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:77, January 2011.
URL, DOI BibTeX
@article{Wilson2011a,
abstract = "Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM). Differentiating physiological from pathological hypertrophy has important implications, since HCM is the commonest cause of exercise-related sudden cardiac death in young individuals. Most deaths have been reported in intermittent 'start-stop' sports such as football (soccer) and basketball. The theory is that individuals with HCM are unable to augment stroke volume sufficiently to meet the demands of endurance sports and are accordingly 'selected-out' of participation in such events. We report the case of an ultra-endurance athlete with 25 years of {\textgreater} 50 km competitive running experience, with genetically confirmed HCM; thereby demonstrating that these can be two compatible entities.",
author = "Wilson, Mathew G and Chandra, Navin and Papadakis, Michael and O'Hanlon, Rory and Prasad, Sanjay K and Sharma, Sanjay",
doi = "10.1186/1532-429X-13-77",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Wilson et al. - 2011 - Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Asymptomatic Diseases,Cardiomyopathy, Hypertrophic, Familial,Cardiomyopathy, Hypertrophic, Familial: diagnosis,Cardiomyopathy, Hypertrophic, Familial: genetics,Cardiomyopathy, Hypertrophic, Familial: physiopath,Carrier Proteins,Carrier Proteins: genetics,DNA Mutational Analysis,Echocardiography, Doppler, Color,Electrocardiography,Exercise Test,Genetic Predisposition to Disease,Humans,Magnetic Resonance Imaging,Male,Mutation,Phenotype,Physical Endurance,Running",
month = "jan",
pages = 77,
pmid = 22122802,
title = "{Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities?}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3243082{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Andrew D Scott, Jennifer Keegan and David N Firmin.
{High-resolution 3D coronary vessel wall imaging with near 100% respiratory efficiency using epicardial fat tracking: reproducibility and comparison with standard methods.}.
Journal of magnetic resonance imaging : JMRI 33(1):77–86, January 2011.
URL, DOI BibTeX
@article{Scott2011a,
abstract = "To quantitatively assess the performance and reproducibility of 3D spiral coronary artery wall imaging with beat-to-beat respiratory-motion-correction (B2B-RMC) compared to navigator gated 2D spiral and turbo-spin-echo (TSE) acquisitions.",
author = "Scott, Andrew D and Keegan, Jennifer and Firmin, David N",
doi = "10.1002/jmri.22398",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adipose Tissue,Adipose Tissue: anatomy {\&} histology,Adult,Algorithms,Cardiac-Gated Imaging Techniques,Cardiac-Gated Imaging Techniques: methods,Coronary Vessels,Coronary Vessels: anatomy {\&} histology,Female,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Imaging, Three-Dimensional,Imaging, Three-Dimensional: methods,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Middle Aged,Pattern Recognition, Automated,Pattern Recognition, Automated: methods,Pericardium,Pericardium: anatomy {\&} histology,Reproducibility of Results,Respiratory-Gated Imaging Techniques,Respiratory-Gated Imaging Techniques: methods,Sensitivity and Specificity,Subtraction Technique",
month = "jan",
number = 1,
pages = "77--86",
pmid = 21182124,
title = "{High-resolution 3D coronary vessel wall imaging with near 100{\%} respiratory efficiency using epicardial fat tracking: reproducibility and comparison with standard methods.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21182124",
volume = 33,
year = 2011
}
Gillian C Smith, Francisco Alpendurada, John Paul Carpenter, Mohammed H Alam, Vasili Berdoukas, Markissia Karagiorga, Vasili Ladis, Antonio Piga, Athanassios Aessopos, Efstathios D Gotsis, Mark A Tanner, Mark A Westwood, Renzo Galanello, Michael Roughton and Dudley J Pennell.
Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:34, January 2011.
URL, DOI BibTeX
@article{Smith2011a,
abstract = "Thalassaemia major (TM) patients need regular blood transfusions that lead to accumulation of iron and death from heart failure. Deferiprone has been reported to be superior to deferoxamine for the removal of cardiac iron and improvement in left ventricular (LV) function but little is known of their relative effects on the right ventricle (RV), which is being increasingly recognised as an important prognostic factor in cardiomyopathy. Therefore data from a prospective randomised controlled trial (RCT) comparing these chelators was retrospectively analysed to assess the RV responses to these drugs.",
author = "Smith, Gillian C and Alpendurada, Francisco and Carpenter, John Paul and Alam, Mohammed H and Berdoukas, Vasili and Karagiorga, Markissia and Ladis, Vasili and Piga, Antonio and Aessopos, Athanassios and Gotsis, Efstathios D and Tanner, Mark A and Westwood, Mark A and Galanello, Renzo and Roughton, Michael and Pennell, Dudley J",
doi = "10.1186/1532-429X-13-34",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Smith et al. - 2011 - Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Analysis of Variance,Blood Transfusion,Blood Transfusion: adverse effects,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathies: drug therapy,Cardiomyopathies: etiology,Cardiomyopathies: metabolism,Cardiomyopathies: physiopathology,Deferoxamine,Deferoxamine: therapeutic use,Female,Greece,Humans,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: diagnosis,Iron Overload: drug therapy,Iron Overload: etiology,Iron Overload: metabolism,Iron Overload: physiopathology,Italy,Magnetic Resonance Imaging,Male,Multicenter Studies as Topic,Myocardium,Myocardium: metabolism,Pyridones,Pyridones: therapeutic use,Randomized Controlled Trials as Topic,Retrospective Studies,Siderophores,Siderophores: therapeutic use,Stroke Volume,Stroke Volume: drug effects,Time Factors,Treatment Outcome,Ventricular Function, Left,Ventricular Function, Left: drug effects,Ventricular Function, Right,Ventricular Function, Right: drug effects,Young Adult,beta-Thalassemia,beta-Thalassemia: blood,beta-Thalassemia: therapy",
month = "jan",
pages = 34,
pmid = 21733147,
title = "{Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3148987{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Dudley J Pennell and Niall G Keenan.
Coronary microvascular dysfunction in systemic lupus erythematosus identified by CMR imaging..
JACC. Cardiovascular imaging 4(1):34–6, January 2011.
URL, DOI BibTeX
@article{Pennell2011b,
author = "Pennell, Dudley J and Keenan, Niall G",
doi = "10.1016/j.jcmg.2010.11.007",
issn = "1876-7591",
journal = "JACC. Cardiovascular imaging",
keywords = "Adult,Coronary Circulation,Exercise Test,Female,Humans,Lupus Erythematosus, Systemic,Lupus Erythematosus, Systemic: complications,Magnetic Resonance Imaging,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Myocardial Ischemia: etiology",
month = "jan",
number = 1,
pages = "34--6",
pmid = 21232701,
title = "{Coronary microvascular dysfunction in systemic lupus erythematosus identified by CMR imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21232701",
volume = 4,
year = 2011
}
Dudley J Pennell, John B Porter, Maria Domenica Cappellini, Lee Lee Chan, Amal El-Beshlawy, Yesim Aydinok, Hishamshah Ibrahim, Chi-Kong Li, Vip Viprakasit, Mohsen Saleh Elalfy, Antonis Kattamis, Gillian Smith, Dany Habr, Gabor Domokos, Bernard Roubert and Ali Taher.
Continued improvement in myocardial T2* over two years of deferasirox therapy in $\beta$-thalassemia major patients with cardiac iron overload..
Haematologica 96(1):48–54, January 2011.
URL, DOI BibTeX
@article{Pennell2011,
abstract = "The efficacy of cardiac iron chelation in transfusion-dependent patients has been demonstrated in one-year prospective trials. Since normalization of cardiac T2* takes several years, the efficacy and safety of deferasirox was assessed for two years in patients with $\beta$-thalassemia major in the cardiac sub-study of the EPIC trial.",
author = "Pennell, Dudley J and Porter, John B and Cappellini, Maria Domenica and Chan, Lee Lee and El-Beshlawy, Amal and Aydinok, Yesim and Ibrahim, Hishamshah and Li, Chi-Kong and Viprakasit, Vip and Elalfy, Mohsen Saleh and Kattamis, Antonis and Smith, Gillian and Habr, Dany and Domokos, Gabor and Roubert, Bernard and Taher, Ali",
doi = "10.3324/haematol.2010.031468",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2011 - Continued improvement in myocardial T2 over two years of deferasirox therapy in $\beta$-thalassemia major patients wit.pdf:pdf",
issn = "1592-8721",
journal = "Haematologica",
keywords = ",Adolescent,Adult,Benzoates,Benzoates: therapeutic use,Child,Female,Ferritins,Ferritins: blood,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: chemically induced,Iron Overload: drug therapy,Iron: metabolism,Left,Left: drug effects,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,Prognosis,Prospective Studies,Triazoles,Triazoles: therapeutic use,Ventricular Function,Young Adult,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: drug therapy",
month = "jan",
number = 1,
pages = "48--54",
pmid = 21071497,
title = "{Continued improvement in myocardial T2* over two years of deferasirox therapy in $\beta$-thalassemia major patients with cardiac iron overload.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3012764{\&}tool=pmcentrez{\&}rendertype=abstract http://www.haematologica.org/content/96/1/48.abstract",
volume = 96,
year = 2011
}
Michael Markl, Philip J Kilner and Tino Ebbers.
Comprehensive 4D velocity mapping of the heart and great vessels by cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:7, January 2011.
URL, DOI BibTeX
@article{Markl2011a,
abstract = "Phase contrast cardiovascular magnetic resonance (CMR) is able to measure all three directional components of the velocities of blood flow relative to the three spatial dimensions and the time course of the heart cycle. In this article, methods used for the acquisition, visualization, and quantification of such datasets are reviewed and illustrated.",
author = "Markl, Michael and Kilner, Philip J and Ebbers, Tino",
doi = "10.1186/1532-429X-13-7",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Markl, Kilner, Ebbers - 2011 - Comprehensive 4D velocity mapping of the heart and great vessels by cardiovascular magnetic resonance.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Blood Flow Velocity,Blood Vessels,Blood Vessels: physiopathology,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: physiopathology,Coronary Circulation,Heart,Heart: physiopathology,Humans,Image Interpretation, Computer-Assisted,Imaging, Three-Dimensional,Magnetic Resonance Imaging, Cine,Predictive Value of Tests,Regional Blood Flow,Respiratory Mechanics,Time Factors",
month = "jan",
pages = 7,
pmid = 21235751,
title = "{Comprehensive 4D velocity mapping of the heart and great vessels by cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3025879{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Sylvia S M Chen, Jennifer Keegan, Andrew W Dowsey, Tevfik Ismail, Ricardo Wage, Wei Li, Guang-Zhong Yang, David N Firmin and Philip J Kilner.
Cardiovascular magnetic resonance tagging of the right ventricular free wall for the assessment of long axis myocardial function in congenital heart disease..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:80, January 2011.
URL, DOI BibTeX
@article{Chen2011a,
abstract = "Right ventricular ejection fraction (RV-EF) has traditionally been used to measure and compare RV function serially over time, but may be a relatively insensitive marker of change in RV myocardial contractile function. We developed a cardiovascular magnetic resonance (CMR) tagging-based technique with a view to rapid and reproducible measurement of RV long axis function and applied it in patients with congenital heart disease.",
author = "Chen, Sylvia S M and Keegan, Jennifer and Dowsey, Andrew W and Ismail, Tevfik and Wage, Ricardo and Li, Wei and Yang, Guang-Zhong and Firmin, David N and Kilner, Philip J",
doi = "10.1186/1532-429X-13-80",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Chen et al. - 2011 - Cardiovascular magnetic resonance tagging of the right ventricular free wall for the assessment of long axis myocar.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Cardiac Surgical Procedures,Case-Control Studies,Female,Heart Defects, Congenital,Heart Defects, Congenital: diagnosis,Heart Defects, Congenital: pathology,Heart Defects, Congenital: physiopathology,Heart Defects, Congenital: surgery,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Humans,Image Interpretation, Computer-Assisted,London,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Observer Variation,Predictive Value of Tests,Prospective Studies,Reproducibility of Results,Stroke Volume,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: diagnosis,Ventricular Dysfunction, Right: pathology,Ventricular Dysfunction, Right: physiopathology,Ventricular Function, Right,Young Adult",
month = "jan",
pages = 80,
pmid = 22168638,
title = "{Cardiovascular magnetic resonance tagging of the right ventricular free wall for the assessment of long axis myocardial function in congenital heart disease.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3286381{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Aurelio Secinaro, Hopewell Ntsinjana, Oliver Tann, Pia K Schuler, Vivek Muthurangu, Marina Hughes, Victor Tsang and Andrew M Taylor.
Cardiovascular magnetic resonance findings in repaired anomalous left coronary artery to pulmonary artery connection (ALCAPA)..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13:27, January 2011.
URL, DOI BibTeX
@article{Secinaro2011,
abstract = "Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare coronary artery anomaly. This study shows the role of cardiovascular magnetic resonance (CMR) in assessing young patients following surgical repair of ALCAPA.",
author = "Secinaro, Aurelio and Ntsinjana, Hopewell and Tann, Oliver and Schuler, Pia K and Muthurangu, Vivek and Hughes, Marina and Tsang, Victor and Taylor, Andrew M",
doi = "10.1186/1532-429X-13-27",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Secinaro et al. - 2011 - Cardiovascular magnetic resonance findings in repaired anomalous left coronary artery to pulmonary artery conne.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adolescent,Cardiac Catheterization,Cardiac Surgical Procedures,Cardiac Surgical Procedures: adverse effects,Child,Contrast Media,Contrast Media: diagnostic use,Coronary Circulation,Coronary Vessel Anomalies,Coronary Vessel Anomalies: diagnosis,Coronary Vessel Anomalies: physiopathology,Coronary Vessel Anomalies: surgery,Coronary Vessels,Coronary Vessels: pathology,Coronary Vessels: physiopathology,Coronary Vessels: surgery,Female,Fibrosis,Humans,Image Interpretation, Computer-Assisted,Imaging, Three-Dimensional,Magnetic Resonance Imaging, Cine,Male,Meglumine,Meglumine: diagnostic use,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Myocardial Ischemia: pathology,Myocardial Ischemia: physiopathology,Myocardial Perfusion Imaging,Myocardial Perfusion Imaging: methods,Myocardium,Myocardium: pathology,Organometallic Compounds,Organometallic Compounds: diagnostic use,Predictive Value of Tests,Pulmonary Artery,Pulmonary Artery: abnormalities,Pulmonary Artery: physiopathology,Pulmonary Artery: surgery,Replantation,Replantation: adverse effects,Retrospective Studies,Stroke Volume,Treatment Outcome,Ventricular Function, Left,Young Adult",
month = "jan",
pages = 27,
pmid = 21575211,
title = "{Cardiovascular magnetic resonance findings in repaired anomalous left coronary artery to pulmonary artery connection (ALCAPA).}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3123558{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 13,
year = 2011
}
Renjith Antony, Marwa Daghem, Gerry P McCann, Safa Daghem, James Moon, Dudley J Pennell, Stefan Neubauer, Henry J Dargie, Colin Berry, John Payne, Mark C Petrie and Nathaniel M Hawkins.
Cardiovascular magnetic resonance activity in the United Kingdom: a survey on behalf of the British Society of Cardiovascular Magnetic Resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 13(1):57, January 2011.
URL, DOI BibTeX
@article{Antony2011,
abstract = "The indications, complexity and capabilities of cardiovascular magnetic resonance (CMR) have rapidly expanded. Whether actual service provision and training have developed in parallel is unknown.",
author = "Antony, Renjith and Daghem, Marwa and McCann, Gerry P and Daghem, Safa and Moon, James and Pennell, Dudley J and Neubauer, Stefan and Dargie, Henry J and Berry, Colin and Payne, John and Petrie, Mark C and Hawkins, Nathaniel M",
doi = "10.1186/1532-429X-13-57",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Antony et al. - 2011 - Cardiovascular magnetic resonance activity in the United Kingdom a survey on behalf of the British Society of Car.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Cardiology,Cardiology Service, Hospital,Cardiology Service, Hospital: economics,Cardiology Service, Hospital: statistics {\&} numeric,Cardiology: education,Cardiology: statistics {\&} numerical data,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: economics,Clinical Competence,Clinical Competence: statistics {\&} numerical data,Delivery of Health Care,Delivery of Health Care: statistics {\&} numerical da,Great Britain,Health Care Surveys,Health Services Accessibility,Health Services Accessibility: statistics {\&} numeri,Healthcare Disparities,Healthcare Disparities: statistics {\&} numerical dat,Hospital Costs,Hospital Costs: statistics {\&} numerical data,Hospitals, Public,Hospitals, Public: economics,Hospitals, Public: statistics {\&} numerical data,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: economics,Magnetic Resonance Imaging: statistics {\&} numerical,Predictive Value of Tests,Quality Indicators, Health Care,Quality Indicators, Health Care: statistics {\&} nume,Questionnaires,Radiology,Radiology Department, Hospital,Radiology Department, Hospital: economics,Radiology Department, Hospital: statistics {\&} numer,Radiology: education,Radiology: statistics {\&} numerical data,Residence Characteristics,Residence Characteristics: statistics {\&} numerical,Societies, Medical,Societies, Scientific",
month = "jan",
number = 1,
pages = 57,
pmid = 21978669,
title = "{Cardiovascular magnetic resonance activity in the United Kingdom: a survey on behalf of the British Society of Cardiovascular Magnetic Resonance.}",
url = "http://www.jcmr-online.com/content/13/1/57",
volume = 13,
year = 2011
}
Anatoli Kiotsekoglou, James C Moggridge, Samir K Saha, Venediktos Kapetanakis, Malini Govindan, Francisco Alpendurada, Michael J Mullen, John Camm, George R Sutherland, Bart H Bijnens and Anne H Child.
Assessment of aortic stiffness in marfan syndrome using two-dimensional and Doppler echocardiography..
Echocardiography (Mount Kisco, N.Y.) 28(1):29–37, January 2011.
URL, DOI BibTeX
@article{Kiotsekoglou2011,
abstract = "Extracellular matrix remodeling in the aortic wall results in increased aortic stiffness (AoS) in Marfan syndrome (MFS). Pulsed-wave velocity (PWV) constitutes the best indirect AoS measurement. We aimed to assess PWV in MFS patients using two-dimensional (2D) and Doppler echocardiography.",
author = "Kiotsekoglou, Anatoli and Moggridge, James C and Saha, Samir K and Kapetanakis, Venediktos and Govindan, Malini and Alpendurada, Francisco and Mullen, Michael J and Camm, John and Sutherland, George R and Bijnens, Bart H and Child, Anne H",
doi = "10.1111/j.1540-8175.2010.01241.x",
issn = "1540-8175",
journal = "Echocardiography (Mount Kisco, N.Y.)",
keywords = "Adolescent,Adult,Age Factors,Aorta,Aorta: pathology,Aorta: ultrasonography,Case-Control Studies,Echocardiography, Doppler,Female,Humans,Male,Marfan Syndrome,Marfan Syndrome: ultrasonography,Middle Aged,Observer Variation,Young Adult",
month = "jan",
number = 1,
pages = "29--37",
pmid = 21198821,
title = "{Assessment of aortic stiffness in marfan syndrome using two-dimensional and Doppler echocardiography.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21198821",
volume = 28,
year = 2011
}
Karim Lekadir, Niall G Keenan, Dudley J Pennell and Guang-Zhong Yang.
An inter-landmark approach to 4-D shape extraction and interpretation: application to myocardial motion assessment in MRI..
IEEE transactions on medical imaging 30(1):52–68, January 2011.
URL, DOI BibTeX
@article{Lekadir2011,
abstract = "This paper presents a novel approach to shape extraction and interpretation in 4-D cardiac magnetic resonance imaging data. Statistical modeling of spatiotemporal interlandmark relationships is performed to enable the decomposition of global shape constraints and subsequently of the image analysis tasks. The introduced descriptors furthermore provide invariance to similarity transformations and thus eliminate pose estimation errors in the presence of image artifacts or geometrical inconsistencies. A set of algorithms are derived to address key technical issues related to constrained boundary tracking, dynamic model relaxation, automatic initialization, and dysfunction localization. The proposed framework is validated with a relatively large dataset of 50 subjects and compared to existing statistical shape modeling methods. The results indicate increased adaptation to spatiotemporal variations and imaging conditions.",
author = "Lekadir, Karim and Keenan, Niall G and Pennell, Dudley J and Yang, Guang-Zhong",
doi = "10.1109/TMI.2010.2060490",
issn = "1558-254X",
journal = "IEEE transactions on medical imaging",
keywords = "Algorithms,Artifacts,Heart,Heart: physiology,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Imaging, Three-Dimensional,Imaging, Three-Dimensional: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Models, Cardiovascular,Models, Statistical,Motion,Myocardial Contraction,Myocardial Contraction: physiology,Pattern Recognition, Automated,Pattern Recognition, Automated: methods",
month = "jan",
number = 1,
pages = "52--68",
pmid = 20656655,
title = "{An inter-landmark approach to 4-D shape extraction and interpretation: application to myocardial motion assessment in MRI.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20656655",
volume = 30,
year = 2011
}
Helmut Baumgartner, Philipp Bonhoeffer, Natasja M S De Groot, Fokko Haan, John Erik Deanfield, Nazzareno Galie, Michael A Gatzoulis, Christa Gohlke-Baerwolf, Harald Kaemmerer, Philip Kilner, Folkert Meijboom, Barbara J M Mulder, Erwin Oechslin, Jose M Oliver, Alain Serraf, Andras Szatmari, Erik Thaulow, Pascal R Vouhe and Edmond Walma.
ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)..
European heart journal 31(23):2915–57, December 2010.
URL, DOI BibTeX
@article{Baumgartner2010,
author = "Baumgartner, Helmut and Bonhoeffer, Philipp and {De Groot}, Natasja M S and de Haan, Fokko and Deanfield, John Erik and Galie, Nazzareno and Gatzoulis, Michael A and Gohlke-Baerwolf, Christa and Kaemmerer, Harald and Kilner, Philip and Meijboom, Folkert and Mulder, Barbara J M and Oechslin, Erwin and Oliver, Jose M and Serraf, Alain and Szatmari, Andras and Thaulow, Erik and Vouhe, Pascal R and Walma, Edmond",
doi = "10.1093/eurheartj/ehq249",
issn = "1522-9645",
journal = "European heart journal",
keywords = "Adult,Arrhythmias, Cardiac,Arrhythmias, Cardiac: therapy,Cardiac Catheterization,Death, Sudden, Cardiac,Death, Sudden, Cardiac: prevention {\&} control,Echocardiography,Echocardiography: methods,Endocarditis,Endocarditis: therapy,Exercise,Exercise Test,Exercise Test: methods,Female,Heart Defects, Congenital,Heart Defects, Congenital: diagnosis,Heart Defects, Congenital: therapy,Heart Failure,Heart Failure: therapy,Humans,Insurance, Health,Life Style,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Patient Care,Patient Care: methods,Pregnancy,Pregnancy Complications, Cardiovascular,Pregnancy Complications, Cardiovascular: therapy,Sports,Thoracic Surgical Procedures,Thoracic Surgical Procedures: methods,Tomography, X-Ray Computed",
month = "dec",
number = 23,
pages = "2915--57",
pmid = 20801927,
title = "{ESC Guidelines for the management of grown-up congenital heart disease (new version 2010).}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20801927",
volume = 31,
year = 2010
}
Ben B Ariff, Fadi P Glor, Lindsey Crowe, Xiao Y Xu, William Vennart, David N Firmin, Simon M Thom and Alun D Hughes.
Carotid artery hemodynamics: observing patient-specific changes with amlodipine and lisinopril by using MR imaging computation fluid dynamics..
Radiology 257(3):662–9, December 2010.
URL, DOI BibTeX
@article{Ariff2010,
abstract = "To assess whether using magnetic resonance (MR) imaging combined with computational fluid dynamics (CFD) could reveal changes in common carotid artery (CCA) flow and wall shear stress (WSS) that might contribute to differences in CCA remodeling between amlodipine, a calcium channel blocker, and lisinopril, an angiotensin-converting enzyme inhibitor, despite similar reductions in blood pressure (BP).",
author = "Ariff, Ben B and Glor, Fadi P and Crowe, Lindsey and Xu, Xiao Y and Vennart, William and Firmin, David N and Thom, Simon M and Hughes, Alun D",
doi = "10.1148/radiol.10100788",
issn = "1527-1315",
journal = "Radiology",
keywords = "Adult,Amlodipine,Amlodipine: therapeutic use,Analysis of Variance,Angiotensin-Converting Enzyme Inhibitors,Angiotensin-Converting Enzyme Inhibitors: therapeu,Blood Flow Velocity,Blood Flow Velocity: drug effects,Calcium Channel Blockers,Calcium Channel Blockers: therapeutic use,Carotid Artery, Common,Cross-Over Studies,Double-Blind Method,Female,Hemodynamics,Hemodynamics: drug effects,Humans,Hypertension,Hypertension: drug therapy,Lisinopril,Lisinopril: therapeutic use,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Placebos,Rheology,Rheology: methods,Statistics, Nonparametric",
month = "dec",
number = 3,
pages = "662--9",
pmid = 20935080,
title = "{Carotid artery hemodynamics: observing patient-specific changes with amlodipine and lisinopril by using MR imaging computation fluid dynamics.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20935080",
volume = 257,
year = 2010
}
Albert Teis, Mary N Sheppard and Francisco Alpendurada.
Subaortic membrane: correlation of imaging with pathology..
European heart journal 31(22):2822, November 2010.
URL, DOI BibTeX
@article{Teis2010,
author = "Teis, Albert and Sheppard, Mary N and Alpendurada, Francisco",
doi = "10.1093/eurheartj/ehq266",
issn = "1522-9645",
journal = "European heart journal",
keywords = "Adult,Discrete Subaortic Stenosis,Discrete Subaortic Stenosis: diagnosis,Discrete Subaortic Stenosis: etiology,Dyspnea,Dyspnea: etiology,Echocardiography, Transesophageal,Fatigue,Fatigue: etiology,Female,Humans,Magnetic Resonance Angiography",
month = "nov",
number = 22,
pages = 2822,
pmid = 20693170,
title = "{Subaortic membrane: correlation of imaging with pathology.}",
url = "http://eurheartj.oxfordjournals.org/content/early/2010/08/05/eurheartj.ehq266.full",
volume = 31,
year = 2010
}
Paul Kirk, Gillian C Smith, Michael Roughton, T He and Dudley J Pennell.
Myocardial T2* is not affected by ageing, myocardial fibrosis, or impaired left ventricular function..
Journal of magnetic resonance imaging : JMRI 32(5):1095–8, November 2010.
URL, DOI BibTeX
@article{Kirk2010a,
abstract = "To evaluate the influence of alterations in myocardial structure and function from increasing age, myocardial fibrosis, or impaired left ventricular function on myocardial T2*.",
author = "Kirk, Paul and Smith, Gillian C and Roughton, Michael and He, T and Pennell, Dudley J",
doi = "10.1002/jmri.22348",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Aged,Aging,Aging: pathology,Female,Fibrosis,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Myocardial Infarction,Myocardial Infarction: complications,Myocardial Infarction: pathology,Myocardium,Myocardium: pathology,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: complications,Ventricular Dysfunction, Left: pathology,Young Adult",
month = "nov",
number = 5,
pages = "1095--8",
pmid = 21031513,
title = "{Myocardial T2* is not affected by ageing, myocardial fibrosis, or impaired left ventricular function.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/21031513",
volume = 32,
year = 2010
}
Francisco Alpendurada, Joyce Wong, Anatoli Kiotsekoglou, Winston Banya, Anne Child, Sanjay K Prasad, Dudley J Pennell and Raad H Mohiaddin.
Evidence for Marfan cardiomyopathy..
European journal of heart failure 12(10):1085–91, October 2010.
URL, DOI BibTeX
@article{Alpendurada2010,
abstract = "Marfan syndrome (MFS) is an inherited connective tissue disease which frequently involves the cardiovascular system. The heart can be affected since valvular regurgitation is a common complication. However, there is still debate whether a primary cardiomyopathy exists. Our aim was to evaluate the existence of a Marfan-related cardiomyopathy using cardiovascular magnetic resonance.",
author = "Alpendurada, Francisco and Wong, Joyce and Kiotsekoglou, Anatoli and Banya, Winston and Child, Anne and Prasad, Sanjay K and Pennell, Dudley J and Mohiaddin, Raad H",
doi = "10.1093/eurjhf/hfq127",
issn = "1879-0844",
journal = "European journal of heart failure",
keywords = "Adolescent,Adult,Aged,Aorta,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathies: pathology,Female,Heart Valve Diseases,Heart Valve Diseases: diagnosis,Heart Valve Diseases: pathology,Heart Ventricles,Heart Ventricles: pathology,Humans,Magnetic Resonance Imaging, Cine,Male,Marfan Syndrome,Marfan Syndrome: complications,Marfan Syndrome: diagnosis,Marfan Syndrome: pathology,Middle Aged,Prognosis,Retrospective Studies,Statistics as Topic,Stroke Volume,Ventricular Function, Left,Young Adult",
month = "oct",
number = 10,
pages = "1085--91",
pmid = 20861133,
title = "{Evidence for Marfan cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20861133",
volume = 12,
year = 2010
}
P Jhooti, J Keegan and D N Firmin.
A fully automatic and highly efficient navigator gating technique for high-resolution free-breathing acquisitions: Continuously adaptive windowing strategy..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 64(4):1015–26, October 2010.
URL, DOI BibTeX
@article{Jhooti2010,
abstract = "A fully automatic and highly efficient free-breathing navigator gated technique, continuously adaptive windowing strategy (CLAWS), is presented. Using a novel and dynamic acquisition strategy that ensures all potential navigator acceptance windows are possible, CLAWS acquires an image with the highest possible efficiency regardless of variations in the respiratory pattern. Unnecessary prolongation of scan durations due to respiratory drift or navigator acceptance window adjustments are avoided. As CLAWS requires no setting of the acceptance window, nor monitoring of the navigator traces during the scan, operator dependence is minimized and ease of use improved. CLAWS was compared against a standard accept/reject algorithm (ARA) and an end-expiratory following ARA (EE-ARA) in 20 healthy subjects and 10 patients (ARA only). The respiratory efficiency was compared against the retrospectively determined best possible respiratory efficiency for each acquisition. On average, the difference between CLAWS scan times and best possible scan times was 0.6{\%} (± 1.3{\%}). For the ARA and EE-ARA techniques, mean differences were 14.4{\%} (± 20.9{\%}) and 32.6 ± 10.9{\%}, respectively. Had the CLAWS algorithm been used with the ARA and EE-ARA traces, mean differences would have been 0.2{\%} (± 1.1{\%}) and 0.5{\%} (± 1.7{\%}), respectively. Image quality was the same for all techniques: respiratory gating, motion artifacts, navigator, and coronary artery imaging.",
author = "Jhooti, P and Keegan, J and Firmin, D N",
doi = "10.1002/mrm.22491",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = "Adolescent,Adult,Aged,Algorithms,Artificial Intelligence,Coronary Vessels,Coronary Vessels: pathology,Female,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Middle Aged,Pattern Recognition, Automated,Pattern Recognition, Automated: methods,Reproducibility of Results,Respiratory Mechanics,Respiratory-Gated Imaging Techniques,Respiratory-Gated Imaging Techniques: methods,Sensitivity and Specificity,Young Adult",
month = "oct",
number = 4,
pages = "1015--26",
pmid = 20593372,
title = "{A fully automatic and highly efficient navigator gating technique for high-resolution free-breathing acquisitions: Continuously adaptive windowing strategy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20593372",
volume = 64,
year = 2010
}
Rory O'Hanlon, Agata Grasso, Michael Roughton, James C Moon, Susan Clark, Ricardo Wage, Jessica Webb, Meghana Kulkarni, Dana Dawson, Leena Sulaibeekh, Badri Chandrasekaran, Chiara Bucciarelli-Ducci, Ferdinando Pasquale, Martin R Cowie, William J McKenna, Mary N Sheppard, Perry M Elliott, Dudley J Pennell and Sanjay K Prasad.
Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy..
Journal of the American College of Cardiology 56(11):867–74, September 2010.
URL, DOI BibTeX
@article{O'Hanlon2010a,
abstract = "We investigated the significance of fibrosis detected by late gadolinium enhancement cardiovascular magnetic resonance for the prediction of major clinical events in hypertrophic cardiomyopathy (HCM).",
author = "O'Hanlon, Rory and Grasso, Agata and Roughton, Michael and Moon, James C and Clark, Susan and Wage, Ricardo and Webb, Jessica and Kulkarni, Meghana and Dawson, Dana and Sulaibeekh, Leena and Chandrasekaran, Badri and Bucciarelli-Ducci, Chiara and Pasquale, Ferdinando and Cowie, Martin R and McKenna, William J and Sheppard, Mary N and Elliott, Perry M and Pennell, Dudley J and Prasad, Sanjay K",
doi = "10.1016/j.jacc.2010.05.010",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Adult,Aged,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: complications,Cardiomyopathy, Hypertrophic: pathology,Death, Sudden,Death, Sudden: etiology,Female,Fibrosis,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: pathology,Prognosis",
month = "sep",
number = 11,
pages = "867--74",
pmid = 20688032,
title = "{Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20688032",
volume = 56,
year = 2010
}
Didier Locca, Chiara Bucciarelli-Ducci, Giuseppe Ferrante, Alessio La Manna, Niall G Keenan, Agata Grasso, Peter Barlis, Francesca Del Furia, Sanjay K Prasad, Juan Carlos Kaski, Dudley J Pennell and Carlo Di Mario.
New universal definition of myocardial infarction applicable after complex percutaneous coronary interventions?.
JACC. Cardiovascular interventions 3(9):950–8, September 2010.
URL, DOI BibTeX
@article{Locca2010,
abstract = "This study aimed to characterize myocardial infarction after percutaneous coronary intervention (PCI) based on cardiac marker elevation as recommended by the new universal definition and on the detection of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR). It is also assessed whether baseline inflammatory biomarkers are higher in patients developing myocardial injury.",
author = "Locca, Didier and Bucciarelli-Ducci, Chiara and Ferrante, Giuseppe and {La Manna}, Alessio and Keenan, Niall G and Grasso, Agata and Barlis, Peter and {Del Furia}, Francesca and Prasad, Sanjay K and Kaski, Juan Carlos and Pennell, Dudley J and {Di Mario}, Carlo",
doi = "10.1016/j.jcin.2010.06.015",
issn = "1876-7605",
journal = "JACC. Cardiovascular interventions",
keywords = "Aged,Angioplasty, Balloon, Coronary,Biological Markers,Biological Markers: blood,C-Reactive Protein,C-Reactive Protein: metabolism,Coronary Angiography,Coronary Angiography: methods,Female,Follow-Up Studies,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Myocardial Infarction,Myocardial Infarction: blood,Myocardial Infarction: diagnosis,Myocardial Infarction: therapy,Neopterin,Neopterin: blood,Prognosis,Prospective Studies,ROC Curve,Treatment Outcome",
month = "sep",
number = 9,
pages = "950--8",
pmid = 20850095,
title = "{New universal definition of myocardial infarction applicable after complex percutaneous coronary interventions?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20850095",
volume = 3,
year = 2010
}
John Pepper, Km John Chan, Jemyrr Gavino, Tal Golesworthy, Raad Mohiaddin and Tom Treasure.
External aortic root support for Marfan syndrome: early clinical results in the first 20 recipients with a bespoke implant..
Journal of the Royal Society of Medicine 103(9):370–5, September 2010.
URL, DOI BibTeX
@article{Pepper2010a,
abstract = "Fatal aortic dissection occurs at young age in Marfan syndrome. Prevention relies on elective replacement of the aortic root. The placement of an external aortic root support, tailored to the anatomy of the individual patient has been proposed as a feasible alternative. DESIGN, SETTING AND MAIN OUTCOME MEASURES: External aortic root support was offered to patients with Marfan syndrome with aortic root diameter of 40-55 mm and without aortic regurgitation. By computer-aided design, a model of the individual patient's aorta was created from cardiac magnetic resonance images and a bespoke external aortic support was manufactured. Comparative measurements were made of the ascending aorta at the level of closure of the aortic valve cusps from magnetic resonance imaging studies taken preoperatively, at first follow-up, and at most recent follow-up. For patients having aortic root surgery at the same institution, in the same time frame as the first 10 patients, clinical data were retrieved on Marfan and other patients having aortic root replacement to serve as a reference data.",
author = "Pepper, John and {John Chan}, Km and Gavino, Jemyrr and Golesworthy, Tal and Mohiaddin, Raad and Treasure, Tom",
doi = "10.1258/jrsm.2010.100070",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pepper et al. - 2010 - External aortic root support for Marfan syndrome early clinical results in the first 20 recipients with a bespoke.pdf:pdf",
issn = "1758-1095",
journal = "Journal of the Royal Society of Medicine",
keywords = "Adolescent,Adult,Aneurysm, Dissecting,Aneurysm, Dissecting: prevention {\&} control,Aorta,Aorta: pathology,Aorta: surgery,Aortic Aneurysm,Aortic Aneurysm: prevention {\&} control,Blood Vessel Prosthesis Implantation,Blood Vessel Prosthesis Implantation: methods,Computer-Aided Design,Female,Humans,Male,Marfan Syndrome,Marfan Syndrome: complications,Marfan Syndrome: pathology,Marfan Syndrome: surgery,Middle Aged,Prospective Studies,Treatment Outcome,Young Adult",
month = "sep",
number = 9,
pages = "370--5",
pmid = 20807993,
title = "{External aortic root support for Marfan syndrome: early clinical results in the first 20 recipients with a bespoke implant.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2930916{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 103,
year = 2010
}
Ryo Torii, Jennifer Keegan, Nigel B Wood, Andrew W Dowsey, Alun D Hughes, Guang-Zhong Yang, David N Firmin, Simon McG A Thom and Yun X Xu.
MR image-based geometric and hemodynamic investigation of the right coronary artery with dynamic vessel motion..
Annals of biomedical engineering 38(8):2606–20, August 2010.
URL, DOI BibTeX
@article{Torii2010,
abstract = "The aim of this study was to develop a fully subject-specific model of the right coronary artery (RCA), including dynamic vessel motion, for computational analysis to assess the effects of cardiac-induced motion on hemodynamics and resulting wall shear stress (WSS). Vascular geometries were acquired in the right coronary artery (RCA) of a healthy volunteer using a navigator-gated interleaved spiral sequence at 14 time points during the cardiac cycle. A high temporal resolution velocity waveform was also acquired in the proximal region. Cardiac-induced dynamic vessel motion was calculated by interpolating the geometries with an active contour model and a computational fluid dynamic (CFD) simulation with fully subject-specific information was carried out using this model. The results showed the expected variation of vessel radius and curvature throughout the cardiac cycle, and also revealed that dynamic motion of the right coronary artery consequent to cardiac motion had significant effects on instantaneous WSS and oscillatory shear index. Subject-specific MRI-based CFD is feasible and, if scan duration could be shortened, this method may have potential as a non-invasive tool to investigate the physiological and pathological role of hemodynamics in human coronary arteries.",
author = "Torii, Ryo and Keegan, Jennifer and Wood, Nigel B and Dowsey, Andrew W and Hughes, Alun D and Yang, Guang-Zhong and Firmin, David N and Thom, Simon A McG and Xu, X Yun",
doi = "10.1007/s10439-010-0008-4",
issn = "1521-6047",
journal = "Annals of biomedical engineering",
keywords = "Adult,Aorta,Aorta: physiology,Blood Vessels,Blood Vessels: physiology,Coronary Vessels,Coronary Vessels: physiology,Heart,Heart: physiology,Hemodynamics,Hemodynamics: physiology,Humans,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Motion,Stress, Mechanical",
month = "aug",
number = 8,
pages = "2606--20",
pmid = 20364324,
title = "{MR image-based geometric and hemodynamic investigation of the right coronary artery with dynamic vessel motion.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20364324",
volume = 38,
year = 2010
}
Paul Kirk, Taigang He, Lisa J Anderson, Michael Roughton, Mark A Tanner, Wynnie W M Lam, Wing Y Au, Winnie C W Chu, Godfrey Chan, Renzo Galanello, Gildo Matta, Mark Fogel, Alan R Cohen, Ru San Tan, Kevin Chen, Ivy Ng, Angie Lai, Suthat Fucharoen, Jiraporn Laothamata, Suporn Chuncharunee, Sutipong Jongjirasiri, David N Firmin, Gillian C Smith and Dudley J Pennell.
International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers..
Journal of magnetic resonance imaging : JMRI 32(2):315–9, August 2010.
URL, DOI BibTeX
@article{Kirk2010,
abstract = "To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.",
author = "Kirk, Paul and He, Taigang and Anderson, Lisa J and Roughton, Michael and Tanner, Mark A and Lam, Wynnie W M and Au, Wing Y and Chu, Winnie C W and Chan, Godfrey and Galanello, Renzo and Matta, Gildo and Fogel, Mark and Cohen, Alan R and Tan, Ru San and Chen, Kevin and Ng, Ivy and Lai, Angie and Fucharoen, Suthat and Laothamata, Jiraporn and Chuncharunee, Suporn and Jongjirasiri, Sutipong and Firmin, David N and Smith, Gillian C and Pennell, Dudley J",
doi = "10.1002/jmri.22245",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Kirk et al. - 2010 - International reproducibility of single breathhold T2 MR for cardiac and liver iron assessment among five thalassem.pdf:pdf",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Female,Humans,Iron,Iron Overload,Iron Overload: pathology,Iron: metabolism,Liver,Liver: pathology,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Myocardium,Myocardium: pathology,Observer Variation,Reference Values,Reproducibility of Results,Thalassemia,Thalassemia: blood",
month = "aug",
number = 2,
pages = "315--9",
pmid = 20677256,
title = "{International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2946327{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 32,
year = 2010
}
Vimal Raj, Sanjiv Joshi, Yuen Chi Ho and Philip J Kilner.
Case report: Completely unroofed coronary sinus with a left superior vena cava draining into the left atrium studied by cardiovascular magnetic resonance..
The Indian journal of radiology & imaging 20(3):215–7, August 2010.
URL, DOI BibTeX
@article{Raj2010a,
abstract = "A persistent left superior vena cava (LSVC) draining through a dilated coronary sinus into the right atrium is a relatively common congenital cardiovascular anomaly. It is readily identified by cardiovascular magnetic resonance (CMR). However, a LSVC draining into the left atrium (LA) and associated with unroofing of the coronary sinus, with resulting interatrial communication, is rare and may have important clinical consequences. As with any large atrial septal defect, it can be associated with a higher than expected incidence of pulmonary arterial hypertension, systemic embolization, and brain abscesses. In this report, we present a case of a completely unroofed coronary sinus with a persistent LSVC draining directly into the LA and illustrate the role of CMR in the diagnosis and evaluation of such anomalies.",
author = "Raj, Vimal and Joshi, Sanjiv and Ho, Yuen Chi and Kilner, Philip J",
doi = "10.4103/0971-3026.69359",
issn = "1998-3808",
journal = "The Indian journal of radiology {\&} imaging",
month = "aug",
number = 3,
pages = "215--7",
pmid = 21042449,
title = "{Case report: Completely unroofed coronary sinus with a left superior vena cava draining into the left atrium studied by cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2963748{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 20,
year = 2010
}
William M Bradlow, Ravi Assomull, Philip J Kilner, Simon J R Gibbs, Mary N Sheppard and Raad H Mohiaddin.
Understanding late gadolinium enhancement in pulmonary hypertension..
Circulation. Cardiovascular imaging 3(4):501–3, July 2010.
URL, DOI BibTeX
@article{Bradlow2010,
author = "Bradlow, William M and Assomull, Ravi and Kilner, Philip J and Gibbs, J Simon R and Sheppard, Mary N and Mohiaddin, Raad H",
doi = "10.1161/CIRCIMAGING.109.919779",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Aged,Cardiac Catheterization,Contrast Media,Contrast Media: diagnostic use,Electrocardiography,Fatal Outcome,Female,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: diagnosis,Hypertension, Pulmonary: pathology,Magnetic Resonance Imaging,Radiography, Thoracic,Tomography, X-Ray Computed",
month = "jul",
number = 4,
pages = "501--3",
pmid = 20647584,
title = "{Understanding late gadolinium enhancement in pulmonary hypertension.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20647584",
volume = 3,
year = 2010
}
C Bucciarelli-Ducci, P E F Daubeney, P J Kilner, A Seale, E Reyes, R Wage and D J Pennell.
Images in cardiovascular medicine: Perfusion cardiovascular magnetic resonance in a child with ischemic heart disease: potential advantages over nuclear medicine..
Circulation 122(3):311–5, July 2010.
URL, DOI BibTeX
@article{Bucciarelli-Ducci2010,
author = "Bucciarelli-Ducci, C and Daubeney, P E F and Kilner, P J and Seale, A and Reyes, E and Wage, R and Pennell, D J",
doi = "10.1161/CIRCULATIONAHA.110.938043",
issn = "1524-4539",
journal = "Circulation",
keywords = "Child,Coronary Angiography,Electrocardiography,Humans,Magnetic Resonance Imaging,Male,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Myocardial Perfusion Imaging,Organophosphorus Compounds,Organophosphorus Compounds: diagnostic use,Organotechnetium Compounds,Organotechnetium Compounds: diagnostic use,Radiopharmaceuticals,Radiopharmaceuticals: diagnostic use,Tomography, Emission-Computed, Single-Photon",
month = "jul",
number = 3,
pages = "311--5",
pmid = 20644027,
title = "{Images in cardiovascular medicine: Perfusion cardiovascular magnetic resonance in a child with ischemic heart disease: potential advantages over nuclear medicine.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20644027",
volume = 122,
year = 2010
}
Vimal Raj, Sanjiv Joshi and Dudley J Pennell.
Images in Cardiovascular Medicine. Cardiac magnetic resonance of acute myocarditis in an human immunodeficiency virus patient presenting with acute chest pain syndrome..
Circulation 121(25):2777–9, June 2010.
URL, DOI BibTeX
@article{Raj2010,
author = "Raj, Vimal and Joshi, Sanjiv and Pennell, Dudley J",
doi = "10.1161/CIRCULATIONAHA.109.888099",
issn = "1524-4539",
journal = "Circulation",
keywords = "Acute Coronary Syndrome,Acute Disease,Adult,Chest Pain,Chest Pain: etiology,Diagnosis, Differential,Female,HIV Infections,HIV Infections: complications,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Myocarditis,Myocarditis: diagnosis,Myocarditis: etiology,Myocarditis: pathology",
month = "jun",
number = 25,
pages = "2777--9",
pmid = 20585023,
title = "{Images in Cardiovascular Medicine. Cardiac magnetic resonance of acute myocarditis in an human immunodeficiency virus patient presenting with acute chest pain syndrome.}",
url = "http://circ.ahajournals.org/content/121/25/2777.full",
volume = 121,
year = 2010
}
Teresa Moroseos, Lee Mitsumori, William S Kerwin, David J Sahn, Willem A Helbing, Philip J Kilner, Alan Shurman, Harold Litt and Florence H Sheehan.
Comparison of Simpson's method and three-dimensional reconstruction for measurement of right ventricular volume in patients with complete or corrected transposition of the great arteries..
The American journal of cardiology 105(11):1603–9, June 2010.
URL, DOI BibTeX
@article{Moroseos2010,
abstract = "The right ventricular (RV) volume is commonly measured from magnetic resonance images using Simpson's method from the stack of short-axis images acquired for analysis of the left ventricle. We compared the RV volume measured using Simpson's method to the RV volume measured using 3-dimensional reconstruction and the piecewise smooth subdivision surface (PSSS) method. We studied 6 normal subjects and 18 patients whose right ventricles carried a systemic pressure load, 1/2 with dexto-transposition of the great arteries repaired with an atrial baffle and 1/2 with levo-transposition of the great arteries. The right ventricle was reconstructed from manually traced borders from the short- and long-axis views using the PSSS method. Simpson's analysis was performed on short-axis views alone. The RV volumes were smaller when analyzed using Simpson's method than using the PSSS method. The underestimation averaged 12 +/- 19 ml (7 +/- 12{\%} of PSSS volume; p {\textless}0.001), without a significant difference between the groups. The ejection fraction was similar using both methods in patients with transposition of the great arteries and was overestimated in normal subjects. Image review revealed that the volume underestimation using Simpson's method was more frequently due to difficulty in interpreting the basal short-axis images than the apical images. In conclusion, to obtain accurate analysis of the short-axis views for RV volume measurement, it would be helpful to incorporate information from additional images, such as the long-axis views, to assist in delineating this chamber's complex anatomy.",
author = "Moroseos, Teresa and Mitsumori, Lee and Kerwin, William S and Sahn, David J and Helbing, Willem A and Kilner, Philip J and Shurman, Alan and Litt, Harold and Sheehan, Florence H",
doi = "10.1016/j.amjcard.2010.01.025",
issn = "1879-1913",
journal = "The American journal of cardiology",
keywords = "Adolescent,Adult,Aged,Algorithms,Child,Female,Heart Function Tests,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Humans,Image Processing, Computer-Assisted,Imaging, Three-Dimensional,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Stroke Volume,Transposition of Great Vessels,Transposition of Great Vessels: diagnosis,Transposition of Great Vessels: surgery,Ventricular Function, Right",
month = "jun",
number = 11,
pages = "1603--9",
pmid = 20494670,
title = "{Comparison of Simpson's method and three-dimensional reconstruction for measurement of right ventricular volume in patients with complete or corrected transposition of the great arteries.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20494670",
volume = 105,
year = 2010
}
Martin R Wilkins, Omar Ali, William Bradlow, John Wharton, Anne Taegtmeyer, Christopher J Rhodes, Hossein A Ghofrani, Luke Howard, Petros Nihoyannopoulos, Raad H Mohiaddin and Simon J R Gibbs.
Simvastatin as a treatment for pulmonary hypertension trial..
American journal of respiratory and critical care medicine 181(10):1106–13, May 2010.
URL, DOI BibTeX
@article{Wilkins2010,
abstract = "In animal models of pulmonary hypertension, simvastatin has been shown to reduce pulmonary artery pressure and induce regression of associated right ventricular (RV) hypertrophy.",
author = "Wilkins, Martin R and Ali, Omar and Bradlow, William and Wharton, John and Taegtmeyer, Anne and Rhodes, Christopher J and Ghofrani, Hossein A and Howard, Luke and Nihoyannopoulos, Petros and Mohiaddin, Raad H and Gibbs, J Simon R",
doi = "10.1164/rccm.200911-1699OC",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Wilkins et al. - 2010 - Simvastatin as a treatment for pulmonary hypertension trial.pdf:pdf",
issn = "1535-4970",
journal = "American journal of respiratory and critical care medicine",
keywords = "Adult,Aged,Antihypertensive Agents,Antihypertensive Agents: therapeutic use,Double-Blind Method,Female,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: blood,Hypertension, Pulmonary: drug therapy,Hypertension, Pulmonary: pathology,Hypertension, Pulmonary: ultrasonography,Hypertrophy, Right Ventricular,Hypertrophy, Right Ventricular: blood,Hypertrophy, Right Ventricular: drug therapy,Hypertrophy, Right Ventricular: pathology,Hypertrophy, Right Ventricular: ultrasonography,Male,Middle Aged,Natriuretic Peptide, Brain,Natriuretic Peptide, Brain: blood,Peptide Fragments,Peptide Fragments: blood,Simvastatin,Simvastatin: therapeutic use,Young Adult",
month = "may",
number = 10,
pages = "1106--13",
pmid = 20460548,
title = "{Simvastatin as a treatment for pulmonary hypertension trial.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20110553",
volume = 181,
year = 2010
}
Niall G Keenan, Mary N Sheppard, Agata Grasso, Cheuk F Chan, Rahul K Mukherjee, Joseph J Boyle, Peter D Gatehouse, David N Firmin and Dudley J Pennell.
Validation of carotid arterial wall volume measurement by cardiovascular magnetic resonance..
Journal of magnetic resonance imaging : JMRI 31(4):935–41, April 2010.
URL, DOI BibTeX
@article{Keenan2010,
abstract = "To validate cardiovascular magnetic resonance (CMR) arterial wall volume measurement using whole arterial specimens ex vivo.",
author = "Keenan, Niall G and Sheppard, Mary N and Grasso, Agata and Chan, Cheuk F and Mukherjee, Rahul K and Boyle, Joseph J and Gatehouse, Peter D and Firmin, David N and Pennell, Dudley J",
doi = "10.1002/jmri.22109",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Aged,Aged, 80 and over,Atherosclerosis,Atherosclerosis: pathology,Cadaver,Cardiovascular Diseases,Cardiovascular Diseases: pathology,Cardiovascular System,Carotid Arteries,Carotid Arteries: pathology,Cerebrovascular Circulation,Female,Humans,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged",
month = "apr",
number = 4,
pages = "935--41",
pmid = 20373439,
title = "{Validation of carotid arterial wall volume measurement by cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20373439",
volume = 31,
year = 2010
}
Philip J Kilner, Tal Geva, Harald Kaemmerer, Pedro T Trindade, Juerg Schwitter and Gary D Webb.
Recommendations for cardiovascular magnetic resonance in adults with congenital heart disease from the respective working groups of the European Society of Cardiology..
European heart journal 31(7):794–805, April 2010.
URL, DOI BibTeX
@article{Kilner2010a,
abstract = "This paper aims to provide information and explanations regarding the clinically relevant options, strengths, and limitations of cardiovascular magnetic resonance (CMR) in relation to adults with congenital heart disease (CHD). Cardiovascular magnetic resonance can provide assessments of anatomical connections, biventricular function, myocardial viability, measurements of flow, angiography, and more, without ionizing radiation. It should be regarded as a necessary facility in a centre specializing in the care of adults with CHD. Also, those using CMR to investigate acquired heart disease should be able to recognize and evaluate previously unsuspected CHD such as septal defects, anomalously connected pulmonary veins, or double-chambered right ventricle. To realize its full potential and to avoid pitfalls, however, CMR of CHD requires training and experience. Appropriate pathophysiological understanding is needed to evaluate cardiovascular function after surgery for tetralogy of Fallot, transposition of the great arteries, and after Fontan operations. For these and other complex CHD, CMR should be undertaken by specialists committed to long-term collaboration with the clinicians and surgeons managing the patients. We provide a table of CMR acquisition protocols in relation to CHD categories as a guide towards appropriate use of this uniquely versatile imaging modality.",
author = "Kilner, Philip J and Geva, Tal and Kaemmerer, Harald and Trindade, Pedro T and Schwitter, Juerg and Webb, Gary D",
doi = "10.1093/eurheartj/ehp586",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Kilner et al. - 2010 - Recommendations for cardiovascular magnetic resonance in adults with congenital heart disease from the respective.pdf:pdf",
issn = "1522-9645",
journal = "European heart journal",
keywords = "Adult,Echocardiography,Heart Defects, Congenital,Heart Defects, Congenital: pathology,Heart Defects, Congenital: surgery,Humans,Magnetic Resonance Angiography,Magnetic Resonance Angiography: contraindications,Magnetic Resonance Angiography: standards,Magnetic Resonance Angiography: utilization,Patient Care Planning,Postoperative Care,Postoperative Care: methods,Professional Practice",
month = "apr",
number = 7,
pages = "794--805",
pmid = 20067914,
title = "{Recommendations for cardiovascular magnetic resonance in adults with congenital heart disease from the respective working groups of the European Society of Cardiology.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2848324{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 31,
year = 2010
}
F M Lodge, S W Dubrey, J Collinson and S K Prasad.
Cardiac amyloidosis: non-invasive diagnosis and current treatment strategies..
British journal of hospital medicine (London, England : 2005) 71(4):230–1, April 2010.
URL BibTeX
@article{Lodge2010,
author = "Lodge, F M and Dubrey, S W and Collinson, J and Prasad, S K",
issn = "1750-8460",
journal = "British journal of hospital medicine (London, England : 2005)",
keywords = "Aged,Amyloidosis,Amyloidosis: diagnosis,Amyloidosis: therapy,Biopsy,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathies: therapy,Echocardiography,Humans,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Myocardium,Myocardium: pathology,Serum Amyloid P-Component,Serum Amyloid P-Component: metabolism",
month = "apr",
number = 4,
pages = "230--1",
pmid = 20393437,
title = "{Cardiac amyloidosis: non-invasive diagnosis and current treatment strategies.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20393437",
volume = 71,
year = 2010
}
Florence H Sheehan, Philip J Kilner, David J Sahn, Wesley G Vick, Karen K Stout, Shuping Ge, Willem A Helbing, Mark Lewin, Alan J Shurman, Emanuela Valsangiacomo Buechel, Harold I Litt and Mary-Pierre Waiss.
Accuracy of knowledge-based reconstruction for measurement of right ventricular volume and function in patients with tetralogy of Fallot..
The American journal of cardiology 105(7):993–9, April 2010.
URL, DOI BibTeX
@article{Sheehan2010,
abstract = "{We tested the accuracy and reproducibility of knowledge-based reconstruction (KBR) for measuring right ventricular (RV) volume and function. KBR enables rapid assessment of the right ventricle from sparse user input by referencing a database. KBR generates a 3-dimensional surface to fit points that the user enters at anatomic landmarks. We measured the RV volume using KBR from magnetic resonance images in 20 patients with repaired tetralogy of Fallot at end-diastole and end-systole. We entered points in the long- and short-axis and/or oblique views. The true volume was computed by manually tracing the RV borders for 3-dimensional reconstruction using the piecewise smooth subdivision surface method. The reference database included 54 patients with tetralogy of Fallot patients. The KBR values agreed closely with the true values for the end-diastolic volume (r = 0.993), end-systolic volume (r = 0.992), and ejection fraction (EF; r = 0.930). KBR slightly overestimated the end-diastolic volume (4 +/- 10 ml",
p = "0.012",
r = "",
author = "Sheehan, Florence H and Kilner, Philip J and Sahn, David J and Vick, G Wesley and Stout, Karen K and Ge, Shuping and Helbing, Willem A and Lewin, Mark and Shurman, Alan J and Buechel, Emanuela Valsangiacomo and Litt, Harold I and Waiss, Mary-Pierre",
doi = "10.1016/j.amjcard.2009.11.032",
issn = "1879-1913",
journal = "The American journal of cardiology",
keywords = "Adolescent,Adult,Diastole,Diastole: physiology,Female,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Humans,Image Processing, Computer-Assisted,Knowledge Bases,Magnetic Resonance Imaging,Male,Middle Aged,Organ Size,Reproducibility of Results,Stroke Volume,Stroke Volume: physiology,Systole,Systole: physiology,Tetralogy of Fallot,Tetralogy of Fallot: diagnosis,Tetralogy of Fallot: pathology,Tetralogy of Fallot: physiopathology",
month = "apr",
number = 7,
pages = "993--9",
pmid = 20346319,
title = "{Accuracy of knowledge-based reconstruction for measurement of right ventricular volume and function in patients with tetralogy of Fallot.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20346319",
volume = 105,
year = 2010
}
John Pepper, Tal Golesworthy, Martin Utley, John Chan, Skandadas Ganeshalingam, Michael Lamperth, Raad Mohiaddin and Tom Treasure.
Manufacturing and placing a bespoke support for the Marfan aortic root: description of the method and technical results and status at one year for the first ten patients..
Interactive cardiovascular and thoracic surgery 10(3):360–5, March 2010.
URL, DOI BibTeX
@article{Pepper2010,
abstract = "Fatal aortic dissection commonly occurs in Marfan syndrome. Prevention currently relies on elective replacement of the aortic root. We are evaluating the placement of a manufactured, bespoke external support derived from a computer aided design in a prospective study. In the first ten patients, measurements were made consistently of the ascending aorta at the level of closure of the aortic valve cusps from magnetic resonance imaging (MRI) studies taken preoperatively and at fixed intervals thereafter. Before and after images were presented for measurement amongst duplicate images of 37 unoperated Marfan patients to permit assessment of intra-observer measurement reproducibility. All images were presented in random sequence to a radiologist unaware of the research question. The largest difference between the preoperative measurement and that made at least one year after surgery was determined. All patients had surgery as planned without complications and were alive at one year. In eight of the ten patients, the largest observed change was a marked reduction in aortic root diameter. The primary objective of this surgery was achieved in each case, reinforcing the ascending aorta whilst leaving the native aortic valve intact and conserving the blood/endothelium interface.",
author = "Pepper, John and Golesworthy, Tal and Utley, Martin and Chan, John and Ganeshalingam, Skandadas and Lamperth, Michael and Mohiaddin, Raad and Treasure, Tom",
doi = "10.1510/icvts.2009.220319",
issn = "1569-9285",
journal = "Interactive cardiovascular and thoracic surgery",
keywords = "Adolescent,Adult,Aortic Aneurysm,Aortic Aneurysm: etiology,Aortic Aneurysm: pathology,Aortic Aneurysm: surgery,Blood Vessel Prosthesis,Blood Vessel Prosthesis Implantation,Blood Vessel Prosthesis Implantation: adverse effe,Blood Vessel Prosthesis Implantation: instrumentat,Computer-Aided Design,Female,Humans,Magnetic Resonance Angiography,Male,Marfan Syndrome,Marfan Syndrome: complications,Marfan Syndrome: pathology,Marfan Syndrome: surgery,Middle Aged,Observer Variation,Predictive Value of Tests,Prospective Studies,Prosthesis Design,Reproducibility of Results,Surgical Mesh,Time Factors,Treatment Outcome,Young Adult",
month = "mar",
number = 3,
pages = "360--5",
pmid = 20007995,
title = "{Manufacturing and placing a bespoke support for the Marfan aortic root: description of the method and technical results and status at one year for the first ten patients.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20007995",
volume = 10,
year = 2010
}
Dudley J Pennell, John B Porter, Maria Domenica Cappellini, Amal El-Beshlawy, Lee Lee Chan, Yesim Aydinok, Mohsen Saleh Elalfy, Pranee Sutcharitchan, Chi-Kong Li, Hishamshah Ibrahim, Vip Viprakasit, Antonis Kattamis, Gillian Smith, Dany Habr, Gabor Domokos, Bernard Roubert and Ali Taher.
Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia..
Blood 115(12):2364–71, March 2010.
URL, DOI BibTeX
@article{Pennell2010,
abstract = "Cardiac iron overload causes most deaths in beta-thalassemia major. The efficacy of deferasirox in reducing or preventing cardiac iron overload was assessed in 192 patients with beta-thalassemia in a 1-year prospective, multicenter study. The cardiac iron reduction arm (n = 114) included patients with magnetic resonance myocardial T2* from 5 to 20 ms (indicating cardiac siderosis), left ventricular ejection fraction (LVEF) of 56{\%} or more, serum ferritin more than 2500 ng/mL, liver iron concentration more than 10 mg Fe/g dry weight, and more than 50 transfused blood units. The prevention arm (n = 78) included otherwise eligible patients whose myocardial T2* was 20 ms or more. The primary end point was the change in myocardial T2* at 1 year. In the cardiac iron reduction arm, the mean deferasirox dose was 32.6 mg/kg per day. Myocardial T2* (geometric mean +/- coefficient of variation) improved from a baseline of 11.2 ms (+/- 40.5{\%}) to 12.9 ms (+/- 49.5{\%}) (+16{\%}; P {\textless} .001). LVEF (mean +/- SD) was unchanged: 67.4 (+/- 5.7{\%}) to 67.0 (+/- 6.0{\%}) (-0.3{\%}; P = .53). In the prevention arm, baseline myocardial T2* was unchanged from baseline of 32.0 ms (+/- 25.6{\%}) to 32.5 ms (+/- 25.1{\%}) (+2{\%}; P = .57) and LVEF increased from baseline 67.7 (+/- 4.7{\%}) to 69.6 (+/- 4.5{\%}) (+1.8{\%}; P {\textless} .001). This prospective study shows that deferasirox is effective in removing and preventing myocardial iron accumulation. This study is registered at http://clinicaltrials.gov as NCT00171821.",
author = "Pennell, Dudley J and Porter, John B and Cappellini, Maria Domenica and El-Beshlawy, Amal and Chan, Lee Lee and Aydinok, Yesim and Elalfy, Mohsen Saleh and Sutcharitchan, Pranee and Li, Chi-Kong and Ibrahim, Hishamshah and Viprakasit, Vip and Kattamis, Antonis and Smith, Gillian and Habr, Dany and Domokos, Gabor and Roubert, Bernard and Taher, Ali",
doi = "10.1182/blood-2009-04-217455",
issn = "1528-0020",
journal = "Blood",
keywords = "Adolescent,Adult,Benzoates,Benzoates: administration {\&} dosage,Benzoates: adverse effects,Child,Dose-Response Relationship, Drug,Female,Ferritins,Ferritins: blood,Heart Failure,Heart Failure: drug therapy,Heart Failure: etiology,Heart Failure: prevention {\&} control,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: administration {\&} dosage,Iron Chelating Agents: adverse effects,Iron Overload,Iron Overload: drug therapy,Iron Overload: etiology,Iron Overload: prevention {\&} control,Iron: metabolism,Male,Myocardium,Myocardium: metabolism,Prospective Studies,Triazoles,Triazoles: administration {\&} dosage,Triazoles: adverse effects,Young Adult,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: drug therapy",
month = "mar",
number = 12,
pages = "2364--71",
pmid = 19996412,
title = "{Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19996412",
volume = 115,
year = 2010
}
A E Grasso and D J Pennell.
Myocardial infarction related to aberrant left circumflex artery..
International journal of cardiology 138(3):e51–2, February 2010.
URL, DOI BibTeX
@article{Grasso2010,
abstract = "We present a case of lateral wall infarction in the territory of an anomalous circumflex artery without significant stenosis. The unusual location of the infarction suggests a causal relation with the anomalous artery through minor plaque rupture, which may have resulted from mechanical stress.",
author = "Grasso, A E and Pennell, D J",
doi = "10.1016/j.ijcard.2008.06.067",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Coronary Angiography,Coronary Artery Disease,Coronary Artery Disease: complications,Coronary Artery Disease: radiography,Coronary Artery Disease: ultrasonography,Coronary Vessel Anomalies,Coronary Vessel Anomalies: complications,Coronary Vessel Anomalies: radiography,Coronary Vessel Anomalies: ultrasonography,Echocardiography,Female,Humans,Middle Aged,Myocardial Infarction,Myocardial Infarction: etiology,Myocardial Infarction: radiography,Myocardial Infarction: ultrasonography",
month = "feb",
number = 3,
pages = "e51--2",
pmid = 18715657,
title = "{Myocardial infarction related to aberrant left circumflex artery.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18715657",
volume = 138,
year = 2010
}
Philip J Kilner.
Letter to the editor: "Postulated functional advantages of a looped as opposed to a linearly arranged heart"..
American journal of physiology. Heart and circulatory physiology 298(2):H726; author reply H727, February 2010.
URL, DOI BibTeX
@article{Kilner2010,
author = "Kilner, Philip J",
doi = "10.1152/ajpheart.00842.2009",
issn = "1522-1539",
journal = "American journal of physiology. Heart and circulatory physiology",
keywords = "Coronary Vessels,Coronary Vessels: physiology,Finite Element Analysis,Heart,Heart Rate,Heart Rate: physiology,Heart: anatomy {\&} histology,Heart: physiology,Hemodynamics,Hemodynamics: physiology,Humans,Myocardial Contraction,Myocardial Contraction: physiology,Regional Blood Flow,Regional Blood Flow: physiology",
month = "feb",
number = 2,
pages = "H726; author reply H727",
pmid = 20090009,
title = {{Letter to the editor: "Postulated functional advantages of a looped as opposed to a linearly arranged heart".}},
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2822588{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 298,
year = 2010
}
Ronak Rajani, Sanjay Prasad, Sean O'Nunain, Manav Sohal and Azad Ghuran.
Heart block: a primary manifestation of sarcoidosis..
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 12(2):284–8, February 2010.
URL, DOI BibTeX
@article{Rajani2010,
abstract = "We present the case of a 55-year-old male who presented with symptoms of dyspnoea and pre-syncope. A 12 lead electrocardiogram demonstrated extensive conduction abnormalities with 2:1 heart block, right bundle branch block and a small Q wave in lead V(1.) This indicated significant myocardial and septal involvement. Echocardiography confirmed the presence of right ventricular infiltration and dysfunction whilst cardiac magnetic resonance showed the infiltration to be nodular in nature. Although a diagnosis of cardiac sarcoidosis and lymphoma were initially considered, sarcoidosis was eventually confirmed following a cervical lymph node biopsy. This case firstly demonstrates the usefulness of the 12-lead electrocardiogram in determining the likely anatomical locality of significant bradyarrhythmias. Secondly it highlights the difficulties in diagnosing cardiac sarcoidosis when cardiac dysfunction is the sole manifestation of the disease.",
author = "Rajani, Ronak and Prasad, Sanjay and O'Nunain, Sean and Sohal, Manav and Ghuran, Azad",
doi = "10.1093/europace/eup381",
issn = "1532-2092",
journal = "Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology",
keywords = "Biopsy,Bundle-Branch Block,Bundle-Branch Block: etiology,Bundle-Branch Block: physiopathology,Cardiomyopathies,Cardiomyopathies: complications,Cardiomyopathies: diagnosis,Cardiomyopathies: pathology,Electrocardiography,Heart Block,Heart Block: etiology,Heart Block: physiopathology,Humans,Lymph Nodes,Lymph Nodes: pathology,Male,Middle Aged,Sarcoidosis,Sarcoidosis: complications,Sarcoidosis: diagnosis,Sarcoidosis: pathology",
month = "feb",
number = 2,
pages = "284--8",
pmid = 19946110,
title = "{Heart block: a primary manifestation of sarcoidosis.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19946110",
volume = 12,
year = 2010
}
Daniel G H Devos and Philip J Kilner.
Calculations of cardiovascular shunts and regurgitation using magnetic resonance ventricular volume and aortic and pulmonary flow measurements..
European radiology 20(2):410–21, February 2010.
URL, DOI BibTeX
@article{Devos2010,
abstract = "BACKGROUND: Cardiovascular magnetic resonance measurements of the volumes of the right and left ventricle and of the flows in the ascending aorta and main pulmonary artery contribute to the assessment of patients with valvular regurgitation or intracardiac or extracardiac shunts. Ventricular volumes are measured by planimetry and summation of end-diastolic and end-systolic areas measured in a stack of ventricular short-axis cines. The volumes of blood flowing through planes transecting the great arteries are measured using phase contrast velocity mapping. The two approaches are essentially different and can be used either for mutual validation, or separately or in combination to quantify regurgitation and/or shunting. In the presence of shunts, the relations between the stroke volumes and arterial flows of each side of the heart vary depending on the level of shunting (for example, atrial, ventricular or ductal). CONCLUSION: This article aims to explain and illustrate the technical and theoretical basis for calculations using volumetric and flow measurements, providing formulae and diagrams to facilitate the interpretation of results.",
author = "Devos, Daniel G H and Kilner, Philip J",
doi = "10.1007/s00330-009-1568-2",
issn = "1432-1084",
journal = "European radiology",
keywords = "Arteriovenous Fistula,Arteriovenous Fistula: diagnosis,Computer Simulation,Humans,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Mitral Valve Insufficiency,Mitral Valve Insufficiency: complications,Mitral Valve Insufficiency: diagnosis,Models, Cardiovascular,Pulmonary Circulation,Stroke Volume,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: diagnosis",
month = "feb",
number = 2,
pages = "410--21",
pmid = 19727751,
title = "{Calculations of cardiovascular shunts and regurgitation using magnetic resonance ventricular volume and aortic and pulmonary flow measurements.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19727751",
volume = 20,
year = 2010
}
Bengt Johansson, Sonya V Babu-Narayan, Philip J Kilner, Timothy M Cannell and Raad H Mohiaddin.
3-dimensional time-resolved contrast-enhanced magnetic resonance angiography for evaluation late after the mustard operation for transposition..
Cardiology in the young 20(1):1–7, February 2010.
URL, DOI BibTeX
@article{Johansson2010,
abstract = "Cardiovascular magnetic resonance assessment of adults late after an atrial redirection operation for transposition is demanding and time consuming. We hypothesised that the relatively fast and standardised 3-dimensional time-resolved contrast-enhanced magnetic resonance angiography, or dynamic angiography, would be valuable in the periodic follow-up of these patients.",
author = "Johansson, Bengt and Babu-Narayan, Sonya V and Kilner, Philip J and Cannell, Timothy M and Mohiaddin, Raad H",
doi = "10.1017/S1047951109990692",
issn = "1467-1107",
journal = "Cardiology in the young",
keywords = "Adolescent,Adult,Cardiac Surgical Procedures,Cardiac Surgical Procedures: adverse effects,Cardiac Surgical Procedures: methods,Cohort Studies,Constriction, Pathologic,Constriction, Pathologic: diagnosis,Contrast Media,Contrast Media: diagnostic use,Female,Follow-Up Studies,Humans,Image Enhancement,Image Enhancement: methods,Imaging, Three-Dimensional,Imaging, Three-Dimensional: methods,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Postoperative Complications,Postoperative Complications: diagnosis,Predictive Value of Tests,Pulmonary Veins,Sensitivity and Specificity,Transposition of Great Vessels,Transposition of Great Vessels: diagnosis,Transposition of Great Vessels: surgery,Vena Cava, Superior,Venous Thrombosis,Venous Thrombosis: diagnosis,Venous Thrombosis: etiology,Young Adult",
language = "English",
month = "feb",
number = 1,
pages = "1--7",
pmid = 19930771,
publisher = "Cambridge University Press",
title = "3-dimensional time-resolved contrast-enhanced magnetic resonance angiography for evaluation late after the mustard operation for transposition.",
url = "http://journals.cambridge.org/abstract{\_}S1047951109990692",
volume = 20,
year = 2010
}
Cheuk F Chan, Niall G Keenan, Sonia Nielles-Vallespin, Peter Gatehouse, Mary N Sheppard, Joseph J Boyle, Dudley J Pennell and David N Firmin.
Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12(1):17, January 2010.
URL, DOI BibTeX
@article{Chan2010,
abstract = "Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability. The aim of this preliminary study was to show the potential of Ultra-short Echo Time (UTE) subtraction MR in detecting calcification.",
author = "Chan, Cheuk F and Keenan, Niall G and Nielles-Vallespin, Sonia and Gatehouse, Peter and Sheppard, Mary N and Boyle, Joseph J and Pennell, Dudley J and Firmin, David N",
doi = "10.1186/1532-429X-12-17",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Chan et al. - 2010 - Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Aged,Aged, 80 and over,Calcinosis,Calcinosis: diagnosis,Calcinosis: radiography,Carotid Artery Diseases,Carotid Artery Diseases: diagnosis,Carotid Artery Diseases: radiography,Carotid Artery, Common,Carotid Artery, Common: pathology,Carotid Artery, Common: radiography,Female,Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Pilot Projects,Predictive Value of Tests,Time Factors,Tomography, X-Ray Computed,Young Adult",
month = "jan",
number = 1,
pages = 17,
pmid = 20346110,
title = "{Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque.}",
url = "http://www.jcmr-online.com/content/12/1/17",
volume = 12,
year = 2010
}
Rory O'Hanlon, Mat Wilson, Riccardo Wage, Gillian Smith, Francisco D Alpendurada, Joyce Wong, Annette Dahl, Dave Oxborough, Richard Godfrey, Sanjay Sharma, Michael Roughton, Keith George, Dudley J Pennell, Greg Whyte and Sanjay K Prasad.
Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12:38, January 2010.
URL, DOI BibTeX
@article{O'Hanlon2010,
abstract = "The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation. Cardiovascular magnetic resonance (CMR) affords us the opportunity to evaluate the presence of myocardial inflammation and focal fibrosis and is the ideal imaging modality to study this hypothesis. We sought to correlate the relationship between acute bouts of ultra endurance exercise leading to cardiac biomarkers elevation and the presence of myocardial inflammation and fibrosis using CMR.",
author = "O'Hanlon, Rory and Wilson, Mat and Wage, Riccardo and Smith, Gillian and Alpendurada, Francisco D and Wong, Joyce and Dahl, Annette and Oxborough, Dave and Godfrey, Richard and Sharma, Sanjay and Roughton, Michael and George, Keith and Pennell, Dudley J and Whyte, Greg and Prasad, Sanjay K",
doi = "10.1186/1532-429X-12-38",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/O'Hanlon et al. - 2010 - Troponin release following endurance exercise is inflammation the cause a cardiovascular magnetic resonance stu.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Biological Markers,Biological Markers: blood,Female,Fibrosis,Fibrosis: blood,Fibrosis: diagnosis,Humans,Inflammation,Inflammation: blood,Inflammation: diagnosis,Magnetic Resonance Imaging,Male,Myocardium,Myocardium: pathology,Physical Endurance,Troponin,Troponin I,Troponin I: blood,Troponin: blood",
month = "jan",
pages = 38,
pmid = 20598139,
title = "{Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2908607{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 12,
year = 2010
}
Dudley J Pennell.
To BOLDly go where positron emission tomography has been before..
Circulation. Cardiovascular imaging 3(1):2–4, January 2010.
URL, DOI BibTeX
@article{Pennell2010a,
author = "Pennell, Dudley J",
doi = "10.1161/CIRCIMAGING.109.932079",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Animals,Coronary Circulation,Coronary Stenosis,Coronary Stenosis: complications,Coronary Stenosis: diagnosis,Coronary Stenosis: metabolism,Coronary Stenosis: physiopathology,Humans,Magnetic Resonance Imaging,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Myocardial Ischemia: etiology,Myocardial Ischemia: metabolism,Myocardial Ischemia: physiopathology,Myocardial Perfusion Imaging,Myocardial Perfusion Imaging: methods,Myocardium,Myocardium: metabolism,Myocardium: pathology,Oxygen,Oxygen Consumption,Oxygen: blood,Positron-Emission Tomography,Predictive Value of Tests,Reproducibility of Results,Severity of Illness Index,Vasodilator Agents,Vasodilator Agents: diagnostic use",
month = "jan",
number = 1,
pages = "2--4",
pmid = 20086223,
title = "{To BOLDly go where positron emission tomography has been before.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20086223",
volume = 3,
year = 2010
}
John-Paul Carpenter, Francisco Alpendurada, Monica Deac, Alicia Maceira, Maciej Garbowski, Paul Kirk, Malcolm J Walker, John B Porter, Farrukh Shah, Winston Banya, Taigang He, Gillian C Smith and Dudley J Pennell.
Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12:24, January 2010.
URL, DOI BibTeX
@article{Carpenter2010,
abstract = "We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload.",
author = "Carpenter, John-Paul and Alpendurada, Francisco and Deac, Monica and Maceira, Alicia and Garbowski, Maciej and Kirk, Paul and Walker, J Malcolm and Porter, John B and Shah, Farrukh and Banya, Winston and He, Taigang and Smith, Gillian C and Pennell, Dudley J",
doi = "10.1186/1532-429X-12-24",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Carpenter et al. - 2010 - Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overloa.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Blood Transfusion,Case-Control Studies,Deferoxamine,Deferoxamine: therapeutic use,Female,Heart Ventricles,Heart Ventricles: pathology,Heart Ventricles: physiopathology,Hemoglobins,Hemoglobins: metabolism,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron: metabolism,Magnetic Resonance Imaging, Cine,Male,Predictive Value of Tests,Reference Values,Retrospective Studies,Stroke Volume,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: diagnosis,Ventricular Dysfunction, Right: etiology,Ventricular Dysfunction, Right: physiopathology,Ventricular Function, Right,Young Adult,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: metabolism,beta-Thalassemia: therapy",
month = "jan",
pages = 24,
pmid = 20416084,
title = "{Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2867986{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 12,
year = 2010
}
D J Pennell, D N Firmin, P J Kilner, W J Manning, R H Mohiaddin, S Neubauer and S K Prasad.
Review of Journal of Cardiovascular Magnetic Resonance 2009..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12:15, January 2010.
URL, DOI BibTeX
@article{Pennell2010b,
abstract = "There were 56 articles published in the Journal of Cardiovascular Magnetic Resonance in 2009. The editors were impressed with the high quality of the submissions, of which our acceptance rate was about 40{\%}. In accordance with open-access publishing, the articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. We have therefore chosen to briefly summarise the papers in this article for quick reference for our readers in broad areas of interest, which we feel will be useful to practitioners of cardiovascular magnetic resonance (CMR). In some cases where it is considered useful, the articles are also put into the wider context with a short narrative and recent CMR references. It has been a privilege to serve as the Editor of the JCMR this past year. I hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR for publication.",
author = "Pennell, D J and Firmin, D N and Kilner, P J and Manning, W J and Mohiaddin, R H and Neubauer, S and Prasad, S K",
doi = "10.1186/1532-429X-12-15",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Pennell et al. - 2010 - Review of Journal of Cardiovascular Magnetic Resonance 2009.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Cardiovascular Diseases: physiopathology,Cardiovascular Diseases: therapy,Humans,Magnetic Resonance Imaging,Periodicals as Topic,Predictive Value of Tests,Prognosis",
month = "jan",
pages = 15,
pmid = 20302618,
title = "{Review of Journal of Cardiovascular Magnetic Resonance 2009.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2847562{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 12,
year = 2010
}
Alicia M Maceira, Juan Cosín-Sales, Michael Roughton, Sanjay K Prasad and Dudley J Pennell.
Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12(1):65, January 2010.
URL, DOI BibTeX
@article{Maceira2010,
abstract = "Left atrial (LA) size is related to cardiovascular morbidity and mortality. Cardiovascular magnetic resonance (CMR) provides high quality images of the left atrium with high temporal resolution steady state free precession (SSFP) cine sequences. We used SSFP cines to define normal ranges for LA volumes and dimensions relative to gender, age and body surface area (BSA), and examine the relative value of 2D atrial imaging techniques in patients.For definition of normal ranges of LA volume we studied 120 healthy subjects after careful exclusion of cardiovascular abnormality (60 men, 60 women; 20 subjects per age decile from 20 to 80 years). Data were generated from 3-dimensional modeling, including tracking of the atrioventricular ring motion and time-volume curves analysis. For definition of the best 2D images-derived predictors of LA enlargement, we studied 120 patients (60 men, 60 women; age range 20 to 80 years) with a clinical indication for CMR.",
author = "Maceira, Alicia M and Cos{\'{i}}n-Sales, Juan and Roughton, Michael and Prasad, Sanjay K and Pennell, Dudley J",
doi = "10.1186/1532-429X-12-65",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Maceira et al. - 2010 - Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Age Factors,Aged,Aged, 80 and over,Analysis of Variance,Atrial Function,Body Surface Area,Female,Heart Atria,Heart Atria: anatomy {\&} histology,Humans,Image Interpretation, Computer-Assisted,Imaging, Three-Dimensional,Linear Models,Logistic Models,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Reference Values,Sex Factors,Young Adult",
month = "jan",
number = 1,
pages = 65,
pmid = 21070636,
title = "{Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance.}",
url = "http://www.jcmr-online.com/content/12/1/65",
volume = 12,
year = 2010
}
William M Bradlow, Marina L Hughes, Niall G Keenan, Chiara Bucciarelli-Ducci, Ravi Assomull, Simon J R Gibbs and Raad H Mohiaddin.
Measuring the heart in pulmonary arterial hypertension (PAH): implications for trial study size..
Journal of magnetic resonance imaging : JMRI 31(1):117–24, January 2010.
URL, DOI BibTeX
@article{Bradlow2010a,
abstract = "To calculate the sample size for a theoretical pulmonary arterial hypertension (PAH) randomized controlled trial (RCT) by using cardiovascular magnetic resonance (CMR) imaging to determine the repeatability of measures between two scans.",
author = "Bradlow, William M and Hughes, Marina L and Keenan, Niall G and Bucciarelli-Ducci, Chiara and Assomull, Ravi and Gibbs, J Simon R and Mohiaddin, Raad H",
doi = "10.1002/jmri.22011",
issn = "1522-2586",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Algorithms,Female,Heart Ventricles,Heart Ventricles: pathology,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: diagnosis,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Information Storage and Retrieval,Information Storage and Retrieval: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Randomized Controlled Trials as Topic,Randomized Controlled Trials as Topic: methods,Reproducibility of Results,Sample Size,Sensitivity and Specificity",
month = "jan",
number = 1,
pages = "117--24",
pmid = 20027579,
title = "{Measuring the heart in pulmonary arterial hypertension (PAH): implications for trial study size.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20027579",
volume = 31,
year = 2010
}
Peter D Gatehouse, Marijn P Rolf, Martin J Graves, Mark Bm Hofman, John Totman, Beat Werner, Rebecca A Quest, Yingmin Liu, Jochen Spiczak, Matthias Dieringer, David N Firmin, Albert Rossum, Massimo Lombardi, Juerg Schwitter, Jeanette Schulz-Menger and Philip J Kilner.
Flow measurement by cardiovascular magnetic resonance: a multi-centre multi-vendor study of background phase offset errors that can compromise the accuracy of derived regurgitant or shunt flow measurements..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12:5, January 2010.
URL, DOI BibTeX
@article{Gatehouse2010,
abstract = "Cardiovascular magnetic resonance (CMR) allows non-invasive phase contrast measurements of flow through planes transecting large vessels. However, some clinically valuable applications are highly sensitive to errors caused by small offsets of measured velocities if these are not adequately corrected, for example by the use of static tissue or static phantom correction of the offset error. We studied the severity of uncorrected velocity offset errors across sites and CMR systems.",
author = "Gatehouse, Peter D and Rolf, Marijn P and Graves, Martin J and Hofman, Mark Bm and Totman, John and Werner, Beat and Quest, Rebecca A and Liu, Yingmin and von Spiczak, Jochen and Dieringer, Matthias and Firmin, David N and van Rossum, Albert and Lombardi, Massimo and Schwitter, Juerg and Schulz-Menger, Jeanette and Kilner, Philip J",
doi = "10.1186/1532-429X-12-5",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Gatehouse et al. - 2010 - Flow measurement by cardiovascular magnetic resonance a multi-centre multi-vendor study of background phase of.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Aorta,Aorta: physiopathology,Artifacts,Blood Flow Velocity,Cardiac Output,Gelatin,Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: instrumentation,Materials Testing,Mitral Valve Insufficiency,Mitral Valve Insufficiency: diagnosis,Mitral Valve Insufficiency: physiopathology,Phantoms, Imaging,Predictive Value of Tests,Pulmonary Artery,Pulmonary Artery: physiopathology,Reproducibility of Results,Respiratory Mechanics",
month = "jan",
pages = 5,
pmid = 20074359,
title = "{Flow measurement by cardiovascular magnetic resonance: a multi-centre multi-vendor study of background phase offset errors that can compromise the accuracy of derived regurgitant or shunt flow measurements.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2818657{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 12,
year = 2010
}
Jack J Mann, John R Payne, Tina Shah, Dudley J Pennell, Steve E Humphries and Hugh E Montgomery.
C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart Study..
Journal of cardiovascular pharmacology 55(1):26–9, January 2010.
URL, DOI BibTeX
@article{Mann2010,
abstract = "Increased levels of C-reactive protein (CRP) are associated with left ventricular (LV) hypertrophy. This association may be causal (either directly or indirectly) or simply a confounder resulting from the recognized relationship between CRP and vascular disease. We attempted to clarify this issue, by assessing the association of a variant of the CRP gene with exercise-induced left ventricular hypertrophy in young healthy males: homozygosity for the T (rather than C) allele of the CRP +1444C{\textgreater}T gene variant is associated with serum CRP levels which are 0.68 mg/L higher than carriers of the C allele.",
author = "Mann, Jack J and Payne, John R and Shah, Tina and Pennell, Dudley J and Humphries, Steve E and Montgomery, Hugh E",
doi = "10.1097/FJC.0b013e3181c37d2d",
issn = "1533-4023",
journal = "Journal of cardiovascular pharmacology",
keywords = "Adolescent,Alleles,C-Reactive Protein,C-Reactive Protein: genetics,Clinical Trials as Topic,Exercise,Genotype,Homozygote,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: etiology,Hypertrophy, Left Ventricular: genetics,Male,Phenotype,Young Adult",
month = "jan",
number = 1,
pages = "26--9",
pmid = 19834334,
title = "{C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart Study.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19834334",
volume = 55,
year = 2010
}
Christopher A Miller, Rory O'Hanlon and Sanjay K Prasad.
Diagnosis of acute myocarditis by cardiovascular magnetic resonance in a patient with chest pain, positive troponin, and normal coronary arteries..
Journal of the American College of Cardiology 55(1):74, December 2009.
URL, DOI BibTeX
@article{Miller2009,
author = "Miller, Christopher A and O'Hanlon, Rory and Prasad, Sanjay K",
doi = "10.1016/j.jacc.2009.03.092",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Chest Pain,Chest Pain: etiology,Coronary Vessels,Coronary Vessels: pathology,Humans,Magnetic Resonance Imaging,Myocarditis,Myocarditis: blood,Myocarditis: complications,Myocarditis: diagnosis,Troponin,Troponin: blood",
month = "dec",
number = 1,
pages = 74,
pmid = 20117367,
title = "{Diagnosis of acute myocarditis by cardiovascular magnetic resonance in a patient with chest pain, positive troponin, and normal coronary arteries.}",
url = "http://dx.doi.org/10.1016/j.jacc.2009.03.092",
volume = 55,
year = 2009
}
Rachael Edwards, Alan Shurman, David J Sahn, Michael Jerosch-Herold, Philip J Kilner and Florence H Sheehan.
Determination of right ventricular end systole by cardiovascular magnetic resonance imaging: a standard method of selection..
The international journal of cardiovascular imaging 25(8):791–6, December 2009.
URL, DOI BibTeX
@article{Edwards2009,
abstract = "For reproducible measurements of right ventricular (RV) volume and function, it may be important to use a consistent method to identify end systole (ES). We determined whether a significant difference exists between RV volumes measured using varying criteria from previous studies to define the timing of ES. In three normal subjects and nine patients with congenital heart disease, we measured RV volume from 3D reconstructions generated from 12 short and long axis magnetic resonance images (MRI). Cine frames analyzed included two frames before and three frames following ES, which we determined as the frame in which chamber area was most frequently minimum. ES coincided with onset of aortic valve closure in ten of 12 subjects; complete closure occurred 1 frame later. The tricuspid valve began to open 1-2 frames after ES, and completely opened 2-4 frames after ES. RV volume was unchanged between ES and the frame following. However, ES volume differed significantly from volume measured 1 or 2 frames before ES and from volume measured 2 or 3 frames following ES, although these volume differences lay within the range of observer variability. The time of minimum RV area in the 4-chamber view agreed closely with that of ES (intraclass correlation coefficient = 0.962). We conclude that minimum RV area in the 4-chamber view is a convenient marker of use for ES, and that aortic valve closure or onset of tricuspid valve opening could also be used, being unlikely to result in clinically significant errors.",
author = "Edwards, Rachael and Shurman, Alan and Sahn, David J and Jerosch-Herold, Michael and Kilner, Philip J and Sheehan, Florence H",
doi = "10.1007/s10554-009-9496-4",
issn = "1875-8312",
journal = "The international journal of cardiovascular imaging",
keywords = "Aortic Valve,Aortic Valve: physiopathology,Female,Heart Defects, Congenital,Heart Defects, Congenital: diagnosis,Heart Defects, Congenital: physiopathology,Humans,Image Interpretation, Computer-Assisted,Imaging, Three-Dimensional,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: standards,Male,Observer Variation,Predictive Value of Tests,Reproducibility of Results,Retrospective Studies,Stroke Volume,Systole,Time Factors,Tricuspid Valve,Tricuspid Valve: physiopathology,Ventricular Function, Right",
month = "dec",
number = 8,
pages = "791--6",
pmid = 19757152,
title = "{Determination of right ventricular end systole by cardiovascular magnetic resonance imaging: a standard method of selection.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19757152",
volume = 25,
year = 2009
}
John-Paul Carpenter and Dudley J Pennell.
Cardiopulmonary exercise testing in thalassemia..
The international journal of cardiovascular imaging 25(8):785–8, December 2009.
URL, DOI BibTeX
@article{Carpenter2009b,
author = "Carpenter, John-Paul and Pennell, Dudley J",
doi = "10.1007/s10554-009-9537-z",
issn = "1875-8312",
journal = "The international journal of cardiovascular imaging",
keywords = "Exercise Test,Exercise Tolerance,Heart Failure,Heart Failure: diagnosis,Heart Failure: metabolism,Heart Failure: pathology,Heart Failure: physiopathology,Humans,Iron,Iron Overload,Iron Overload: diagnosis,Iron Overload: metabolism,Iron Overload: pathology,Iron Overload: physiopathology,Iron: metabolism,Magnetic Resonance Imaging,Myocardium,Myocardium: metabolism,Myocardium: pathology,Predictive Value of Tests,Spirometry,Stroke Volume,Ventricular Function, Left,beta-Thalassemia,beta-Thalassemia: diagnosis,beta-Thalassemia: metabolism,beta-Thalassemia: pathology,beta-Thalassemia: physiopathology",
month = "dec",
number = 8,
pages = "785--8",
pmid = 19937125,
title = "{Cardiopulmonary exercise testing in thalassemia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19937125",
volume = 25,
year = 2009
}
Anatoli Kiotsekoglou, James C Moggridge, Bart H Bijnens, Venediktos Kapetanakis, Francisco Alpendurada, Michael J Mullen, Samir Saha, Dariush K Nassiri, John Camm, George R Sutherland and Anne H Child.
Biventricular and atrial diastolic function assessment using conventional echocardiography and tissue-Doppler imaging in adults with Marfan syndrome..
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 10(8):947–55, December 2009.
URL, DOI BibTeX
@article{Kiotsekoglou2009,
abstract = "Previous studies provided evidence about left ventricular systolic and diastolic dysfunction in adults with Marfan syndrome (MFS). However, in the literature, data on right ventricular and bi-atrial diastolic function are limited. We aimed to investigate whether, in the absence of significant valvular disease, diastolic dysfunction is present not only in both ventricles but also in the atrial cavities.",
author = "Kiotsekoglou, Anatoli and Moggridge, James C and Bijnens, Bart H and Kapetanakis, Venediktos and Alpendurada, Francisco and Mullen, Michael J and Saha, Samir and Nassiri, Dariush K and Camm, John and Sutherland, George R and Child, Anne H",
doi = "10.1093/ejechocard/jep110",
issn = "1532-2114",
journal = "European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology",
keywords = "Adult,Case-Control Studies,Chi-Square Distribution,Diastole,Diastole: physiology,Echocardiography,Echocardiography, Doppler,Echocardiography, Doppler: methods,Echocardiography: methods,Female,Humans,Male,Marfan Syndrome,Marfan Syndrome: physiopathology,Marfan Syndrome: ultrasonography,Microfilament Proteins,Microfilament Proteins: analysis,Regression Analysis,Systole,Systole: physiology,Transforming Growth Factor beta,Transforming Growth Factor beta: analysis,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: physiopathology,Ventricular Dysfunction, Left: ultrasonography,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: physiopathology,Ventricular Dysfunction, Right: ultrasonography",
month = "dec",
number = 8,
pages = "947--55",
pmid = 19793727,
title = "{Biventricular and atrial diastolic function assessment using conventional echocardiography and tissue-Doppler imaging in adults with Marfan syndrome.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19793727",
volume = 10,
year = 2009
}
P Kirk, M Roughton, J B Porter, J M Walker, M A Tanner, J Patel, D Wu, J Taylor, M A Westwood, L J Anderson and D J Pennell.
Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major..
Circulation 120(20):1961–8, November 2009.
URL, DOI BibTeX
@article{Kirk2009,
abstract = "The goal of this study was to determine the predictive value of cardiac T2* magnetic resonance for heart failure and arrhythmia in thalassemia major.",
author = "Kirk, P and Roughton, M and Porter, J B and Walker, J M and Tanner, M A and Patel, J and Wu, D and Taylor, J and Westwood, M A and Anderson, L J and Pennell, D J",
doi = "10.1161/CIRCULATIONAHA.109.874487",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Kirk et al. - 2009 - Cardiac T2 magnetic resonance for prediction of cardiac complications in thalassemia major.pdf:pdf",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adolescent,Adult,Arrhythmias, Cardiac,Arrhythmias, Cardiac: blood,Arrhythmias, Cardiac: epidemiology,Arrhythmias, Cardiac: etiology,Arrhythmias, Cardiac: radiography,Female,Ferritins,Ferritins: blood,Follow-Up Studies,Great Britain,Great Britain: epidemiology,Heart Failure,Heart Failure: blood,Heart Failure: epidemiology,Heart Failure: etiology,Heart Failure: radiography,Hemosiderosis,Hemosiderosis: blood,Hemosiderosis: epidemiology,Hemosiderosis: radiography,Humans,Iron,Iron: metabolism,Liver,Liver: metabolism,Liver: radiography,Magnetic Resonance Imaging,Male,Predictive Value of Tests,Retrospective Studies,Risk Factors,beta-Thalassemia,beta-Thalassemia: blood,beta-Thalassemia: complications,beta-Thalassemia: epidemiology,beta-Thalassemia: radiography",
month = "nov",
number = 20,
pages = "1961--8",
pmid = 19801505,
title = "{Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2784198{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 120,
year = 2009
}
John-Paul Carpenter, Sanjay K Prasad and Dudley J Pennell.
Myocardial fibrosis in thalassaemia: recalling the past or telling the future?.
Heart (British Cardiac Society) 95(20):1646–7, October 2009.
URL, DOI BibTeX
@article{Carpenter2009a,
author = "Carpenter, John-Paul and Prasad, Sanjay K and Pennell, Dudley J",
doi = "10.1136/hrt.2009.166587",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = "Blood Transfusion,Blood Transfusion: adverse effects,Endomyocardial Fibrosis,Endomyocardial Fibrosis: diagnosis,Endomyocardial Fibrosis: etiology,Humans,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: diagnosis,Iron Overload: therapy,Magnetic Resonance Angiography,Thalassemia,Thalassemia: complications",
month = "oct",
number = 20,
pages = "1646--7",
pmid = 19628469,
title = "{Myocardial fibrosis in thalassaemia: recalling the past or telling the future?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19628469",
volume = 95,
year = 2009
}
A E Grasso, Rory O'Hanlon, Didier Locca and D J Pennell.
Images in cardiovascular medicine. Cardiovascular magnetic resonance of thymoma..
Circulation 120(14):1453–5, October 2009.
URL, DOI BibTeX
@article{Grasso2009,
author = "Grasso, A E and O'Hanlon, Rory and Locca, Didier and Pennell, D J",
doi = "10.1161/CIRCULATIONAHA.108.830588",
issn = "1524-4539",
journal = "Circulation",
keywords = "Echocardiography,Electrocardiography,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Neoplasm Staging,Thymoma,Thymoma: pathology,Thymoma: physiopathology,Thymus Neoplasms,Thymus Neoplasms: pathology,Thymus Neoplasms: physiopathology",
month = "oct",
number = 14,
pages = "1453--5",
pmid = 19805662,
title = "{Images in cardiovascular medicine. Cardiovascular magnetic resonance of thymoma.}",
url = "http://circ.ahajournals.org/content/120/14/1453.full",
volume = 120,
year = 2009
}
Ankur Gulati, Cheuk Chan, Achim Viertel, Peter Drivas and Sanjay Prasad.
Quadricuspid aortic valve: the four-leaf clover discovered by cardiac MRI..
The Journal of heart valve disease 18(5):583–4, September 2009.
URL BibTeX
@article{Gulati2009,
author = "Gulati, Ankur and Chan, Cheuk and Viertel, Achim and Drivas, Peter and Prasad, Sanjay",
issn = "0966-8519",
journal = "The Journal of heart valve disease",
keywords = "Aortic Valve,Aortic Valve Insufficiency,Aortic Valve Insufficiency: diagnosis,Aortic Valve Insufficiency: etiology,Aortic Valve Insufficiency: pathology,Aortic Valve: abnormalities,Dyspnea,Dyspnea: etiology,Humans,Magnetic Resonance Imaging,Male,Middle Aged",
month = "sep",
number = 5,
pages = "583--4",
pmid = 20099705,
title = "{Quadricuspid aortic valve: the four-leaf clover discovered by cardiac MRI.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20099705",
volume = 18,
year = 2009
}
Martin S Maron, Iacopo Olivotto, Barry J Maron, Sanjay K Prasad, Franco Cecchi, James E Udelson and Paolo G Camici.
The case for myocardial ischemia in hypertrophic cardiomyopathy..
Journal of the American College of Cardiology 54(9):866–75, August 2009.
URL, DOI BibTeX
@article{Maron2009,
abstract = "Since its original description 50 years ago, myocardial ischemia has been a recognized but underappreciated aspect of the pathophysiology of hypertrophic cardiomyopathy (HCM). Nevertheless, the assessment of myocardial ischemia is still not part of routine clinical diagnostic or management strategies. Morphologic abnormalities of the intramural coronary arterioles represent the primary morphologic substrate for microvascular dysfunction and its functional consequence-that is, blunted myocardial blood flow (MBF) during stress. Recently, a number of studies using contemporary cardiovascular imaging modalities such as positron emission tomography (PET) and cardiovascular magnetic resonance (CMR) have led to an enhanced understanding of the role that myocardial ischemia and its sequelae fibrosis play on clinical outcome. In this regard, studies with PET have shown that HCM patients have impaired MBF after dipyridamole infusion and that this blunted MBF is a powerful independent predictor of cardiovascular mortality and adverse LV remodeling associated with LV systolic dysfunction. Stress CMR with late gadolinium enhancement (LGE) has also shown that MBF is reduced in relation to magnitude of wall thickness and in those LV segments occupied by LGE (i.e., fibrosis). These CMR observations show an association between ischemia, myocardial fibrosis, and LV remodeling, providing support that abnormal MBF caused by microvascular dysfunction is responsible for myocardial ischemia-mediated myocyte death, and ultimately replacement fibrosis. Efforts should now focus on detecting myocardial ischemia before adverse LV remodeling begins, so that interventional treatment strategies can be initiated earlier in the clinical course to mitigate ischemia and beneficially alter the natural history of HCM.",
author = "Maron, Martin S and Olivotto, Iacopo and Maron, Barry J and Prasad, Sanjay K and Cecchi, Franco and Udelson, James E and Camici, Paolo G",
doi = "10.1016/j.jacc.2009.04.072",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Adult,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: complications,Cardiomyopathy, Hypertrophic: pathology,Humans,Male,Myocardial Ischemia,Myocardial Ischemia: etiology,Myocardial Ischemia: pathology",
month = "aug",
number = 9,
pages = "866--75",
pmid = 19695469,
title = "{The case for myocardial ischemia in hypertrophic cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19695469",
volume = 54,
year = 2009
}
Edward D Nicol, Henryk Kafka, James Stirrup, Simon P G Padley, Michael B Rubens, Philip J Kilner and Michael A Gatzoulis.
A single, comprehensive non-invasive cardiovascular assessment in pulmonary arterial hypertension: combined computed tomography pulmonary and coronary angiography..
International journal of cardiology 136(3):278–88, August 2009.
URL, DOI BibTeX
@article{Nicol2009,
abstract = "Comprehensive assessment of pulmonary arterial hypertension (PAH) should identify structural causes and subsequent cardiopulmonary consequences of PAH. This currently requires the use of several imaging modalities. Computed tomography (CT) is routinely used for pulmonary angiography (CTPA). Our aim was to assess whether combined pulmonary and coronary angiography (CTPCA) using ECG-gated, multi-detector CT (MDCT) would allow satisfactory pulmonary angiography, coronary angiography and ventriculography to be combined into a single acquisition using a single imaging modality.",
author = "Nicol, Edward D and Kafka, Henryk and Stirrup, James and Padley, Simon P G and Rubens, Michael B and Kilner, Philip J and Gatzoulis, Michael A",
doi = "10.1016/j.ijcard.2008.05.049",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adult,Coronary Angiography,Coronary Angiography: methods,Coronary Angiography: standards,Coronary Angiography: statistics {\&} numerical data,Electrocardiography,Female,Humans,Hypertension, Pulmonary,Hypertension, Pulmonary: pathology,Hypertension, Pulmonary: radiography,Magnetic Resonance Imaging,Male,Middle Aged,Observer Variation,Prospective Studies,Reproducibility of Results,Stroke Volume,Tomography, X-Ray Computed,Tomography, X-Ray Computed: methods,Tomography, X-Ray Computed: standards,Tomography, X-Ray Computed: statistics {\&} numerical,Ventricular Function, Left,Ventricular Function, Right,Young Adult",
month = "aug",
number = 3,
pages = "278--88",
pmid = 18687494,
title = "{A single, comprehensive non-invasive cardiovascular assessment in pulmonary arterial hypertension: combined computed tomography pulmonary and coronary angiography.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18687494",
volume = 136,
year = 2009
}
Niall G Keenan, Didier Locca, Anitha Varghese, Michael Roughton, Peter D Gatehouse, James Hooper, David N Firmin and Dudley J Pennell.
Magnetic resonance of carotid artery ageing in healthy subjects..
Atherosclerosis 205(1):168–73, July 2009.
URL, DOI BibTeX
@article{Keenan2009,
abstract = "To assess how the arterial wall of the carotid artery changes with age in normal subjects by cardiovascular magnetic resonance (CMR).",
author = "Keenan, Niall G and Locca, Didier and Varghese, Anitha and Roughton, Michael and Gatehouse, Peter D and Hooper, James and Firmin, David N and Pennell, Dudley J",
doi = "10.1016/j.atherosclerosis.2008.11.018",
issn = "1879-1484",
journal = "Atherosclerosis",
keywords = "Adult,Age Factors,Aged,Atherosclerosis,Atherosclerosis: diagnosis,Atherosclerosis: therapy,Carotid Arteries,Carotid Arteries: pathology,Carotid Arteries: radiography,Female,Humans,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Imaging, Three-Dimensional,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Middle Aged,Risk Factors,Sex Factors,Software",
month = "jul",
number = 1,
pages = "168--73",
pmid = 19159883,
title = "{Magnetic resonance of carotid artery ageing in healthy subjects.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19159883",
volume = 205,
year = 2009
}
Monica O Deac, Mary N Sheppard, Neil Moat, Stephen J Burke, Tim Christmas and Raad H Mohiaddin.
Images in cardiovascular medicine. From uterus to pulmonary embolus: an uncommon association..
Circulation 120(3):e16–9, July 2009.
URL, DOI BibTeX
@article{Deac2009,
author = "Deac, Monica O and Sheppard, Mary N and Moat, Neil and Burke, Stephen J and Christmas, Tim and Mohiaddin, Raad H",
doi = "10.1161/CIRCULATIONAHA.108.826107",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adult,Diagnostic Imaging,Diagnostic Imaging: methods,Female,Humans,Leiomyomatosis,Leiomyomatosis: complications,Leiomyomatosis: diagnosis,Leiomyomatosis: surgery,Magnetic Resonance Angiography,Pulmonary Embolism,Pulmonary Embolism: diagnosis,Pulmonary Embolism: etiology,Pulmonary Embolism: surgery,Uterus,Uterus: pathology,Uterus: surgery,Vascular Neoplasms,Vascular Neoplasms: complications,Vascular Neoplasms: diagnosis,Vascular Neoplasms: surgery",
month = "jul",
number = 3,
pages = "e16--9",
pmid = 19620520,
title = "{Images in cardiovascular medicine. From uterus to pulmonary embolus: an uncommon association.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19620520",
volume = 120,
year = 2009
}
Constantinos H Davos, Antonia C Moutafi, Anastasia Alexandridi, Evdokia Petropoulou, Emily Varela, Aikaterini C Chamakou, Darrel P Francis, Philippe J Kilner, Massimo F Piepoli and Michael A Gatzoulis.
Heart rate turbulence in adults with repaired tetralogy of Fallot..
International journal of cardiology 135(3):308–14, July 2009.
URL, DOI BibTeX
@article{Davos2009,
abstract = "Tetralogy of Fallot (ToF) patients face an increased risk of sudden cardiac death late after repair. Heart rate turbulence (HRT) indices are well-known predictors of sudden cardiac death. We aimed to estimate whether HRT is impaired in repaired ToF patients compared to healthy controls and relate those HRT parameters to already recognized prognostic markers.",
author = "Davos, Constantinos H and Moutafi, Antonia C and Alexandridi, Anastasia and Petropoulou, Evdokia and Varela, Emily and Chamakou, Aikaterini C and Francis, Darrel P and Kilner, Philippe J and Piepoli, Massimo F and Gatzoulis, Michael A",
doi = "10.1016/j.ijcard.2008.03.096",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adolescent,Adult,Age Factors,Aged,Female,Heart Rate,Heart Rate: physiology,Humans,Male,Middle Aged,Predictive Value of Tests,Tetralogy of Fallot,Tetralogy of Fallot: mortality,Tetralogy of Fallot: physiopathology,Tetralogy of Fallot: surgery,Young Adult",
month = "jul",
number = 3,
pages = "308--14",
pmid = 18603320,
title = "{Heart rate turbulence in adults with repaired tetralogy of Fallot.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18603320",
volume = 135,
year = 2009
}
Rory O'Hanlon and Dudley J Pennell.
Cardiovascular magnetic resonance in the evaluation of hypertrophic and infiltrative cardiomyopathies..
Heart failure clinics 5(3):369–87, vi, July 2009.
URL, DOI BibTeX
@article{O'Hanlon2009,
abstract = "There is often considerable phenotypic overlap in hypertrophic and infiltrative cardiomyopathies. This overlap creates difficulties, when using routine imaging modalities, in arriving at a conclusive diagnosis. Cardiovascular magnetic resonance (CMR) can make diagnosis easier and more certain. Used with gadolinium contrast agent for tissue characterization, CMR offers a superior field of view and temporal resolution, enabling clinicians to make more confident assessments of etiology. CMR may also be a useful modality for stratifying risk and monitoring treatment responses over time in patients with hypertrophic or infiltrative cardiomyopathies. This article highlights the role of CMR in the assessment and, if relevant, the risk stratification of hypertrophic and infiltrative cardiomyopathies.",
author = "O'Hanlon, Rory and Pennell, Dudley J",
doi = "10.1016/j.hfc.2009.02.003",
issn = "1551-7136",
journal = "Heart failure clinics",
keywords = "Amyloidosis,Amyloidosis: complications,Amyloidosis: diagnosis,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathies: etiology,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Chagas Cardiomyopathy,Chagas Cardiomyopathy: diagnosis,Churg-Strauss Syndrome,Churg-Strauss Syndrome: complications,Churg-Strauss Syndrome: diagnosis,Diagnosis, Differential,Endomyocardial Fibrosis,Endomyocardial Fibrosis: complications,Endomyocardial Fibrosis: diagnosis,Eosinophilia,Eosinophilia: complications,Eosinophilia: diagnosis,Fabry Disease,Fabry Disease: complications,Fabry Disease: diagnosis,Glycogen Storage Disease,Glycogen Storage Disease: complications,Glycogen Storage Disease: diagnosis,Humans,Iron Overload,Iron Overload: complications,Iron Overload: diagnosis,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Risk Assessment,Risk Assessment: methods,Sarcoidosis,Sarcoidosis: complications,Sarcoidosis: diagnosis",
month = "jul",
number = 3,
pages = "369--87, vi",
pmid = 19564014,
title = "{Cardiovascular magnetic resonance in the evaluation of hypertrophic and infiltrative cardiomyopathies.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19564014",
volume = 5,
year = 2009
}
Didier Locca, Marina Hughes and Raad Mohiaddin.
Cardiovascular magnetic resonance diagnosis of a previously unreported association: cor triatriatum with right partial anomalous pulmonary venous return to the azygos vein..
International journal of cardiology 135(3):e80–2, July 2009.
URL, DOI BibTeX
@article{Locca2009,
abstract = "We present images from a cardiovascular magnetic resonance (CMR) study that enabled the rapid, non-invasive, complete diagnosis of a previously unreported congenital anomaly. Cor triatriatum of the left atrium thought to be an anomaly of the embryonic pulmonary venous connection to the left atrium. In association with this, many types of partially anomalous pulmonary venous connection are described, but we know of no previous description of pulmonary venous egress occurring on the right side, via the azygos vein.",
author = "Locca, Didier and Hughes, Marina and Mohiaddin, Raad",
doi = "10.1016/j.ijcard.2008.04.041",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adult,Azygos Vein,Azygos Vein: abnormalities,Azygos Vein: pathology,Cor Triatriatum,Cor Triatriatum: diagnosis,Cor Triatriatum: pathology,Cor Triatriatum: therapy,Female,Heart Atria,Heart Atria: abnormalities,Heart Atria: pathology,Humans,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Pulmonary Veins,Pulmonary Veins: abnormalities,Pulmonary Veins: pathology",
month = "jul",
number = 3,
pages = "e80--2",
pmid = 18639943,
title = "{Cardiovascular magnetic resonance diagnosis of a previously unreported association: cor triatriatum with right partial anomalous pulmonary venous return to the azygos vein.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18639943",
volume = 135,
year = 2009
}
Tom Treasure, Steve Gallivan, Tal Golesworthy, Warren Thornton, Michael Lamperth, Raad Mohiaddin, John Pepper and Robert H Anderson.
Unknown unknowns: the aorta through the looking glass..
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 35(6):925–6, June 2009.
URL, DOI BibTeX
@article{Treasure2009,
author = "Treasure, Tom and Gallivan, Steve and Golesworthy, Tal and Thornton, Warren and Lamperth, Michael and Mohiaddin, Raad and Pepper, John and Anderson, Robert H",
doi = "10.1016/j.ejcts.2009.02.032",
issn = "1873-734X",
journal = "European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery",
keywords = "Aorta,Aorta: pathology,Aorta: surgery,Computer-Aided Design,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Marfan Syndrome,Marfan Syndrome: surgery,Models, Cardiovascular,Prostheses and Implants,Prosthesis Design,Prosthesis Design: methods",
month = "jun",
number = 6,
pages = "925--6",
pmid = 19346134,
title = "{Unknown unknowns: the aorta through the looking glass.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19346134",
volume = 35,
year = 2009
}
Suzi Su-Hsin Chen and Shri Kumar Prasad.
Traumatic pseudoaneurysm of superficial temporal artery: a case report..
Journal of clinical ultrasound : JCU 37(5):312–4, June 2009.
URL, DOI BibTeX
@article{Chen2009,
abstract = "We report a case of a 36-year-old male who presented with a pulsatile mass at the left temporal region after a head injury. Duplex sonographic examination confirmed the diagnosis of traumatic pseudoaneurysm of the superficial temporal artery. Imaging showed the pseudoaneurysm was partially thrombosed.",
author = "Chen, Suzi Su-Hsin and Prasad, Shri Kumar",
doi = "10.1002/jcu.20558",
issn = "1097-0096",
journal = "Journal of clinical ultrasound : JCU",
keywords = "Adult,Aneurysm, False,Aneurysm, False: etiology,Aneurysm, False: ultrasonography,Head Injuries, Closed,Head Injuries, Closed: complications,Humans,Male,Temporal Arteries,Temporal Arteries: injuries,Temporal Arteries: ultrasonography,Ultrasonography, Doppler",
month = "jun",
number = 5,
pages = "312--4",
pmid = 19253353,
title = "{Traumatic pseudoaneurysm of superficial temporal artery: a case report.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19253353",
volume = 37,
year = 2009
}
Philip J Kilner, Rossella Balossino, Gabriele Dubini, Sonya V Babu-Narayan, Andrew M Taylor, Giancarlo Pennati and Francesco Migliavacca.
Pulmonary regurgitation: the effects of varying pulmonary artery compliance, and of increased resistance proximal or distal to the compliance..
International journal of cardiology 133(2):157–66, April 2009.
URL, DOI BibTeX
@article{Kilner2009,
abstract = "Pulmonary regurgitation is common after repair of tetralogy of Fallot, predisposing to right ventricular dilatation and potentially fatal arrhythmias. Magnetic resonance studies of such patients led us to hypothesize that the amount of regurgitation, in the absence of an effective valve, depends on pulmonary arterial compliance and on the location of resistance relative to the compliance.",
author = "Kilner, Philip J and Balossino, Rossella and Dubini, Gabriele and Babu-Narayan, Sonya V and Taylor, Andrew M and Pennati, Giancarlo and Migliavacca, Francesco",
doi = "10.1016/j.ijcard.2008.06.078",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Compliance,Compliance: physiology,Humans,Models, Cardiovascular,Pulmonary Artery,Pulmonary Artery: physiology,Pulmonary Valve Insufficiency,Pulmonary Valve Insufficiency: physiopathology,Vascular Resistance,Vascular Resistance: physiology",
month = "apr",
number = 2,
pages = "157--66",
pmid = 18722025,
title = "{Pulmonary regurgitation: the effects of varying pulmonary artery compliance, and of increased resistance proximal or distal to the compliance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18722025",
volume = 133,
year = 2009
}
Matthias G Friedrich, Udo Sechtem, Jeanette Schulz-Menger, Godtfred Holmvang, Pauline Alakija, Leslie T Cooper, James A White, Hassan Abdel-Aty, Matthias Gutberlet, Sanjay Prasad, Anthony Aletras, Jean-Pierre Laissy, Ian Paterson, Neil G Filipchuk, Andreas Kumar, Matthias Pauschinger and Peter Liu.
Cardiovascular magnetic resonance in myocarditis: A JACC White Paper..
Journal of the American College of Cardiology 53(17):1475–87, April 2009.
URL, DOI BibTeX
@article{Friedrich2009,
abstract = {Cardiovascular magnetic resonance (CMR) has become the primary tool for noninvasive assessment of myocardial inflammation in patients with suspected myocarditis. The International Consensus Group on CMR Diagnosis of Myocarditis was founded in 2006 to achieve consensus among CMR experts and develop recommendations on the current state-of-the-art use of CMR for myocarditis. The recommendations include indications for CMR in patients with suspected myocarditis, CMR protocol standards, terminology for reporting CMR findings, and diagnostic CMR criteria for myocarditis (i.e., "Lake Louise Criteria").},
author = "Friedrich, Matthias G and Sechtem, Udo and Schulz-Menger, Jeanette and Holmvang, Godtfred and Alakija, Pauline and Cooper, Leslie T and White, James A and Abdel-Aty, Hassan and Gutberlet, Matthias and Prasad, Sanjay and Aletras, Anthony and Laissy, Jean-Pierre and Paterson, Ian and Filipchuk, Neil G and Kumar, Andreas and Pauschinger, Matthias and Liu, Peter",
doi = "10.1016/j.jacc.2009.02.007",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Friedrich et al. - 2009 - Cardiovascular magnetic resonance in myocarditis A JACC White Paper.pdf:pdf",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Canada,Canada: epidemiology,Consensus,Humans,Inflammation,Inflammation: epidemiology,Inflammation: physiopathology,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Models, Cardiovascular,Myocarditis,Myocarditis: diagnosis,Myocarditis: epidemiology,Myocarditis: etiology,Myocarditis: physiopathology,Myocardium,Myocardium: pathology,Risk Factors,Societies, Medical",
month = "apr",
number = 17,
pages = "1475--87",
pmid = 19389557,
title = "{Cardiovascular magnetic resonance in myocarditis: A JACC White Paper.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2743893{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 53,
year = 2009
}
Taigang He, Gillian C Smith, Peter D Gatehouse, Raad H Mohiaddin, David N Firmin and Dudley J Pennell.
On using T2 to assess extrinsic magnetic field inhomogeneity effects on T2* measurements in myocardial siderosis in thalassemia..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 61(3):501–6, March 2009.
URL, DOI BibTeX
@article{He2009,
abstract = "Magnetic resonance T(2)* has been validated as a noninvasive means of assessing myocardial iron overload. However, the effect on myocardial T(2)* of factors such as shimming, variations in capillary geometry, and susceptibility in relation to the effects of iron has not been fully clarified. Since T(2) is not affected by extrinsic magnetic field inhomogeneity and has different sensitivity to capillary geometry, investigation into the in vivo relationship between myocardial T(2)* and T(2) measurements can shed light on this important issue. This study was performed in 136 thalassemia patients. The myocardial T(2) and T(2)* thresholds for normality created identical no-iron-overload and iron-overloaded patient groups. In the no-iron group, there was no correlation between myocardial T(2) and T(2)*. In the iron-overloaded patients, there was a linear correlation (R(2) = 0.89) between myocardial T(2)* and T(2) measurements, which indicates that the iron deposition is the dominant factor in determining these two relaxation values in this scenario.",
author = "He, Taigang and Smith, Gillian C and Gatehouse, Peter D and Mohiaddin, Raad H and Firmin, David N and Pennell, Dudley J",
doi = "10.1002/mrm.21874",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = "Adult,Algorithms,Anisotropy,Cardiomyopathies,Cardiomyopathies: complications,Cardiomyopathies: diagnosis,Electromagnetic Fields,Female,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Reproducibility of Results,Sensitivity and Specificity,Siderosis,Siderosis: complications,Siderosis: diagnosis,Thalassemia,Thalassemia: complications,Thalassemia: diagnosis",
month = "mar",
number = 3,
pages = "501--6",
pmid = 19097241,
title = "{On using T2 to assess extrinsic magnetic field inhomogeneity effects on T2* measurements in myocardial siderosis in thalassemia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19097241",
volume = 61,
year = 2009
}
Andrew D Scott, Jennifer Keegan and David N Firmin.
Motion in cardiovascular MR imaging..
Radiology 250(2):331–51, February 2009.
URL, DOI BibTeX
@article{Scott2009,
abstract = "Modern rapid magnetic resonance (MR) imaging techniques have led to widespread use of the modality in cardiac imaging. Despite this progress, many MR studies suffer from image degradation due to involuntary motion during the acquisition. This review describes the type and extent of the motion of the heart due to the cardiac and respiratory cycles, which create image artifacts. Methods of eliminating or reducing the problems caused by the cardiac cycle are discussed, including electrocardiogram gating, subject-specific acquisition windows, and section tracking. Similarly, for respiratory motion of the heart, techniques such as breath holding, respiratory gating, section tracking, phase-encoding ordering, subject-specific translational models, and a range of new techniques are considered.",
author = "Scott, Andrew D and Keegan, Jennifer and Firmin, David N",
doi = "10.1148/radiol.2502071998",
issn = "1527-1315",
journal = "Radiology",
keywords = "Artifacts,Cardiovascular Diseases,Cardiovascular Diseases: diagnosis,Electrocardiography,Humans,Image Enhancement,Image Enhancement: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Motion,Myocardial Contraction,Myocardial Contraction: physiology,Respiration",
month = "feb",
number = 2,
pages = "331--51",
pmid = 19188310,
title = "{Motion in cardiovascular MR imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19188310",
volume = 250,
year = 2009
}
Maria Isabel Sá, Christoph H Kiesewetter, Rohan Jagathesan and Sanjay K Prasad.
Images in Cardiovascular Medicine. Acute pericarditis assessed with magnetic resonance imaging: a new approach..
Circulation 119(4):e183–6, February 2009.
URL, DOI BibTeX
@article{Sa2009,
author = "S{\'{a}}, Maria Isabel and Kiesewetter, Christoph H and Jagathesan, Rohan and Prasad, Sanjay K",
doi = "10.1161/CIRCULATIONAHA.108.771006",
issn = "1524-4539",
journal = "Circulation",
keywords = "Acute Disease,Adult,Echocardiography,Electrocardiography,Humans,Magnetic Resonance Imaging,Male,Pericarditis,Pericarditis: pathology,Pericarditis: ultrasonography",
month = "feb",
number = 4,
pages = "e183--6",
pmid = 19188514,
title = "{Images in Cardiovascular Medicine. Acute pericarditis assessed with magnetic resonance imaging: a new approach.}",
url = "http://circ.ahajournals.org/content/119/4/e183.figures-only",
volume = 119,
year = 2009
}
Pedro Ferreira, Peter Gatehouse, Peter Kellman, Chiara Bucciarelli-Ducci and David Firmin.
Variability of myocardial perfusion dark rim Gibbs artifacts due to sub-pixel shifts..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 11:17, January 2009.
URL, DOI BibTeX
@article{Ferreira2009,
abstract = "Gibbs ringing has been shown as a possible source of dark rim artifacts in myocardial perfusion studies. This type of artifact is usually described as transient, lasting a few heart beats, and localised in random segments of the myocardial wall. Dark rim artifacts are known to be unpredictably variable. This article aims to illustrate that a sub-pixel shift, i.e. a small displacement of the pixels with respect to the endocardial border, can result in different Gibbs ringing and hence different artifacts. Therefore a hypothesis for one cause of dark rim artifact variability is given based on the sub-pixel position of the endocardial border. This article also demonstrates the consequences for Gibbs artifacts when two different methods of image interpolation are applied (post-FFT interpolation, and pre-FFT zero-filling).",
author = "Ferreira, Pedro and Gatehouse, Peter and Kellman, Peter and Bucciarelli-Ducci, Chiara and Firmin, David",
doi = "10.1186/1532-429X-11-17",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Ferreira et al. - 2009 - Variability of myocardial perfusion dark rim Gibbs artifacts due to sub-pixel shifts.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adenosine,Adenosine: diagnostic use,Artifacts,Computer Simulation,Contrast Media,Contrast Media: diagnostic use,Electrocardiography,Endocardium,Endocardium: pathology,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Humans,Image Interpretation, Computer-Assisted,Models, Cardiovascular,Myocardial Perfusion Imaging,Myocardial Perfusion Imaging: instrumentation,Myocardium,Myocardium: pathology,Phantoms, Imaging,Predictive Value of Tests,Reproducibility of Results,Retrospective Studies",
month = "jan",
pages = 17,
pmid = 19473492,
title = "{Variability of myocardial perfusion dark rim Gibbs artifacts due to sub-pixel shifts.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2693509{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 11,
year = 2009
}
Bengt Johansson, Sonya V Babu-Narayan and Philip J Kilner.
The effects of breath-holding on pulmonary regurgitation measured by cardiovascular magnetic resonance velocity mapping..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 11:1, January 2009.
URL, DOI BibTeX
@article{Johansson2009,
abstract = "Pulmonary regurgitation is a common and clinically important residual lesion after repair of tetralogy of Fallot. Cardiovascular magnetic resonance (CMR) phase contrast velocity mapping is widely used for measurement of pulmonary regurgitant fraction. Breath-hold acquisitions, usually acquired during held expiration, are more convenient than the non-breath-hold approach, but we hypothesized that breath-holding might affect the amount of pulmonary regurgitation.",
author = "Johansson, Bengt and Babu-Narayan, Sonya V and Kilner, Philip J",
doi = "10.1186/1532-429X-11-1",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Johansson, Babu-Narayan, Kilner - 2009 - The effects of breath-holding on pulmonary regurgitation measured by cardiovascular magnetic re.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Cardiac Surgical Procedures,Cardiac Surgical Procedures: adverse effects,Exhalation,Female,Humans,Inhalation,Magnetic Resonance Imaging, Cine,Male,Predictive Value of Tests,Prospective Studies,Pulmonary Valve Insufficiency,Pulmonary Valve Insufficiency: diagnosis,Pulmonary Valve Insufficiency: etiology,Pulmonary Valve Insufficiency: physiopathology,Pulmonary Valve Stenosis,Pulmonary Valve Stenosis: diagnosis,Pulmonary Valve Stenosis: etiology,Pulmonary Valve Stenosis: physiopathology,Stroke Volume,Tetralogy of Fallot,Tetralogy of Fallot: surgery,Treatment Outcome,Ventricular Function, Left,Ventricular Function, Right,Young Adult",
month = "jan",
pages = 1,
pmid = 19144178,
title = "{The effects of breath-holding on pulmonary regurgitation measured by cardiovascular magnetic resonance velocity mapping.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2629465{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 11,
year = 2009
}
R Torii, J Keegan, N B Wood, A W Dowsey, A D Hughes, G-Z Yang, D N Firmin, S A Mcg Thom and X Y Xu.
The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study..
The British journal of radiology 82 Spec No:S24–32, January 2009.
URL, DOI BibTeX
@article{Torii2009,
abstract = "Human right coronary artery (RCA) haemodynamics is investigated using computational fluid dynamics (CFD) based on subject-specific information from magnetic resonance (MR) acquisitions. The dynamically varying vascular geometry is reconstructed from MR images, incorporated in CFD in conjunction with pulsatile flow conditions obtained from MR velocity mapping performed on the same subject. The effects of dynamic vessel motion on instantaneous and cycle-averaged haemodynamic parameters, such as wall shear stress (WSS), time-averaged WSS (TAWSS) and oscillatory shear index (OSI), are examined by comparing an RCA model with a time-varying geometry and those with a static geometry, corresponding to nine different time-points in the cardiac cycle. The results show that the TAWSS is similar for the dynamic and static wall models, both qualitatively and quantitatively (correlation coefficient 0.89-0.95). Conversely, the OSI shows much poorer correlations (correlation coefficient 0.38-0.60), with the best correspondence being observed with the static models constructed from images acquired in late diastole (at t = 0 and 800 ms, the cardiac cycle is 900 ms). These findings suggest that neglecting dynamic motion of the RCA is acceptable if TAWSS is the primary focus but may result in underestimation of haemodynamic parameters related to the oscillatory nature of the blood flow.",
author = "Torii, R and Keegan, J and Wood, N B and Dowsey, A W and Hughes, A D and Yang, G-Z and Firmin, D N and {Mcg Thom}, S A and Xu, X Y",
doi = "10.1259/bjr/62450556",
issn = "1748-880X",
journal = "The British journal of radiology",
keywords = "Adult,Blood Flow Velocity,Blood Flow Velocity: physiology,Coronary Vessels,Coronary Vessels: anatomy {\&} histology,Coronary Vessels: physiology,Hemodynamics,Hemorheology,Hemorheology: physiology,Humans,Image Processing, Computer-Assisted,Image Processing, Computer-Assisted: methods,Magnetic Resonance Angiography,Magnetic Resonance Angiography: methods,Male,Models, Cardiovascular,Motion,Pulsatile Flow,Pulsatile Flow: physiology,Stress, Mechanical",
month = "jan",
pages = "S24--32",
pmid = 20348532,
title = "{The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/20348532",
volume = "82 Spec No",
year = 2009
}
Shahina Daar, Anil V Pathare, Rajeev Jain, Shoaib Al Zadjali and Dudley J Pennell.
T2* cardiovascular magnetic resonance in the management of thalassemia patients in Oman..
Haematologica 94(1):140–1, January 2009.
URL, DOI BibTeX
@article{Daar2009,
author = "Daar, Shahina and Pathare, Anil V and Jain, Rajeev and Zadjali, Shoaib Al and Pennell, Dudley J",
doi = "10.3324/haematol.13845",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Daar et al. - 2009 - T2 cardiovascular magnetic resonance in the management of thalassemia patients in Oman.pdf:pdf",
issn = "1592-8721",
journal = "Haematologica",
keywords = "Adolescent,Adult,Age Distribution,Child,Female,Humans,Magnetic Resonance Imaging,Male,Oman,Thalassemia,Thalassemia: diagnosis,Thalassemia: drug therapy,Thalassemia: pathology",
month = "jan",
number = 1,
pages = "140--1",
pmid = 19001285,
title = "{T2* cardiovascular magnetic resonance in the management of thalassemia patients in Oman.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2625422{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 94,
year = 2009
}
John-Paul Carpenter and Dudley J Pennell.
Role of T2* magnetic resonance in monitoring iron chelation therapy..
Acta haematologica 122(2-3):146–54, January 2009.
URL, DOI BibTeX
@article{Carpenter2009,
abstract = "The monitoring of chelation therapy is a very important part of the management of transfusion-dependent patients. Classical methods of monitoring iron loading are either unreliable or unable to detect important myocardial siderosis which can predispose to the development of cardiac complications such as heart failure. The development of the T2* technique using cardiovascular magnetic resonance has allowed clinicians to have a reliable method for measuring cardiac iron to guide chelation therapy. T2* can identify early those patients who are at risk of developing cardiac complications, enabling personalised, tailored therapy to avoid potential problems.",
author = "Carpenter, John-Paul and Pennell, Dudley J",
doi = "10.1159/000243799",
issn = "1421-9662",
journal = "Acta haematologica",
keywords = "Clinical Trials as Topic,Ferritins,Ferritins: blood,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron: metabolism,Liver,Liver: metabolism,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Monitoring, Physiologic,Monitoring, Physiologic: methods,Myocardium,Myocardium: metabolism,Reproducibility of Results,Thalassemia,Thalassemia: drug therapy,Thalassemia: metabolism",
month = "jan",
number = "2-3",
pages = "146--54",
pmid = 19907152,
title = "{Role of T2* magnetic resonance in monitoring iron chelation therapy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19907152",
volume = 122,
year = 2009
}
Cheuk F Chan, Peter D Gatehouse, Ray Hughes, Michael Roughton, Dudley J Pennell and David N Firmin.
Novel technique used to detect swallowing in volume-selective turbo spin-echo (TSE) for carotid artery wall imaging..
Journal of magnetic resonance imaging : JMRI 29(1):211–6, January 2009.
URL, DOI BibTeX
@article{Chan2009,
abstract = "To improve three-dimensional (3D) volume-selective turbo spin-echo (TSE) carotid wall imaging by the addition of a novel body surface swallowing detection device.",
author = "Chan, Cheuk F and Gatehouse, Peter D and Hughes, Ray and Roughton, Michael and Pennell, Dudley J and Firmin, David N",
doi = "10.1002/jmri.21607",
issn = "1053-1807",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Algorithms,Artifacts,Carotid Arteries,Carotid Arteries: anatomy {\&} histology,Echo-Planar Imaging,Echo-Planar Imaging: instrumentation,Echo-Planar Imaging: methods,Equipment Design,Equipment Failure Analysis,Female,Humans,Image Enhancement,Image Enhancement: instrumentation,Image Enhancement: methods,Imaging, Three-Dimensional,Imaging, Three-Dimensional: instrumentation,Imaging, Three-Dimensional: methods,Magnetics,Magnetics: instrumentation,Male,Motion,Reproducibility of Results,Sensitivity and Specificity",
month = "jan",
number = 1,
pages = "211--6",
pmid = 19097078,
title = "{Novel technique used to detect swallowing in volume-selective turbo spin-echo (TSE) for carotid artery wall imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19097078",
volume = 29,
year = 2009
}
Syed Afzal M Sohaib, John R Payne, Rajeev Shukla, Michael World, Dudley J Pennell and Hugh E Montgomery.
Electrocardiographic (ECG) criteria for determining left ventricular mass in young healthy men; data from the LARGE Heart study..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 11:2, January 2009.
URL, DOI BibTeX
@article{Sohaib2009,
abstract = "Doubts remain over the use of the ECG in identifying those with increased left ventricular (LV) mass. This is especially so in young individuals, despite their high prevalence of ECG criteria for LV hypertrophy. We performed a study using cardiovascular magnetic resonance (CMR), which provides an in vivo non-invasive gold standard method of measuring LV mass, allowing accurate assessment of electrocardiography as a tool for defining LV hypertrophy in the young.",
author = "Sohaib, Syed M Afzal and Payne, John R and Shukla, Rajeev and World, Michael and Pennell, Dudley J and Montgomery, Hugh E",
doi = "10.1186/1532-429X-11-2",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Sohaib et al. - 2009 - Electrocardiographic (ECG) criteria for determining left ventricular mass in young healthy men data from the LARG.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Electrocardiography,Great Britain,Great Britain: epidemiology,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: diagnosis,Hypertrophy, Left Ventricular: epidemiology,Hypertrophy, Left Ventricular: physiopathology,Magnetic Resonance Imaging,Male,Prevalence,ROC Curve,Risk Factors,Sensitivity and Specificity",
month = "jan",
pages = 2,
pmid = 19149884,
title = "{Electrocardiographic (ECG) criteria for determining left ventricular mass in young healthy men; data from the LARGE Heart study.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2647921{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 11,
year = 2009
}
Anitha Varghese, Michael S Yee, Cheuk F Chan, Lindsey A Crowe, Niall G Keenan, Desmond G Johnston and Dudley J Pennell.
Effect of rosiglitazone on progression of atherosclerosis: insights using 3D carotid cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 11:24, January 2009.
URL, DOI BibTeX
@article{Varghese2009,
abstract = "There is recent evidence suggesting that rosiglitazone increases death from cardiovascular causes. We investigated the direct effect of this drug on atheroma using 3D carotid cardiovascular magnetic resonance.",
author = "Varghese, Anitha and Yee, Michael S and Chan, Cheuk F and Crowe, Lindsey A and Keenan, Niall G and Johnston, Desmond G and Pennell, Dudley J",
doi = "10.1186/1532-429X-11-24",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Varghese et al. - 2009 - Effect of rosiglitazone on progression of atherosclerosis insights using 3D carotid cardiovascular magnetic res.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Aged,Antihypertensive Agents,Antihypertensive Agents: therapeutic use,Blood Glucose,Blood Glucose: drug effects,Carotid Arteries,Carotid Arteries: pathology,Carotid Artery Diseases,Carotid Artery Diseases: complications,Carotid Artery Diseases: drug therapy,Carotid Artery Diseases: pathology,Diabetes Mellitus, Type 2,Diabetes Mellitus, Type 2: blood,Diabetes Mellitus, Type 2: complications,Diabetes Mellitus, Type 2: drug therapy,Disease Progression,Double-Blind Method,Female,Hemoglobin A, Glycosylated,Hemoglobin A, Glycosylated: metabolism,Humans,Hypertension,Hypertension: complications,Hypertension: drug therapy,Hypoglycemic Agents,Hypoglycemic Agents: adverse effects,Hypoglycemic Agents: therapeutic use,Hypolipidemic Agents,Hypolipidemic Agents: therapeutic use,Imaging, Three-Dimensional,Magnetic Resonance Angiography,Male,Middle Aged,Thiazolidinediones,Thiazolidinediones: adverse effects,Thiazolidinediones: therapeutic use,Time Factors,Treatment Outcome",
month = "jan",
pages = 24,
pmid = 19635160,
title = "{Effect of rosiglitazone on progression of atherosclerosis: insights using 3D carotid cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2726137{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 11,
year = 2009
}
Henryk Kafka and Raad H Mohiaddin.
Cardiac MRI and pulmonary MR angiography of sinus venosus defect and partial anomalous pulmonary venous connection in cause of right undiagnosed ventricular enlargement..
AJR. American journal of roentgenology 192(1):259–66, January 2009.
URL, DOI BibTeX
@article{Kafka2009,
abstract = "Patients may be referred for cardiology assessment because of an enlarged right ventricle (RV) with no cause apparent on echocardiography. Cardiac MRI can contribute to the management of these patients by detecting sinus venosus defect or partial anomalous pulmonary venous connection (PAPVC). We sought to show how often sinus venosus defect or PAPVC was detected on MRI in patients with an enlarged RV without a previously established definite diagnosis.",
author = "Kafka, Henryk and Mohiaddin, Raad H",
doi = "10.2214/AJR.07.3430",
issn = "1546-3141",
journal = "AJR. American journal of roentgenology",
keywords = "Adolescent,Adult,Aged,Female,Heart Defects, Congenital,Heart Defects, Congenital: complications,Heart Defects, Congenital: diagnosis,Humans,Hypertrophy, Right Ventricular,Hypertrophy, Right Ventricular: diagnosis,Hypertrophy, Right Ventricular: etiology,Magnetic Resonance Imaging,Magnetic Resonance Imaging, Cine,Magnetic Resonance Imaging, Cine: methods,Magnetic Resonance Imaging: methods,Male,Middle Aged,Pulmonary Veins,Pulmonary Veins: abnormalities,Pulmonary Veins: pathology,Vena Cava, Superior,Vena Cava, Superior: abnormalities,Vena Cava, Superior: pathology,Young Adult",
month = "jan",
number = 1,
pages = "259--66",
pmid = 19098208,
title = "{Cardiac MRI and pulmonary MR angiography of sinus venosus defect and partial anomalous pulmonary venous connection in cause of right undiagnosed ventricular enlargement.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19098208",
volume = 192,
year = 2009
}
Kieran R O'Brien, Ruvin S Gabriel, Andreas Greiser, Brett R Cowan, Alistair A Young and Andrew J Kerr.
Aortic valve stenotic area calculation from phase contrast cardiovascular magnetic resonance: the importance of short echo time..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 11(1):49, January 2009.
URL, DOI BibTeX
@article{O'Brien2009,
abstract = "Cardiovascular magnetic resonance (CMR) can potentially quantify aortic valve area (AVA) in aortic stenosis (AS) using a single-slice phase contrast (PC) acquisition at valve level: AVA = aortic flow/aortic velocity-time integral (VTI). However, CMR has been shown to underestimate aortic flow in turbulent high velocity jets, due to intra-voxel dephasing. This study investigated the effect of decreasing intra-voxel dephasing by reducing the echo time (TE) on AVA estimates in patients with AS.",
author = "O'Brien, Kieran R and Gabriel, Ruvin S and Greiser, Andreas and Cowan, Brett R and Young, Alistair A and Kerr, Andrew J",
doi = "10.1186/1532-429X-11-49",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/O'Brien et al. - 2009 - Aortic valve stenotic area calculation from phase contrast cardiovascular magnetic resonance the importance of s.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Aortic Valve,Aortic Valve Stenosis,Aortic Valve Stenosis: pathology,Aortic Valve Stenosis: physiopathology,Aortic Valve Stenosis: ultrasonography,Aortic Valve: pathology,Aortic Valve: physiopathology,Aortic Valve: ultrasonography,Blood Flow Velocity,Echocardiography, Doppler,Heart Ventricles,Heart Ventricles: pathology,Humans,Magnetic Resonance Imaging, Cine,Predictive Value of Tests,Pulmonary Artery,Pulmonary Artery: pathology,Severity of Illness Index,Stroke Volume,Time Factors",
month = "jan",
number = 1,
pages = 49,
pmid = 19925667,
title = "{Aortic valve stenotic area calculation from phase contrast cardiovascular magnetic resonance: the importance of short echo time.}",
url = "http://www.jcmr-online.com/content/11/1/49",
volume = 11,
year = 2009
}
Ronak Rajani, Dev K Bhanot, Sanjay K Prasad and Phyllis M Holt.
Mitral valve myxoma: a case of mistaken identity..
Journal of cardiovascular medicine (Hagerstown, Md.) 9(12):1290–2, December 2008.
URL, DOI BibTeX
@article{Rajani2008,
abstract = "A case of a rare mitral valve myxoma is reported in a 61-year-old gentleman who presented with recurrent embolic events. The mass was initially diagnosed as thrombus on cardiac MRI, but was later confirmed to be myxomatous in origin, at surgery, and histological examination.",
author = "Rajani, Ronak and Bhanot, Dev K and Prasad, Sanjay K and Holt, Phyllis M",
doi = "10.2459/JCM.0b013e3283168d65",
issn = "1558-2027",
journal = "Journal of cardiovascular medicine (Hagerstown, Md.)",
keywords = "Diagnosis, Differential,Heart Atria,Heart Neoplasms,Heart Neoplasms: diagnosis,Humans,Male,Middle Aged,Myxoma,Myxoma: diagnosis,Thrombosis,Thrombosis: diagnosis",
month = "dec",
number = 12,
pages = "1290--2",
pmid = 19001944,
title = "{Mitral valve myxoma: a case of mistaken identity.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19001944",
volume = 9,
year = 2008
}
Srijita Sen-Chowdhry, Petros Syrris, Sanjay K Prasad, Siân E Hughes, Robert Merrifield, Deirdre Ward, Dudley J Pennell and William J McKenna.
Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity..
Journal of the American College of Cardiology 52(25):2175–87, December 2008.
URL, DOI BibTeX
@article{Sen-Chowdhry2008a,
abstract = "We sought to investigate the clinical-genetic profile of left-dominant arrhythmogenic cardiomyopathy (LDAC).",
author = "Sen-Chowdhry, Srijita and Syrris, Petros and Prasad, Sanjay K and Hughes, Si{\^{a}}n E and Merrifield, Robert and Ward, Deirdre and Pennell, Dudley J and McKenna, William J",
doi = "10.1016/j.jacc.2008.09.019",
issn = "1558-3597",
journal = "Journal of the American College of Cardiology",
keywords = "Adolescent,Adult,Aged,Aged, 80 and over,Arrhythmias, Cardiac,Arrhythmias, Cardiac: diagnosis,Arrhythmias, Cardiac: etiology,Arrhythmias, Cardiac: physiopathology,Cardiomyopathies,Cardiomyopathies: diagnosis,Cardiomyopathies: etiology,Cardiomyopathies: physiopathology,Cohort Studies,Death, Sudden, Cardiac,Death, Sudden, Cardiac: etiology,Death, Sudden, Cardiac: pathology,Diagnosis, Differential,Electrocardiography,Female,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Risk Assessment,Risk Factors,Systole,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: complications,Ventricular Dysfunction, Left: diagnosis,Ventricular Dysfunction, Left: physiopathology,Young Adult",
month = "dec",
number = 25,
pages = "2175--87",
pmid = 19095136,
title = "{Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19095136",
volume = 52,
year = 2008
}
Sanjay K Prasad, Angela Clerk, Timothy E Cullingford, Alexander W Y Chen, Timothy J Kemp, Timothy M Cannell, Martin R Cowie and Mario Petrou.
Gene expression profiling of human hibernating myocardium: increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart..
European journal of heart failure 10(12):1177–80, December 2008.
URL, DOI BibTeX
@article{Prasad2008,
abstract = "A greater understanding of the molecular basis of hibernating myocardium may assist in identifying those patients who would most benefit from revascularization. Paired heart biopsies were taken from hypocontractile and normally-contracting myocardium (identified by cardiovascular magnetic resonance) from 6 patients with chronic stable angina scheduled for bypass grafting. Gene expression profiles of hypocontractile and normally-contracting samples were compared using Affymetrix microarrays. The data for patients with confirmed hibernating myocardium were analysed separately and a different, though overlapping, set (up to 380) of genes was identified which may constitute a molecular fingerprint for hibernating myocardium. The expression of B-type natriuretic peptide (BNP) was increased in hypocontractile relative to normally-contracting myocardium. The expression of BNP correlated most closely with the expression of proenkephalin and follistatin 3, which may constitute additional heart failure markers. Our data illustrate differential gene expression in hypocontractile and/hibernating myocardium relative to normally-contracting myocardium within individual human hearts. Changes in expression of these genes, including increased relative expression of natriuretic and other factors, may constitute a molecular signature for hypocontractile and/or hibernating myocardium.",
author = "Prasad, Sanjay K and Clerk, Angela and Cullingford, Timothy E and Chen, Alexander W Y and Kemp, Timothy J and Cannell, Timothy M and Cowie, Martin R and Petrou, Mario",
doi = "10.1016/j.ejheart.2008.08.008",
issn = "1388-9842",
journal = "European journal of heart failure",
keywords = "Angina Pectoris,Angina Pectoris: physiopathology,Atrial Natriuretic Factor,Atrial Natriuretic Factor: biosynthesis,Atrial Natriuretic Factor: genetics,Enkephalins,Enkephalins: biosynthesis,Enkephalins: genetics,Follistatin-Related Proteins,Follistatin-Related Proteins: biosynthesis,Follistatin-Related Proteins: genetics,Gene Expression Profiling,Humans,Myocardial Contraction,Myocardium,Myocardium: metabolism,Natriuretic Peptide, Brain,Natriuretic Peptide, Brain: biosynthesis,Natriuretic Peptide, Brain: genetics,Protein Precursors,Protein Precursors: biosynthesis,Protein Precursors: genetics,RNA, Messenger,RNA, Messenger: biosynthesis,RNA, Messenger: genetics,Ventricular Function, Left",
month = "dec",
number = 12,
pages = "1177--80",
pmid = 18974021,
title = "{Gene expression profiling of human hibernating myocardium: increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18974021",
volume = 10,
year = 2008
}
Niall G Keenan, Agata Grasso, Didier Locca, Anitha Varghese, Michael Roughton, Peter D Gatehouse, David N Firmin and Dudley J Pennell.
Comparison of 2D and multislab 3D magnetic resonance techniques for measuring carotid wall volumes..
Journal of magnetic resonance imaging : JMRI 28(6):1476–82, December 2008.
URL, DOI BibTeX
@article{Keenan2008a,
abstract = "To compare a multislab three-dimensional volume-selective fast spin-echo (FSE) magnetic resonance (MR) sequence with a routine two-dimensional FSE sequence for quantification of carotid wall volume.",
author = "Keenan, Niall G and Grasso, Agata and Locca, Didier and Varghese, Anitha and Roughton, Michael and Gatehouse, Peter D and Firmin, David N and Pennell, Dudley J",
doi = "10.1002/jmri.21582",
issn = "1053-1807",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Adult,Aged,Carotid Arteries,Carotid Arteries: pathology,Female,Humans,Image Processing, Computer-Assisted,Imaging, Three-Dimensional,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Regression Analysis",
month = "dec",
number = 6,
pages = "1476--82",
pmid = 19025935,
title = "{Comparison of 2D and multislab 3D magnetic resonance techniques for measuring carotid wall volumes.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19025935",
volume = 28,
year = 2008
}
S Sen-Chowdhry, E Sevdalis, R Wage, B Mist, P J Kilner and W J McKenna.
Syncope in an adolescent: a case of conflicting tests and dual pathology..
International journal of clinical practice 62(11):1803–7, November 2008.
URL, DOI BibTeX
@article{Sen-Chowdhry2008,
author = "Sen-Chowdhry, S and Sevdalis, E and Wage, R and Mist, B and Kilner, P J and McKenna, W J",
doi = "10.1111/j.1742-1241.2006.00898.x",
issn = "1742-1241",
journal = "International journal of clinical practice",
keywords = "Adolescent,Arrhythmias, Cardiac,Arrhythmias, Cardiac: diagnosis,Electrocardiography,Electrocardiography, Ambulatory,Emergency Treatment,Exercise Test,Female,Hospitalization,Humans,Hypertrophy, Right Ventricular,Hypertrophy, Right Ventricular: diagnosis,Magnetic Resonance Angiography,Syncope,Syncope: etiology",
month = "nov",
number = 11,
pages = "1803--7",
pmid = 19143866,
title = "{Syncope in an adolescent: a case of conflicting tests and dual pathology.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19143866",
volume = 62,
year = 2008
}
Taigang He, Peter D Gatehouse, Gillian C Smith, Raad H Mohiaddin, Dudley J Pennell and David N Firmin.
Myocardial T2* measurements in iron-overloaded thalassemia: An in vivo study to investigate optimal methods of quantification..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 60(5):1082–9, November 2008.
URL, DOI BibTeX
@article{He2008a,
abstract = "Reproducible and accurate myocardial T2* measurements are required for the quantification of iron in heart tissue in transfused thalassemia. The aim of this study was to determine the best method to measure the myocardial T2* from multi-gradient-echo data acquired both with and without black-blood preparation. Sixteen thalassemia patients from six centers were scanned twice locally, within 1 week, using an optimized bright-blood T2* sequence and then subsequently scanned at the standardization center in London within 4 weeks, using a T2* sequence both with and without black-blood preparation. Different curve-fitting models (monoexponential, truncation, and offset) were applied to the data and the results were compared by means of reproducibility. T2* measurements obtained using the bright- and black-blood techniques. The black-blood data were well fitted by the monoexponential model, which suggests that a more accurate measure of T2* can be obtained by removing the main source of errors in the bright-blood data. For bright-blood data, the offset model appeared to underestimate T2* values substantially and was less reproducible. The truncation model gave rise to more reproducible T2* measurements, which were also closer to the values obtained from the black-blood data.",
author = "He, Taigang and Gatehouse, Peter D and Smith, Gillian C and Mohiaddin, Raad H and Pennell, Dudley J and Firmin, David N",
doi = "10.1002/mrm.21744",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/He et al. - 2008 - Myocardial T2 measurements in iron-overloaded thalassemia An in vivo study to investigate optimal methods of quantifi.pdf:pdf",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = "Adult,Algorithms,Female,Great Britain,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Iron,Iron Overload,Iron Overload: diagnosis,Iron Overload: metabolism,Iron: analysis,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Myocardium,Myocardium: metabolism,Reproducibility of Results,Sensitivity and Specificity,Thalassemia,Thalassemia: diagnosis,Thalassemia: metabolism",
month = "nov",
number = 5,
pages = "1082--9",
pmid = 18956471,
title = "{Myocardial T2* measurements in iron-overloaded thalassemia: An in vivo study to investigate optimal methods of quantification.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2593631{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 60,
year = 2008
}
F Alpendurada and S K Prasad.
The missing spade: apical hypertrophic cardiomyopathy investigation..
The international journal of cardiovascular imaging 24(7):687–9, October 2008.
URL, DOI BibTeX
@article{Alpendurada2008a,
author = "Alpendurada, F and Prasad, S K",
doi = "10.1007/s10554-008-9335-z",
issn = "1569-5794",
journal = "The international journal of cardiovascular imaging",
keywords = "Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Chest Pain,Chest Pain: etiology,Contrast Media,Coronary Angiography,Echocardiography, Doppler,Electrocardiography,Gadolinium,Gadolinium: diagnostic use,Humans,Image Enhancement,Image Enhancement: methods,Magnetic Resonance Imaging,Radionuclide Ventriculography,Tomography, Emission-Computed, Single-Photon",
month = "oct",
number = 7,
pages = "687--9",
pmid = 18595001,
title = "{The missing spade: apical hypertrophic cardiomyopathy investigation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18595001",
volume = 24,
year = 2008
}
Pedro Ferreira, Peter Gatehouse, Chiara Bucciarelli-Ducci, Ricardo Wage and David Firmin.
Measurement of myocardial frequency offsets during first pass of a gadolinium-based contrast agent in perfusion studies..
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 60(4):860–70, October 2008.
URL, DOI BibTeX
@article{Ferreira2008,
abstract = "MRI of myocardial perfusion observed with an extracellular contrast agent has proven valuable for the detection of coronary artery disease. During contrast enhancement transient dark rim artifacts are sometimes visible, complicating diagnosis and quantification. In this work a quantification of the frequency offsets caused solely by the first pass of Gd-DTPA in a typical perfusion setup was made in vivo and compared with both phantom work and numerical simulations data. The results show that numerically simulated and phantom data agree well with in vivo frequency offsets. During the first pass main field distortion occurs mainly in the subendocardium, and the same pattern is always observed: positive for posterior/anterior regions, negative for septal/lateral regions (from -69 to 85 Hz). The larger myocardial frequency offsets were measured for patients with greater angles between the long axis of the heart and the direction of the main field. From these results it would appear that the frequency offsets are too weak to cause dark rim artifacts due simply to intravoxel dephasing in a typical perfusion sequence. However, when added to other sources of off-resonance it can cause dark rims in particular regions of the myocardium wall in balanced-SSFP sequences.",
author = "Ferreira, Pedro and Gatehouse, Peter and Bucciarelli-Ducci, Chiara and Wage, Ricardo and Firmin, David",
doi = "10.1002/mrm.21723",
issn = "1522-2594",
journal = "Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine",
keywords = "Adult,Algorithms,Computer Simulation,Contrast Media,Contrast Media: administration {\&} dosage,Coronary Artery Disease,Coronary Artery Disease: complications,Coronary Artery Disease: diagnosis,Female,Gadolinium DTPA,Gadolinium DTPA: administration {\&} dosage,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: instrumentation,Magnetic Resonance Imaging: methods,Male,Models, Cardiovascular,Phantoms, Imaging,Reproducibility of Results,Sensitivity and Specificity,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: diagnosis,Ventricular Dysfunction, Left: etiology",
month = "oct",
number = 4,
pages = "860--70",
pmid = 18816870,
title = "{Measurement of myocardial frequency offsets during first pass of a gadolinium-based contrast agent in perfusion studies.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18816870",
volume = 60,
year = 2008
}
Francisco Alpendurada, Ricardo Wage and Raad Mohiaddin.
Evaluation of a sinus venosus atrial septal defect by magnetic resonance: a case report..
Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 27(10):1317–21, October 2008.
URL BibTeX
@article{Alpendurada2008,
abstract = "Although superior sinus venosus is one of the major types of atrial septal defect (ASD), diagnosis is usually more difficult than the more common forms. We report a case in which cardiovascular magnetic resonance (CMR) was useful in evaluating a patient presenting with right heart dilatation. Besides establishing the diagnosis of atrial septal defect, it also documented the anomalous drainage of a pulmonary vein.",
author = "Alpendurada, Francisco and Wage, Ricardo and Mohiaddin, Raad",
issn = "0870-2551",
journal = "Revista portuguesa de cardiologia : org{\~{a}}o oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology",
keywords = "Adult,Female,Heart Septal Defects, Atrial,Heart Septal Defects, Atrial: diagnosis,Humans,Magnetic Resonance Imaging",
month = "oct",
number = 10,
pages = "1317--21",
pmid = 19178032,
title = "{Evaluation of a sinus venosus atrial septal defect by magnetic resonance: a case report.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19178032",
volume = 27,
year = 2008
}
Dudley J Pennell.
T2* magnetic resonance: iron and gold..
JACC. Cardiovascular imaging 1(5):579–81, September 2008.
URL, DOI BibTeX
@article{Pennell2008,
author = "Pennell, Dudley J",
doi = "10.1016/j.jcmg.2008.05.001",
issn = "1876-7591",
journal = "JACC. Cardiovascular imaging",
keywords = "Echocardiography, Doppler,Heart Diseases,Heart Diseases: chemically induced,Heart Diseases: metabolism,Heart Diseases: physiopathology,Humans,Iron,Iron Chelating Agents,Iron Chelating Agents: administration {\&} dosage,Iron Chelating Agents: adverse effects,Iron Overload,Iron Overload: chemically induced,Iron Overload: diagnosis,Iron Overload: metabolism,Iron Overload: physiopathology,Iron: metabolism,Magnetic Resonance Imaging,Myocardium,Myocardium: metabolism,Predictive Value of Tests,Risk Assessment,Stroke Volume,Stroke Volume: drug effects,Thalassemia,Thalassemia: drug therapy,Thalassemia: metabolism,Thalassemia: pathology,Ventricular Function, Left,Ventricular Function, Left: drug effects",
month = "sep",
number = 5,
pages = "579--81",
pmid = 19356484,
title = "{T2* magnetic resonance: iron and gold.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19356484",
volume = 1,
year = 2008
}
Rory O'Hanlon, Karen Teo, Chiara Bucciarelli-Ducci and Dudley J Pennell.
Perfusion CMR and SPECT in hypertrophic cardiomyopathy..
International journal of cardiology 129(1):e27–9, September 2008.
URL, DOI BibTeX
@article{O'Hanlon2008,
author = "O'Hanlon, Rory and Teo, Karen and Bucciarelli-Ducci, Chiara and Pennell, Dudley J",
doi = "10.1016/j.ijcard.2007.06.089",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Cardiomyopathy, Hypertrophic: radionuclide imaging,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Middle Aged,Perfusion,Perfusion: methods,Tomography, Emission-Computed, Single-Photon,Tomography, Emission-Computed, Single-Photon: meth",
month = "sep",
number = 1,
pages = "e27--9",
pmid = 17706805,
title = "{Perfusion CMR and SPECT in hypertrophic cardiomyopathy.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/17706805",
volume = 129,
year = 2008
}
Maria Isabel Sá, Wei Lli, Mary N Sheppard and Philip J Kilner.
Images in cardiovascular medicine. Mycotic left ventricular false aneurysm at the site of an apical vent presenting 24 years after aortic valve surgery..
Circulation 118(13):e501–3, September 2008.
URL, DOI BibTeX
@article{Sa2008,
author = "S{\'{a}}, Maria Isabel and Lli, Wei and Sheppard, Mary N and Kilner, Philip J",
doi = "10.1161/CIRCULATIONAHA.107.732115",
issn = "1524-4539",
journal = "Circulation",
keywords = "Aneurysm, False,Aneurysm, False: diagnosis,Aneurysm, Infected,Aneurysm, Infected: diagnosis,Aortic Valve Stenosis,Aortic Valve Stenosis: surgery,Echocardiography, Doppler, Color,Electrocardiography,Heart Ventricles,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Postoperative Complications,Postoperative Complications: diagnosis,Time Factors,X-Rays",
month = "sep",
number = 13,
pages = "e501--3",
pmid = 18809801,
title = "{Images in cardiovascular medicine. Mycotic left ventricular false aneurysm at the site of an apical vent presenting 24 years after aortic valve surgery.}",
url = "http://circ.ahajournals.org/content/118/13/e501.full",
volume = 118,
year = 2008
}
Elisabeth D Burman, Jennifer Keegan and Philip J Kilner.
Aortic root measurement by cardiovascular magnetic resonance: specification of planes and lines of measurement and corresponding normal values..
Circulation. Cardiovascular imaging 1(2):104–13, September 2008.
URL, DOI BibTeX
@article{Burman2008,
abstract = "Cardiovascular magnetic resonance is widely used for aortic root visualization and measurement, but methods still need to be standardized. Our aim was to identify appropriate planes of acquisition and lines of measurement and record corresponding normal values.",
author = "Burman, Elisabeth D and Keegan, Jennifer and Kilner, Philip J",
doi = "10.1161/CIRCIMAGING.108.768911",
issn = "1942-0080",
journal = "Circulation. Cardiovascular imaging",
keywords = "Adult,Aged,Aged, 80 and over,Aorta,Aorta: anatomy {\&} histology,Female,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Reference Values,Young Adult",
month = "sep",
number = 2,
pages = "104--13",
pmid = 19808527,
title = "{Aortic root measurement by cardiovascular magnetic resonance: specification of planes and lines of measurement and corresponding normal values.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/19808527",
volume = 1,
year = 2008
}
Shi-Joon Yoo, Siew Yen Ho, Philip J Kilner, Jeong-Wook Seo and Robert H Anderson.
Sectional anatomy of the ventricular septal defect in double outlet right ventricle—correlation of magnetic resonance images from autopsied hearts with anatomic sections.
Cardiology in the Young 3(02):118–123, August 2008.
URL, DOI BibTeX
@article{Yoo2008,
author = "Yoo, Shi-Joon and Ho, Siew Yen and Kilner, Philip J. and Seo, Jeong-Wook and Anderson, Robert H.",
doi = "10.1017/S1047951100001372",
issn = "1047-9511",
journal = "Cardiology in the Young",
keywords = "Double outlet right ventricle,magnetic resonance imaging,sectional anatomy,ventricular septal defect",
language = "English",
month = "aug",
number = 02,
pages = "118--123",
publisher = "Cambridge University Press",
title = "{Sectional anatomy of the ventricular septal defect in double outlet right ventricle—correlation of magnetic resonance images from autopsied hearts with anatomic sections}",
url = "http://journals.cambridge.org/abstract{\_}S1047951100001372",
volume = 3,
year = 2008
}
Philip J Kilner, Tokuko Shinohara, Cynthia Sampson, Raad H Mohiaddin, David N Firmin and Jane Somerville.
Repaired aortic coarctation in adults—magnetic resonance imaging with velocity mapping shows distortions of anatomy and flow.
Cardiology in the Young 6(01):20–27, August 2008.
URL, DOI BibTeX
@article{Kilner2008,
author = "Kilner, Philip J. and Shinohara, Tokuko and Sampson, Cynthia and Mohiaddin, Raad H. and Firmin, David N. and Somerville, Jane",
doi = "10.1017/S104795110000319X",
issn = "1047-9511",
journal = "Cardiology in the Young",
keywords = "Aorta,coarctation,magnetic resonance imaging,velocity",
language = "English",
month = "aug",
number = 01,
pages = "20--27",
publisher = "Cambridge University Press",
title = "{Repaired aortic coarctation in adults—magnetic resonance imaging with velocity mapping shows distortions of anatomy and flow}",
url = "http://journals.cambridge.org/abstract{\_}S104795110000319X",
volume = 6,
year = 2008
}
Kalina Kawecka-Jaszcz, Danuta Czarnecka, Agnieszka Olszanecka, Artur Klecha, Agnieszka Kwiecień-Sobstel, Katarzyna Stolarz-Skrzypek, Dudley J Pennell, Mieczysław Pasowicz, Piotr Klimeczek and Robert P Banyś.
Myocardial perfusion in hypertensive patients with normal coronary angiograms..
Journal of hypertension 26(8):1686–94, August 2008.
URL, DOI BibTeX
@article{Kawecka-Jaszcz2008,
abstract = "Pressure-induced left ventricular hypertrophy is one of the mechanisms responsible for an impaired coronary vasodilating capacity leading to myocardial ischemia and angina. The aim of the study was to investigate myocardial perfusion using cardiovascular magnetic resonance in patients with arterial hypertension and a history of chest pain and normal coronary angiography, and to estimate the influence of left ventricular hypertrophy on the parameters of myocardial perfusion.",
author = "Kawecka-Jaszcz, Kalina and Czarnecka, Danuta and Olszanecka, Agnieszka and Klecha, Artur and Kwiecie{\'{n}}-Sobstel, Agnieszka and Stolarz-Skrzypek, Katarzyna and Pennell, Dudley J and Pasowicz, Mieczys{\l}aw and Klimeczek, Piotr and Bany{\'{s}}, Robert P",
doi = "10.1097/HJH.0b013e328303df42",
issn = "0263-6352",
journal = "Journal of hypertension",
keywords = "Adult,Aged,Angina Pectoris,Angina Pectoris: pathology,Angina Pectoris: physiopathology,Angina Pectoris: radiography,Blood Pressure,Coronary Angiography,Coronary Circulation,Female,Humans,Hypertension,Hypertension: pathology,Hypertension: physiopathology,Hypertension: radiography,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: pathology,Hypertrophy, Left Ventricular: physiopathology,Hypertrophy, Left Ventricular: radiography,Magnetic Resonance Imaging,Male,Middle Aged,Myocardial Ischemia,Myocardial Ischemia: pathology,Myocardial Ischemia: physiopathology,Myocardial Ischemia: radiography",
month = "aug",
number = 8,
pages = "1686--94",
pmid = 18622249,
title = "{Myocardial perfusion in hypertensive patients with normal coronary angiograms.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18622249",
volume = 26,
year = 2008
}
Simon Tc Peake, Justin C Mason, Tarun Mittal, Mohamed Amrani, Raad Mohiaddin, Alex Bell, Richard Grocott-Mason and Simon W Dubrey.
Growing pains–and a heart attack..
Lancet 372(9638):600, August 2008.
URL, DOI BibTeX
@article{Peake2008,
author = "Peake, Simon Tc and Mason, Justin C and Mittal, Tarun and Amrani, Mohamed and Mohiaddin, Raad and Bell, Alex and Grocott-Mason, Richard and Dubrey, Simon W",
doi = "10.1016/S0140-6736(08)61238-6",
issn = "1474-547X",
journal = "Lancet",
keywords = "Adult,Coronary Artery Bypass,Electrocardiography,Female,Humans,Takayasu Arteritis,Takayasu Arteritis: diagnosis,Takayasu Arteritis: therapy",
month = "aug",
number = 9638,
pages = 600,
pmid = 18707988,
title = "{Growing pains--and a heart attack.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18707988",
volume = 372,
year = 2008
}
Gregory P Whyte, Nigel Stephens, Roxy Senior, Nicholas Peters, Rory O'Hanlon and Sanjay Sharma.
Differentiation of RVOT-VT and ARVC in an elite athlete..
Medicine and science in sports and exercise 40(8):1357–61, August 2008.
URL, DOI BibTeX
@article{Whyte2008a,
abstract = "BACKGROUND: Differentiation of right ventricular outflow tract-ventricular tachycardia (RVOT-VT) and arrhythmogenic right ventricular cardiomyopathy (ARVC) can be problematic in athletes. The high incidence of sudden death as the first clinical manifestation in ARVC highlights the importance of correct diagnosis and treatment. We report on the case of RVOT-VT in an elite female sprinter, and we review the literature on ventricular tachycardia (VT) in the absence of structural heart disease and ARVC. DISCUSSION: Of patients who present with VT, 10{\%} have no obvious structural disease. In the case of idiopathic VT from the RVOT and LVOT, the arrhythmia is monomorphic and generally not familial. In both disorders, the resting ECG has no identifiable abnormalities, and the echocardiogram and coronary angiography are usually normal. ARVC is a heart muscle disorder characterized by structural and functional abnormalities of the right ventricle due to a fibro-fatty replacement of the myocardium. The natural history of ARVC is considered to include four distinct phases. The early concealed phase of ARVC demonstrates ECG abnormalities concomitant to right and left ventricular dyskinesias. Differential diagnosis during this phase is problematic due to the presence of left bundle branch block morphology VT together with ECG anomalies commonly observed in athletes in RVOT-VT. Furthermore, long-standing VT in RVOT-VT may result in ventricular wall motion abnormalities mimicking ARVC. Radiofrequency ablation may be a valuable tool in the differential diagnosis, because this technique is highly effective in the treatment of RVOT-VT and of limited value in ARVC. Continued follow-up evaluation is an important for the confirmation of disease status after the diagnosis of idiopathic RVOT-VT.",
author = "Whyte, Gregory P and Stephens, Nigel and Senior, Roxy and Peters, Nicholas and O'Hanlon, Rory and Sharma, Sanjay",
doi = "10.1249/MSS.0b013e31816feead",
issn = "1530-0315",
journal = "Medicine and science in sports and exercise",
keywords = "Adult,Athletic Performance,Athletic Performance: physiology,Death, Sudden,Death, Sudden: etiology,Death, Sudden: pathology,Diagnosis, Differential,Electrocardiography,Female,Humans,Sports Medicine,Tachycardia, Ventricular,Tachycardia, Ventricular: diagnosis,Tachycardia, Ventricular: physiopathology,Ventricular Dysfunction, Right,Ventricular Dysfunction, Right: diagnosis,Ventricular Dysfunction, Right: physiopathology",
month = "aug",
number = 8,
pages = "1357--61",
pmid = 18614961,
title = "{Differentiation of RVOT-VT and ARVC in an elite athlete.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18614961",
volume = 40,
year = 2008
}
William Keeble and Raad Mohiaddin.
Technical failure to perform cardiac resynchronization therapy: use of cardiac magnetic resonance imaging techniques to clarify a left-sided superior vena cava and coronary sinus morphology..
The Canadian journal of cardiology 24(7):589–90, July 2008.
URL BibTeX
@article{Keeble2008,
abstract = "The most common reason for failure to implant a left ventricular lead to deliver cardiac resynchronization therapy is the presence of unfavourable coronary venous anatomy. The present report illustrates the use of cardiac magnetic resonance imaging to delineate the anatomy of a left-sided superior vena cava in two patients in whom permanent cardiac pacing was unattainable.",
author = "Keeble, William and Mohiaddin, Raad",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Keeble, Mohiaddin - 2008 - Technical failure to perform cardiac resynchronization therapy use of cardiac magnetic resonance imaging tech.pdf:pdf",
issn = "1916-7075",
journal = "The Canadian journal of cardiology",
keywords = "Aged,Aged, 80 and over,Cardiac Pacing, Artificial,Cardiac Pacing, Artificial: methods,Coronary Sinus,Coronary Sinus: pathology,Follow-Up Studies,Heart Failure,Heart Failure: diagnosis,Heart Failure: physiopathology,Heart Failure: therapy,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Tachycardia, Ventricular,Tachycardia, Ventricular: diagnosis,Tachycardia, Ventricular: physiopathology,Tachycardia, Ventricular: therapy,Treatment Failure,Vena Cava, Superior,Vena Cava, Superior: abnormalities",
month = "jul",
number = 7,
pages = "589--90",
pmid = 18612503,
title = "{Technical failure to perform cardiac resynchronization therapy: use of cardiac magnetic resonance imaging techniques to clarify a left-sided superior vena cava and coronary sinus morphology.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2640338{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 24,
year = 2008
}
Chiara Bucciarelli-Ducci, Fu Siong Ng, Karen Symmonds, Eliana Reyes, Carl Schultz, Sam Kaddoura and Sanjay K Prasad.
Images in cardiovascular medicine. The complex pathophysiology of acute myocardial infarction imaged by cardiovascular magnetic resonance: infarction, edema, microvascular obstruction, and inducible ischemia..
Circulation 118(5):e89–92, July 2008.
URL, DOI BibTeX
@article{Bucciarelli-Ducci2008,
author = "Bucciarelli-Ducci, Chiara and Ng, Fu Siong and Symmonds, Karen and Reyes, Eliana and Schultz, Carl and Kaddoura, Sam and Prasad, Sanjay K",
doi = "10.1161/CIRCULATIONAHA.107.747691",
issn = "1524-4539",
journal = "Circulation",
keywords = "Coronary Angiography,Coronary Circulation,Edema,Edema: diagnosis,Edema: physiopathology,Electrocardiography,Humans,Magnetic Resonance Imaging,Male,Microcirculation,Middle Aged,Myocardial Infarction,Myocardial Infarction: diagnosis,Myocardial Infarction: physiopathology,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Myocardial Ischemia: physiopathology,Radionuclide Imaging",
month = "jul",
number = 5,
pages = "e89--92",
pmid = 18663092,
title = "{Images in cardiovascular medicine. The complex pathophysiology of acute myocardial infarction imaged by cardiovascular magnetic resonance: infarction, edema, microvascular obstruction, and inducible ischemia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18663092",
volume = 118,
year = 2008
}
Ricardo Wage, Henryk Kafka and Sanjay Prasad.
Images in cardiovascular medicine. Cardiac rhabdomyoma in an adult with a previous presumptive diagnosis of septal hypertrophy..
Circulation 117(22):e469–70, June 2008.
URL, DOI BibTeX
@article{Wage2008,
author = "Wage, Ricardo and Kafka, Henryk and Prasad, Sanjay",
doi = "10.1161/CIRCULATIONAHA.107.744904",
issn = "1524-4539",
journal = "Circulation",
keywords = "Adolescent,Cardiomyopathy, Hypertrophic,Cardiomyopathy, Hypertrophic: diagnosis,Female,Heart Septum,Heart Septum: pathology,Humans,Magnetic Resonance Imaging,Rhabdomyoma,Rhabdomyoma: diagnosis",
month = "jun",
number = 22,
pages = "e469--70",
pmid = 18519852,
title = "{Images in cardiovascular medicine. Cardiac rhabdomyoma in an adult with a previous presumptive diagnosis of septal hypertrophy.}",
url = "http://circ.ahajournals.org/content/117/22/e469",
volume = 117,
year = 2008
}
Q Long, R Merrifield, X Y Xu, P Kilner, D N Firmin and Yang G-Z.
Subject-specific computational simulation of left ventricular flow based on magnetic resonance imaging..
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 222(4):475–85, May 2008.
URL BibTeX
@article{Long2008,
abstract = "A detailed investigation of left ventricle (LV) flow patterns could improve our understanding of the function of the heart and provide further insight into the mechanisms of heart failure. This study presents patient-specific modelling with magnetic resonance imaging (MRI) to investigate LV blood flow patterns in normal subjects. In the study, the prescribed LV wall movements based on the MRI measurements drove the blood flow in and out of the LV in computational fluid dynamics simulation. For the six subjects studied, the simulated LV flow swirls towards the aortic valve and is ejected into the ascending aorta with a vertical flow pattern that follows the left-hand rule. In diastole, the inflow adopts a reasonably straight route (with no significant secondary flow) towards the apex in the rapid filling phase with slight variations in the jet direction between different cases. When the jet reaches about two thirds of the distance from the inflow plane to the apex, the blood flow starts to change direction and swirls towards the apex. In the more slowly filling phase, a centrally located jet is evident with vortices located on both sides of the jet on an anterior-posterior plane that passes through the mitral and aortic valves. In the inferior-superior plane, a main vortex appears for most of the cases in which an anticlockwise vortex appears for three cases and a clockwise vortex occurs for one case. The simulated flow patterns agree well qualitatively with MRI-measured flow fields.",
author = "Long, Q and Merrifield, R and Xu, X Y and Kilner, P and Firmin, D N and G-Z, Yang",
issn = "0954-4119",
journal = "Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine",
keywords = "Blood Flow Velocity,Blood Flow Velocity: physiology,Blood Pressure,Blood Pressure: physiology,Computer Simulation,Heart Ventricles,Heart Ventricles: anatomy {\&} histology,Humans,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Models, Cardiovascular,Stroke Volume,Stroke Volume: physiology,Ventricular Function",
month = "may",
number = 4,
pages = "475--85",
pmid = 18595359,
title = "{Subject-specific computational simulation of left ventricular flow based on magnetic resonance imaging.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18595359",
volume = 222,
year = 2008
}
Enrico Petretto, Rizwan Sarwar, Ian Grieve, Han Lu, Mande K Kumaran, Phillip J Muckett, Jonathan Mangion, Blanche Schroen, Matthew Benson, Prakash P Punjabi, Sanjay K Prasad, Dudley J Pennell, Chris Kiesewetter, Elena S Tasheva, Lolita M Corpuz, Megan D Webb, Gary W Conrad, Theodore W Kurtz, Vladimir Kren, Judith Fischer, Norbert Hubner, Yigal M Pinto, Michal Pravenec, Timothy J Aitman and Stuart A Cook.
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass..
Nature genetics 40(5):546–52, May 2008.
URL, DOI BibTeX
@article{Petretto2008,
abstract = "Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript (QTT) analyses of the cardiac transcriptome in the rat. Using these methods and in vitro functional assays, we identified osteoglycin (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM. We also applied genome-wide QTT analysis to the human heart and observed that, out of 22,000 transcripts, OGN transcript abundance had the highest correlation with LVM. We further confirmed a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice. Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.",
author = "Petretto, Enrico and Sarwar, Rizwan and Grieve, Ian and Lu, Han and Kumaran, Mande K and Muckett, Phillip J and Mangion, Jonathan and Schroen, Blanche and Benson, Matthew and Punjabi, Prakash P and Prasad, Sanjay K and Pennell, Dudley J and Kiesewetter, Chris and Tasheva, Elena S and Corpuz, Lolita M and Webb, Megan D and Conrad, Gary W and Kurtz, Theodore W and Kren, Vladimir and Fischer, Judith and Hubner, Norbert and Pinto, Yigal M and Pravenec, Michal and Aitman, Timothy J and Cook, Stuart A",
doi = "10.1038/ng.134",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Petretto et al. - 2008 - Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.pdf:pdf",
issn = "1546-1718",
journal = "Nature genetics",
keywords = "Animals,Aortic Valve Stenosis,Aortic Valve Stenosis: complications,Aortic Valve Stenosis: genetics,Blood Pressure,Blood Pressure: genetics,Chromosome Mapping,Gene Expression Profiling,Gene Expression Regulation,Genomics,Glycoproteins,Glycoproteins: genetics,Glycoproteins: physiology,Heart Ventricles,Heart Ventricles: anatomy {\&} histology,Heart Ventricles: metabolism,Humans,Hypertension,Hypertension: complications,Hypertension: genetics,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: genetics,Intercellular Signaling Peptides and Proteins,Intercellular Signaling Peptides and Proteins: gen,Intercellular Signaling Peptides and Proteins: phy,Mice,Mice, Knockout,Organ Size,Organ Size: genetics,Quantitative Trait Loci,Rats,Rats, Mutant Strains,Rats: genetics",
month = "may",
number = 5,
pages = "546--52",
pmid = 18443592,
title = "{Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2742198{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 40,
year = 2008
}
Konstantinos Dimopoulos, Carlo Di Mario, Peter Barlis, Dudley Pennell, Omer Goktekin, Sam Kaddoura and Michael A Gatzoulis.
Haemodynamic significance of an anomalous right coronary with inter-arterial course assessed with intracoronary pressure measurements during dobutamine challenge..
International journal of cardiology 126(2):e32–5, May 2008.
URL, DOI BibTeX
@article{Dimopoulos2008,
abstract = "Autopsy studies have associated congenital coronary anomalies with the risk of sudden cardiac death. However, not all patients with anomalous coronary arteries die suddenly. A means of assessing the potential for ischaemia and thus predicting the risk of sudden death in these patients may be necessary for directing treatment. We present the case of a patient with an anomalous right coronary artery originating from the aortic wall above the left sinus of Valsalva, with an anterior inter-arterial course. The haemodynamic significance of this anomaly was assessed using intracoronary pressure-wire measurements at rest and during dobutamine stress. This technique could be a valid means for assessing stress-induced ischaemia and, therefore, by inference, the risk of sudden cardiac death in these patients.",
author = "Dimopoulos, Konstantinos and {Di Mario}, Carlo and Barlis, Peter and Pennell, Dudley and Goktekin, Omer and Kaddoura, Sam and Gatzoulis, Michael A",
doi = "10.1016/j.ijcard.2007.01.015",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Catheters, Indwelling,Coronary Angiography,Coronary Angiography: methods,Coronary Vessel Anomalies,Coronary Vessel Anomalies: diagnosis,Coronary Vessel Anomalies: physiopathology,Coronary Vessel Anomalies: radiography,Coronary Vessels,Coronary Vessels: drug effects,Coronary Vessels: physiology,Dobutamine,Dobutamine: diagnostic use,Dobutamine: pharmacology,Female,Hemodynamics,Hemodynamics: drug effects,Hemodynamics: physiology,Humans,Middle Aged",
month = "may",
number = 2,
pages = "e32--5",
pmid = 17428559,
title = "{Haemodynamic significance of an anomalous right coronary with inter-arterial course assessed with intracoronary pressure measurements during dobutamine challenge.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/17428559",
volume = 126,
year = 2008
}
Steven P Downie, Sheila M Raynor, David N Firmin, Nigel B Wood, Simon A Thom, Alun D Hughes, Kim H Parker, John H N Wolfe and Yun X Xu.
Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf..
American journal of physiology. Heart and circulatory physiology 294(5):H2112–20, May 2008.
URL, DOI BibTeX
@article{Downie2008,
abstract = "The purpose of this study was to estimate wall shear stress (WSS) in individual vessels of the venous circulation of the calf and quantify the effects of elastic compression based on change of vessel geometry and velocity waveform. The great saphenous vein and either a peroneal or posterior tibial vein have been imaged in four healthy subjects using magnetic resonance imaging, with and without the presence of a grade 1 medical stocking. Flow through image-based reconstructed geometries was numerically simulated for both a range of steady flow rates and ultrasound-derived transient velocity waveforms, scaled to give a standardized time averaged flow rate. For steady flow, the stocking produced an average percentage increase in mean WSS of approximately 100{\%} in the great saphenous vein across a range of 0.125-1.25 ml/s. The percentage increase in the peroneal/posterior tibial veins varied from 490 to 650{\%} across a range of 0.5-5 ml/s. In addition, application of the stocking eliminated periods of very low or zero flow from the transient waveforms. The average minimum value of WSS in all vessels without the stocking was {\textless}0.1 Pa. With the stocking, this was increased to 0.7 Pa in the great saphenous and 0.9 Pa in the peroneal/posterior tibial veins. The pathophysiological effects of these changes are discussed. In conclusion, the flight stocking was effective in raising venous WSS levels in prone subjects, and this effect was much more pronounced in the deep vessels. The stocking also tended to prevent cessation of flow during periods of increased downstream pressure produced by respiration.",
author = "Downie, Steven P and Raynor, Sheila M and Firmin, David N and Wood, Nigel B and Thom, Simon A and Hughes, Alun D and Parker, Kim H and Wolfe, John H N and Xu, X Yun",
doi = "10.1152/ajpheart.01302.2007",
issn = "0363-6135",
journal = "American journal of physiology. Heart and circulatory physiology",
keywords = "Adult,Blood Flow Velocity,Computer Simulation,Hemodynamics,Humans,Image Interpretation, Computer-Assisted,Leg,Leg: blood supply,Magnetic Resonance Angiography,Male,Models, Cardiovascular,Prone Position,Reference Values,Regional Blood Flow,Respiration,Saphenous Vein,Saphenous Vein: anatomy {\&} histology,Saphenous Vein: physiology,Saphenous Vein: ultrasonography,Stockings, Compression,Stress, Mechanical,Time Factors,Ultrasonography, Doppler, Pulsed",
month = "may",
number = 5,
pages = "H2112--20",
pmid = 18326802,
title = "{Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18326802",
volume = 294,
year = 2008
}
G Whyte, M Sheppard, K George, R Shave, M Wilson, S Prasad, R O'Hanlon and S Sharma.
Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?.
British journal of sports medicine 42(4):304–5, April 2008.
URL, DOI BibTeX
@article{Whyte2008,
abstract = "A growing body of evidence reporting altered cardiac function and myocardial damage after arduous exercise, together with the increased prevalence of arrhythmias observed in highly trained athletes, suggests that repetitive bouts of prolonged, arduous exercise may be deleterious to long-term cardiac health. We report the case of an experienced, highly trained marathon runner who died suddenly while running. On post-mortem examination, left ventricle hypertrophy and idiopathic interstitial myocardial fibrosis was found. We believe that life-long, repetitive bouts of arduous physical activity resulted in fibrous replacement of the myocardium, causing a pathological substrate for the propagation of fatal arrhythmias.",
author = "Whyte, G and Sheppard, M and George, K and Shave, R and Wilson, M and Prasad, S and O'Hanlon, R and Sharma, S",
doi = "10.1136/bjsm.2007.038158",
issn = "1473-0480",
journal = "British journal of sports medicine",
keywords = "Death, Sudden, Cardiac,Death, Sudden, Cardiac: etiology,Fibrosis,Fibrosis: pathology,Humans,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: pathology,Male,Middle Aged,Myocardium,Myocardium: pathology,Physical Endurance,Physical Endurance: physiology,Running,Running: physiology",
month = "apr",
number = 4,
pages = "304--5",
pmid = 17720799,
title = "{Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/17720799",
volume = 42,
year = 2008
}
Alicia M Maceira, Sanjay K Prasad, Dudley J Pennell and Raad H Mohiaddin.
Integrated evaluation of hypertensive patients with cardiovascular magnetic resonance..
International journal of cardiology 125(3):383–90, April 2008.
URL, DOI BibTeX
@article{Maceira2008,
abstract = "Hypertension causes cardiac morbidity and premature mortality. Accurate evaluation to exclude potentially curable causes is important. Cardiovascular Magnetic Resonance and Magnetic Resonance Angiography (CMR/CE-MRA) provide an integrated approach to the assessment of hypertensive patients - a single study can identify certain secondary causes and assess left ventricular (LV) mass and function. The aim of this study was to prospectively evaluate the feasibility of CMR/CE-MRA to define LV dimensions and exclude some secondary causes in a selected group of hypertensives.",
author = "Maceira, Alicia M and Prasad, Sanjay K and Pennell, Dudley J and Mohiaddin, Raad H",
doi = "10.1016/j.ijcard.2007.03.002",
issn = "1874-1754",
journal = "International journal of cardiology",
keywords = "Adenoma,Adenoma: diagnosis,Adrenal Gland Neoplasms,Adrenal Gland Neoplasms: diagnosis,Adult,Aortic Coarctation,Aortic Coarctation: diagnosis,Atherosclerosis,Atherosclerosis: diagnosis,Case-Control Studies,Contrast Media,Creatinine,Creatinine: analysis,Drug Resistance,Feasibility Studies,Female,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Heart Ventricles,Heart Ventricles: pathology,Humans,Hypertension,Hypertension: drug therapy,Hypertension: etiology,Hypertension: physiopathology,Hypertrophy, Left Ventricular,Hypertrophy, Left Ventricular: physiopathology,Imaging, Three-Dimensional,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Prospective Studies,Renal Artery Obstruction,Renal Artery Obstruction: diagnosis,Systole,Systole: physiology,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: physiopathology,Ventricular Remodeling,Ventricular Remodeling: physiology",
month = "apr",
number = 3,
pages = "383--90",
pmid = 17475351,
title = "{Integrated evaluation of hypertensive patients with cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/17475351",
volume = 125,
year = 2008
}
Rohit Khurana, Joseph Shalhoub, Anju Verma, Ravi Assomull, Sanjay K Prasad, Jaspal S Kooner and Amarjit Sethi.
Tubercular myocarditis presenting with ventricular tachycardia..
Nature clinical practice. Cardiovascular medicine 5(3):169–74, March 2008.
URL, DOI BibTeX
@article{Khurana2008,
abstract = "A previously fit and healthy 30-year-old man reported experiencing palpitations accompanied by nausea, sweating and presyncope. These symptoms were found to be associated with episodes of nonsustained ventricular tachycardia. He was a nonsmoker, did not drink excessively, denied illicit drug use and had no family history of structural cardiac disease or sudden death.",
author = "Khurana, Rohit and Shalhoub, Joseph and Verma, Anju and Assomull, Ravi and Prasad, Sanjay K and Kooner, Jaspal S and Sethi, Amarjit",
doi = "10.1038/ncpcardio1111",
issn = "1743-4300",
journal = "Nature clinical practice. Cardiovascular medicine",
keywords = "Adult,Antitubercular Agents,Antitubercular Agents: therapeutic use,Diagnosis, Differential,Electrocardiography,Emergency Service, Hospital,Follow-Up Studies,Gadolinium,Gadolinium: diagnostic use,Humans,Magnetic Resonance Imaging,Male,Myocarditis,Myocarditis: diagnosis,Myocarditis: drug therapy,Myocarditis: microbiology,Risk Assessment,Severity of Illness Index,Tachycardia, Ventricular,Tachycardia, Ventricular: diagnosis,Tachycardia, Ventricular: therapy,Tomography, X-Ray Computed,Treatment Outcome,Tuberculosis, Cardiovascular,Tuberculosis, Cardiovascular: diagnosis,Tuberculosis, Cardiovascular: drug therapy",
month = "mar",
number = 3,
pages = "169--74",
pmid = 18212772,
title = "{Tubercular myocarditis presenting with ventricular tachycardia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18212772",
volume = 5,
year = 2008
}
Carolyn M Webb, Andrew G Elkington, Mustafa M Kraidly, Niall Keenan, Dudley J Pennell and Peter Collins.
Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease..
The American journal of cardiology 101(5):618–24, March 2008.
URL, DOI BibTeX
@article{Webb2008,
abstract = "Intracoronary testosterone infusions induce coronary vasodilatation and increase coronary blood flow. Longer term testosterone supplementation favorably affected signs of myocardial ischemia in men with low plasma testosterone and coronary heart disease. However, the effects on myocardial perfusion are unknown. Effects of longer term testosterone treatment on myocardial perfusion and vascular function were investigated in men with CHD and low plasma testosterone. Twenty-two men (mean age 57 +/- 9 [SD] years) were randomly assigned to oral testosterone undecanoate (TU; 80 mg twice daily) or placebo in a crossover study design. After each 8-week period, subjects underwent at rest and adenosine-stress first-pass myocardial perfusion cardiovascular magnetic resonance, pulse-wave analysis, and endothelial function measurements using radial artery tonometry, blood sampling, anthropomorphic measurements, and quality-of-life assessment. Although no difference was found in global myocardial perfusion after TU compared with placebo, myocardium supplied by unobstructed coronary arteries showed increased perfusion (1.83 +/- 0.9 vs 1.52 +/- 0.65; p = 0.037). TU decreased basal radial and aortic augmentation indexes (p = 0.03 and p = 0.02, respectively), indicating decreased arterial stiffness, but there was no effect on endothelial function. TU significantly decreased high-density lipoprotein cholesterol and increased hip circumference, but had no effect on hemostatic factors, quality of life, and angina symptoms. In conclusion, oral TU had selective and modest enhancing effects on perfusion in myocardium supplied by unobstructed coronary arteries, in line with previous intracoronary findings. The TU-related decrease in basal arterial stiffness may partly explain previously shown effects of exogenous testosterone on signs of exercise-induced myocardial ischemia.",
author = "Webb, Carolyn M and Elkington, Andrew G and Kraidly, Mustafa M and Keenan, Niall and Pennell, Dudley J and Collins, Peter",
doi = "10.1016/j.amjcard.2007.09.114",
issn = "0002-9149",
journal = "The American journal of cardiology",
keywords = "Administration, Oral,Adult,Aged,Androgens,Androgens: therapeutic use,Blood Flow Velocity,Blood Flow Velocity: drug effects,Blood Pressure,Blood Pressure: drug effects,Coronary Circulation,Coronary Circulation: drug effects,Coronary Disease,Coronary Disease: epidemiology,Cross-Over Studies,Endothelium, Vascular,Endothelium, Vascular: drug effects,Hematocrit,Hip,Hip: anatomy {\&} histology,Humans,Lipoproteins,Lipoproteins: blood,Lipoproteins: drug effects,Magnetic Resonance Imaging, Cine,Male,Manometry,Middle Aged,Stroke Volume,Stroke Volume: drug effects,Testosterone,Testosterone: analogs {\&} derivatives,Testosterone: blood,Testosterone: therapeutic use",
month = "mar",
number = 5,
pages = "618--24",
pmid = 18308009,
title = "{Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2258313{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 101,
year = 2008
}
Julian W Strange, Chiara Bucciarelli-Ducci, Anthony Mathur and Dudley J Pennell.
Images in cardiovascular medicine. Multiple coronary fistulae: a cause of subendocardial ischemia..
Circulation 117(6):853–6, February 2008.
URL, DOI BibTeX
@article{Strange2008,
author = "Strange, Julian W and Bucciarelli-Ducci, Chiara and Mathur, Anthony and Pennell, Dudley J",
doi = "10.1161/CIRCULATIONAHA.107.725515",
issn = "1524-4539",
journal = "Circulation",
keywords = "Coronary Angiography,Coronary Disease,Coronary Disease: pathology,Coronary Disease: radiography,Electrocardiography,Female,Fistula,Fistula: complications,Fistula: pathology,Fistula: radiography,Heart Diseases,Heart Diseases: pathology,Heart Diseases: radiography,Humans,Magnetic Resonance Imaging,Middle Aged,Myocardial Ischemia,Myocardial Ischemia: etiology,Vascular Fistula,Vascular Fistula: pathology,Vascular Fistula: radiography",
month = "feb",
number = 6,
pages = "853--6",
pmid = 18268162,
title = "{Images in cardiovascular medicine. Multiple coronary fistulae: a cause of subendocardial ischemia.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18268162",
volume = 117,
year = 2008
}
N G Keenan, D J Pennell and R H Mohiaddin.
Glagov remodelling in the atherosclerotic carotid artery by cardiovascular magnetic resonance..
Heart (British Cardiac Society) 94(2):228, February 2008.
URL, DOI BibTeX
@article{Keenan2008,
author = "Keenan, N G and Pennell, D J and Mohiaddin, R H",
doi = "10.1136/hrt.2006.108225",
issn = "1468-201X",
journal = "Heart (British Cardiac Society)",
keywords = "Aged,Atherosclerosis,Atherosclerosis: diagnosis,Carotid Artery, Internal,Carotid Artery, Internal: physiopathology,Carotid Stenosis,Carotid Stenosis: diagnosis,Carotid Stenosis: physiopathology,Humans,Magnetic Resonance Angiography,Male",
month = "feb",
number = 2,
pages = 228,
pmid = 18195127,
title = "{Glagov remodelling in the atherosclerotic carotid artery by cardiovascular magnetic resonance.}",
url = "http://heart.bmj.com/content/94/2/228.extract",
volume = 94,
year = 2008
}
Abbas Rashid, Gurpal Ahluwalia, Massimo Griselli, Michaela Scheuermann-Freestone, Stefan Neubauer, Michael Gaztoulis, Phillip Kilner and Darryl F Shore.
Congenital partial absence of the left pericardium associated with tricuspid regurgitation..
The Annals of thoracic surgery 85(2):645–7, February 2008.
URL, DOI BibTeX
@article{Rashid2008,
abstract = "We report the case of a 47-year-old man who presented with several episodes of left precordial pain, one of which had been severe, but was unrelated to exertion or posture. Transthoracic echocardiography and cardiovascular magnetic resonance showed evidence of congenital partial absence of the left pericardium and severe tricuspid regurgitation. Both diagnoses were confirmed at surgery when the pericardial defect was repaired and the tricuspid valve was replaced at the same operation. He went on to make a good recovery.",
author = "Rashid, Abbas and Ahluwalia, Gurpal and Griselli, Massimo and Scheuermann-Freestone, Michaela and Neubauer, Stefan and Gaztoulis, Michael and Kilner, Phillip and Shore, Darryl F",
doi = "10.1016/j.athoracsur.2007.08.053",
issn = "1552-6259",
journal = "The Annals of thoracic surgery",
keywords = "Chest Pain,Chest Pain: diagnosis,Chest Pain: etiology,Combined Modality Therapy,Echocardiography, Transesophageal,Follow-Up Studies,Heart Defects, Congenital,Heart Defects, Congenital: diagnosis,Heart Defects, Congenital: surgery,Heart Valve Prosthesis Implantation,Heart Valve Prosthesis Implantation: methods,Humans,Male,Middle Aged,Pericardium,Pericardium: abnormalities,Pericardium: surgery,Risk Assessment,Treatment Outcome,Tricuspid Valve Insufficiency,Tricuspid Valve Insufficiency: surgery,Tricuspid Valve Insufficiency: ultrasonography",
month = "feb",
number = 2,
pages = "645--7",
pmid = 18222287,
title = "{Congenital partial absence of the left pericardium associated with tricuspid regurgitation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18222287",
volume = 85,
year = 2008
}
Robin Nijveldt, Philip J Kilner and Aernout M Beek.
Anomalies of ventricular septation and apical formation..
Cardiology in the young 18(1):117–8, February 2008.
URL, DOI BibTeX
@article{Nijveldt2008,
author = "Nijveldt, Robin and Kilner, Philip J and Beek, Aernout M",
doi = "10.1017/S1047951107001606",
issn = "1047-9511",
journal = "Cardiology in the young",
keywords = "Abnormalities, Multiple,Abnormalities, Multiple: diagnosis,Adolescent,Child,Diagnosis, Differential,Echocardiography,Female,Heart Septal Defects, Ventricular,Heart Septal Defects, Ventricular: diagnosis,Heart Ventricles,Heart Ventricles: abnormalities,Humans,Magnetic Resonance Imaging,Male,Severity of Illness Index",
month = "feb",
number = 1,
pages = "117--8",
pmid = 18031589,
title = "{Anomalies of ventricular septation and apical formation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18031589",
volume = 18,
year = 2008
}
John K M Chan, Ricardo Wage, Karen Symmonds, Shelley Rahman-Haley, Raad H Mohiaddin, David N Firmin, John R Pepper, Dudley J Pennell and Philip J Kilner.
Towards comprehensive assessment of mitral regurgitation using cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 10:61, January 2008.
URL, DOI BibTeX
@article{Chan2008,
abstract = "Cardiovascular magnetic resonance (CMR) is increasingly used to assess patients with mitral regurgitation. Its advantages include quantitative determination of ventricular volumes and function and the mitral regurgitant fraction, and in ischemic mitral regurgitation, regional myocardial function and viability. In addition to these, identification of leaflet prolapse or restriction is necessary when valve repair is contemplated. We describe a systematic approach to the evaluation of mitral regurgitation using CMR which we have used in 149 patients with varying etiologies and severity of regurgitation over a 15 month period. Following standard ventricular cine acquisitions, including 2, 3 and 4 chamber long axis views and a short axis stack for biventricular function, we image movements of all parts of the mitral leaflets using a contiguous stack of oblique long axis cines aligned orthogonal to the central part of the line of coaptation. The 8-10 slices in the stack, orientated approximately parallel to a 3-chamber view, are acquired sequentially from the superior (antero-lateral) mitral commissure to the inferior (postero-medial) commissure, visualising each apposing pair of anterior and posterior leaflet scallops in turn (A1-P1, A2-P2 and A3-P3). We use balanced steady state free precession imaging at 1.5 Tesla, slice thickness 5 mm, with no inter-slice gaps. Where the para-commissural coaptation lines curve relative to the central region, two further oblique cines are acquired orthogonal to the line of coaptation adjacent to each commissure. To quantify mitral regurgitation, we use phase contrast velocity mapping to measure aortic outflow, subtracting this from the left ventricular stroke volume to calculate the mitral regurgitant volume which, when divided by the left ventricular stroke volume, gives the mitral regurgitant fraction. In patients with ischemic mitral regurgitation, we further assess regional left ventricular function and, with late gadolinium enhancement, myocardial viability. Comprehensive assessment of mitral regurgitation using CMR is feasible and enables determination of mitral regurgitation severity, associated leaflet prolapse or restriction, ventricular function and viability in a single examination and is now routinely performed at our centre. The mitral valve stack of images is particularly useful and easy to acquire.",
author = "Chan, K M John and Wage, Ricardo and Symmonds, Karen and Rahman-Haley, Shelley and Mohiaddin, Raad H and Firmin, David N and Pepper, John R and Pennell, Dudley J and Kilner, Philip J",
doi = "10.1186/1532-429X-10-61",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Chan et al. - 2008 - Towards comprehensive assessment of mitral regurgitation using cardiovascular magnetic resonance.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging, Cine,Mitral Valve Insufficiency,Mitral Valve Insufficiency: etiology,Mitral Valve Insufficiency: pathology,Mitral Valve Insufficiency: physiopathology,Predictive Value of Tests,Severity of Illness Index,Ventricular Function, Left",
month = "jan",
pages = 61,
pmid = 19102740,
title = "{Towards comprehensive assessment of mitral regurgitation using cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2621154{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 10,
year = 2008
}
Paolo G Camici, Sanjay Kumak Prasad and Ornella E Rimoldi.
Stunning, hibernation, and assessment of myocardial viability..
Circulation 117(1):103–14, January 2008.
URL, DOI BibTeX
@article{Camici2008,
author = "Camici, Paolo G and Prasad, Sanjay Kumak and Rimoldi, Ornella E",
doi = "10.1161/CIRCULATIONAHA.107.702993",
issn = "1524-4539",
journal = "Circulation",
keywords = "Algorithms,Coronary Artery Disease,Heart Function Tests,Humans,Myocardial Stunning,Myocardial Stunning: physiopathology,Myocardium,Myocardium: pathology,Ventricular Dysfunction, Left",
month = "jan",
number = 1,
pages = "103--14",
pmid = 18172050,
title = "{Stunning, hibernation, and assessment of myocardial viability.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18172050",
volume = 117,
year = 2008
}
Taigang He, Paul Kirk, David N Firmin, Wynnie M Lam, Winnie C W Chu, Wing-Yan Au, Godfrey C F Chan, Ru San Tan, Ivy Ng, Selen Biceroglu, Yesim Aydinok, Mark A Fogel, Alan R Cohen and Dudley J Pennell.
Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 10:11, January 2008.
URL, DOI BibTeX
@article{He2008,
abstract = "Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated.",
author = "He, Taigang and Kirk, Paul and Firmin, David N and Lam, Wynnie M and Chu, Winnie C W and Au, Wing-Yan and Chan, Godfrey C F and Tan, Ru San and Ng, Ivy and Biceroglu, Selen and Aydinok, Yesim and Fogel, Mark A and Cohen, Alan R and Pennell, Dudley J",
doi = "10.1186/1532-429X-10-11",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/He et al. - 2008 - Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adult,Hong Kong,Humans,Iron,Iron: metabolism,London,Magnetic Resonance Imaging,Magnetic Resonance Imaging: instrumentation,Magnetic Resonance Imaging: methods,Myocardium,Myocardium: metabolism,Myocardium: pathology,Observer Variation,Philadelphia,Predictive Value of Tests,Reproducibility of Results,Respiration,Singapore,Turkey,beta-Thalassemia,beta-Thalassemia: diagnosis,beta-Thalassemia: metabolism,beta-Thalassemia: physiopathology",
month = "jan",
pages = 11,
pmid = 18291040,
title = "{Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2279115{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 10,
year = 2008
}
Didier Locca, Pedro T Trindade, Michael Mullen and Philip J Kilner.
Late presentation of pulmonary valve stenosis confirmed by cardiovascular magnetic resonance..
Congenital heart disease 3(3):216–8, 2008.
URL, DOI BibTeX
@article{Locca,
abstract = "We describe the case of a 70-year-old man who presented with increasing exertional dyspnea. He was found to have an ejection systolic murmur and evidence of right ventricular outflow tract obstruction, with a peak velocity of 4.5 m/s recorded by transthoracic Doppler echocardiography. Cardiovascular magnetic resonance showed right ventricular hypertrophy, pulmonary valve stenosis, peak recorded velocity 4.2 m/s, with thickened pulmonary valve leaflets of reduced mobility, and poststenotic dilatation of the main pulmonary artery. The case illustrates that severe pulmonary valve stenosis can present late in life and that cardiovascular magnetic resonance can be useful in clarifying nature and level of right ventricular outflow tract obstruction in an adult.",
author = "Locca, Didier and Trindade, Pedro T and Mullen, Michael and Kilner, Philip J",
doi = "10.1111/j.1747-0803.2008.00152.x",
issn = "1747-0803",
journal = "Congenital heart disease",
keywords = "Aged,Humans,Magnetic Resonance Imaging,Male,Pulmonary Valve Stenosis,Pulmonary Valve Stenosis: diagnosis,Severity of Illness Index",
number = 3,
pages = "216--8",
pmid = 18557887,
title = "{Late presentation of pulmonary valve stenosis confirmed by cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18557887",
volume = 3,
year = 2008
}
Bernadette Modell, Maren Khan, Matthew Darlison, Mark A Westwood, David Ingram and Dudley J Pennell.
Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 10:42, January 2008.
URL, DOI BibTeX
@article{Modell2008,
abstract = "The UK Thalassaemia Register records births, deaths and selected clinical data of patients with thalassaemia who are resident in the UK. A study of survival and causes of death was undertaken which aimed to include the possible impact of T2* cardiovascular magnetic resonance (CMR).",
author = "Modell, Bernadette and Khan, Maren and Darlison, Matthew and Westwood, Mark A and Ingram, David and Pennell, Dudley J",
doi = "10.1186/1532-429X-10-42",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Modell et al. - 2008 - Improved survival of thalassaemia major in the UK and relation to T2 cardiovascular magnetic resonance.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Adolescent,Adult,Anemia,Anemia: etiology,Anemia: mortality,Bone Marrow Transplantation,Bone Marrow Transplantation: adverse effects,Bone Marrow Transplantation: mortality,Cardiomyopathies,Cardiomyopathies: etiology,Cardiomyopathies: mortality,Cardiomyopathies: pathology,Cardiomyopathies: therapy,Cause of Death,Child,Child, Preschool,Communicable Diseases,Communicable Diseases: complications,Communicable Diseases: mortality,Female,Great Britain,Humans,Iron Chelating Agents,Iron Chelating Agents: therapeutic use,Iron Overload,Iron Overload: etiology,Iron Overload: mortality,Iron Overload: pathology,Iron Overload: therapy,Life Expectancy,Magnetic Resonance Imaging,Male,Middle Aged,Pyridones,Pyridones: therapeutic use,Registries,Time Factors,Treatment Outcome,Young Adult,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: mortality,beta-Thalassemia: pathology,beta-Thalassemia: therapy",
month = "jan",
pages = 42,
pmid = 18817553,
title = "{Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2563008{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 10,
year = 2008
}
William A Schiavone, Christopher Baker and Sanjay K Prasad.
Imaging myocardial carcinoid with T2-STIR CMR..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 10(1):14, January 2008.
URL, DOI BibTeX
@article{Schiavone2008,
abstract = "We used T2-STIR (Short Tau Inversion Recovery) cardiovascular magnetic resonance to demonstrate carcinoid tumor metastases to the heart and liver in a 64-year-old woman with a biopsy-proven ileal carcinoid tumor who was referred because of an abnormal echocardiogram.",
author = "Schiavone, William A and Baker, Christopher and Prasad, Sanjay K",
doi = "10.1186/1532-429X-10-14",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Schiavone, Baker, Prasad - 2008 - Imaging myocardial carcinoid with T2-STIR CMR.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Carcinoid Tumor,Carcinoid Tumor: diagnosis,Carcinoid Tumor: secondary,Contrast Media,Female,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Heart Neoplasms,Heart Neoplasms: diagnosis,Heart Neoplasms: secondary,Humans,Ileal Neoplasms,Ileal Neoplasms: pathology,Liver Neoplasms,Liver Neoplasms: diagnosis,Liver Neoplasms: secondary,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Middle Aged",
month = "jan",
number = 1,
pages = 14,
pmid = 18353183,
title = "{Imaging myocardial carcinoid with T2-STIR CMR.}",
url = "http://www.jcmr-online.com/content/10/1/14",
volume = 10,
year = 2008
}
Rory O'Hanlon, Sanjay K Prasad and Dudley J Pennell.
Evaluation of nonischemic cardiomyopathies using cardiovascular magnetic resonance..
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 15(3):400–16, 2008.
URL, DOI BibTeX
@article{O'Hanlon,
author = "O'Hanlon, Rory and Prasad, Sanjay K and Pennell, Dudley J",
doi = "10.1016/j.nuclcard.2008.03.006",
issn = "1532-6551",
journal = "Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology",
keywords = "Cardiomyopathies,Cardiomyopathies: complications,Cardiomyopathies: diagnosis,Computer-Assisted,Computer-Assisted: methods,Humans,Image Enhancement,Image Enhancement: methods,Image Interpretation,Left,Left: complications,Left: diagnosis,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Myocardial Ischemia,Myocardial Ischemia: diagnosis,Ventricular Dysfunction",
number = 3,
pages = "400--16",
pmid = 18513647,
title = "{Evaluation of nonischemic cardiomyopathies using cardiovascular magnetic resonance.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18513647",
volume = 15,
year = 2008
}
Mark A Tanner, Renzo Galanello, Carlo Dessi, Gillian C Smith, Mark A Westwood, Annalisa Agus, Martina Pibiri, Sunil V Nair, Malcolm J Walker and Dudley J Pennell.
Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 10:12, January 2008.
URL, DOI BibTeX
@article{Tanner2008,
abstract = "In thalassemia major (TM), severe cardiac siderosis can be treated by continuous parenteral deferoxamine, but poor compliance, complications and deaths occur. Combined chelation therapy with deferiprone and deferoxamine is effective for moderate myocardial siderosis, but has not been prospectively examined in severe myocardial siderosis.",
author = "Tanner, Mark A and Galanello, Renzo and Dessi, Carlo and Smith, Gillian C and Westwood, Mark A and Agus, Annalisa and Pibiri, Martina and Nair, Sunil V and Walker, J Malcolm and Pennell, Dudley J",
doi = "10.1186/1532-429X-10-12",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Tanner et al. - 2008 - Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventri.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Administration, Oral,Adult,Cardiomyopathies,Cardiomyopathies: complications,Cardiomyopathies: drug therapy,Cardiomyopathies: etiology,Cardiomyopathies: metabolism,Cardiomyopathies: pathology,Cardiomyopathies: physiopathology,Deferoxamine,Deferoxamine: administration {\&} dosage,Deferoxamine: adverse effects,Deferoxamine: therapeutic use,Drug Therapy, Combination,Female,Ferritins,Ferritins: blood,Humans,Injections, Subcutaneous,Iron,Iron Chelating Agents,Iron Chelating Agents: administration {\&} dosage,Iron Chelating Agents: adverse effects,Iron Chelating Agents: therapeutic use,Iron: metabolism,Italy,Liver,Liver: drug effects,Liver: metabolism,Magnetic Resonance Imaging,Male,Myocardium,Myocardium: metabolism,Natriuretic Peptide, Brain,Natriuretic Peptide, Brain: blood,Prospective Studies,Pyridones,Pyridones: administration {\&} dosage,Pyridones: adverse effects,Pyridones: therapeutic use,Severity of Illness Index,Siderosis,Siderosis: complications,Siderosis: drug therapy,Siderosis: etiology,Siderosis: metabolism,Siderosis: pathology,Siderosis: physiopathology,Stroke Volume,Stroke Volume: drug effects,Treatment Outcome,Ventricular Dysfunction, Left,Ventricular Dysfunction, Left: drug therapy,Ventricular Dysfunction, Left: etiology,Ventricular Dysfunction, Left: metabolism,Ventricular Dysfunction, Left: physiopathology,beta-Thalassemia,beta-Thalassemia: complications,beta-Thalassemia: drug therapy,beta-Thalassemia: metabolism,beta-Thalassemia: pathology,beta-Thalassemia: physiopathology",
month = "jan",
pages = 12,
pmid = 18298856,
title = "{Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2289829{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 10,
year = 2008
}
Alicia M Maceira, Sanjay K Prasad, Philip N Hawkins, Michael Roughton and Dudley J Pennell.
Cardiovascular magnetic resonance and prognosis in cardiac amyloidosis..
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 10:54, January 2008.
URL, DOI BibTeX
@article{Maceira2008a,
abstract = "Cardiac involvement is common in amyloidosis and associated with a variably adverse outcome. We have previously shown that cardiovascular magnetic resonance (CMR) can assess deposition of amyloid protein in the myocardial interstitium. In this study we assessed the prognostic value of late gadolinium enhancement (LGE) and gadolinium kinetics in cardiac amyloidosis in a prospective longitudinal study.",
author = "Maceira, Alicia M and Prasad, Sanjay K and Hawkins, Philip N and Roughton, Michael and Pennell, Dudley J",
doi = "10.1186/1532-429X-10-54",
file = ":C$\backslash$:/Users/yk822/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Maceira et al. - 2008 - Cardiovascular magnetic resonance and prognosis in cardiac amyloidosis.pdf:pdf",
issn = "1532-429X",
journal = "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
keywords = "Aged,Amyloidosis,Amyloidosis: metabolism,Amyloidosis: mortality,Amyloidosis: pathology,Biological Markers,Biological Markers: blood,Biopsy,Cardiomyopathies,Cardiomyopathies: metabolism,Cardiomyopathies: mortality,Cardiomyopathies: pathology,Contrast Media,Contrast Media: diagnostic use,Contrast Media: pharmacokinetics,Echocardiography, Doppler,Female,Gadolinium DTPA,Gadolinium DTPA: diagnostic use,Gadolinium DTPA: pharmacokinetics,Humans,Kaplan-Meier Estimate,Longitudinal Studies,Magnetic Resonance Imaging,Male,Middle Aged,Myocardium,Myocardium: metabolism,Myocardium: pathology,Natriuretic Peptide, Brain,Natriuretic Peptide, Brain: blood,Peptide Fragments,Peptide Fragments: blood,Predictive Value of Tests,Prognosis,Prospective Studies,Risk Assessment,Severity of Illness Index,Time Factors",
month = "jan",
pages = 54,
pmid = 19032744,
title = "{Cardiovascular magnetic resonance and prognosis in cardiac amyloidosis.}",
url = "http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2605441{\&}tool=pmcentrez{\&}rendertype=abstract",
volume = 10,
year = 2008
}
Anna S John, Marco Mongillo, Christophe Depre, Muhammad T Khan, Ornella E Rimoldi, John R Pepper, Gilles D Dreyfus, Dudley J Pennell and Paolo G Camici.
Pre- and post-synaptic sympathetic function in human hibernating myocardium..
European journal of nuclear medicine and molecular imaging 34(12):1973–80, December 2007.
URL, DOI BibTeX
@article{John2007,
abstract = "Impaired pre-synaptic noradrenaline uptake-1 mechanism has been reported in a swine model of hibernating myocardium (HM). To ascertain whether adrenergic neuroeffector abnormalities are present in human HM, we combined functional measurements in vivo using cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) to assess pre- and post-synaptic sympathetic function.",
author = "John, Anna S and Mongillo, Marco and Depre, Christophe and Khan, Muhammad T and Rimoldi, Ornella E and Pepper, John R and Dreyfus, Gilles D and Pennell, Dudley J and Camici, Paolo G",
doi = "10.1007/s00259-007-0507-1",
issn = "1619-7070",
journal = "European journal of nuclear medicine and molecular imaging",
keywords = "Aged,Aged, 80 and over,Coronary Artery Disease,Coronary Artery Disease: complications,Coronary Artery Disease: metabolism,Coronary Artery Disease: radionuclide imaging,Humans,Middle Aged,Myocardial Stunning,Myocardial Stunning: etiology,Myocardial Stunning: metabolism,Myocardial Stunning: radionuclide imaging,Norepinephrine,Norepinephrine: metabolism,Receptors, Adrenergic, beta,Receptors, Adrenergic, beta: metabolism,Sympathetic Nervous System,Sympathetic Nervous System: physiopathology,Sympathetic Nervous System: radionuclide imaging,Synapses,Synapses: metabolism,Synapses: radionuclide imaging",
month = "dec",
number = 12,
pages = "1973--80",
pmid = 17661029,
title = "{Pre- and post-synaptic sympathetic function in human hibernating myocardium.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/17661029",
volume = 34,
year = 2007
}
Caterina Silva, James C Moon, Andrew G Elkington, Anna S John, Raad H Mohiaddin and Dudley J Pennell.
Myocardial late gadolinium enhancement in specific cardiomyopathies by cardiovascular magnetic resonance: a preliminary experience..
Journal of cardiovascular medicine (Hagerstown, Md.) 8(12):1076–9, December 2007.
URL, DOI BibTeX
@article{Silva2007a,
abstract = "Late gadolinium enhancement cardiovascular magnetic resonance (CMR) can visualize myocardial interstitial abnormalities. The aim of this study was to assess whether regions of abnormal myocardium can also be visualized by late enhancement gadolinium CMR in the specific cardiomyopathies. A retrospective review of all referrals for gadolinium CMR with specific cardiomyopathy over 20 months. Nine patients with different specific cardiomyopathies were identified. Late enhancement was demonstrated in all patients, with a mean signal intensity of 390 +/- 220{\%} compared with normal regions. The distribution pattern of late enhancement was unlike the subendocardial late enhancement related to coronary territories found in myocardial infarction. The affected areas included papillary muscles (sarcoid), the mid-myocardium (Anderson-Fabry disease, glycogen storage disease, myocarditis, Becker muscular dystrophy) and the global sub-endocardium (systemic sclerosis, Loeffler's endocarditis, amyloid, Churg-Strauss). Focal myocardial late gadolinium enhancement is found in the specific cardiomyopathies, and the pattern is distinct from that seen in infarction. Further systematic studies are warranted to assess whether the pattern and extent of late enhancement may aid diagnosis and prognostic assessment.",
author = "Silva, Caterina and Moon, James C and Elkington, Andrew G and John, Anna S and Mohiaddin, Raad H and Pennell, Dudley J",
doi = "10.2459/01.JCM.0000296538.82763.f0",
issn = "1558-2027",
journal = "Journal of cardiovascular medicine (Hagerstown, Md.)",
keywords = "Adult,Cardiomyopathies,Cardiomyopathies: etiology,Cardiomyopathies: pathology,Contrast Media,Endocardium,Endocardium: pathology,Female,Gadolinium,Gadolinium: diagnostic use,Humans,Image Interpretation, Computer-Assisted,Magnetic Resonance Imaging, Cine,Male,Middle Aged,Myocardium,Myocardium: pathology,Papillary Muscles,Papillary Muscles: pathology,Predictive Value of Tests,Retrospective Studies",
month = "dec",
number = 12,
pages = "1076--9",
pmid = 18163027,
title = "{Myocardial late gadolinium enhancement in specific cardiomyopathies by cardiovascular magnetic resonance: a preliminary experience.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/18163027",
volume = 8,
year = 2007
}
Mauricio Arruda, Hanka Mlcochova, Subramanya K Prasad, Fethi Kilicaslan, Walid Saliba, Dimpi Patel, Tamer Fahmy, Luis Saenz Morales, Robert Schweikert, David Martin, David Burkhardt, Jennifer Cummings, Mandeep Bhargava, Thomas Dresing, Oussama Wazni, Mohamed Kanj and Andrea Natale.
Electrical isolation of the superior vena cava: an adjunctive strategy to pulmonary vein antrum isolation improving the outcome of AF ablation..
Journal of cardiovascular electrophysiology 18(12):1261–6, December 2007.
URL, DOI BibTeX
@article{Arruda2007,
abstract = "PV isolation at the antrum (PVAI) has improved safety and efficacy of ablation procedures for atrial fibrillation (AF). AF triggers from the superior vena cava (SVC) may compromise the outcome of PVAI.",
author = "Arruda, Mauricio and Mlcochova, Hanka and Prasad, Subramanya K and Kilicaslan, Fethi and Saliba, Walid and Patel, Dimpi and Fahmy, Tamer and Morales, Luis Saenz and Schweikert, Robert and Martin, David and Burkhardt, David and Cummings, Jennifer and Bhargava, Mandeep and Dresing, Thomas and Wazni, Oussama and Kanj, Mohamed and Natale, Andrea",
doi = "10.1111/j.1540-8167.2007.00953.x",
issn = "1540-8167",
journal = "Journal of cardiovascular electrophysiology",
keywords = "Atrial Fibrillation,Atrial Fibrillation: diagnosis,Atrial Fibrillation: epidemiology,Atrial Fibrillation: surgery,Catheter Ablation,Catheter Ablation: statistics {\&} numerical data,Combined Modality Therapy,Female,Heart Conduction System,Heart Conduction System: surgery,Humans,Male,Middle Aged,Ohio,Ohio: epidemiology,Pulmonary Veins,Pulmonary Veins: surgery,Treatment Outcome,Vena Cava, Superior,Vena Cava, Superior: surgery",
month = "dec",
number = 12,
pages = "1261--6",
pmid = 17850288,
title = "{Electrical isolation of the superior vena cava: an adjunctive strategy to pulmonary vein antrum isolation improving the outcome of AF ablation.}",
url = "http://www.ncbi.nlm.nih.gov/pubmed/17850288",
volume = 18,
year = 2007
}
Jonathan C Lyne, Peter D Gatehouse, Ravi G Assomull, Gillian C Smith, Peter Kellman, David N Firmin and Dudley J Pennell.
Direct comparison of myocardial perfusion cardiovascular magnetic resonance sequences with parallel acquisition..
Journal of magnetic resonance imaging : JMRI 26(6):1444–51, December 2007.
URL, DOI BibTeX
@article{Lyne2007a,
abstract = "To directly compare the three main myocardial perfusion cardiovascular magnetic resonance (CMR) sequences incorporating parallel acquisition methods.",
author = "Lyne, Jonathan C and Gatehouse, Peter D and Assomull, Ravi G and Smith, Gillian C and Kellman, Peter and Firmin, David N and Pennell, Dudley J",
doi = "10.1002/jmri.21167",
issn = "1053-1807",
journal = "Journal of magnetic resonance imaging : JMRI",
keywords = "Artifacts,Contrast Media,Coronary Vessels,Coronary Vessels: anatomy {\&} histology,Female,Gadolinium DTPA,Humans,Image Enhancement,Image Interpr